1sh0 - Revision history

OCA at 06:16, 23 August 2023

OCA — Wed, 23 Aug 2023 06:16:45 GMT

←Older revision		Revision as of 06:16, 23 August 2023
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	<StructureSection load='1sh0' size='340' side='right'caption='[[1sh0]], [[Resolution\|resolution]] 2.17Å' scene=''>		<StructureSection load='1sh0' size='340' side='right'caption='[[1sh0]], [[Resolution\|resolution]] 2.17Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1sh0]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Norwalk_calicivirus~~ Norwalk ~~calicivirus~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SH0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1SH0 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1sh0]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Norwalk_virus Norwalk virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SH0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1SH0 FirstGlance]. <br>
-	</td></tr><tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat">~~<div style='overflow: auto; max~~-~~height: 3em;'>[[1khv\|1khv]]~~, [[~~1sh2~~\|~~1sh2~~]]~~, [[1sh3\|1sh3]]</div></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.17Å</td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/RNA-directed_RNA_polymerase RNA-directed RNA polymerase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.~~7.7.48 2.7.7.48] </span>~~</td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1sh0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1sh0 OCA], [https://pdbe.org/1sh0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1sh0 RCSB], [https://www.ebi.ac.uk/pdbsum/1sh0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1sh0 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1sh0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1sh0 OCA], [https://pdbe.org/1sh0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1sh0 RCSB], [https://www.ebi.ac.uk/pdbsum/1sh0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1sh0 ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/Q70ET3_9CALI Q70ET3_9CALI]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Norwalk ~~calicivirus]]~~	+	[[Category: Norwalk virus]]
-	~~[[Category: RNA-directed RNA polymerase~~]]	+	[[Category: Alonso JM]]
-	[[Category: Alonso~~, J M~~]]	+	[[Category: Boga JA]]
-	[[Category: Boga~~, J A~~]]	+	[[Category: Machin A]]
-	[[Category: Machin, A]]	+	[[Category: Ng KK]]
-	[[Category: Ng~~, K K~~]]	+	[[Category: Parra F]]
-	[[Category: Parra, F]]	+	[[Category: Pendas-Franco N]]
-	[[Category: Pendas-Franco, N]]	+	[[Category: Rojo J]]
-	[[Category: Rojo, J]]	+
-	~~[[Category: Rna polymerase]]~~	+
-	~~[[Category: Transferase]]~~	+
-	~~[[Category: Viral replication enzyme~~]]	+

OCA at 07:31, 22 September 2021

OCA — Wed, 22 Sep 2021 07:31:18 GMT

←Older revision		Revision as of 07:31, 22 September 2021
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	<StructureSection load='1sh0' size='340' side='right'caption='[[1sh0]], [[Resolution\|resolution]] 2.17Å' scene=''>		<StructureSection load='1sh0' size='340' side='right'caption='[[1sh0]], [[Resolution\|resolution]] 2.17Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1sh0]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Norwalk_calicivirus Norwalk calicivirus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SH0 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1SH0 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1sh0]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Norwalk_calicivirus Norwalk calicivirus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SH0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1SH0 FirstGlance]. <br>
-	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1khv\|1khv]], [[1sh2\|1sh2]], [[1sh3\|1sh3]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1khv\|1khv]], [[1sh2\|1sh2]], [[1sh3\|1sh3]]</div></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/RNA-directed_RNA_polymerase RNA-directed RNA polymerase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.48 2.7.7.48] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/RNA-directed_RNA_polymerase RNA-directed RNA polymerase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.48 2.7.7.48] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1sh0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1sh0 OCA], [~~http~~://pdbe.org/1sh0 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1sh0 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1sh0 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1sh0 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1sh0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1sh0 OCA], [https://pdbe.org/1sh0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1sh0 RCSB], [https://www.ebi.ac.uk/pdbsum/1sh0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1sh0 ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 29:		Line 29:

	==See Also==		==See Also==
-	*[[RNA polymerase\|RNA polymerase]]	+	*[[RNA polymerase 3D structures\|RNA polymerase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 19:34, 11 December 2019

