1ruw - Revision history

OCA at 13:29, 13 March 2024

OCA — Wed, 13 Mar 2024 13:29:30 GMT

←Older revision		Revision as of 13:29, 13 March 2024
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	<StructureSection load='1ruw' size='340' side='right'caption='[[1ruw]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='1ruw' size='340' side='right'caption='[[1ruw]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1ruw]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Atcc_18824 Atcc 18824~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RUW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1RUW FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1ruw]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RUW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1RUW FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=IMD:IMIDAZOLE'>IMD</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.8Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"><~~div style~~='~~overflow~~: ~~auto; max-height: 3em;~~'>~~[[1oot\|1oot]]~~</~~div~~></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=IMD:IMIDAZOLE'>IMD</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ruw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ruw OCA], [https://pdbe.org/1ruw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ruw RCSB], [https://www.ebi.ac.uk/pdbsum/1ruw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ruw ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ruw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ruw OCA], [https://pdbe.org/1ruw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ruw RCSB], [https://www.ebi.ac.uk/pdbsum/1ruw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ruw ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/MYO3_YEAST MYO3_YEAST]] One of two redundant type-I myosins implicated in the organization of the actin cytoskeleton. Required for proper actin cytoskeleton polarization and for the internalization step in endocytosis. At the cell cortex, assembles in patch-like structures together with proteins from the actin-polymerizing machinery and promotes actin assembly. Functions redundantly with LAS17 as actin nucleation-promoting factor (NPF) for the Arp2/3 complex. Motor domain phosphorylation by PAK kinases CLA4 and STE20 promotes CDC42-regulated actin assembly. Functions together with the NPF PAN1 in late stages of endocytosis. Motor domain phosphorylation by PDK1 kinases PKH1 and PKH2, and by SGK kinases YPK1 and YPK2, promotes ligand-induced, but not constitutive endocytosis of the G protein-coupled receptor STE2.<ref>PMID:8682864</ref> <ref>PMID:8614799</ref> <ref>PMID:9388196</ref> <ref>PMID:10648568</ref> <ref>PMID:10648569</ref> <ref>PMID:12725728</ref> <ref>PMID:12808026</ref>	+	[https://www.uniprot.org/uniprot/MYO3_YEAST MYO3_YEAST] One of two redundant type-I myosins implicated in the organization of the actin cytoskeleton. Required for proper actin cytoskeleton polarization and for the internalization step in endocytosis. At the cell cortex, assembles in patch-like structures together with proteins from the actin-polymerizing machinery and promotes actin assembly. Functions redundantly with LAS17 as actin nucleation-promoting factor (NPF) for the Arp2/3 complex. Motor domain phosphorylation by PAK kinases CLA4 and STE20 promotes CDC42-regulated actin assembly. Functions together with the NPF PAN1 in late stages of endocytosis. Motor domain phosphorylation by PDK1 kinases PKH1 and PKH2, and by SGK kinases YPK1 and YPK2, promotes ligand-induced, but not constitutive endocytosis of the G protein-coupled receptor STE2.<ref>PMID:8682864</ref> <ref>PMID:8614799</ref> <ref>PMID:9388196</ref> <ref>PMID:10648568</ref> <ref>PMID:10648569</ref> <ref>PMID:12725728</ref> <ref>PMID:12808026</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Atcc 18824]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Kursula, I]]	+	[[Category: Saccharomyces cerevisiae]]
-	[[Category: Kursula, P]]	+	[[Category: Kursula I]]
-	[[Category: Lehmann, F]]	+	[[Category: Kursula P]]
-	[[Category: Song~~, Y H~~]]	+	[[Category: Lehmann F]]
-	[[Category: Wilmanns, M]]	+	[[Category: Song YH]]
-	~~[[Category: Contractile protein]]~~	+	[[Category: Wilmanns M]]
-	~~[[Category: High-throughput]]~~	+
-	~~[[Category: Myo3]]~~	+
-	~~[[Category: Sh3 domain]]~~	+
-	~~[[Category: Structural genomic]]~~	+
-	~~[[Category: Yeast~~]]	+

