1ruq - Revision history

OCA at 06:08, 23 August 2023

OCA — Wed, 23 Aug 2023 06:08:29 GMT

←Older revision		Revision as of 06:08, 23 August 2023
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1ruq]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RUQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1RUQ FirstGlance]. <br>		<table><tr><td colspan='2'>[[1ruq]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RUQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1RUQ FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.86Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"><~~div style~~='~~overflow~~: ~~auto; max-height: 3em;~~'>~~[[1a3l\|1a3l]], [[1rur\|1rur]]~~</~~div~~></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ruq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ruq OCA], [https://pdbe.org/1ruq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ruq RCSB], [https://www.ebi.ac.uk/pdbsum/1ruq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ruq ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ruq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ruq OCA], [https://pdbe.org/1ruq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ruq RCSB], [https://www.ebi.ac.uk/pdbsum/1ruq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ruq ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/IGKC_MOUSE IGKC_MOUSE]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 36:		Line 38:
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
-	[[Category: Eschenmoser, A]]	+	[[Category: Eschenmoser A]]
-	[[Category: Lerner~~, R A~~]]	+	[[Category: Lerner RA]]
-	[[Category: Wentworth~~, A D~~]]	+	[[Category: Wentworth AD]]
-	[[Category: Wentworth, P]]	+	[[Category: Wentworth Jr P]]
-	[[Category: Wilson~~, I A~~]]	+	[[Category: Wilson IA]]
-	[[Category: Zhu, X]]	+	[[Category: Zhu X]]
-	~~[[Category: Amino acid modification]]~~	+
-	~~[[Category: Catalytic antibody]]~~	+
-	~~[[Category: Immune system]]~~	+
-	~~[[Category: Immunoglobulin]]~~	+
-	~~[[Category: Water oxidation~~]]	+

OCA at 07:22, 22 September 2021

OCA — Wed, 22 Sep 2021 07:22:15 GMT

←Older revision		Revision as of 07:22, 22 September 2021
Line 3:		Line 3:
	<StructureSection load='1ruq' size='340' side='right'caption='[[1ruq]], [[Resolution\|resolution]] 1.86Å' scene=''>		<StructureSection load='1ruq' size='340' side='right'caption='[[1ruq]], [[Resolution\|resolution]] 1.86Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1ruq]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RUQ OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1RUQ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1ruq]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RUQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1RUQ FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1a3l\|1a3l]], [[1rur\|1rur]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1a3l\|1a3l]], [[1rur\|1rur]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1ruq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ruq OCA], [~~http~~://pdbe.org/1ruq PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1ruq RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1ruq PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1ruq ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ruq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ruq OCA], [https://pdbe.org/1ruq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ruq RCSB], [https://www.ebi.ac.uk/pdbsum/1ruq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ruq ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==

OCA at 19:09, 11 December 2019

OCA — Wed, 11 Dec 2019 19:09:29 GMT

←Older revision		Revision as of 19:09, 11 December 2019
Line 1:		Line 1:

	==Crystal Structure (H) of u.v.-irradiated Diels-Alder antibody 13G5 Fab at pH 8.0 with a data set collected in house.==		==Crystal Structure (H) of u.v.-irradiated Diels-Alder antibody 13G5 Fab at pH 8.0 with a data set collected in house.==
-	<StructureSection load='1ruq' size='340' side='right' caption='[[1ruq]], [[Resolution\|resolution]] 1.86Å' scene=''>	+	<StructureSection load='1ruq' size='340' side='right'caption='[[1ruq]], [[Resolution\|resolution]] 1.86Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1ruq]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RUQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1RUQ FirstGlance]. <br>		<table><tr><td colspan='2'>[[1ruq]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RUQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1RUQ FirstGlance]. <br>
Line 34:		Line 34:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
	[[Category: Eschenmoser, A]]		[[Category: Eschenmoser, A]]

