1s94 - Revision history

OCA at 06:14, 23 August 2023

OCA — Wed, 23 Aug 2023 06:14:37 GMT

←Older revision		Revision as of 06:14, 23 August 2023
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	<StructureSection load='1s94' size='340' side='right'caption='[[1s94]], [[Resolution\|resolution]] 3.34Å' scene=''>		<StructureSection load='1s94' size='340' side='right'caption='[[1s94]], [[Resolution\|resolution]] 3.34Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1s94]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1S94 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1S94 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1s94]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Doryteuthis_pealeii Doryteuthis pealeii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1S94 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1S94 FirstGlance]. <br>
-	</td></tr><tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat">~~<div style='overflow: auto; max~~-~~height: 3em;'>[[1epu\|1epu]]~~, [[~~1l4a~~\|~~1l4a~~]]~~, [[1br0\|1br0]], [[1dn1\|1dn1]], [[1ez3\|1ez3]]</div>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 3.34Å</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1s94 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1s94 OCA], [https://pdbe.org/1s94 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1s94 RCSB], [https://www.ebi.ac.uk/pdbsum/1s94 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1s94 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1s94 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1s94 OCA], [https://pdbe.org/1s94 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1s94 RCSB], [https://www.ebi.ac.uk/pdbsum/1s94 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1s94 ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/O46345_DORPE O46345_DORPE]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Doryteuthis pealeii]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Bracher, A]]	+	[[Category: Bracher A]]
-	[[Category: Weissenhorn, W]]	+	[[Category: Weissenhorn W]]
-	~~[[Category: Endocytosis-exocytosis complex]]~~	+
-	~~[[Category: Structural plasticity]]~~	+
-	~~[[Category: Three helix bundle~~]]	+

OCA at 07:27, 22 September 2021

OCA — Wed, 22 Sep 2021 07:27:49 GMT

←Older revision		Revision as of 07:27, 22 September 2021
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	<StructureSection load='1s94' size='340' side='right'caption='[[1s94]], [[Resolution\|resolution]] 3.34Å' scene=''>		<StructureSection load='1s94' size='340' side='right'caption='[[1s94]], [[Resolution\|resolution]] 3.34Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1s94]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1S94 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1S94 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1s94]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1S94 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1S94 FirstGlance]. <br>
-	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1epu\|1epu]], [[1l4a\|1l4a]], [[1br0\|1br0]], [[1dn1\|1dn1]], [[1ez3\|1ez3]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1epu\|1epu]], [[1l4a\|1l4a]], [[1br0\|1br0]], [[1dn1\|1dn1]], [[1ez3\|1ez3]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1s94 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1s94 OCA], [~~http~~://pdbe.org/1s94 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1s94 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1s94 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1s94 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1s94 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1s94 OCA], [https://pdbe.org/1s94 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1s94 RCSB], [https://www.ebi.ac.uk/pdbsum/1s94 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1s94 ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 28:		Line 28:

	==See Also==		==See Also==
-	*[[Syntaxin\|Syntaxin]]	+	*[[Syntaxin 3D structures\|Syntaxin 3D structures]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 19:04, 11 December 2019

OCA — Wed, 11 Dec 2019 19:04:22 GMT

←Older revision		Revision as of 19:04, 11 December 2019
Line 1:		Line 1:

	==Crystal structure of the Habc domain of neuronal syntaxin from the squid Loligo pealei==		==Crystal structure of the Habc domain of neuronal syntaxin from the squid Loligo pealei==
-	<StructureSection load='1s94' size='340' side='right' caption='[[1s94]], [[Resolution\|resolution]] 3.34Å' scene=''>	+	<StructureSection load='1s94' size='340' side='right'caption='[[1s94]], [[Resolution\|resolution]] 3.34Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1s94]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1S94 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1S94 FirstGlance]. <br>		<table><tr><td colspan='2'>[[1s94]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1S94 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1S94 FirstGlance]. <br>
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	</div>		</div>
	<div class="pdbe-citations 1s94" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 1s94" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Syntaxin\|Syntaxin]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Bracher, A]]		[[Category: Bracher, A]]
	[[Category: Weissenhorn, W]]		[[Category: Weissenhorn, W]]

