1s6n - Revision history

OCA at 21:35, 28 June 2023

OCA — Wed, 28 Jun 2023 21:35:15 GMT

←Older revision		Revision as of 21:35, 28 June 2023
Line 1:		Line 1:

	==NMR Structure of Domain III of the West Nile Virus Envelope Protein, Strain 385-99==		==NMR Structure of Domain III of the West Nile Virus Envelope Protein, Strain 385-99==
-	<StructureSection load='1s6n' size='340' side='right'caption='[[1s6n~~]], [[NMR_Ensembles_of_Models \| 15 NMR models~~]]' scene=''>	+	<StructureSection load='1s6n' size='340' side='right'caption='[[1s6n]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1s6n]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~West_nile_virus_strain_385~~-99 West ~~nile~~ virus strain 385-99]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1S6N OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1S6N FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1s6n]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/West_Nile_virus_strain_385-99 West Nile virus strain 385-99]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1S6N OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1S6N FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1s6n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1s6n OCA], [https://pdbe.org/1s6n PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1s6n RCSB], [https://www.ebi.ac.uk/pdbsum/1s6n PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1s6n ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1s6n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1s6n OCA], [https://pdbe.org/1s6n PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1s6n RCSB], [https://www.ebi.ac.uk/pdbsum/1s6n PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1s6n ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/Q913C7_WNV Q913C7_WNV]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 20:		Line 23:
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: West ~~nile~~ virus strain 385-99]]	+	[[Category: West Nile virus strain 385-99]]
-	[[Category: Barrett~~, A D~~]]	+	[[Category: Barrett AD]]
-	[[Category: Beasley~~, D W~~]]	+	[[Category: Beasley DW]]
-	[[Category: Gorenstein~~, D G~~]]	+	[[Category: Gorenstein DG]]
-	[[Category: Holbrook~~, M R~~]]	+	[[Category: Holbrook MR]]
-	[[Category: Kallick~~, D A~~]]	+	[[Category: Kallick DA]]
-	[[Category: Volk~~, D E]]~~	+	[[Category: Volk DE]]
-	~~[[Category: Beta barrel]]~~	+
-	~~[[Category: Flavivirus]]~~	+
-	~~[[Category: Viral protein~~]]	+

OCA at 07:27, 22 September 2021

OCA — Wed, 22 Sep 2021 07:27:20 GMT

←Older revision		Revision as of 07:27, 22 September 2021
Line 3:		Line 3:
	<StructureSection load='1s6n' size='340' side='right'caption='[[1s6n]], [[NMR_Ensembles_of_Models \| 15 NMR models]]' scene=''>		<StructureSection load='1s6n' size='340' side='right'caption='[[1s6n]], [[NMR_Ensembles_of_Models \| 15 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1s6n]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/West_nile_virus_strain_385-99 West nile virus strain 385-99]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1S6N OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1S6N FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1s6n]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/West_nile_virus_strain_385-99 West nile virus strain 385-99]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1S6N OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1S6N FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1s6n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1s6n OCA], [~~http~~://pdbe.org/1s6n PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1s6n RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1s6n PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1s6n ProSAT]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1s6n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1s6n OCA], [https://pdbe.org/1s6n PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1s6n RCSB], [https://www.ebi.ac.uk/pdbsum/1s6n PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1s6n ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 19:11, 11 December 2019

OCA — Wed, 11 Dec 2019 19:11:19 GMT

←Older revision		Revision as of 19:11, 11 December 2019
Line 1:		Line 1:

	==NMR Structure of Domain III of the West Nile Virus Envelope Protein, Strain 385-99==		==NMR Structure of Domain III of the West Nile Virus Envelope Protein, Strain 385-99==
-	<StructureSection load='1s6n' size='340' side='right' caption='[[1s6n]], [[NMR_Ensembles_of_Models \| 15 NMR models]]' scene=''>	+	<StructureSection load='1s6n' size='340' side='right'caption='[[1s6n]], [[NMR_Ensembles_of_Models \| 15 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1s6n]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/West_nile_virus_strain_385-99 West nile virus strain 385-99]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1S6N OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1S6N FirstGlance]. <br>		<table><tr><td colspan='2'>[[1s6n]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/West_nile_virus_strain_385-99 West nile virus strain 385-99]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1S6N OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1S6N FirstGlance]. <br>
Line 19:		Line 19:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: West nile virus strain 385-99]]		[[Category: West nile virus strain 385-99]]
	[[Category: Barrett, A D]]		[[Category: Barrett, A D]]