OCA — Wed, 11 Dec 2019 19:34:07 GMT

←Older revision		Revision as of 19:34, 11 December 2019
Line 1:		Line 1:

	==Crystal Structure of Norwalk Virus Polymerase (Triclinic)==		==Crystal Structure of Norwalk Virus Polymerase (Triclinic)==
-	<StructureSection load='1sh0' size='340' side='right' caption='[[1sh0]], [[Resolution\|resolution]] 2.17Å' scene=''>	+	<StructureSection load='1sh0' size='340' side='right'caption='[[1sh0]], [[Resolution\|resolution]] 2.17Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1sh0]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Norwalk_calicivirus Norwalk calicivirus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SH0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1SH0 FirstGlance]. <br>		<table><tr><td colspan='2'>[[1sh0]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Norwalk_calicivirus Norwalk calicivirus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SH0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1SH0 FirstGlance]. <br>
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Norwalk calicivirus]]		[[Category: Norwalk calicivirus]]
	[[Category: RNA-directed RNA polymerase]]		[[Category: RNA-directed RNA polymerase]]

OCA at 07:04, 8 March 2018

OCA — Thu, 08 Mar 2018 07:04:22 GMT

←Older revision		Revision as of 07:04, 8 March 2018
Line 1:		Line 1:
		+
	==Crystal Structure of Norwalk Virus Polymerase (Triclinic)==		==Crystal Structure of Norwalk Virus Polymerase (Triclinic)==
	<StructureSection load='1sh0' size='340' side='right' caption='[[1sh0]], [[Resolution\|resolution]] 2.17Å' scene=''>		<StructureSection load='1sh0' size='340' side='right' caption='[[1sh0]], [[Resolution\|resolution]] 2.17Å' scene=''>
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	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1khv\|1khv]], [[1sh2\|1sh2]], [[1sh3\|1sh3]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1khv\|1khv]], [[1sh2\|1sh2]], [[1sh3\|1sh3]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/RNA-directed_RNA_polymerase RNA-directed RNA polymerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.48 2.7.7.48] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/RNA-directed_RNA_polymerase RNA-directed RNA polymerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.48 2.7.7.48] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1sh0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1sh0 OCA], [http://pdbe.org/1sh0 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1sh0 RCSB], [http://www.ebi.ac.uk/pdbsum/1sh0 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1sh0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1sh0 OCA], [http://pdbe.org/1sh0 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1sh0 RCSB], [http://www.ebi.ac.uk/pdbsum/1sh0 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1sh0 ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 11:		Line 12:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/sh/1sh0_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/sh/1sh0_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 20:54, 9 February 2016

OCA — Tue, 09 Feb 2016 20:54:55 GMT

←Older revision		Revision as of 20:54, 9 February 2016
Line 15:		Line 15:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1sh0 ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 01:56, 11 September 2015

OCA — Fri, 11 Sep 2015 01:56:52 GMT

←Older revision		Revision as of 01:56, 11 September 2015
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	<StructureSection load='1sh0' size='340' side='right' caption='[[1sh0]], [[Resolution\|resolution]] 2.17Å' scene=''>		<StructureSection load='1sh0' size='340' side='right' caption='[[1sh0]], [[Resolution\|resolution]] 2.17Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1sh0]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Norwalk_virus~~ Norwalk ~~virus~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SH0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1SH0 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1sh0]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Norwalk_calicivirus Norwalk calicivirus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SH0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1SH0 FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1khv\|1khv]], [[1sh2\|1sh2]], [[1sh3\|1sh3]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1khv\|1khv]], [[1sh2\|1sh2]], [[1sh3\|1sh3]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/RNA-directed_RNA_polymerase RNA-directed RNA polymerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.48 2.7.7.48] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/RNA-directed_RNA_polymerase RNA-directed RNA polymerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.48 2.7.7.48] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1sh0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1sh0 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1sh0 RCSB], [http://www.ebi.ac.uk/pdbsum/1sh0 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1sh0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1sh0 OCA], [http://pdbe.org/1sh0 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1sh0 RCSB], [http://www.ebi.ac.uk/pdbsum/1sh0 PDBsum]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 25:		Line 25:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1sh0" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 32:		Line 33:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Norwalk ~~virus~~]]	+	[[Category: Norwalk calicivirus]]
	[[Category: RNA-directed RNA polymerase]]		[[Category: RNA-directed RNA polymerase]]
	[[Category: Alonso, J M]]		[[Category: Alonso, J M]]

