1rpw - Revision history

OCA at 06:07, 23 August 2023

OCA — Wed, 23 Aug 2023 06:07:11 GMT

←Older revision		Revision as of 06:07, 23 August 2023
Line 3:		Line 3:
	<StructureSection load='1rpw' size='340' side='right'caption='[[1rpw]], [[Resolution\|resolution]] 2.90Å' scene=''>		<StructureSection load='1rpw' size='340' side='right'caption='[[1rpw]], [[Resolution\|resolution]] 2.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1rpw]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/~~"micrococcus_aureus"_(rosenbach_1884)_zopf_1885 "micrococcus~~ aureus~~" (rosenbach 1884) zopf 1885~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RPW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1RPW FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1rpw]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RPW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1RPW FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=DID:4~~,4[~~1,6-HEXANEDIYLBIS(OXY)~~]~~BISBENZENECARBOXIMIDAMIDE'>DID</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.9Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"><~~div style~~='~~overflow~~: ~~auto; max-height: 3em;'>[[1jt6\|1jt6]]~~, [~~[1jty\|1jty]]~~, ~~[[1jus\|1jus~~]~~]</div~~></td><~~/tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DID:4,4[1,6-HEXANEDIYLBIS(OXY)]BISBENZENECARBOXIMIDAMIDE'>DID</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	~~<tr id~~='~~gene'><td class~~=~~"sblockLbl"><b>[[Gene\|Gene~~:~~]]</b~~></td>~~<td class="sblockDat">QACR, SAVP031 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1280 "Micrococcus aureus" (Rosenbach 1884) Zopf 1885])~~</td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1rpw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1rpw OCA], [https://pdbe.org/1rpw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1rpw RCSB], [https://www.ebi.ac.uk/pdbsum/1rpw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1rpw ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1rpw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1rpw OCA], [https://pdbe.org/1rpw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1rpw RCSB], [https://www.ebi.ac.uk/pdbsum/1rpw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1rpw ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/QACR_STAAU QACR_STAAU]] Transcriptional repressor of qacA. Binds to IR1, an unusually long 28 bp operator, which is located downstream from the qacA promoter and overlaps its transcription start site. QacR is induced from its IR1 site by binding to one of many structurally dissimilar cationic lipophilic compounds, which are also substrates of QacA.	+	[https://www.uniprot.org/uniprot/QACR_STAAU QACR_STAAU] Transcriptional repressor of qacA. Binds to IR1, an unusually long 28 bp operator, which is located downstream from the qacA promoter and overlaps its transcription start site. QacR is induced from its IR1 site by binding to one of many structurally dissimilar cationic lipophilic compounds, which are also substrates of QacA.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 33:		Line 32:
	==See Also==		==See Also==
	*[[Tetracycline repressor protein 3D structures\|Tetracycline repressor protein 3D structures]]		*[[Tetracycline repressor protein 3D structures\|Tetracycline repressor protein 3D structures]]
		+	*[[Transcriptional activator 3D structures\|Transcriptional activator 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 38:		Line 38:
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Brennan, R G~~]]	+	[[Category: Staphylococcus aureus]]
-	[[Category: ~~Murray, D S~~]]	+	[[Category: Brennan RG]]
-	[[Category: ~~Schumacher, M A~~]]	+	[[Category: Murray DS]]
-	[[Category: ~~Qacr hexamidine]]~~	+	[[Category: Schumacher MA]]
-	~~[[Category: Transcription~~]]	+

