1sc4 - Revision history

OCA at 06:15, 23 August 2023

OCA — Wed, 23 Aug 2023 06:15:24 GMT

←Older revision		Revision as of 06:15, 23 August 2023
Line 3:		Line 3:
	<StructureSection load='1sc4' size='340' side='right'caption='[[1sc4]], [[Resolution\|resolution]] 2.10Å' scene=''>		<StructureSection load='1sc4' size='340' side='right'caption='[[1sc4]], [[Resolution\|resolution]] 2.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1sc4]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SC4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1SC4 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1sc4]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SC4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1SC4 FirstGlance]. <br>
-	</td></tr><tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"~~><div style='overflow: auto; max-height: 3em;'>[[1sc1\|1sc1]], [[1sc3\|1sc3]]</div></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.1Å</td></tr>
-	~~<tr~~ id~~='gene'><td class~~="~~sblockLbl~~">~~<b>~~[[~~Gene~~\|~~Gene:~~]]~~</b></td><td class="sblockDat">CASP1, IL1BC, IL1BCE ([https://www~~.~~ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info~~&~~srchmode=5&id=9606 HUMAN])</td></tr>~~	+
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Caspase-1 Caspase-1], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.22.36 3.4.22.36] </span></td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1sc4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1sc4 OCA], [https://pdbe.org/1sc4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1sc4 RCSB], [https://www.ebi.ac.uk/pdbsum/1sc4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1sc4 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1sc4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1sc4 OCA], [https://pdbe.org/1sc4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1sc4 RCSB], [https://www.ebi.ac.uk/pdbsum/1sc4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1sc4 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/CASP1_HUMAN CASP1_HUMAN]] Thiol protease that cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes. Important for defense against pathogens. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Can also promote apoptosis.<ref>PMID:7876192</ref> <ref>PMID:15498465</ref>	+	[https://www.uniprot.org/uniprot/CASP1_HUMAN CASP1_HUMAN] Thiol protease that cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes. Important for defense against pathogens. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Can also promote apoptosis.<ref>PMID:7876192</ref> <ref>PMID:15498465</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 37:		Line 35:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Caspase-1]]~~	+	[[Category: Homo sapiens]]
-	~~[[Category: Human~~]]	+
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Brien, T O~~]]	+	[[Category: McDowell RS]]
-	[[Category: ~~McDowell, R S~~]]	+	[[Category: O'Brien T]]
-	[[Category: Romanowski~~, M J~~]]	+	[[Category: Romanowski MJ]]
-	[[Category: Scheer~~, J M]]~~	+	[[Category: Scheer JM]]
-	~~[[Category: Caspase-1 after removal of malonate]]~~	+
-	~~[[Category: Hydrolase~~]]	+

OCA at 15:31, 27 October 2021

OCA — Wed, 27 Oct 2021 15:31:55 GMT

←Older revision		Revision as of 15:31, 27 October 2021
Line 3:		Line 3:
	<StructureSection load='1sc4' size='340' side='right'caption='[[1sc4]], [[Resolution\|resolution]] 2.10Å' scene=''>		<StructureSection load='1sc4' size='340' side='right'caption='[[1sc4]], [[Resolution\|resolution]] 2.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1sc4]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SC4 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=1SC4 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1sc4]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SC4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1SC4 FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1sc1\|1sc1]], [[1sc3\|1sc3]]</div></td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1sc1\|1sc1]], [[1sc3\|1sc3]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CASP1, IL1BC, IL1BCE ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CASP1, IL1BC, IL1BCE ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Caspase-1 Caspase-1], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.22.36 3.4.22.36] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Caspase-1 Caspase-1], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.22.36 3.4.22.36] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=1sc4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1sc4 OCA], [~~http~~://pdbe.org/1sc4 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1sc4 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1sc4 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1sc4 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1sc4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1sc4 OCA], [https://pdbe.org/1sc4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1sc4 RCSB], [https://www.ebi.ac.uk/pdbsum/1sc4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1sc4 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/CASP1_HUMAN CASP1_HUMAN]] Thiol protease that cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes. Important for defense against pathogens. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Can also promote apoptosis.<ref>PMID:7876192</ref> <ref>PMID:15498465</ref>	+	[[https://www.uniprot.org/uniprot/CASP1_HUMAN CASP1_HUMAN]] Thiol protease that cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes. Important for defense against pathogens. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Can also promote apoptosis.<ref>PMID:7876192</ref> <ref>PMID:15498465</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 13:45, 16 December 2020