OCA at 06:36, 8 March 2018

OCA — Thu, 08 Mar 2018 06:36:11 GMT

←Older revision		Revision as of 06:36, 8 March 2018
Line 1:		Line 1:
		+
	==Crystal structure of the Habc domain of neuronal syntaxin from the squid Loligo pealei==		==Crystal structure of the Habc domain of neuronal syntaxin from the squid Loligo pealei==
	<StructureSection load='1s94' size='340' side='right' caption='[[1s94]], [[Resolution\|resolution]] 3.34Å' scene=''>		<StructureSection load='1s94' size='340' side='right' caption='[[1s94]], [[Resolution\|resolution]] 3.34Å' scene=''>
Line 4:		Line 5:
	<table><tr><td colspan='2'>[[1s94]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1S94 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1S94 FirstGlance]. <br>		<table><tr><td colspan='2'>[[1s94]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1S94 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1S94 FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1epu\|1epu]], [[1l4a\|1l4a]], [[1br0\|1br0]], [[1dn1\|1dn1]], [[1ez3\|1ez3]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1epu\|1epu]], [[1l4a\|1l4a]], [[1br0\|1br0]], [[1dn1\|1dn1]], [[1ez3\|1ez3]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1s94 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1s94 OCA], [http://pdbe.org/1s94 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1s94 RCSB], [http://www.ebi.ac.uk/pdbsum/1s94 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1s94 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1s94 OCA], [http://pdbe.org/1s94 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1s94 RCSB], [http://www.ebi.ac.uk/pdbsum/1s94 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1s94 ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 10:		Line 11:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/s9/1s94_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/s9/1s94_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 00:27, 9 February 2016

OCA — Tue, 09 Feb 2016 00:27:23 GMT

←Older revision		Revision as of 00:27, 9 February 2016
Line 14:		Line 14:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1s94 ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 16:49, 10 September 2015

OCA — Thu, 10 Sep 2015 16:49:50 GMT

←Older revision		Revision as of 16:49, 10 September 2015
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	<StructureSection load='1s94' size='340' side='right' caption='[[1s94]], [[Resolution\|resolution]] 3.34Å' scene=''>		<StructureSection load='1s94' size='340' side='right' caption='[[1s94]], [[Resolution\|resolution]] 3.34Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1s94]] is a 2 chain structure ~~with sequence from [http://en.wikipedia.org/wiki/Doryteuthis_pealeii Doryteuthis pealeii]~~. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1S94 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1S94 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1s94]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1S94 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1S94 FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1epu\|1epu]], [[1l4a\|1l4a]], [[1br0\|1br0]], [[1dn1\|1dn1]], [[1ez3\|1ez3]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1epu\|1epu]], [[1l4a\|1l4a]], [[1br0\|1br0]], [[1dn1\|1dn1]], [[1ez3\|1ez3]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1s94 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1s94 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1s94 RCSB], [http://www.ebi.ac.uk/pdbsum/1s94 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1s94 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1s94 OCA], [http://pdbe.org/1s94 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1s94 RCSB], [http://www.ebi.ac.uk/pdbsum/1s94 PDBsum]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1s94" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Doryteuthis pealeii]]
	[[Category: Bracher, A]]		[[Category: Bracher, A]]
	[[Category: Weissenhorn, W]]		[[Category: Weissenhorn, W]]

OCA at 07:38, 6 January 2015

OCA — Tue, 06 Jan 2015 07:38:49 GMT

←Older revision		Revision as of 07:38, 6 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1s94]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Doryteuthis_pealeii Doryteuthis pealeii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1S94 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1S94 FirstGlance]. <br>		<table><tr><td colspan='2'>[[1s94]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Doryteuthis_pealeii Doryteuthis pealeii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1S94 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1S94 FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1epu\|1epu]], [[1l4a\|1l4a]], [[1br0\|1br0]], [[1dn1\|1dn1]], [[1ez3\|1ez3]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1epu\|1epu]], [[1l4a\|1l4a]], [[1br0\|1br0]], [[1dn1\|1dn1]], [[1ez3\|1ez3]]</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1s94 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1s94 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1s94 RCSB], [http://www.ebi.ac.uk/pdbsum/1s94 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1s94 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1s94 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1s94 RCSB], [http://www.ebi.ac.uk/pdbsum/1s94 PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 29:		Line 29:
	</StructureSection>		</StructureSection>
	[[Category: Doryteuthis pealeii]]		[[Category: Doryteuthis pealeii]]
-	[[Category: Bracher, A.]]	+	[[Category: Bracher, A]]
-	[[Category: Weissenhorn, W.]]	+	[[Category: Weissenhorn, W]]
	[[Category: Endocytosis-exocytosis complex]]		[[Category: Endocytosis-exocytosis complex]]
	[[Category: Structural plasticity]]		[[Category: Structural plasticity]]
	[[Category: Three helix bundle]]		[[Category: Three helix bundle]]