OCA at 06:42, 8 March 2018

OCA — Thu, 08 Mar 2018 06:42:57 GMT

←Older revision		Revision as of 06:42, 8 March 2018
Line 1:		Line 1:
		+
	==NMR Structure of Domain III of the West Nile Virus Envelope Protein, Strain 385-99==		==NMR Structure of Domain III of the West Nile Virus Envelope Protein, Strain 385-99==
	<StructureSection load='1s6n' size='340' side='right' caption='[[1s6n]], [[NMR_Ensembles_of_Models \| 15 NMR models]]' scene=''>		<StructureSection load='1s6n' size='340' side='right' caption='[[1s6n]], [[NMR_Ensembles_of_Models \| 15 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1s6n]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/West_nile_virus_strain_385-99 West nile virus strain 385-99]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1S6N OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1S6N FirstGlance]. <br>		<table><tr><td colspan='2'>[[1s6n]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/West_nile_virus_strain_385-99 West nile virus strain 385-99]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1S6N OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1S6N FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1s6n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1s6n OCA], [http://pdbe.org/1s6n PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1s6n RCSB], [http://www.ebi.ac.uk/pdbsum/1s6n PDBsum]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1s6n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1s6n OCA], [http://pdbe.org/1s6n PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1s6n RCSB], [http://www.ebi.ac.uk/pdbsum/1s6n PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1s6n ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 11:41, 10 September 2015

OCA — Thu, 10 Sep 2015 11:41:51 GMT

←Older revision		Revision as of 11:41, 10 September 2015
Line 2:		Line 2:
	<StructureSection load='1s6n' size='340' side='right' caption='[[1s6n]], [[NMR_Ensembles_of_Models \| 15 NMR models]]' scene=''>		<StructureSection load='1s6n' size='340' side='right' caption='[[1s6n]], [[NMR_Ensembles_of_Models \| 15 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1s6n]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~West_nile_virus~~ West nile virus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1S6N OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1S6N FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1s6n]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/West_nile_virus_strain_385-99 West nile virus strain 385-99]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1S6N OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1S6N FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1s6n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1s6n OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1s6n RCSB], [http://www.ebi.ac.uk/pdbsum/1s6n PDBsum]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1s6n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1s6n OCA], [http://pdbe.org/1s6n PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1s6n RCSB], [http://www.ebi.ac.uk/pdbsum/1s6n PDBsum]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 13:		Line 13:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1s6n" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: West nile virus]]	+	[[Category: West nile virus strain 385-99]]
	[[Category: Barrett, A D]]		[[Category: Barrett, A D]]
	[[Category: Beasley, D W]]		[[Category: Beasley, D W]]

OCA at 16:15, 15 January 2015

OCA — Thu, 15 Jan 2015 16:15:31 GMT

←Older revision		Revision as of 16:15, 15 January 2015
Line 18:		Line 18:
	</StructureSection>		</StructureSection>
	[[Category: West nile virus]]		[[Category: West nile virus]]
-	[[Category: Barrett, A D.]]	+	[[Category: Barrett, A D]]
-	[[Category: Beasley, D W.]]	+	[[Category: Beasley, D W]]
-	[[Category: Gorenstein, D G.]]	+	[[Category: Gorenstein, D G]]
-	[[Category: Holbrook, M R.]]	+	[[Category: Holbrook, M R]]
-	[[Category: Kallick, D A.]]	+	[[Category: Kallick, D A]]
-	[[Category: Volk, D E.]]	+	[[Category: Volk, D E]]
	[[Category: Beta barrel]]		[[Category: Beta barrel]]
	[[Category: Flavivirus]]		[[Category: Flavivirus]]
	[[Category: Viral protein]]		[[Category: Viral protein]]

