1s7u - Revision history

OCA at 06:14, 23 August 2023

OCA — Wed, 23 Aug 2023 06:14:08 GMT

←Older revision		Revision as of 06:14, 23 August 2023
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	<StructureSection load='1s7u' size='340' side='right'caption='[[1s7u]], [[Resolution\|resolution]] 2.20Å' scene=''>		<StructureSection load='1s7u' size='340' side='right'caption='[[1s7u]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1s7u]] is a 12 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Lk3_transgenic_mice Lk3 transgenic mice~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1S7U OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=1S7U FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1s7u]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Lymphocytic_choriomeningitis_virus_(strain_WE) Lymphocytic choriomeningitis virus (strain WE)] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1S7U OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1S7U FirstGlance]. <br>
-	</td></tr><tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"~~><div style='overflow: auto; max-height: 3em;'>[[1n5a\|1n5a]], [[1s7q\|1s7q]], [[1s7r\|1s7r]], [[1s7s\|1s7s]], [[1s7t\|1s7t]], [[1s7v\|1s7v]], [[1s7w\|1s7w]], [[1s7x\|1s7x]]</div></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.2Å</td></tr>
-	~~<tr~~ id~~='gene'><td class~~="~~sblockLbl~~">~~<b>~~[[~~Gene~~\|~~Gene:~~]]~~</b></td><td class="sblockDat">H2-D1 ([http://www~~.~~ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info~~&~~srchmode=5&id=10090 LK3 transgenic mice]), B2M ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])~~</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1s7u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1s7u OCA], [https://pdbe.org/1s7u PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1s7u RCSB], [https://www.ebi.ac.uk/pdbsum/1s7u PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1s7u ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=1s7u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1s7u OCA], [~~http~~://pdbe.org/1s7u PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1s7u RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1s7u PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1s7u ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/HA11_MOUSE HA11_MOUSE]] Involved in the presentation of foreign antigens to the immune system. [[http://www.uniprot.org/uniprot/GLYC_LYCVW GLYC_LYCVW]] The stable signal peptide (SSP) is cleaved and functions as a signal peptide. In addition, it is apparently retained as the third component of the GP complex. The SSP is required for efficient glycoprotein expression, post-translational maturation cleavage of GP1 and GP2, glycoprotein transport to the cell surface plasma membrane, formation of infectious virus particles, and acid pH-dependent glycoprotein-mediated cell fusion (By similarity). Glycoprotein G1 mediates virus attachment to host receptor alpha-dystroglycan DAG1. This attachment induces virion internalization predominantly through clathrin- and caveolin-independent endocytosis (By similarity). Glycoprotein G2 is a viral fusion protein. Membrane fusion is mediated by conformational changes induced upon acidification in the endosome (Potential). [[http://www.uniprot.org/uniprot/B2MG_MOUSE B2MG_MOUSE]] Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.	+	[https://www.uniprot.org/uniprot/HA11_MOUSE HA11_MOUSE] Involved in the presentation of foreign antigens to the immune system.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	*[[Beta-2 microglobulin 3D structures\|Beta-2 microglobulin 3D structures]]		*[[Beta-2 microglobulin 3D structures\|Beta-2 microglobulin 3D structures]]
	*[[MHC 3D structures\|MHC 3D structures]]		*[[MHC 3D structures\|MHC 3D structures]]
		+	*[[MHC I 3D structures\|MHC I 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
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	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Lk3 transgenic mice~~]]	+	[[Category: Mus musculus]]
-	[[Category: Achour, A]]	+	[[Category: Achour A]]
-	[[Category: Ljunggren~~, H G~~]]	+	[[Category: Ljunggren HG]]
-	[[Category: Michaelsson, J]]	+	[[Category: Michaelsson J]]
-	[[Category: Schneider, G]]	+	[[Category: Schneider G]]
-	[[Category: Velloso~~, L M]]~~	+	[[Category: Velloso LM]]
-	~~[[Category: Immune escape]]~~	+
-	~~[[Category: Immune system]]~~	+
-	~~[[Category: Lcmv]]~~	+
-	~~[[Category: Mhc class i~~]]	+