OCA at 14:22, 29 September 2014

OCA — Mon, 29 Sep 2014 14:22:43 GMT

←Older revision		Revision as of 14:22, 29 September 2014
Line 1:		Line 1:
-	[[~~Image:~~1s94.~~png~~\|~~left~~\|200px]]	+	==Crystal structure of the Habc domain of neuronal syntaxin from the squid Loligo pealei==
		+	<StructureSection load='1s94' size='340' side='right' caption='[[1s94]], [[Resolution\|resolution]] 3.34Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1s94]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Doryteuthis_pealeii Doryteuthis pealeii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1S94 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1S94 FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1epu\|1epu]], [[1l4a\|1l4a]], [[1br0\|1br0]], [[1dn1\|1dn1]], [[1ez3\|1ez3]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1s94 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1s94 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1s94 RCSB], [http://www.ebi.ac.uk/pdbsum/1s94 PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/s9/1s94_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	BACKGROUND: Intracellular membrane fusion processes are mediated by the spatial and temporal control of SNARE complex assembly that results in the formation of a four-helical bundle, composed of one vesicle SNARE and three target membrane SNARE polypeptide chains. Syntaxins are essential t-SNAREs and are characterized by an N-terminal Habc domain, a flexible linker region, a coiled-coil or SNARE motif and a membrane anchor. The N-terminal Habc domain fulfills important regulatory functions while the coiled-coil motif, present in all SNAREs, is sufficient for SNARE complex formation, which is thought to drive membrane fusion. RESULTS: Here we report the crystal structure of the Habc domain of neuronal syntaxin from the squid Loligo pealei, s-syntaxin. Squid Habc crystallizes as a dimer and the monomer structure consists of a three-helical bundle. One molecule is strikingly similar to mammalian syntaxin 1A while the second one shows a structural deviation from the common fold in that the C-terminal part of helix C unwinds and adopts an extended conformation. CONCLUSION: Conservation of surface residues indicates that the cytosolic part of s-syntaxin can adopt an auto-inhibitory closed conformation that may bind squid neuronal Sec1, s-Sec1, in the same manner as observed in structure of the rat nSec1/syntaxin 1A complex. Furthermore, despite the overall structural similarity, the observed changes at the C-terminus of one molecule indicate structural plasticity in neuronal syntaxin. Implications of the structural conservation and the changes are discussed with respect to potential Habc domain binding partners such as Munc13, which facilitates the transition from the closed to the open conformation.

-	~~{{STRUCTURE_1s94\| PDB=1s94 \| SCENE= }}~~	+	Crystal structure of the Habc domain of neuronal syntaxin from the squid Loligo pealei reveals conformational plasticity at its C-terminus.,Bracher A, Weissenhorn W BMC Struct Biol. 2004 Mar 15;4:6. PMID:15113421<ref>PMID:15113421</ref>

-	~~===Crystal structure~~ of the ~~Habc domain of neuronal syntaxin from the squid Loligo pealei===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_15113421}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[1s94]] is a 2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Doryteuthis_pealeii Doryteuthis pealeii]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=1S94 OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:015113421<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Doryteuthis pealeii]]		[[Category: Doryteuthis pealeii]]
	[[Category: Bracher, A.]]		[[Category: Bracher, A.]]

OCA: Protected "1s94" [edit=sysop:move=sysop]

OCA — Fri, 04 Jan 2013 09:59:48 GMT

Protected "1s94" [edit=sysop:move=sysop]

←Older revision

Revision as of 09:59, 4 January 2013

OCA at 09:59, 4 January 2013

OCA — Fri, 04 Jan 2013 09:59:46 GMT

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	[[Image:1s94.png\|left\|200px]]		[[Image:1s94.png\|left\|200px]]

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	{{STRUCTURE_1s94\| PDB=1s94 \| SCENE= }}		{{STRUCTURE_1s94\| PDB=1s94 \| SCENE= }}

	===Crystal structure of the Habc domain of neuronal syntaxin from the squid Loligo pealei===		===Crystal structure of the Habc domain of neuronal syntaxin from the squid Loligo pealei===

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	{{ABSTRACT_PUBMED_15113421}}		{{ABSTRACT_PUBMED_15113421}}

	==About this Structure==		==About this Structure==
-	~~1S94~~ is a 2 ~~chains~~ structure ~~of sequences~~ from [http://en.wikipedia.org/wiki/~~Loligo_pealei Loligo pealei~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1S94 OCA].	+	[[1s94]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Doryteuthis_pealeii Doryteuthis pealeii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1S94 OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~15113421~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:015113421</ref><references group="xtra"/>
-	[[Category: ~~Loligo pealei~~]]	+	[[Category: Doryteuthis pealeii]]
	[[Category: Bracher, A.]]		[[Category: Bracher, A.]]
	[[Category: Weissenhorn, W.]]		[[Category: Weissenhorn, W.]]
		+	[[Category: Endocytosis-exocytosis complex]]
	[[Category: Structural plasticity]]		[[Category: Structural plasticity]]
	[[Category: Three helix bundle]]		[[Category: Three helix bundle]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 04:52:49 2009''