OCA at 15:27, 27 October 2021

OCA — Wed, 27 Oct 2021 15:27:27 GMT

←Older revision		Revision as of 15:27, 27 October 2021
Line 3:		Line 3:
	<StructureSection load='1rpw' size='340' side='right'caption='[[1rpw]], [[Resolution\|resolution]] 2.90Å' scene=''>		<StructureSection load='1rpw' size='340' side='right'caption='[[1rpw]], [[Resolution\|resolution]] 2.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1rpw]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/"micrococcus_aureus"_(rosenbach_1884)_zopf_1885 "micrococcus aureus" (rosenbach 1884) zopf 1885]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RPW OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=1RPW FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1rpw]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/"micrococcus_aureus"_(rosenbach_1884)_zopf_1885 "micrococcus aureus" (rosenbach 1884) zopf 1885]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RPW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1RPW FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DID:4,4[1,6-HEXANEDIYLBIS(OXY)]BISBENZENECARBOXIMIDAMIDE'>DID</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DID:4,4[1,6-HEXANEDIYLBIS(OXY)]BISBENZENECARBOXIMIDAMIDE'>DID</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1jt6\|1jt6]], [[1jty\|1jty]], [[1jus\|1jus]]</div></td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1jt6\|1jt6]], [[1jty\|1jty]], [[1jus\|1jus]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">QACR, SAVP031 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1280 "Micrococcus aureus" (Rosenbach 1884) Zopf 1885])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">QACR, SAVP031 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1280 "Micrococcus aureus" (Rosenbach 1884) Zopf 1885])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=1rpw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1rpw OCA], [~~http~~://pdbe.org/1rpw PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1rpw RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1rpw PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1rpw ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1rpw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1rpw OCA], [https://pdbe.org/1rpw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1rpw RCSB], [https://www.ebi.ac.uk/pdbsum/1rpw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1rpw ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/QACR_STAAU QACR_STAAU]] Transcriptional repressor of qacA. Binds to IR1, an unusually long 28 bp operator, which is located downstream from the qacA promoter and overlaps its transcription start site. QacR is induced from its IR1 site by binding to one of many structurally dissimilar cationic lipophilic compounds, which are also substrates of QacA.	+	[[https://www.uniprot.org/uniprot/QACR_STAAU QACR_STAAU]] Transcriptional repressor of qacA. Binds to IR1, an unusually long 28 bp operator, which is located downstream from the qacA promoter and overlaps its transcription start site. QacR is induced from its IR1 site by binding to one of many structurally dissimilar cationic lipophilic compounds, which are also substrates of QacA.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 13:31, 16 December 2020

OCA — Wed, 16 Dec 2020 13:31:27 GMT

←Older revision		Revision as of 13:31, 16 December 2020
Line 1:		Line 1:

	==Crystal Structure Of The Multidrug Binding Protein Qacr Bound To The Diamidine Hexamidine==		==Crystal Structure Of The Multidrug Binding Protein Qacr Bound To The Diamidine Hexamidine==
-	<StructureSection load='1rpw' size='340' side='right' caption='[[1rpw]], [[Resolution\|resolution]] 2.90Å' scene=''>	+	<StructureSection load='1rpw' size='340' side='right'caption='[[1rpw]], [[Resolution\|resolution]] 2.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1rpw]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/"micrococcus_aureus"_(rosenbach_1884)_zopf_1885 "micrococcus aureus" (rosenbach 1884) zopf 1885]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RPW OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1RPW FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1rpw]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/"micrococcus_aureus"_(rosenbach_1884)_zopf_1885 "micrococcus aureus" (rosenbach 1884) zopf 1885]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RPW OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=1RPW FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DID:4,4[1,6-HEXANEDIYLBIS(OXY)]BISBENZENECARBOXIMIDAMIDE'>DID</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DID:4,4[1,6-HEXANEDIYLBIS(OXY)]BISBENZENECARBOXIMIDAMIDE'>DID</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1jt6\|1jt6]], [[1jty\|1jty]], [[1jus\|1jus]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1jt6\|1jt6]], [[1jty\|1jty]], [[1jus\|1jus]]</div></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">QACR, SAVP031 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1280 "Micrococcus aureus" (Rosenbach 1884) Zopf 1885])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">QACR, SAVP031 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1280 "Micrococcus aureus" (Rosenbach 1884) Zopf 1885])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1rpw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1rpw OCA], [http://pdbe.org/1rpw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1rpw RCSB], [http://www.ebi.ac.uk/pdbsum/1rpw PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1rpw ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=1rpw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1rpw OCA], [http://pdbe.org/1rpw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1rpw RCSB], [http://www.ebi.ac.uk/pdbsum/1rpw PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1rpw ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	</div>		</div>
	<div class="pdbe-citations 1rpw" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 1rpw" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Tetracycline repressor protein 3D structures\|Tetracycline repressor protein 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Brennan, R G]]		[[Category: Brennan, R G]]
	[[Category: Murray, D S]]		[[Category: Murray, D S]]

