1rxz - Revision history

OCA at 06:09, 23 August 2023

OCA — Wed, 23 Aug 2023 06:09:36 GMT

←Older revision		Revision as of 06:09, 23 August 2023
Line 3:		Line 3:
	<StructureSection load='1rxz' size='340' side='right'caption='[[1rxz]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='1rxz' size='340' side='right'caption='[[1rxz]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1rxz]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Arcfl Arcfl~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RXZ OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=1RXZ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1rxz]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Archaeoglobus_fulgidus Archaeoglobus fulgidus] and [https://en.wikipedia.org/wiki/Archaeoglobus_fulgidus_DSM_4304 Archaeoglobus fulgidus DSM 4304]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RXZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1RXZ FirstGlance]. <br>
-	</td></tr><tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"~~><div style='overflow: auto; max-height: 3em;'>[[1rwz\|1rwz]], [[1rxm\|1rxm]], [[1rxv\|1rxv]], [[1rxw\|1rxw]]</div></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2Å</td></tr>
-	~~<tr~~ id~~='gene'><td class~~="~~sblockLbl~~">~~<b>~~[[~~Gene~~\|~~Gene:~~]]~~</b></td><td class="sblockDat">PCN, AF0335 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info~~&~~srchmode=5&id=2234 ARCFL])~~</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1rxz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1rxz OCA], [https://pdbe.org/1rxz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1rxz RCSB], [https://www.ebi.ac.uk/pdbsum/1rxz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1rxz ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=1rxz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1rxz OCA], [~~http~~://pdbe.org/1rxz PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1rxz RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1rxz PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1rxz ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/PCNA_ARCFU PCNA_ARCFU]] Sliding clamp subunit. Responsible for tethering the catalytic subunit of DNA polymerase to DNA during high-speed replication (By similarity). [[http://www.uniprot.org/uniprot/FEN_ARCFU FEN_ARCFU]] Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. Acts as a genome stabilization factor that prevents flaps from equilibrating into structures that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA (By similarity).	+	[https://www.uniprot.org/uniprot/PCNA_ARCFU PCNA_ARCFU] Sliding clamp subunit. Responsible for tethering the catalytic subunit of DNA polymerase to DNA during high-speed replication (By similarity).
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 37:		Line 36:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Arcfl~~]]	+	[[Category: Archaeoglobus fulgidus]]
		+	[[Category: Archaeoglobus fulgidus DSM 4304]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Chapados~~, B R~~]]	+	[[Category: Chapados BR]]
-	[[Category: Han, S]]	+	[[Category: Han S]]
-	[[Category: Hosfield~~, D J~~]]	+	[[Category: Hosfield DJ]]
-	[[Category: Qiu, J]]	+	[[Category: Qiu J]]
-	[[Category: Shen, B]]	+	[[Category: Shen B]]
-	[[Category: Tainer~~, J A~~]]	+	[[Category: Tainer JA]]
-	[[Category: Yelent, B]]	+	[[Category: Yelent B]]
-	~~[[Category: Beta-zipper]]~~	+
-	~~[[Category: Dna repair]]~~	+
-	~~[[Category: Dna replication]]~~	+
-	~~[[Category: Interdomain connecting loop]]~~	+
-	~~[[Category: Replication~~]]	+

OCA at 13:35, 16 December 2020

OCA — Wed, 16 Dec 2020 13:35:51 GMT

←Older revision		Revision as of 13:35, 16 December 2020
Line 1:		Line 1:

	==C-terminal region of A. fulgidus FEN-1 complexed with A. fulgidus PCNA==		==C-terminal region of A. fulgidus FEN-1 complexed with A. fulgidus PCNA==
-	<StructureSection load='1rxz' size='340' side='right' caption='[[1rxz]], [[Resolution\|resolution]] 2.00Å' scene=''>	+	<StructureSection load='1rxz' size='340' side='right'caption='[[1rxz]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1rxz]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Arcfl Arcfl]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RXZ OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1RXZ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1rxz]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Arcfl Arcfl]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RXZ OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=1RXZ FirstGlance]. <br>
-	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1rwz\|1rwz]], [[1rxm\|1rxm]], [[1rxv\|1rxv]], [[1rxw\|1rxw]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1rwz\|1rwz]], [[1rxm\|1rxm]], [[1rxv\|1rxv]], [[1rxw\|1rxw]]</div></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PCN, AF0335 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=2234 ARCFL])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PCN, AF0335 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=2234 ARCFL])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1rxz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1rxz OCA], [http://pdbe.org/1rxz PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1rxz RCSB], [http://www.ebi.ac.uk/pdbsum/1rxz PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1rxz ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=1rxz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1rxz OCA], [http://pdbe.org/1rxz PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1rxz RCSB], [http://www.ebi.ac.uk/pdbsum/1rxz PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1rxz ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 31:		Line 31:

	==See Also==		==See Also==
-	*[[Endonuclease\|Endonuclease]]	+	*[[Endonuclease 3D structures\|Endonuclease 3D structures]]
-	*[[Proliferating ~~Cell Nuclear Antigen~~\|Proliferating ~~Cell Nuclear Antigen~~]]	+	*[[Proliferating cell nuclear antigen 3D structures\|Proliferating cell nuclear antigen 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 38:		Line 38:
	</StructureSection>		</StructureSection>
	[[Category: Arcfl]]		[[Category: Arcfl]]
		+	[[Category: Large Structures]]
	[[Category: Chapados, B R]]		[[Category: Chapados, B R]]
	[[Category: Han, S]]		[[Category: Han, S]]

OCA at 07:08, 8 March 2018

OCA — Thu, 08 Mar 2018 07:08:05 GMT

←Older revision		Revision as of 07:08, 8 March 2018
Line 1:		Line 1:
		+
	==C-terminal region of A. fulgidus FEN-1 complexed with A. fulgidus PCNA==		==C-terminal region of A. fulgidus FEN-1 complexed with A. fulgidus PCNA==
	<StructureSection load='1rxz' size='340' side='right' caption='[[1rxz]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='1rxz' size='340' side='right' caption='[[1rxz]], [[Resolution\|resolution]] 2.00Å' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1rwz\|1rwz]], [[1rxm\|1rxm]], [[1rxv\|1rxv]], [[1rxw\|1rxw]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1rwz\|1rwz]], [[1rxm\|1rxm]], [[1rxv\|1rxv]], [[1rxw\|1rxw]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PCN, AF0335 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=2234 ARCFL])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PCN, AF0335 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=2234 ARCFL])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1rxz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1rxz OCA], [http://pdbe.org/1rxz PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1rxz RCSB], [http://www.ebi.ac.uk/pdbsum/1rxz PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1rxz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1rxz OCA], [http://pdbe.org/1rxz PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1rxz RCSB], [http://www.ebi.ac.uk/pdbsum/1rxz PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1rxz ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 13:		Line 14:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/rx/1rxz_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/rx/1rxz_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1rxz ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 00:09, 12 September 2015

OCA — Sat, 12 Sep 2015 00:09:15 GMT

←Older revision		Revision as of 00:09, 12 September 2015
Line 2:		Line 2:
	<StructureSection load='1rxz' size='340' side='right' caption='[[1rxz]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='1rxz' size='340' side='right' caption='[[1rxz]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1rxz]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Archaeoglobus_fulgidus Archaeoglobus fulgidus~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RXZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1RXZ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1rxz]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Arcfl Arcfl]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RXZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1RXZ FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1rwz\|1rwz]], [[1rxm\|1rxm]], [[1rxv\|1rxv]], [[1rxw\|1rxw]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1rwz\|1rwz]], [[1rxm\|1rxm]], [[1rxv\|1rxv]], [[1rxw\|1rxw]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PCN, AF0335 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=2234 ~~Archaeoglobus fulgidus~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PCN, AF0335 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=2234 ARCFL])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1rxz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1rxz OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1rxz RCSB], [http://www.ebi.ac.uk/pdbsum/1rxz PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1rxz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1rxz OCA], [http://pdbe.org/1rxz PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1rxz RCSB], [http://www.ebi.ac.uk/pdbsum/1rxz PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 27:		Line 27:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1rxz" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 35:		Line 36:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Archaeoglobus fulgidus~~]]	+	[[Category: Arcfl]]
	[[Category: Chapados, B R]]		[[Category: Chapados, B R]]
	[[Category: Han, S]]		[[Category: Han, S]]