OCA at 07:22, 22 September 2021

OCA — Wed, 22 Sep 2021 07:22:22 GMT

←Older revision		Revision as of 07:22, 22 September 2021
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	<StructureSection load='1ruw' size='340' side='right'caption='[[1ruw]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='1ruw' size='340' side='right'caption='[[1ruw]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1ruw]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Atcc_18824 Atcc 18824]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RUW OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1RUW FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1ruw]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Atcc_18824 Atcc 18824]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RUW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1RUW FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=IMD:IMIDAZOLE'>IMD</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=IMD:IMIDAZOLE'>IMD</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1oot\|1oot]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1oot\|1oot]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1ruw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ruw OCA], [~~http~~://pdbe.org/1ruw PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1ruw RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1ruw PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1ruw ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ruw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ruw OCA], [https://pdbe.org/1ruw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ruw RCSB], [https://www.ebi.ac.uk/pdbsum/1ruw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ruw ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/MYO3_YEAST MYO3_YEAST]] One of two redundant type-I myosins implicated in the organization of the actin cytoskeleton. Required for proper actin cytoskeleton polarization and for the internalization step in endocytosis. At the cell cortex, assembles in patch-like structures together with proteins from the actin-polymerizing machinery and promotes actin assembly. Functions redundantly with LAS17 as actin nucleation-promoting factor (NPF) for the Arp2/3 complex. Motor domain phosphorylation by PAK kinases CLA4 and STE20 promotes CDC42-regulated actin assembly. Functions together with the NPF PAN1 in late stages of endocytosis. Motor domain phosphorylation by PDK1 kinases PKH1 and PKH2, and by SGK kinases YPK1 and YPK2, promotes ligand-induced, but not constitutive endocytosis of the G protein-coupled receptor STE2.<ref>PMID:8682864</ref> <ref>PMID:8614799</ref> <ref>PMID:9388196</ref> <ref>PMID:10648568</ref> <ref>PMID:10648569</ref> <ref>PMID:12725728</ref> <ref>PMID:12808026</ref>	+	[[https://www.uniprot.org/uniprot/MYO3_YEAST MYO3_YEAST]] One of two redundant type-I myosins implicated in the organization of the actin cytoskeleton. Required for proper actin cytoskeleton polarization and for the internalization step in endocytosis. At the cell cortex, assembles in patch-like structures together with proteins from the actin-polymerizing machinery and promotes actin assembly. Functions redundantly with LAS17 as actin nucleation-promoting factor (NPF) for the Arp2/3 complex. Motor domain phosphorylation by PAK kinases CLA4 and STE20 promotes CDC42-regulated actin assembly. Functions together with the NPF PAN1 in late stages of endocytosis. Motor domain phosphorylation by PDK1 kinases PKH1 and PKH2, and by SGK kinases YPK1 and YPK2, promotes ligand-induced, but not constitutive endocytosis of the G protein-coupled receptor STE2.<ref>PMID:8682864</ref> <ref>PMID:8614799</ref> <ref>PMID:9388196</ref> <ref>PMID:10648568</ref> <ref>PMID:10648569</ref> <ref>PMID:12725728</ref> <ref>PMID:12808026</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 19:15, 11 December 2019

OCA — Wed, 11 Dec 2019 19:15:45 GMT

←Older revision		Revision as of 19:15, 11 December 2019
Line 1:		Line 1:

	==Crystal structure of the SH3 domain from S. cerevisiae Myo3==		==Crystal structure of the SH3 domain from S. cerevisiae Myo3==
-	<StructureSection load='1ruw' size='340' side='right' caption='[[1ruw]], [[Resolution\|resolution]] 1.80Å' scene=''>	+	<StructureSection load='1ruw' size='340' side='right'caption='[[1ruw]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1ruw]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_18824 Atcc 18824]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RUW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1RUW FirstGlance]. <br>		<table><tr><td colspan='2'>[[1ruw]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_18824 Atcc 18824]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RUW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1RUW FirstGlance]. <br>
Line 22:		Line 22:

	==See Also==		==See Also==
-	*[[Myosin\|Myosin]]	+	*[[Myosin 3D Structures\|Myosin 3D Structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 28:		Line 28:
	</StructureSection>		</StructureSection>
	[[Category: Atcc 18824]]		[[Category: Atcc 18824]]
		+	[[Category: Large Structures]]
	[[Category: Kursula, I]]		[[Category: Kursula, I]]
	[[Category: Kursula, P]]		[[Category: Kursula, P]]