OCA at 06:41, 8 March 2018

OCA — Thu, 08 Mar 2018 06:41:21 GMT

←Older revision		Revision as of 06:41, 8 March 2018
Line 1:		Line 1:
		+
	==Crystal Structure (H) of u.v.-irradiated Diels-Alder antibody 13G5 Fab at pH 8.0 with a data set collected in house.==		==Crystal Structure (H) of u.v.-irradiated Diels-Alder antibody 13G5 Fab at pH 8.0 with a data set collected in house.==
	<StructureSection load='1ruq' size='340' side='right' caption='[[1ruq]], [[Resolution\|resolution]] 1.86Å' scene=''>		<StructureSection load='1ruq' size='340' side='right' caption='[[1ruq]], [[Resolution\|resolution]] 1.86Å' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1a3l\|1a3l]], [[1rur\|1rur]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1a3l\|1a3l]], [[1rur\|1rur]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ruq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ruq OCA], [http://pdbe.org/1ruq PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1ruq RCSB], [http://www.ebi.ac.uk/pdbsum/1ruq PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ruq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ruq OCA], [http://pdbe.org/1ruq PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1ruq RCSB], [http://www.ebi.ac.uk/pdbsum/1ruq PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1ruq ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 11:		Line 12:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ru/1ruq_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ru/1ruq_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 28:		Line 29:

	==See Also==		==See Also==
-	*[[Monoclonal ~~Antibody~~\|Monoclonal ~~Antibody~~]]	+	*[[Monoclonal Antibodies 3D structures\|Monoclonal Antibodies 3D structures]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 02:06, 8 February 2016

OCA — Mon, 08 Feb 2016 02:06:07 GMT

←Older revision		Revision as of 02:06, 8 February 2016
Line 15:		Line 15:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1ruq ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 06:51, 10 September 2015

OCA — Thu, 10 Sep 2015 06:51:32 GMT

←Older revision		Revision as of 06:51, 10 September 2015
Line 5:		Line 5:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1a3l\|1a3l]], [[1rur\|1rur]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1a3l\|1a3l]], [[1rur\|1rur]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ruq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ruq OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1ruq RCSB], [http://www.ebi.ac.uk/pdbsum/1ruq PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ruq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ruq OCA], [http://pdbe.org/1ruq PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1ruq RCSB], [http://www.ebi.ac.uk/pdbsum/1ruq PDBsum]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 25:		Line 25:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1ruq" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==

OCA at 06:44, 6 January 2015

OCA — Tue, 06 Jan 2015 06:44:13 GMT

←Older revision		Revision as of 06:44, 6 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1ruq]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RUQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1RUQ FirstGlance]. <br>		<table><tr><td colspan='2'>[[1ruq]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RUQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1RUQ FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1a3l\|1a3l]], [[1rur\|1rur]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1a3l\|1a3l]], [[1rur\|1rur]]</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ruq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ruq OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1ruq RCSB], [http://www.ebi.ac.uk/pdbsum/1ruq PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ruq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ruq OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1ruq RCSB], [http://www.ebi.ac.uk/pdbsum/1ruq PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 33:		Line 33:
	</StructureSection>		</StructureSection>
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
-	[[Category: Eschenmoser, A.]]	+	[[Category: Eschenmoser, A]]
-	[[Category: Lerner, R A.]]	+	[[Category: Lerner, R A]]
-	[[Category: Wentworth, A D.]]	+	[[Category: Wentworth, A D]]
-	[[Category: Wentworth, P.]]	+	[[Category: Wentworth, P]]
-	[[Category: Wilson, I A.]]	+	[[Category: Wilson, I A]]
-	[[Category: Zhu, X.]]	+	[[Category: Zhu, X]]
	[[Category: Amino acid modification]]		[[Category: Amino acid modification]]
	[[Category: Catalytic antibody]]		[[Category: Catalytic antibody]]