OCA at 21:13, 25 December 2014

OCA — Thu, 25 Dec 2014 21:13:23 GMT

←Older revision		Revision as of 21:13, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1rxz]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Archaeoglobus_fulgidus Archaeoglobus fulgidus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RXZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1RXZ FirstGlance]. <br>		<table><tr><td colspan='2'>[[1rxz]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Archaeoglobus_fulgidus Archaeoglobus fulgidus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RXZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1RXZ FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1rwz\|1rwz]], [[1rxm\|1rxm]], [[1rxv\|1rxv]], [[1rxw\|1rxw]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1rwz\|1rwz]], [[1rxm\|1rxm]], [[1rxv\|1rxv]], [[1rxw\|1rxw]]</td></tr>
-	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PCN, AF0335 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=2234 Archaeoglobus fulgidus])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PCN, AF0335 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=2234 Archaeoglobus fulgidus])</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1rxz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1rxz OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1rxz RCSB], [http://www.ebi.ac.uk/pdbsum/1rxz PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1rxz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1rxz OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1rxz RCSB], [http://www.ebi.ac.uk/pdbsum/1rxz PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/PCNA_ARCFU PCNA_ARCFU]] Sliding clamp subunit. Responsible for tethering the catalytic subunit of DNA polymerase to DNA during high-speed replication (By similarity). [[http://www.uniprot.org/uniprot/FEN_ARCFU FEN_ARCFU]] Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. Acts as a genome stabilization factor that prevents flaps from equilibrating into structures that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA (By similarity).
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 34:		Line 36:
	</StructureSection>		</StructureSection>
	[[Category: Archaeoglobus fulgidus]]		[[Category: Archaeoglobus fulgidus]]
-	[[Category: Chapados, B R.]]	+	[[Category: Chapados, B R]]
-	[[Category: Han, S.]]	+	[[Category: Han, S]]
-	[[Category: Hosfield, D J.]]	+	[[Category: Hosfield, D J]]
-	[[Category: Qiu, J.]]	+	[[Category: Qiu, J]]
-	[[Category: Shen, B.]]	+	[[Category: Shen, B]]
-	[[Category: Tainer, J A.]]	+	[[Category: Tainer, J A]]
-	[[Category: Yelent, B.]]	+	[[Category: Yelent, B]]
	[[Category: Beta-zipper]]		[[Category: Beta-zipper]]
	[[Category: Dna repair]]		[[Category: Dna repair]]

OCA at 22:31, 28 September 2014

OCA — Sun, 28 Sep 2014 22:31:49 GMT

←Older revision		Revision as of 22:31, 28 September 2014
Line 1:		Line 1:
-	[[~~Image:~~1rxz.~~png~~\|~~left~~\|200px]]	+	==C-terminal region of A. fulgidus FEN-1 complexed with A. fulgidus PCNA==
		+	<StructureSection load='1rxz' size='340' side='right' caption='[[1rxz]], [[Resolution\|resolution]] 2.00Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1rxz]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Archaeoglobus_fulgidus Archaeoglobus fulgidus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RXZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1RXZ FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1rwz\|1rwz]], [[1rxm\|1rxm]], [[1rxv\|1rxv]], [[1rxw\|1rxw]]</td></tr>
		+	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PCN, AF0335 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=2234 Archaeoglobus fulgidus])</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1rxz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1rxz OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1rxz RCSB], [http://www.ebi.ac.uk/pdbsum/1rxz PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/rx/1rxz_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Flap EndoNuclease-1 (FEN-1) and the processivity factor proliferating cell nuclear antigen (PCNA) are central to DNA replication and repair. To clarify the molecular basis of FEN-1 specificity and PCNA activation, we report here structures of FEN-1:DNA and PCNA:FEN-1-peptide complexes, along with fluorescence resonance energy transfer (FRET) and mutational results. FEN-1 binds the unpaired 3' DNA end (3' flap), opens and kinks the DNA, and promotes conformational closing of a flexible helical clamp to facilitate 5' cleavage specificity. Ordering of unstructured C-terminal regions in FEN-1 and PCNA creates an intermolecular beta sheet interface that directly links adjacent PCNA and DNA binding regions of FEN-1 and suggests how PCNA stimulates FEN-1 activity. The DNA and protein conformational changes, composite complex structures, FRET, and mutational results support enzyme-PCNA alignments and a kinked DNA pivot point that appear suitable to coordinate rotary handoffs of kinked DNA intermediates among enzymes localized by the three PCNA binding sites.

-	~~{{STRUCTURE_1rxz\| PDB=1rxz \| SCENE= }}~~	+	Structural basis for FEN-1 substrate specificity and PCNA-mediated activation in DNA replication and repair.,Chapados BR, Hosfield DJ, Han S, Qiu J, Yelent B, Shen B, Tainer JA Cell. 2004 Jan 9;116(1):39-50. PMID:14718165<ref>PMID:14718165</ref>

-	~~===C-terminal region~~ of A. ~~fulgidus FEN-1 complexed with A~~. ~~fulgidus PCNA===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_14718165}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[1rxz]] is a 2 chain structure with sequence from [http:~~/~~/en.wikipedia.org/wiki/Archaeoglobus_fulgidus Archaeoglobus fulgidus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RXZ OCA].~~	+

	==See Also==		==See Also==
		+	*[[Endonuclease\|Endonuclease]]
	*[[Proliferating Cell Nuclear Antigen\|Proliferating Cell Nuclear Antigen]]		*[[Proliferating Cell Nuclear Antigen\|Proliferating Cell Nuclear Antigen]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:014718165<~~/~~ref~~><~~references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Archaeoglobus fulgidus]]		[[Category: Archaeoglobus fulgidus]]
	[[Category: Chapados, B R.]]		[[Category: Chapados, B R.]]

