1rz1 - Revision history

OCA at 07:25, 25 October 2023

OCA — Wed, 25 Oct 2023 07:25:18 GMT

←Older revision		Revision as of 07:25, 25 October 2023
Line 3:		Line 3:
	<StructureSection load='1rz1' size='340' side='right'caption='[[1rz1]], [[Resolution\|resolution]] 2.10Å' scene=''>		<StructureSection load='1rz1' size='340' side='right'caption='[[1rz1]], [[Resolution\|resolution]] 2.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1rz1]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/~~'geobacillus_thermoglucosidans' 'geobacillus thermoglucosidans'~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RZ1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1RZ1 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1rz1]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Parageobacillus_thermoglucosidasius Parageobacillus thermoglucosidasius]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RZ1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1RZ1 FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=FAD:FLAVIN~~-~~ADENINE+DINUCLEOTIDE'>FAD</scene>~~, ~~<scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.1Å</td></tr>
-	<tr id='~~NonStdRes~~'><td class="sblockLbl"><b>[[~~Non-Standard_Residue~~\|~~NonStd Res~~:]]</b></td><td class="sblockDat"><scene name='pdbligand=~~MSE~~:~~SELENOMETHIONINE~~'>~~MSE~~</scene><~~/td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene></td></tr>
-	~~<tr id~~='~~related'><td class~~=~~"sblockLbl"><b>[[Related_structure\|Related~~:~~]]</b~~></td><~~td class~~=~~"sblockDat"><div style~~=~~'overflow~~: ~~auto; max~~-~~height: 3em;~~'>~~[[1rz0\|1rz0]]~~</~~div~~></td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1rz1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1rz1 OCA], [https://pdbe.org/1rz1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1rz1 RCSB], [https://www.ebi.ac.uk/pdbsum/1rz1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1rz1 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1rz1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1rz1 OCA], [https://pdbe.org/1rz1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1rz1 RCSB], [https://www.ebi.ac.uk/pdbsum/1rz1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1rz1 ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/Q9LAG2_PARTM Q9LAG2_PARTM]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 35:		Line 36:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Geobacillus thermoglucosidans]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Berkel, W J.Van~~]]	+	[[Category: Parageobacillus thermoglucosidasius]]
-	[[Category: Heck~~, A J]]~~	+	[[Category: Heck AJ]]
-	~~[[Category: Heuvel, R H.Van Den~~]]	+	[[Category: Mattevi A]]
-	[[Category: Mattevi, A]]	+	[[Category: Rovida S]]
-	[[Category: Rovida, S]]	+	[[Category: Van Berkel WJ]]
-	[[Category: ~~Walsh, M A~~]]	+	[[Category: Van Den Heuvel RH]]
-	[[Category: ~~Westphal, A H~~]]	+	[[Category: Walsh MA]]
-	[[Category: ~~Flavin~~]]	+	[[Category: Westphal AH]]
-	[[Category: ~~Nad]]~~	+
-	~~[[Category: Oxidoreductase~~]]	+

OCA at 09:00, 21 April 2021

OCA — Wed, 21 Apr 2021 09:00:57 GMT

←Older revision		Revision as of 09:00, 21 April 2021
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	<StructureSection load='1rz1' size='340' side='right'caption='[[1rz1]], [[Resolution\|resolution]] 2.10Å' scene=''>		<StructureSection load='1rz1' size='340' side='right'caption='[[1rz1]], [[Resolution\|resolution]] 2.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1rz1]] is a 8 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/'geobacillus_thermoglucosidans' 'geobacillus thermoglucosidans']. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RZ1 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1RZ1 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1rz1]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/'geobacillus_thermoglucosidans' 'geobacillus thermoglucosidans']. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RZ1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1RZ1 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1rz0\|1rz0]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1rz0\|1rz0]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1rz1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1rz1 OCA], [~~http~~://pdbe.org/1rz1 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1rz1 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1rz1 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1rz1 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1rz1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1rz1 OCA], [https://pdbe.org/1rz1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1rz1 RCSB], [https://www.ebi.ac.uk/pdbsum/1rz1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1rz1 ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==

OCA at 12:56, 17 July 2019

OCA — Wed, 17 Jul 2019 12:56:35 GMT

←Older revision		Revision as of 12:56, 17 July 2019
Line 1:		Line 1:

	==Reduced flavin reductase PheA2 in complex with NAD==		==Reduced flavin reductase PheA2 in complex with NAD==
-	<StructureSection load='1rz1' size='340' side='right' caption='[[1rz1]], [[Resolution\|resolution]] 2.10Å' scene=''>	+	<StructureSection load='1rz1' size='340' side='right'caption='[[1rz1]], [[Resolution\|resolution]] 2.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1rz1]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/'geobacillus_thermoglucosidans' 'geobacillus thermoglucosidans']. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RZ1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1RZ1 FirstGlance]. <br>		<table><tr><td colspan='2'>[[1rz1]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/'geobacillus_thermoglucosidans' 'geobacillus thermoglucosidans']. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RZ1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1RZ1 FirstGlance]. <br>
Line 13:		Line 13:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/rz/1rz1_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/rz/1rz1_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 28:		Line 28:
	</div>		</div>
	<div class="pdbe-citations 1rz1" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 1rz1" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Flavin reductase\|Flavin reductase]]
	== References ==		== References ==
	<references/>		<references/>
Line 33:		Line 36:
	</StructureSection>		</StructureSection>
	[[Category: Geobacillus thermoglucosidans]]		[[Category: Geobacillus thermoglucosidans]]
		+	[[Category: Large Structures]]
	[[Category: Berkel, W J.Van]]		[[Category: Berkel, W J.Van]]
	[[Category: Heck, A J]]		[[Category: Heck, A J]]

OCA at 07:43, 12 October 2017

OCA — Thu, 12 Oct 2017 07:43:08 GMT

←Older revision		Revision as of 07:43, 12 October 2017
Line 1:		Line 1:
		+
	==Reduced flavin reductase PheA2 in complex with NAD==		==Reduced flavin reductase PheA2 in complex with NAD==
	<StructureSection load='1rz1' size='340' side='right' caption='[[1rz1]], [[Resolution\|resolution]] 2.10Å' scene=''>		<StructureSection load='1rz1' size='340' side='right' caption='[[1rz1]], [[Resolution\|resolution]] 2.10Å' scene=''>
Line 6:		Line 7:
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1rz0\|1rz0]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1rz0\|1rz0]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1rz1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1rz1 OCA], [http://pdbe.org/1rz1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1rz1 RCSB], [http://www.ebi.ac.uk/pdbsum/1rz1 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1rz1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1rz1 OCA], [http://pdbe.org/1rz1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1rz1 RCSB], [http://www.ebi.ac.uk/pdbsum/1rz1 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1rz1 ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 27:		Line 28:
	</div>		</div>
	<div class="pdbe-citations 1rz1" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 1rz1" style="background-color:#fffaf0;"></div>
-
-	==See Also==
-	*[[Flavin reductase\|Flavin reductase]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 02:26, 10 February 2016

OCA — Wed, 10 Feb 2016 02:26:26 GMT

←Older revision		Revision as of 02:26, 10 February 2016
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	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1rz1 ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 04:28, 11 September 2015

OCA — Fri, 11 Sep 2015 04:28:01 GMT

←Older revision		Revision as of 04:28, 11 September 2015
Line 2:		Line 2:
	<StructureSection load='1rz1' size='340' side='right' caption='[[1rz1]], [[Resolution\|resolution]] 2.10Å' scene=''>		<StructureSection load='1rz1' size='340' side='right' caption='[[1rz1]], [[Resolution\|resolution]] 2.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1rz1]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Geobacillus_thermoglucosidasius Geobacillus thermoglucosidasius~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RZ1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1RZ1 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1rz1]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/'geobacillus_thermoglucosidans' 'geobacillus thermoglucosidans']. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RZ1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1RZ1 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1rz0\|1rz0]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1rz0\|1rz0]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1rz1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1rz1 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1rz1 RCSB], [http://www.ebi.ac.uk/pdbsum/1rz1 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1rz1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1rz1 OCA], [http://pdbe.org/1rz1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1rz1 RCSB], [http://www.ebi.ac.uk/pdbsum/1rz1 PDBsum]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 26:		Line 26:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1rz1" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 33:		Line 34:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Geobacillus ~~thermoglucosidasius~~]]	+	[[Category: Geobacillus thermoglucosidans]]
	[[Category: Berkel, W J.Van]]		[[Category: Berkel, W J.Van]]
	[[Category: Heck, A J]]		[[Category: Heck, A J]]

OCA at 06:35, 6 January 2015

OCA — Tue, 06 Jan 2015 06:35:49 GMT

←Older revision		Revision as of 06:35, 6 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1rz1]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Geobacillus_thermoglucosidasius Geobacillus thermoglucosidasius]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RZ1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1RZ1 FirstGlance]. <br>		<table><tr><td colspan='2'>[[1rz1]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Geobacillus_thermoglucosidasius Geobacillus thermoglucosidasius]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RZ1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1RZ1 FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>	+	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1rz0\|1rz0]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1rz0\|1rz0]]</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1rz1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1rz1 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1rz1 RCSB], [http://www.ebi.ac.uk/pdbsum/1rz1 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1rz1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1rz1 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1rz1 RCSB], [http://www.ebi.ac.uk/pdbsum/1rz1 PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 34:		Line 34:
	</StructureSection>		</StructureSection>
	[[Category: Geobacillus thermoglucosidasius]]		[[Category: Geobacillus thermoglucosidasius]]
-	[[Category: Berkel, W J.Van.]]	+	[[Category: Berkel, W J.Van]]
-	[[Category: Heck, A J.]]	+	[[Category: Heck, A J]]
-	[[Category: Heuvel, R H.Van Den.]]	+	[[Category: Heuvel, R H.Van Den]]
-	[[Category: Mattevi, A.]]	+	[[Category: Mattevi, A]]
-	[[Category: Rovida, S.]]	+	[[Category: Rovida, S]]
-	[[Category: Walsh, M A.]]	+	[[Category: Walsh, M A]]
-	[[Category: Westphal, A H.]]	+	[[Category: Westphal, A H]]
	[[Category: Flavin]]		[[Category: Flavin]]
	[[Category: Nad]]		[[Category: Nad]]
	[[Category: Oxidoreductase]]		[[Category: Oxidoreductase]]