OCA at 15:53, 29 September 2014

OCA — Mon, 29 Sep 2014 15:53:22 GMT

←Older revision		Revision as of 15:53, 29 September 2014
Line 1:		Line 1:
-	[[~~Image:~~1ruq.~~png~~\|~~left~~\|200px]]	+	==Crystal Structure (H) of u.v.-irradiated Diels-Alder antibody 13G5 Fab at pH 8.0 with a data set collected in house.==
		+	<StructureSection load='1ruq' size='340' side='right' caption='[[1ruq]], [[Resolution\|resolution]] 1.86Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1ruq]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RUQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1RUQ FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1a3l\|1a3l]], [[1rur\|1rur]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ruq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ruq OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1ruq RCSB], [http://www.ebi.ac.uk/pdbsum/1ruq PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ru/1ruq_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Antibodies can catalyze the generation of hydrogen peroxide (H2O2) from singlet dioxygen (1O2*) and water via the postulated intermediacy of dihydrogen trioxide (H2O3) and other trioxygen species. Nine different crystal structures were determined to elucidate the chemical consequences to the antibody molecule itself of exposure to such reactive intermediates and to provide insights into the location on the antibody where these species could be generated. Herein, we report structural evidence for modifications of two specific antibody residues within the interfacial region of the variable and constant domains of different murine antibody antigen-binding fragments (Fabs) by reactive species generated during the antibody-catalyzed water oxidation process. Crystal structure analyses of murine Fabs 4C6 and 13G5 after UV-irradiation revealed complex oxidative modifications to tryptophan L163 and, in 4C6, hydroxylation of the Cgamma of glutamine H6. These discrete modifications of specific residues add further support for the "active site" of the water-oxidation pathway being located within the interfacial region of the constant and variable domains and highlight the general resistance of the antibody molecule to oxidation by reactive oxygen species generated during the water-oxidation process.

-	~~{{STRUCTURE_1ruq\| PDB=1ruq \| SCENE= }}~~	+	Probing the antibody-catalyzed water-oxidation pathway at atomic resolution.,Zhu X, Wentworth P Jr, Wentworth AD, Eschenmoser A, Lerner RA, Wilson IA Proc Natl Acad Sci U S A. 2004 Feb 24;101(8):2247-52. PMID:14982995<ref>PMID:14982995</ref>

-	~~===Crystal Structure (H)~~ of u.v.~~-irradiated Diels-Alder antibody 13G5 Fab at pH 8.0 with a data set collected in house~~.~~===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>

-	~~{{ABSTRACT_PUBMED_14982995}}~~	+	==See Also==
-		+	*[[Monoclonal Antibody\|Monoclonal Antibody]]
-	==~~About this Structure~~==	+	== References ==
-	[[~~1ruq~~]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RUQ OCA].	+	<references/>
-		+	__TOC__
-	==~~Reference~~==	+	</StructureSection>
-	<~~ref group="xtra">PMID:014982995<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
	[[Category: Eschenmoser, A.]]		[[Category: Eschenmoser, A.]]

OCA at 09:32, 16 January 2013

OCA — Wed, 16 Jan 2013 09:32:23 GMT

←Older revision		Revision as of 09:32, 16 January 2013
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	[[Image:1ruq.png\|left\|200px]]		[[Image:1ruq.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_1ruq", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_1ruq\| PDB=1ruq \| SCENE= }}		{{STRUCTURE_1ruq\| PDB=1ruq \| SCENE= }}

	===Crystal Structure (H) of u.v.-irradiated Diels-Alder antibody 13G5 Fab at pH 8.0 with a data set collected in house.===		===Crystal Structure (H) of u.v.-irradiated Diels-Alder antibody 13G5 Fab at pH 8.0 with a data set collected in house.===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_14982995}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 14982995 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_14982995}}		{{ABSTRACT_PUBMED_14982995}}

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	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~14982995</ref><ref group="xtra">PMID:9506943~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:014982995</ref><references group="xtra"/>
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
	[[Category: Eschenmoser, A.]]		[[Category: Eschenmoser, A.]]

OCA: Protected "1ruq" [edit=sysop:move=sysop]

OCA — Mon, 14 Mar 2011 17:57:10 GMT

Protected "1ruq" [edit=sysop:move=sysop]

←Older revision

Revision as of 17:57, 14 March 2011