OCA at 13:43, 16 December 2020

OCA — Wed, 16 Dec 2020 13:43:04 GMT

←Older revision		Revision as of 13:43, 16 December 2020
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	==Crystal structures of the murine class I major histocompatibility complex H-2Db in complex with LCMV-derived gp33 index peptide and three of its escape variants==		==Crystal structures of the murine class I major histocompatibility complex H-2Db in complex with LCMV-derived gp33 index peptide and three of its escape variants==
-	<StructureSection load='1s7u' size='340' side='right' caption='[[1s7u]], [[Resolution\|resolution]] 2.20Å' scene=''>	+	<StructureSection load='1s7u' size='340' side='right'caption='[[1s7u]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1s7u]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1S7U OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1S7U FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1s7u]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1S7U OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=1S7U FirstGlance]. <br>
-	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1n5a\|1n5a]], [[1s7q\|1s7q]], [[1s7r\|1s7r]], [[1s7s\|1s7s]], [[1s7t\|1s7t]], [[1s7v\|1s7v]], [[1s7w\|1s7w]], [[1s7x\|1s7x]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1n5a\|1n5a]], [[1s7q\|1s7q]], [[1s7r\|1s7r]], [[1s7s\|1s7s]], [[1s7t\|1s7t]], [[1s7v\|1s7v]], [[1s7w\|1s7w]], [[1s7x\|1s7x]]</div></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">H2-D1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice]), B2M ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">H2-D1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice]), B2M ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1s7u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1s7u OCA], [http://pdbe.org/1s7u PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1s7u RCSB], [http://www.ebi.ac.uk/pdbsum/1s7u PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1s7u ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=1s7u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1s7u OCA], [http://pdbe.org/1s7u PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1s7u RCSB], [http://www.ebi.ac.uk/pdbsum/1s7u PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1s7u ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 31:		Line 31:

	==See Also==		==See Also==
-	*[[Beta-2 microglobulin\|Beta-2 microglobulin]]	+	*[[Beta-2 microglobulin 3D structures\|Beta-2 microglobulin 3D structures]]
-	*[[~~Major histocompatibility complex~~\|~~Major histocompatibility complex~~]]	+	*[[MHC 3D structures\|MHC 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Lk3 transgenic mice]]		[[Category: Lk3 transgenic mice]]
	[[Category: Achour, A]]		[[Category: Achour, A]]

OCA at 06:52, 8 March 2018

OCA — Thu, 08 Mar 2018 06:52:39 GMT

←Older revision		Revision as of 06:52, 8 March 2018
Line 1:		Line 1:
		+
	==Crystal structures of the murine class I major histocompatibility complex H-2Db in complex with LCMV-derived gp33 index peptide and three of its escape variants==		==Crystal structures of the murine class I major histocompatibility complex H-2Db in complex with LCMV-derived gp33 index peptide and three of its escape variants==
	<StructureSection load='1s7u' size='340' side='right' caption='[[1s7u]], [[Resolution\|resolution]] 2.20Å' scene=''>		<StructureSection load='1s7u' size='340' side='right' caption='[[1s7u]], [[Resolution\|resolution]] 2.20Å' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1n5a\|1n5a]], [[1s7q\|1s7q]], [[1s7r\|1s7r]], [[1s7s\|1s7s]], [[1s7t\|1s7t]], [[1s7v\|1s7v]], [[1s7w\|1s7w]], [[1s7x\|1s7x]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1n5a\|1n5a]], [[1s7q\|1s7q]], [[1s7r\|1s7r]], [[1s7s\|1s7s]], [[1s7t\|1s7t]], [[1s7v\|1s7v]], [[1s7w\|1s7w]], [[1s7x\|1s7x]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">H2-D1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice]), B2M ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">H2-D1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice]), B2M ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1s7u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1s7u OCA], [http://pdbe.org/1s7u PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1s7u RCSB], [http://www.ebi.ac.uk/pdbsum/1s7u PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1s7u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1s7u OCA], [http://pdbe.org/1s7u PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1s7u RCSB], [http://www.ebi.ac.uk/pdbsum/1s7u PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1s7u ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/s7/1s7u_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/s7/1s7u_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1s7u ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 08:28, 11 September 2015