OCA at 07:19, 8 March 2018

OCA — Thu, 08 Mar 2018 07:19:02 GMT

←Older revision		Revision as of 07:19, 8 March 2018
Line 1:		Line 1:
		+
	==Crystal Structure Of The Multidrug Binding Protein Qacr Bound To The Diamidine Hexamidine==		==Crystal Structure Of The Multidrug Binding Protein Qacr Bound To The Diamidine Hexamidine==
	<StructureSection load='1rpw' size='340' side='right' caption='[[1rpw]], [[Resolution\|resolution]] 2.90Å' scene=''>		<StructureSection load='1rpw' size='340' side='right' caption='[[1rpw]], [[Resolution\|resolution]] 2.90Å' scene=''>
Line 6:		Line 7:
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1jt6\|1jt6]], [[1jty\|1jty]], [[1jus\|1jus]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1jt6\|1jt6]], [[1jty\|1jty]], [[1jus\|1jus]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">QACR, SAVP031 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1280 "Micrococcus aureus" (Rosenbach 1884) Zopf 1885])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">QACR, SAVP031 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1280 "Micrococcus aureus" (Rosenbach 1884) Zopf 1885])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1rpw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1rpw OCA], [http://pdbe.org/1rpw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1rpw RCSB], [http://www.ebi.ac.uk/pdbsum/1rpw PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1rpw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1rpw OCA], [http://pdbe.org/1rpw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1rpw RCSB], [http://www.ebi.ac.uk/pdbsum/1rpw PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1rpw ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 14:		Line 15:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/rp/1rpw_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/rp/1rpw_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1rpw ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 23:32, 11 September 2015

OCA — Fri, 11 Sep 2015 23:32:28 GMT

←Older revision		Revision as of 23:32, 11 September 2015
Line 2:		Line 2:
	<StructureSection load='1rpw' size='340' side='right' caption='[[1rpw]], [[Resolution\|resolution]] 2.90Å' scene=''>		<StructureSection load='1rpw' size='340' side='right' caption='[[1rpw]], [[Resolution\|resolution]] 2.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1rpw]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Staphylococcus_aureus Staphylococcus~~ aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RPW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1RPW FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1rpw]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/"micrococcus_aureus"_(rosenbach_1884)_zopf_1885 "micrococcus aureus" (rosenbach 1884) zopf 1885]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RPW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1RPW FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DID:4,4[1,6-HEXANEDIYLBIS(OXY)]BISBENZENECARBOXIMIDAMIDE'>DID</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DID:4,4[1,6-HEXANEDIYLBIS(OXY)]BISBENZENECARBOXIMIDAMIDE'>DID</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1jt6\|1jt6]], [[1jty\|1jty]], [[1jus\|1jus]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1jt6\|1jt6]], [[1jty\|1jty]], [[1jus\|1jus]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">QACR, SAVP031 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1280 ~~Staphylococcus~~ aureus])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">QACR, SAVP031 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1280 "Micrococcus aureus" (Rosenbach 1884) Zopf 1885])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1rpw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1rpw OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1rpw RCSB], [http://www.ebi.ac.uk/pdbsum/1rpw PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1rpw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1rpw OCA], [http://pdbe.org/1rpw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1rpw RCSB], [http://www.ebi.ac.uk/pdbsum/1rpw PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 28:		Line 28:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1rpw" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Staphylococcus aureus]]
	[[Category: Brennan, R G]]		[[Category: Brennan, R G]]
	[[Category: Murray, D S]]		[[Category: Murray, D S]]