OCA at 08:22, 8 October 2014

OCA — Wed, 08 Oct 2014 08:22:29 GMT

←Older revision		Revision as of 08:22, 8 October 2014
Line 1:		Line 1:
-	[[~~Image~~:1s6n.~~png\|left\|200px~~]]	+	==NMR Structure of Domain III of the West Nile Virus Envelope Protein, Strain 385-99==
		+	<StructureSection load='1s6n' size='340' side='right' caption='[[1s6n]], [[NMR_Ensembles_of_Models \| 15 NMR models]]' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1s6n]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/West_nile_virus West nile virus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1S6N OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1S6N FirstGlance]. <br>
		+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1s6n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1s6n OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1s6n RCSB], [http://www.ebi.ac.uk/pdbsum/1s6n PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The solution structure of domain III from the New York West Nile virus strain 385-99 (WN-rED3) has been determined by NMR methods. The West Nile domain III structure is a beta-barrel structure formed from seven anti-parallel beta-strands in two beta-sheets. One anti-parallel beta-sheet consists of beta-strands beta1 (Phe(299)-Asp(307)), beta2 (Val(313)-Tyr(319)), beta4 (Arg(354)-Leu(355)), and beta5 (Lys(370)-Glu(376)) arranged so that beta2 is flanked on either side by beta1 and beta5. The short beta4 flanks the end of the remaining side of beta5. The remaining anti-parallel beta-sheet is formed from strands beta3 (Ile(340)-Val(343)), beta6 (Gly(380)-Arg(388)), and beta7 (Gln(391)-Lys(399)) arranged with beta6 at the center. Residues implicated in antigenic differences between different West Nile virus strains (and other flaviviruses) and neutralization are located on the outer surface of the protein. Characterization of the binding of monoclonal antibodies to WN-rED3 mutants, which were identified through neutralization escape experiments, indicate that antibody neutralization directly correlates with binding affinities. These studies provide an insight into theoretical virus-receptor interaction points, structure of immunogenic determinants, and potential targets for antiviral agents against West Nile virus and highlight differences between West Nile virus and other flavivirus structures that may represent critical determinants of virulence.

-	~~{{STRUCTURE_1s6n\| PDB=1s6n \| SCENE= }}~~	+	Solution structure and antibody binding studies of the envelope protein domain III from the New York strain of West Nile virus.,Volk DE, Beasley DW, Kallick DA, Holbrook MR, Barrett AD, Gorenstein DG J Biol Chem. 2004 Sep 10;279(37):38755-61. Epub 2004 Jun 9. PMID:15190071<ref>PMID:15190071</ref>

-	~~===NMR Structure~~ of ~~Domain III~~ of ~~the West Nile Virus Envelope Protein, Strain 385-99===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_15190071}}~~	+	== References ==
-		+	<references/>
-	==~~About this Structure~~==	+	__TOC__
-	~~[[1s6n]] is a 1 chain structure with sequence from [http:~~//~~en.wikipedia.org/wiki/West_nile_virus West nile virus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1S6N OCA].~~	+	</StructureSection>
	[[Category: West nile virus]]		[[Category: West nile virus]]
	[[Category: Barrett, A D.]]		[[Category: Barrett, A D.]]

OCA: Protected "1s6n" [edit=sysop:move=sysop]

OCA — Fri, 04 Jan 2013 10:07:55 GMT

Protected "1s6n" [edit=sysop:move=sysop]

←Older revision

Revision as of 10:07, 4 January 2013

OCA at 10:07, 4 January 2013

OCA — Fri, 04 Jan 2013 10:07:51 GMT

←Older revision		Revision as of 10:07, 4 January 2013
Line 1:		Line 1:
-	{{Seed}}
	[[Image:1s6n.png\|left\|200px]]		[[Image:1s6n.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_1s6n", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_1s6n\| PDB=1s6n \| SCENE= }}		{{STRUCTURE_1s6n\| PDB=1s6n \| SCENE= }}

	===NMR Structure of Domain III of the West Nile Virus Envelope Protein, Strain 385-99===		===NMR Structure of Domain III of the West Nile Virus Envelope Protein, Strain 385-99===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_15190071}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 15190071 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_15190071}}		{{ABSTRACT_PUBMED_15190071}}