OCA — Fri, 11 Sep 2015 08:28:07 GMT

←Older revision		Revision as of 08:28, 11 September 2015
Line 2:		Line 2:
	<StructureSection load='1s7u' size='340' side='right' caption='[[1s7u]], [[Resolution\|resolution]] 2.20Å' scene=''>		<StructureSection load='1s7u' size='340' side='right' caption='[[1s7u]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1s7u]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Mus_musculus Mus musculus~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1S7U OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1S7U FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1s7u]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1S7U OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1S7U FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1n5a\|1n5a]], [[1s7q\|1s7q]], [[1s7r\|1s7r]], [[1s7s\|1s7s]], [[1s7t\|1s7t]], [[1s7v\|1s7v]], [[1s7w\|1s7w]], [[1s7x\|1s7x]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1n5a\|1n5a]], [[1s7q\|1s7q]], [[1s7r\|1s7r]], [[1s7s\|1s7s]], [[1s7t\|1s7t]], [[1s7v\|1s7v]], [[1s7w\|1s7w]], [[1s7x\|1s7x]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">H2-D1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 ~~Mus musculus~~]), B2M ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 ~~Mus musculus~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">H2-D1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice]), B2M ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1s7u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1s7u OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1s7u RCSB], [http://www.ebi.ac.uk/pdbsum/1s7u PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1s7u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1s7u OCA], [http://pdbe.org/1s7u PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1s7u RCSB], [http://www.ebi.ac.uk/pdbsum/1s7u PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1s7u" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 35:		Line 36:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Mus musculus~~]]	+	[[Category: Lk3 transgenic mice]]
	[[Category: Achour, A]]		[[Category: Achour, A]]
	[[Category: Ljunggren, H G]]		[[Category: Ljunggren, H G]]

OCA at 13:52, 25 December 2014

OCA — Thu, 25 Dec 2014 13:52:36 GMT

←Older revision		Revision as of 13:52, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1s7u]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1S7U OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1S7U FirstGlance]. <br>		<table><tr><td colspan='2'>[[1s7u]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1S7U OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1S7U FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1n5a\|1n5a]], [[1s7q\|1s7q]], [[1s7r\|1s7r]], [[1s7s\|1s7s]], [[1s7t\|1s7t]], [[1s7v\|1s7v]], [[1s7w\|1s7w]], [[1s7x\|1s7x]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1n5a\|1n5a]], [[1s7q\|1s7q]], [[1s7r\|1s7r]], [[1s7s\|1s7s]], [[1s7t\|1s7t]], [[1s7v\|1s7v]], [[1s7w\|1s7w]], [[1s7x\|1s7x]]</td></tr>
-	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">H2-D1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus]), B2M ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">H2-D1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus]), B2M ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus])</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1s7u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1s7u OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1s7u RCSB], [http://www.ebi.ac.uk/pdbsum/1s7u PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1s7u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1s7u OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1s7u RCSB], [http://www.ebi.ac.uk/pdbsum/1s7u PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/HA11_MOUSE HA11_MOUSE]] Involved in the presentation of foreign antigens to the immune system. [[http://www.uniprot.org/uniprot/GLYC_LYCVW GLYC_LYCVW]] The stable signal peptide (SSP) is cleaved and functions as a signal peptide. In addition, it is apparently retained as the third component of the GP complex. The SSP is required for efficient glycoprotein expression, post-translational maturation cleavage of GP1 and GP2, glycoprotein transport to the cell surface plasma membrane, formation of infectious virus particles, and acid pH-dependent glycoprotein-mediated cell fusion (By similarity). Glycoprotein G1 mediates virus attachment to host receptor alpha-dystroglycan DAG1. This attachment induces virion internalization predominantly through clathrin- and caveolin-independent endocytosis (By similarity). Glycoprotein G2 is a viral fusion protein. Membrane fusion is mediated by conformational changes induced upon acidification in the endosome (Potential). [[http://www.uniprot.org/uniprot/B2MG_MOUSE B2MG_MOUSE]] Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 34:		Line 36:
	</StructureSection>		</StructureSection>
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
-	[[Category: Achour, A.]]	+	[[Category: Achour, A]]
-	[[Category: Ljunggren, H G.]]	+	[[Category: Ljunggren, H G]]
-	[[Category: Michaelsson, J.]]	+	[[Category: Michaelsson, J]]
-	[[Category: Schneider, G.]]	+	[[Category: Schneider, G]]
-	[[Category: Velloso, L M.]]	+	[[Category: Velloso, L M]]
	[[Category: Immune escape]]		[[Category: Immune escape]]
	[[Category: Immune system]]		[[Category: Immune system]]
	[[Category: Lcmv]]		[[Category: Lcmv]]
	[[Category: Mhc class i]]		[[Category: Mhc class i]]