OCA at 20:52, 25 December 2014

OCA — Thu, 25 Dec 2014 20:52:28 GMT

←Older revision		Revision as of 20:52, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1rpw]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RPW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1RPW FirstGlance]. <br>		<table><tr><td colspan='2'>[[1rpw]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RPW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1RPW FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DID:4,4[1,6-HEXANEDIYLBIS(OXY)]BISBENZENECARBOXIMIDAMIDE'>DID</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DID:4,4[1,6-HEXANEDIYLBIS(OXY)]BISBENZENECARBOXIMIDAMIDE'>DID</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1jt6\|1jt6]], [[1jty\|1jty]], [[1jus\|1jus]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1jt6\|1jt6]], [[1jty\|1jty]], [[1jus\|1jus]]</td></tr>
-	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">QACR, SAVP031 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1280 Staphylococcus aureus])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">QACR, SAVP031 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1280 Staphylococcus aureus])</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1rpw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1rpw OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1rpw RCSB], [http://www.ebi.ac.uk/pdbsum/1rpw PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1rpw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1rpw OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1rpw RCSB], [http://www.ebi.ac.uk/pdbsum/1rpw PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/QACR_STAAU QACR_STAAU]] Transcriptional repressor of qacA. Binds to IR1, an unusually long 28 bp operator, which is located downstream from the qacA promoter and overlaps its transcription start site. QacR is induced from its IR1 site by binding to one of many structurally dissimilar cationic lipophilic compounds, which are also substrates of QacA.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 31:		Line 33:
	</StructureSection>		</StructureSection>
	[[Category: Staphylococcus aureus]]		[[Category: Staphylococcus aureus]]
-	[[Category: Brennan, R G.]]	+	[[Category: Brennan, R G]]
-	[[Category: Murray, D S.]]	+	[[Category: Murray, D S]]
-	[[Category: Schumacher, M A.]]	+	[[Category: Schumacher, M A]]
	[[Category: Qacr hexamidine]]		[[Category: Qacr hexamidine]]
	[[Category: Transcription]]		[[Category: Transcription]]

OCA at 15:48, 29 September 2014

OCA — Mon, 29 Sep 2014 15:48:10 GMT

←Older revision		Revision as of 15:48, 29 September 2014
Line 1:		Line 1:
-	[[~~Image:~~1rpw.~~png~~\|~~left~~\|200px]]	+	==Crystal Structure Of The Multidrug Binding Protein Qacr Bound To The Diamidine Hexamidine==
		+	<StructureSection load='1rpw' size='340' side='right' caption='[[1rpw]], [[Resolution\|resolution]] 2.90Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1rpw]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RPW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1RPW FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DID:4,4[1,6-HEXANEDIYLBIS(OXY)]BISBENZENECARBOXIMIDAMIDE'>DID</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1jt6\|1jt6]], [[1jty\|1jty]], [[1jus\|1jus]]</td></tr>
		+	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">QACR, SAVP031 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1280 Staphylococcus aureus])</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1rpw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1rpw OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1rpw RCSB], [http://www.ebi.ac.uk/pdbsum/1rpw PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/rp/1rpw_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The Staphylococcus aureus multidrug-binding protein QacR represses transcription of the plasmid-encoded membrane protein QacA, a multidrug efflux transporter. QacR is induced by multiple structurally dissimilar monovalent and bivalent cationic lipophilic compounds, many of which are effluxed from the cell by QacA via the proton motive force. The multidrug-binding pocket of QacR has been shown to be quite extensive and features several glutamates and multiple aromatic residues. To date, the structure of only one QacR-bivalent cationic drug complex (that of QacR bound to dequalinium) has been determined, and how other longer or shorter bivalent cationic compounds bind is unknown. Here we report the crystal structures of QacR bound to two cytotoxic bivalent diamidines, pentamidine and hexamidine. These compounds are structurally similar, differing by only one methylene carbon in the alkyl chain linker. However, this small difference results in very dissimilar binding modes. Similar to dequalinium, hexamidine spans the multidrug-binding pocket, and its positively charged benzamidine groups are neutralized by residues Glu-57 and Glu-120. Pentamidine binds QacR in a novel fashion whereby one of its benzamidine groups interacts with residue Glu-63, and the other is neutralized by carbonyl and side chain oxygen atoms. Thus, these structures demonstrate that a formal negative charge is not a prerequisite for binding positively charged drugs and underscore the versatility of the QacR and, likely, all multidrug-binding pockets.