OCA at 19:14, 28 September 2014

OCA — Sun, 28 Sep 2014 19:14:58 GMT

←Older revision		Revision as of 19:14, 28 September 2014
Line 1:		Line 1:
-	[[~~Image:~~1rz1.~~png~~\|~~left~~\|200px]]	+	==Reduced flavin reductase PheA2 in complex with NAD==
		+	<StructureSection load='1rz1' size='340' side='right' caption='[[1rz1]], [[Resolution\|resolution]] 2.10Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1rz1]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Geobacillus_thermoglucosidasius Geobacillus thermoglucosidasius]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RZ1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1RZ1 FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1rz0\|1rz0]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1rz1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1rz1 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1rz1 RCSB], [http://www.ebi.ac.uk/pdbsum/1rz1 PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/rz/1rz1_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The catabolism of toxic phenols in the thermophilic organism Bacillus thermoglucosidasius A7 is initiated by a two-component enzyme system. The smaller flavin reductase PheA2 component catalyzes the NADH-dependent reduction of free FAD according to a ping-pong bisubstrate-biproduct mechanism. The reduced FAD is then used by the larger oxygenase component PheA1 to hydroxylate phenols to the corresponding catechols. We have determined the x-ray structure of PheA2 containing a bound FAD cofactor (2.2 A), which is the first structure of a member of this flavin reductase family. We have also determined the x-ray structure of reduced holo-PheA2 in complex with oxidized NAD (2.1 A). PheA2 is a single domain homodimeric protein with each FAD-containing subunit being organized around a six-stranded beta-sheet and a capping alpha-helix. The tightly bound FAD prosthetic group (K(d) = 10 nm) binds near the dimer interface, and the re face of the FAD isoalloxazine ring is fully exposed to solvent. The addition of NADH to crystalline PheA2 reduced the flavin cofactor, and the NAD product was bound in a wide solvent-accessible groove adopting an unusual folded conformation with ring stacking. This is the first observation of an enzyme that is very likely to react with a folded compact pyridine nucleotide. The PheA2 crystallographic models strongly suggest that reactive exogenous FAD substrate binds in the NADH cleft after release of NAD product. Nanoflow electrospray mass spectrometry data indeed showed that PheA2 is able to bind one FAD cofactor and one FAD substrate. In conclusion, the structural data provide evidence that PheA2 contains a dual binding cleft for NADH and FAD substrate, which alternate during catalysis.

-	~~{{STRUCTURE_1rz1\| PDB=1rz1 \| SCENE= }}~~	+	Structural studies on flavin reductase PheA2 reveal binding of NAD in an unusual folded conformation and support novel mechanism of action.,van den Heuvel RH, Westphal AH, Heck AJ, Walsh MA, Rovida S, van Berkel WJ, Mattevi A J Biol Chem. 2004 Mar 26;279(13):12860-7. Epub 2003 Dec 31. PMID:14703520<ref>PMID:14703520</ref>

-	~~===Reduced flavin reductase PheA2 in complex with NAD===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_14703520}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[1rz1]] is~~ a ~~8 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Geobacillus_thermoglucosidasius Geobacillus thermoglucosidasius]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=1RZ1 OCA].~~	+

	==See Also==		==See Also==
	*[[Flavin reductase\|Flavin reductase]]		*[[Flavin reductase\|Flavin reductase]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:014703520<~~/~~ref~~><~~references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Geobacillus thermoglucosidasius]]		[[Category: Geobacillus thermoglucosidasius]]
	[[Category: Berkel, W J.Van.]]		[[Category: Berkel, W J.Van.]]

OCA at 16:00, 20 October 2012

OCA — Sat, 20 Oct 2012 16:00:12 GMT

←Older revision		Revision as of 16:00, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[1rz1]] is a 8 chain structure ~~of [[Flavin reductase]]~~ with sequence from [http://en.wikipedia.org/wiki/Geobacillus_thermoglucosidasius Geobacillus thermoglucosidasius]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RZ1 OCA].	+	[[1rz1]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Geobacillus_thermoglucosidasius Geobacillus thermoglucosidasius]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RZ1 OCA].

	==See Also==		==See Also==

OCA: Protected "1rz1" [edit=sysop:move=sysop]

OCA — Thu, 26 Jul 2012 20:16:33 GMT

Protected "1rz1" [edit=sysop:move=sysop]

←Older revision

Revision as of 20:16, 26 July 2012