OCA — Wed, 16 Dec 2020 13:45:24 GMT

←Older revision		Revision as of 13:45, 16 December 2020
Line 1:		Line 1:

	==Crystal structure of the human caspase-1 C285A mutant after removal of malonate==		==Crystal structure of the human caspase-1 C285A mutant after removal of malonate==
-	<StructureSection load='1sc4' size='340' side='right' caption='[[1sc4]], [[Resolution\|resolution]] 2.10Å' scene=''>	+	<StructureSection load='1sc4' size='340' side='right'caption='[[1sc4]], [[Resolution\|resolution]] 2.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1sc4]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SC4 OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1SC4 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1sc4]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SC4 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=1SC4 FirstGlance]. <br>
-	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1sc1\|1sc1]], [[1sc3\|1sc3]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1sc1\|1sc1]], [[1sc3\|1sc3]]</div></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CASP1, IL1BC, IL1BCE ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CASP1, IL1BC, IL1BCE ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Caspase-1 Caspase-1], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.22.36 3.4.22.36] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Caspase-1 Caspase-1], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.22.36 3.4.22.36] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1sc4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1sc4 OCA], [http://pdbe.org/1sc4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1sc4 RCSB], [http://www.ebi.ac.uk/pdbsum/1sc4 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1sc4 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=1sc4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1sc4 OCA], [http://pdbe.org/1sc4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1sc4 RCSB], [http://www.ebi.ac.uk/pdbsum/1sc4 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1sc4 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 32:		Line 32:

	==See Also==		==See Also==
-	*[[Caspase\|Caspase]]	+	*[[Caspase 3D structures\|Caspase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 39:		Line 39:
	[[Category: Caspase-1]]		[[Category: Caspase-1]]
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Brien, T O]]		[[Category: Brien, T O]]
	[[Category: McDowell, R S]]		[[Category: McDowell, R S]]

OCA at 06:54, 8 March 2018

OCA — Thu, 08 Mar 2018 06:54:34 GMT

←Older revision		Revision as of 06:54, 8 March 2018
Line 1:		Line 1:
		+
	==Crystal structure of the human caspase-1 C285A mutant after removal of malonate==		==Crystal structure of the human caspase-1 C285A mutant after removal of malonate==
	<StructureSection load='1sc4' size='340' side='right' caption='[[1sc4]], [[Resolution\|resolution]] 2.10Å' scene=''>		<StructureSection load='1sc4' size='340' side='right' caption='[[1sc4]], [[Resolution\|resolution]] 2.10Å' scene=''>
Line 6:		Line 7:
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CASP1, IL1BC, IL1BCE ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CASP1, IL1BC, IL1BCE ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Caspase-1 Caspase-1], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.22.36 3.4.22.36] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Caspase-1 Caspase-1], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.22.36 3.4.22.36] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1sc4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1sc4 OCA], [http://pdbe.org/1sc4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1sc4 RCSB], [http://www.ebi.ac.uk/pdbsum/1sc4 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1sc4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1sc4 OCA], [http://pdbe.org/1sc4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1sc4 RCSB], [http://www.ebi.ac.uk/pdbsum/1sc4 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1sc4 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 14:		Line 15:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/sc/1sc4_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/sc/1sc4_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1sc4 ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 02:19, 12 September 2015