OCA at 22:50, 28 September 2014

OCA — Sun, 28 Sep 2014 22:50:19 GMT

←Older revision		Revision as of 22:50, 28 September 2014
Line 1:		Line 1:
-	[[~~Image:~~1s7u.~~png~~\|~~left~~\|200px]]	+	==Crystal structures of the murine class I major histocompatibility complex H-2Db in complex with LCMV-derived gp33 index peptide and three of its escape variants==
		+	<StructureSection load='1s7u' size='340' side='right' caption='[[1s7u]], [[Resolution\|resolution]] 2.20Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1s7u]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1S7U OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1S7U FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1n5a\|1n5a]], [[1s7q\|1s7q]], [[1s7r\|1s7r]], [[1s7s\|1s7s]], [[1s7t\|1s7t]], [[1s7v\|1s7v]], [[1s7w\|1s7w]], [[1s7x\|1s7x]]</td></tr>
		+	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">H2-D1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus]), B2M ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus])</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1s7u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1s7u OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1s7u RCSB], [http://www.ebi.ac.uk/pdbsum/1s7u PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/s7/1s7u_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Lymphocytic choriomeningitis virus infection of H-2(b) mice generates a strong CD8(+) CTL response mainly directed toward three immunodominant epitopes, one of which, gp33, is presented by both H-2D(b) and H-2K(b) MHC class I molecules. This CTL response acts as a selective agent for the emergence of viral escape variants. These variants generate altered peptide ligands (APLs) that, when presented by class I MHC molecules, antagonize CTL recognition and ultimately allow the virus to evade the cellular immune response. The emergence of APLs of the gp33 epitope is particularly advantageous for LCMV, as it allows viral escape in the context of both H-2D(b) and H-2K(b) MHC class I molecules. We have determined crystal structures of three different APLs of gp33 in complex with both H-2D(b) and H-2K(b). Comparison between these APL/MHC structures and those of the index gp33 peptide/MHC reveals the structural basis for three different strategies used by LCMV viral escape mutations: 1) conformational changes in peptide and MHC residues that are potential TCR contacts, 2) impairment of APL binding to the MHC peptide binding cleft, and 3) introduction of subtle changes at the TCR/pMHC interface, such as the removal of a single hydroxyl group.

-	~~{{STRUCTURE_1s7u\| PDB=1s7u \| SCENE= }}~~	+	Determination of structural principles underlying three different modes of lymphocytic choriomeningitis virus escape from CTL recognition.,Velloso LM, Michaelsson J, Ljunggren HG, Schneider G, Achour A J Immunol. 2004 May 1;172(9):5504-11. PMID:15100292<ref>PMID:15100292</ref>

-	~~===Crystal structures~~ of the ~~murine class I major histocompatibility complex H-2Db in complex with LCMV-derived gp33 index peptide and three of its escape variants===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_15100292}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[1s7u]] is a 12 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Mus_musculus Mus musculus]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=1S7U OCA].~~	+

	==See Also==		==See Also==
	*[[Beta-2 microglobulin\|Beta-2 microglobulin]]		*[[Beta-2 microglobulin\|Beta-2 microglobulin]]
	*[[Major histocompatibility complex\|Major histocompatibility complex]]		*[[Major histocompatibility complex\|Major histocompatibility complex]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:015100292<~~/~~ref~~><~~references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
	[[Category: Achour, A.]]		[[Category: Achour, A.]]