OCA at 06:47, 8 March 2018

OCA — Thu, 08 Mar 2018 06:47:09 GMT

←Older revision		Revision as of 06:47, 8 March 2018
Line 1:		Line 1:
		+
	==Crystal structure of the SH3 domain from S. cerevisiae Myo3==		==Crystal structure of the SH3 domain from S. cerevisiae Myo3==
	<StructureSection load='1ruw' size='340' side='right' caption='[[1ruw]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='1ruw' size='340' side='right' caption='[[1ruw]], [[Resolution\|resolution]] 1.80Å' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=IMD:IMIDAZOLE'>IMD</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=IMD:IMIDAZOLE'>IMD</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1oot\|1oot]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1oot\|1oot]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ruw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ruw OCA], [http://pdbe.org/1ruw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1ruw RCSB], [http://www.ebi.ac.uk/pdbsum/1ruw PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ruw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ruw OCA], [http://pdbe.org/1ruw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1ruw RCSB], [http://www.ebi.ac.uk/pdbsum/1ruw PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1ruw ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 13:		Line 14:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ru/1ruw_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ru/1ruw_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1ruw ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>

OCA at 02:11, 12 September 2015

OCA — Sat, 12 Sep 2015 02:11:12 GMT

←Older revision		Revision as of 02:11, 12 September 2015
Line 2:		Line 2:
	<StructureSection load='1ruw' size='340' side='right' caption='[[1ruw]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='1ruw' size='340' side='right' caption='[[1ruw]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1ruw]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Saccharomyces_cerevisiae Saccharomyces cerevisiae~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RUW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1RUW FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1ruw]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_18824 Atcc 18824]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RUW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1RUW FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=IMD:IMIDAZOLE'>IMD</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=IMD:IMIDAZOLE'>IMD</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1oot\|1oot]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1oot\|1oot]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ruw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ruw OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1ruw RCSB], [http://www.ebi.ac.uk/pdbsum/1ruw PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ruw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ruw OCA], [http://pdbe.org/1ruw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1ruw RCSB], [http://www.ebi.ac.uk/pdbsum/1ruw PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 26:		Line 26:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Saccharomyces cerevisiae~~]]	+	[[Category: Atcc 18824]]
	[[Category: Kursula, I]]		[[Category: Kursula, I]]
	[[Category: Kursula, P]]		[[Category: Kursula, P]]

OCA at 22:31, 25 December 2014

OCA — Thu, 25 Dec 2014 22:31:05 GMT

←Older revision		Revision as of 22:31, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1ruw]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RUW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1RUW FirstGlance]. <br>		<table><tr><td colspan='2'>[[1ruw]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RUW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1RUW FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=IMD:IMIDAZOLE'>IMD</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=IMD:IMIDAZOLE'>IMD</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1oot\|1oot]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1oot\|1oot]]</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ruw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ruw OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1ruw RCSB], [http://www.ebi.ac.uk/pdbsum/1ruw PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ruw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ruw OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1ruw RCSB], [http://www.ebi.ac.uk/pdbsum/1ruw PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/MYO3_YEAST MYO3_YEAST]] One of two redundant type-I myosins implicated in the organization of the actin cytoskeleton. Required for proper actin cytoskeleton polarization and for the internalization step in endocytosis. At the cell cortex, assembles in patch-like structures together with proteins from the actin-polymerizing machinery and promotes actin assembly. Functions redundantly with LAS17 as actin nucleation-promoting factor (NPF) for the Arp2/3 complex. Motor domain phosphorylation by PAK kinases CLA4 and STE20 promotes CDC42-regulated actin assembly. Functions together with the NPF PAN1 in late stages of endocytosis. Motor domain phosphorylation by PDK1 kinases PKH1 and PKH2, and by SGK kinases YPK1 and YPK2, promotes ligand-induced, but not constitutive endocytosis of the G protein-coupled receptor STE2.<ref>PMID:8682864</ref> <ref>PMID:8614799</ref> <ref>PMID:9388196</ref> <ref>PMID:10648568</ref> <ref>PMID:10648569</ref> <ref>PMID:12725728</ref> <ref>PMID:12808026</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 20:		Line 22:
	==See Also==		==See Also==
	*[[Myosin\|Myosin]]		*[[Myosin\|Myosin]]
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Saccharomyces cerevisiae]]		[[Category: Saccharomyces cerevisiae]]
-	[[Category: Kursula, I.]]	+	[[Category: Kursula, I]]
-	[[Category: Kursula, P.]]	+	[[Category: Kursula, P]]
-	[[Category: Lehmann, F.]]	+	[[Category: Lehmann, F]]
-	[[Category: Song, Y H.]]	+	[[Category: Song, Y H]]
-	[[Category: Wilmanns, M.]]	+	[[Category: Wilmanns, M]]
	[[Category: Contractile protein]]		[[Category: Contractile protein]]
	[[Category: High-throughput]]		[[Category: High-throughput]]