OCA at 21:43, 20 October 2012

OCA — Sat, 20 Oct 2012 21:43:27 GMT

←Older revision		Revision as of 21:43, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[1rxz]] is a 2 chain structure ~~of [[Proliferating Cell Nuclear Antigen]]~~ with sequence from [http://en.wikipedia.org/wiki/Archaeoglobus_fulgidus Archaeoglobus fulgidus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RXZ OCA].	+	[[1rxz]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Archaeoglobus_fulgidus Archaeoglobus fulgidus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RXZ OCA].

	==See Also==		==See Also==

OCA: Protected "1rxz" [edit=sysop:move=sysop]

OCA — Fri, 27 Jul 2012 14:05:39 GMT

Protected "1rxz" [edit=sysop:move=sysop]

←Older revision

Revision as of 14:05, 27 July 2012

OCA at 14:05, 27 July 2012

OCA — Fri, 27 Jul 2012 14:05:38 GMT

←Older revision		Revision as of 14:05, 27 July 2012
Line 1:		Line 1:
-	{{Seed}}
	[[Image:1rxz.png\|left\|200px]]		[[Image:1rxz.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_1rxz", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_1rxz\| PDB=1rxz \| SCENE= }}		{{STRUCTURE_1rxz\| PDB=1rxz \| SCENE= }}

	===C-terminal region of A. fulgidus FEN-1 complexed with A. fulgidus PCNA===		===C-terminal region of A. fulgidus FEN-1 complexed with A. fulgidus PCNA===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_14718165}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 14718165 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_14718165}}		{{ABSTRACT_PUBMED_14718165}}

	==About this Structure==		==About this Structure==
-	~~1RXZ~~ is a 2 ~~chains~~ structure of ~~sequences~~ from [http://en.wikipedia.org/wiki/Archaeoglobus_fulgidus Archaeoglobus fulgidus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RXZ OCA].	+	[[1rxz]] is a 2 chain structure of [[Proliferating Cell Nuclear Antigen]] with sequence from [http://en.wikipedia.org/wiki/Archaeoglobus_fulgidus Archaeoglobus fulgidus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RXZ OCA].
		+
		+	==See Also==
		+	*[[Proliferating Cell Nuclear Antigen\|Proliferating Cell Nuclear Antigen]]

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~14718165~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:014718165</ref><references group="xtra"/>
	[[Category: Archaeoglobus fulgidus]]		[[Category: Archaeoglobus fulgidus]]
	[[Category: Chapados, B R.]]		[[Category: Chapados, B R.]]
Line 36:		Line 27:
	[[Category: Dna replication]]		[[Category: Dna replication]]
	[[Category: Interdomain connecting loop]]		[[Category: Interdomain connecting loop]]
-		+	[[Category: Replication]]
-	~~''Page seeded by~~ [~~http~~:~~//oca.weizmann.ac.il/oca OCA~~ ] ~~on Wed Feb 18 07:47:09 2009''~~	+

OCA at 05:47, 18 February 2009

OCA — Wed, 18 Feb 2009 05:47:11 GMT

←Older revision		Revision as of 05:47, 18 February 2009
Line 20:		Line 20:

	==About this Structure==		==About this Structure==
-	1RXZ is a ~~[[Protein complex]]~~ structure of sequences from [http://en.wikipedia.org/wiki/Archaeoglobus_fulgidus Archaeoglobus fulgidus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RXZ OCA].	+	1RXZ is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Archaeoglobus_fulgidus Archaeoglobus fulgidus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RXZ OCA].

	==Reference==		==Reference==
-	Structural basis for FEN-1 substrate specificity and PCNA-mediated activation in DNA replication and repair., Chapados BR, Hosfield DJ, Han S, Qiu J, Yelent B, Shen B, Tainer JA, Cell. 2004 Jan 9;116(1):39-50. PMID:~~[http:~~//~~www.ncbi.nlm.nih.gov/pubmed/14718165 14718165]~~	+	<ref group="xtra">PMID:14718165</ref><references group="xtra"/>
	[[Category: Archaeoglobus fulgidus]]		[[Category: Archaeoglobus fulgidus]]
-	[[Category: Protein complex]]
	[[Category: Chapados, B R.]]		[[Category: Chapados, B R.]]
	[[Category: Han, S.]]		[[Category: Han, S.]]
Line 38:		Line 37:
	[[Category: Interdomain connecting loop]]		[[Category: Interdomain connecting loop]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Tue Jul 29 14~~:14:~~01 2008~~''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 18 07:47:09 2009''