OCA — Sat, 12 Sep 2015 02:19:21 GMT

←Older revision		Revision as of 02:19, 12 September 2015
Line 2:		Line 2:
	<StructureSection load='1sc4' size='340' side='right' caption='[[1sc4]], [[Resolution\|resolution]] 2.10Å' scene=''>		<StructureSection load='1sc4' size='340' side='right' caption='[[1sc4]], [[Resolution\|resolution]] 2.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1sc4]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SC4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1SC4 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1sc4]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SC4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1SC4 FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1sc1\|1sc1]], [[1sc3\|1sc3]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1sc1\|1sc1]], [[1sc3\|1sc3]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CASP1, IL1BC, IL1BCE ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CASP1, IL1BC, IL1BCE ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Caspase-1 Caspase-1], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.22.36 3.4.22.36] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Caspase-1 Caspase-1], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.22.36 3.4.22.36] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1sc4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1sc4 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1sc4 RCSB], [http://www.ebi.ac.uk/pdbsum/1sc4 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1sc4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1sc4 OCA], [http://pdbe.org/1sc4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1sc4 RCSB], [http://www.ebi.ac.uk/pdbsum/1sc4 PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 28:		Line 28:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1sc4" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 36:		Line 37:
	</StructureSection>		</StructureSection>
	[[Category: Caspase-1]]		[[Category: Caspase-1]]
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Brien, T O]]		[[Category: Brien, T O]]
	[[Category: McDowell, R S]]		[[Category: McDowell, R S]]

OCA at 22:36, 25 December 2014

OCA — Thu, 25 Dec 2014 22:36:24 GMT

←Older revision		Revision as of 22:36, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1sc4]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SC4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1SC4 FirstGlance]. <br>		<table><tr><td colspan='2'>[[1sc4]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SC4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1SC4 FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1sc1\|1sc1]], [[1sc3\|1sc3]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1sc1\|1sc1]], [[1sc3\|1sc3]]</td></tr>
-	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CASP1, IL1BC, IL1BCE ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CASP1, IL1BC, IL1BCE ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
-	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Caspase-1 Caspase-1], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.22.36 3.4.22.36] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Caspase-1 Caspase-1], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.22.36 3.4.22.36] </span></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1sc4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1sc4 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1sc4 RCSB], [http://www.ebi.ac.uk/pdbsum/1sc4 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1sc4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1sc4 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1sc4 RCSB], [http://www.ebi.ac.uk/pdbsum/1sc4 PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/CASP1_HUMAN CASP1_HUMAN]] Thiol protease that cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes. Important for defense against pathogens. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Can also promote apoptosis.<ref>PMID:7876192</ref> <ref>PMID:15498465</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 35:		Line 37:
	[[Category: Caspase-1]]		[[Category: Caspase-1]]
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Brien, T O.]]	+	[[Category: Brien, T O]]
-	[[Category: McDowell, R S.]]	+	[[Category: McDowell, R S]]
-	[[Category: Romanowski, M J.]]	+	[[Category: Romanowski, M J]]
-	[[Category: Scheer, J M.]]	+	[[Category: Scheer, J M]]
	[[Category: Caspase-1 after removal of malonate]]		[[Category: Caspase-1 after removal of malonate]]
	[[Category: Hydrolase]]		[[Category: Hydrolase]]