	==About this Structure==		==About this Structure==
-	~~1S6N is a~~ [[~~Single protein~~]] structure of sequence from [http://en.wikipedia.org/wiki/West_nile_virus West nile virus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1S6N OCA].	+	[[1s6n]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/West_nile_virus West nile virus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1S6N OCA].
-		+
-	~~==Reference==~~	+
-	Solution structure and antibody binding studies of the envelope protein domain III from the New York strain of West Nile virus., Volk DE, Beasley DW, Kallick DA, Holbrook MR, Barrett AD, Gorenstein DG, J Biol Chem. 2004 Sep 10;279(37):38755-61. Epub 2004 Jun 9. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15190071 15190071]	+
-	~~[[Category: Single protein]]~~	+
	[[Category: West nile virus]]		[[Category: West nile virus]]
	[[Category: Barrett, A D.]]		[[Category: Barrett, A D.]]
Line 34:		Line 18:
	[[Category: Beta barrel]]		[[Category: Beta barrel]]
	[[Category: Flavivirus]]		[[Category: Flavivirus]]
-		+	[[Category: Viral protein]]
-	~~''Page seeded by~~ [~~http~~:~~//oca.weizmann.ac.il/oca OCA~~ ] ~~on Mon Jul 28 03:06:53 2008''~~	+

OCA at 00:06, 28 July 2008

OCA — Mon, 28 Jul 2008 00:06:58 GMT

←Older revision		Revision as of 00:06, 28 July 2008
Line 1:		Line 1:
-	[[Image:1s6n.~~gif~~\|left\|200px]]	+	{{Seed}}
		+	[[Image:1s6n.png\|left\|200px]]

	<!--		<!--
Line 9:		Line 10:
	{{STRUCTURE_1s6n\| PDB=1s6n \| SCENE= }}		{{STRUCTURE_1s6n\| PDB=1s6n \| SCENE= }}

-	~~'''~~NMR Structure of Domain III of the West Nile Virus Envelope Protein, Strain 385-99~~'''~~	+	===NMR Structure of Domain III of the West Nile Virus Envelope Protein, Strain 385-99===


-	~~==Overview==~~	+	<!--
-	~~The solution structure of domain III from the New York West Nile virus strain 385~~-~~99 (WN~~-~~rED3) has been determined by NMR methods.~~ The West Nile domain III structure is a beta-barrel structure formed from seven anti-parallel beta-strands in two beta-sheets. One anti-parallel beta-sheet consists of beta-strands beta1 (Phe(299)-Asp(307)), ~~beta2 (Val(313)-Tyr(319))~~, ~~beta4~~ (~~Arg(354)-Leu(355)), and beta5 (Lys(370)-Glu(376)) arranged so that beta2 is flanked~~ on ~~either side by beta1 and beta5~~. ~~The short beta4 flanks the end of the remaining side of beta5~~. ~~The remaining anti-parallel beta-sheet is formed from strands beta3 (Ile(340)-Val(343)~~), ~~beta6 (Gly(380)-Arg(388)), and beta7 (Gln(391)-Lys(399)) arranged with beta6 at~~ the ~~center~~. Residues implicated in antigenic differences between different West Nile virus strains (and other flaviviruses) and neutralization are located on the outer surface of the protein. Characterization of the binding of monoclonal antibodies to WN-rED3 mutants, which were identified through neutralization escape experiments, indicate that antibody neutralization directly correlates with binding affinities. These studies provide an insight into theoretical virus-receptor interaction points, structure of immunogenic determinants, and potential targets for antiviral agents against West Nile virus and highlight differences between West Nile virus and other flavivirus structures that may represent critical determinants of virulence.	+	The line below this paragraph, {{ABSTRACT_PUBMED_15190071}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 15190071 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_15190071}}

	==About this Structure==		==About this Structure==
-	1S6N is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/West_nile_virus West nile virus]. Full ~~crystallographic~~ information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1S6N OCA].	+	1S6N is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/West_nile_virus West nile virus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1S6N OCA].

	==Reference==		==Reference==
Line 30:		Line 34:
	[[Category: Beta barrel]]		[[Category: Beta barrel]]
	[[Category: Flavivirus]]		[[Category: Flavivirus]]
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Sat May 3 08~~:21:58 2008''	+
		+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 03:06:53 2008''