OCA at 17:28, 20 October 2012

OCA — Sat, 20 Oct 2012 17:28:21 GMT

←Older revision		Revision as of 17:28, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[1s7u]] is a 12 chain structure ~~of [[Beta-2 microglobulin]] and [[Major histocompatibility complex]]~~ with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1S7U OCA].	+	[[1s7u]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1S7U OCA].

	==See Also==		==See Also==

OCA: Protected "1s7u" [edit=sysop:move=sysop]

OCA — Fri, 27 Jul 2012 00:59:36 GMT

Protected "1s7u" [edit=sysop:move=sysop]

←Older revision

Revision as of 00:59, 27 July 2012

OCA at 00:59, 27 July 2012

OCA — Fri, 27 Jul 2012 00:59:35 GMT

←Older revision		Revision as of 00:59, 27 July 2012
Line 1:		Line 1:
-	{{Seed}}
	[[Image:1s7u.png\|left\|200px]]		[[Image:1s7u.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_1s7u", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_1s7u\| PDB=1s7u \| SCENE= }}		{{STRUCTURE_1s7u\| PDB=1s7u \| SCENE= }}

	===Crystal structures of the murine class I major histocompatibility complex H-2Db in complex with LCMV-derived gp33 index peptide and three of its escape variants===		===Crystal structures of the murine class I major histocompatibility complex H-2Db in complex with LCMV-derived gp33 index peptide and three of its escape variants===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_15100292}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 15100292 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_15100292}}		{{ABSTRACT_PUBMED_15100292}}

	==About this Structure==		==About this Structure==
-	~~1S7U~~ is a 12 ~~chains~~ structure of ~~sequences~~ from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1S7U OCA].	+	[[1s7u]] is a 12 chain structure of [[Beta-2 microglobulin]] and [[Major histocompatibility complex]] with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1S7U OCA].
		+
		+	==See Also==
		+	*[[Beta-2 microglobulin\|Beta-2 microglobulin]]
		+	*[[Major histocompatibility complex\|Major histocompatibility complex]]

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~15100292~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:015100292</ref><references group="xtra"/>
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
	[[Category: Achour, A.]]		[[Category: Achour, A.]]
Line 31:		Line 23:
	[[Category: Velloso, L M.]]		[[Category: Velloso, L M.]]
	[[Category: Immune escape]]		[[Category: Immune escape]]
		+	[[Category: Immune system]]
	[[Category: Lcmv]]		[[Category: Lcmv]]
	[[Category: Mhc class i]]		[[Category: Mhc class i]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 17:55:56 2009''

OCA at 15:55, 17 February 2009

OCA — Tue, 17 Feb 2009 15:55:57 GMT

←Older revision		Revision as of 15:55, 17 February 2009
Line 20:		Line 20:

	==About this Structure==		==About this Structure==
-	1S7U is a ~~[[Protein complex]]~~ structure of sequences from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1S7U OCA].	+	1S7U is a 12 chains structure of sequences from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1S7U OCA].

	==Reference==		==Reference==
-	Determination of structural principles underlying three different modes of lymphocytic choriomeningitis virus escape from CTL recognition., Velloso LM, Michaelsson J, Ljunggren HG, Schneider G, Achour A, J Immunol. 2004 May 1;172(9):5504-11. PMID:~~[http:~~//~~www.ncbi.nlm.nih.gov/pubmed/15100292 15100292]~~	+	<ref group="xtra">PMID:15100292</ref><references group="xtra"/>
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
-	[[Category: Protein complex]]
	[[Category: Achour, A.]]		[[Category: Achour, A.]]
	[[Category: Ljunggren, H G.]]		[[Category: Ljunggren, H G.]]
Line 35:		Line 34:
	[[Category: Mhc class i]]		[[Category: Mhc class i]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue ~~Jul 29 01~~:03:~~06 2008~~''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 17:55:56 2009''