OCA at 23:55, 28 September 2014

OCA — Sun, 28 Sep 2014 23:55:45 GMT

←Older revision		Revision as of 23:55, 28 September 2014
Line 1:		Line 1:
-	[[~~Image:~~1sc4.~~png~~\|~~left~~\|200px]]	+	==Crystal structure of the human caspase-1 C285A mutant after removal of malonate==
		+	<StructureSection load='1sc4' size='340' side='right' caption='[[1sc4]], [[Resolution\|resolution]] 2.10Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1sc4]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SC4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1SC4 FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1sc1\|1sc1]], [[1sc3\|1sc3]]</td></tr>
		+	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CASP1, IL1BC, IL1BCE ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
		+	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Caspase-1 Caspase-1], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.22.36 3.4.22.36] </span></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1sc4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1sc4 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1sc4 RCSB], [http://www.ebi.ac.uk/pdbsum/1sc4 PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/sc/1sc4_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Caspase-1, a mediator of the posttranslational processing of IL-1beta and IL-18, requires an aspartic acid in the P1 position of its substrates. The mechanisms of caspase-1 activation remain poorly understood despite numerous structures of the enzyme complexed with aspartate-based inhibitors. Here we report a crystal structure of ligand-free caspase-1 that displays dramatic rearrangements of loops defining the active site to generate a closed conformation that is incompatible with substrate binding. A structure of the enzyme complexed with malonate shows the protein in its open (active-site ligand-bound) conformation in which malonate reproduces the hydrogen bonding network observed in structures with covalent inhibitors. These results illustrate the essential function of the obligatory aspartate recognition element that opens the active site of caspase-1 to substrates and may be the determinant responsible for the conformational changes between ligand-free and -bound forms of the enzyme, and suggest a new approach for identifying novel aspartic acid mimetics.

-	~~{{STRUCTURE_1sc4\| PDB=1sc4 \| SCENE= }}~~	+	Crystal structures of a ligand-free and malonate-bound human caspase-1: implications for the mechanism of substrate binding.,Romanowski MJ, Scheer JM, O'Brien T, McDowell RS Structure. 2004 Aug;12(8):1361-71. PMID:15296730<ref>PMID:15296730</ref>

-	~~===Crystal structure~~ of the ~~human caspase-1 C285A mutant after removal of malonate===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_15296730}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[1sc4]] is a 2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Homo_sapiens Homo sapiens]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=1SC4 OCA].~~	+

	==See Also==		==See Also==
	*[[Caspase\|Caspase]]		*[[Caspase\|Caspase]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:015296730<~~/~~ref~~><~~references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Caspase-1]]		[[Category: Caspase-1]]
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]

OCA at 22:27, 20 October 2012

OCA — Sat, 20 Oct 2012 22:27:48 GMT

←Older revision		Revision as of 22:27, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[1sc4]] is a 2 chain structure ~~of [[Caspase]]~~ with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SC4 OCA].	+	[[1sc4]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SC4 OCA].

	==See Also==		==See Also==

OCA: Protected "1sc4" [edit=sysop:move=sysop]

OCA — Fri, 27 Jul 2012 16:23:01 GMT

Protected "1sc4" [edit=sysop:move=sysop]

←Older revision

Revision as of 16:23, 27 July 2012

OCA at 16:22, 27 July 2012

OCA — Fri, 27 Jul 2012 16:22:59 GMT

←Older revision		Revision as of 16:22, 27 July 2012
Line 1:		Line 1:
-	{{Seed}}
	[[Image:1sc4.png\|left\|200px]]		[[Image:1sc4.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_1sc4", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_1sc4\| PDB=1sc4 \| SCENE= }}		{{STRUCTURE_1sc4\| PDB=1sc4 \| SCENE= }}

	===Crystal structure of the human caspase-1 C285A mutant after removal of malonate===		===Crystal structure of the human caspase-1 C285A mutant after removal of malonate===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_15296730}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 15296730 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_15296730}}		{{ABSTRACT_PUBMED_15296730}}

	==About this Structure==		==About this Structure==
-	~~1SC4~~ is a 2 ~~chains~~ structure of ~~sequences~~ from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SC4 OCA].	+	[[1sc4]] is a 2 chain structure of [[Caspase]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SC4 OCA].
		+
		+	==See Also==
		+	*[[Caspase\|Caspase]]

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~15296730~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:015296730</ref><references group="xtra"/>
	[[Category: Caspase-1]]		[[Category: Caspase-1]]
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
Line 31:		Line 22:
	[[Category: Scheer, J M.]]		[[Category: Scheer, J M.]]
	[[Category: Caspase-1 after removal of malonate]]		[[Category: Caspase-1 after removal of malonate]]
-		+	[[Category: Hydrolase]]
-	~~''Page seeded by~~ [~~http~~:~~//oca.weizmann.ac.il/oca OCA~~ ] ~~on Wed Feb 18 09:53:59 2009''~~	+