-	~~{{STRUCTURE_1rpw\| PDB=1rpw \| SCENE= }}~~	+	Crystal structures of QacR-diamidine complexes reveal additional multidrug-binding modes and a novel mechanism of drug charge neutralization.,Murray DS, Schumacher MA, Brennan RG J Biol Chem. 2004 Apr 2;279(14):14365-71. Epub 2004 Jan 15. PMID:14726520<ref>PMID:14726520</ref>

-	~~===Crystal Structure Of The Multidrug Binding Protein Qacr Bound To The Diamidine Hexamidine===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_14726520}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[1rpw]] is~~ a ~~4 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Staphylococcus_aureus Staphylococcus aureus]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=1RPW OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:014726520<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Staphylococcus aureus]]		[[Category: Staphylococcus aureus]]
	[[Category: Brennan, R G.]]		[[Category: Brennan, R G.]]

OCA: Protected "1rpw" [edit=sysop:move=sysop]

OCA — Fri, 04 Jan 2013 10:55:06 GMT

Protected "1rpw" [edit=sysop:move=sysop]

←Older revision

Revision as of 10:55, 4 January 2013

OCA at 10:55, 4 January 2013

OCA — Fri, 04 Jan 2013 10:55:03 GMT

←Older revision		Revision as of 10:55, 4 January 2013
Line 1:		Line 1:
-	{{Seed}}
	[[Image:1rpw.png\|left\|200px]]		[[Image:1rpw.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_1rpw", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_1rpw\| PDB=1rpw \| SCENE= }}		{{STRUCTURE_1rpw\| PDB=1rpw \| SCENE= }}

	===Crystal Structure Of The Multidrug Binding Protein Qacr Bound To The Diamidine Hexamidine===		===Crystal Structure Of The Multidrug Binding Protein Qacr Bound To The Diamidine Hexamidine===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_14726520}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 14726520 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_14726520}}		{{ABSTRACT_PUBMED_14726520}}

	==About this Structure==		==About this Structure==
-	~~1RPW~~ is a 4 ~~chains~~ structure ~~of sequences~~ from [http://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RPW OCA].	+	[[1rpw]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RPW OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~14726520~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:014726520</ref><references group="xtra"/>
	[[Category: Staphylococcus aureus]]		[[Category: Staphylococcus aureus]]
	[[Category: Brennan, R G.]]		[[Category: Brennan, R G.]]
Line 30:		Line 18:
	[[Category: Qacr hexamidine]]		[[Category: Qacr hexamidine]]
	[[Category: Transcription]]		[[Category: Transcription]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Jun 4 07:37:41 2009''

OCA at 04:37, 4 June 2009

OCA — Thu, 04 Jun 2009 04:37:43 GMT

←Older revision		Revision as of 04:37, 4 June 2009
Line 29:		Line 29:
	[[Category: Schumacher, M A.]]		[[Category: Schumacher, M A.]]
	[[Category: Qacr hexamidine]]		[[Category: Qacr hexamidine]]
		+	[[Category: Transcription]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Wed Feb 18 06:52~~:37 2009''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Jun 4 07:37:41 2009''