OCA at 23:51, 28 September 2014

OCA — Sun, 28 Sep 2014 23:51:03 GMT

←Older revision		Revision as of 23:51, 28 September 2014
Line 1:		Line 1:
-	~~[[Image:1ruw.png\|left\|200px]]~~	+	==Crystal structure of the SH3 domain from S. cerevisiae Myo3==
-		+	<StructureSection load='1ruw' size='340' side='right' caption='[[1ruw]], [[Resolution\|resolution]] 1.80Å' scene=''>
-	~~{{STRUCTURE_1ruw\| PDB=1ruw \| SCENE= }}~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[1ruw]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RUW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1RUW FirstGlance]. <br>
-	===Crystal structure of the SH3 domain from S. cerevisiae Myo3===	+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=IMD:IMIDAZOLE'>IMD</scene><br>
-		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1oot\|1oot]]</td></tr>
-		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ruw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ruw OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1ruw RCSB], [http://www.ebi.ac.uk/pdbsum/1ruw PDBsum]</span></td></tr>
-	==~~About this Structure~~==	+	<table>
-	[[1ruw]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RUW OCA].	+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ru/1ruw_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>

	==See Also==		==See Also==
	*[[Myosin\|Myosin]]		*[[Myosin\|Myosin]]
		+	__TOC__
		+	</StructureSection>
	[[Category: Saccharomyces cerevisiae]]		[[Category: Saccharomyces cerevisiae]]
	[[Category: Kursula, I.]]		[[Category: Kursula, I.]]

OCA at 22:24, 20 October 2012

OCA — Sat, 20 Oct 2012 22:24:39 GMT

←Older revision		Revision as of 22:24, 20 October 2012
Line 7:		Line 7:

	==About this Structure==		==About this Structure==
-	[[1ruw]] is a 1 chain structure ~~of [[Myosin]]~~ with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RUW OCA].	+	[[1ruw]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RUW OCA].

	==See Also==		==See Also==

OCA: Protected "1ruw" [edit=sysop:move=sysop]

OCA — Fri, 27 Jul 2012 16:12:13 GMT

Protected "1ruw" [edit=sysop:move=sysop]

←Older revision

Revision as of 16:12, 27 July 2012

OCA at 16:12, 27 July 2012

OCA — Fri, 27 Jul 2012 16:12:11 GMT

←Older revision		Revision as of 16:12, 27 July 2012
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-	{{Seed}}
	[[Image:1ruw.png\|left\|200px]]		[[Image:1ruw.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_1ruw", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_1ruw\| PDB=1ruw \| SCENE= }}		{{STRUCTURE_1ruw\| PDB=1ruw \| SCENE= }}

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	==About this Structure==		==About this Structure==
-	~~1RUW~~ is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RUW OCA].	+	[[1ruw]] is a 1 chain structure of [[Myosin]] with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RUW OCA].
		+
		+	==See Also==
		+	*[[Myosin\|Myosin]]
	[[Category: Saccharomyces cerevisiae]]		[[Category: Saccharomyces cerevisiae]]
	[[Category: Kursula, I.]]		[[Category: Kursula, I.]]
Line 21:		Line 17:
	[[Category: Song, Y H.]]		[[Category: Song, Y H.]]
	[[Category: Wilmanns, M.]]		[[Category: Wilmanns, M.]]
		+	[[Category: Contractile protein]]
	[[Category: High-throughput]]		[[Category: High-throughput]]
	[[Category: Myo3]]		[[Category: Myo3]]
Line 26:		Line 23:
	[[Category: Structural genomic]]		[[Category: Structural genomic]]
	[[Category: Yeast]]		[[Category: Yeast]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 18 09:47:33 2009''