OCA at 07:17, 6 January 2015

OCA — Tue, 06 Jan 2015 07:17:21 GMT

←Older revision		Revision as of 07:17, 6 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1sh0]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Norwalk_virus Norwalk virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SH0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1SH0 FirstGlance]. <br>		<table><tr><td colspan='2'>[[1sh0]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Norwalk_virus Norwalk virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SH0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1SH0 FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1khv\|1khv]], [[1sh2\|1sh2]], [[1sh3\|1sh3]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1khv\|1khv]], [[1sh2\|1sh2]], [[1sh3\|1sh3]]</td></tr>
-	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/RNA-directed_RNA_polymerase RNA-directed RNA polymerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.48 2.7.7.48] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/RNA-directed_RNA_polymerase RNA-directed RNA polymerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.48 2.7.7.48] </span></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1sh0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1sh0 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1sh0 RCSB], [http://www.ebi.ac.uk/pdbsum/1sh0 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1sh0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1sh0 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1sh0 RCSB], [http://www.ebi.ac.uk/pdbsum/1sh0 PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 34:		Line 34:
	[[Category: Norwalk virus]]		[[Category: Norwalk virus]]
	[[Category: RNA-directed RNA polymerase]]		[[Category: RNA-directed RNA polymerase]]
-	[[Category: Alonso, J M.]]	+	[[Category: Alonso, J M]]
-	[[Category: Boga, J A.]]	+	[[Category: Boga, J A]]
-	[[Category: Machin, A.]]	+	[[Category: Machin, A]]
-	[[Category: Ng, K K.]]	+	[[Category: Ng, K K]]
-	[[Category: Parra, F.]]	+	[[Category: Parra, F]]
-	[[Category: Pendas-Franco, N.]]	+	[[Category: Pendas-Franco, N]]
-	[[Category: Rojo, J.]]	+	[[Category: Rojo, J]]
	[[Category: Rna polymerase]]		[[Category: Rna polymerase]]
	[[Category: Transferase]]		[[Category: Transferase]]
	[[Category: Viral replication enzyme]]		[[Category: Viral replication enzyme]]

OCA at 22:29, 28 September 2014

OCA — Sun, 28 Sep 2014 22:29:45 GMT

←Older revision		Revision as of 22:29, 28 September 2014
Line 1:		Line 1:
-	[[~~Image:~~1sh0.~~png~~\|~~left~~\|200px]]	+	==Crystal Structure of Norwalk Virus Polymerase (Triclinic)==
		+	<StructureSection load='1sh0' size='340' side='right' caption='[[1sh0]], [[Resolution\|resolution]] 2.17Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1sh0]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Norwalk_virus Norwalk virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SH0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1SH0 FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1khv\|1khv]], [[1sh2\|1sh2]], [[1sh3\|1sh3]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/RNA-directed_RNA_polymerase RNA-directed RNA polymerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.48 2.7.7.48] </span></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1sh0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1sh0 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1sh0 RCSB], [http://www.ebi.ac.uk/pdbsum/1sh0 PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/sh/1sh0_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Norwalk virus is a major cause of acute gastroenteritis for which effective treatments are sorely lacking. To provide a basis for the rational design of novel antiviral agents, the main replication enzyme in Norwalk virus, the virally encoded RNA-dependent RNA polymerase (RdRP), has been expressed in an enzymatically active form, and its structure has been crystallographically determined both in the presence and absence of divalent metal cations. Although the overall fold of the enzyme is similar to that seen previously in the RdRP from rabbit hemorrhagic disease virus, the carboxyl terminus, surprisingly, is located in the active site cleft in five independent copies of the protein in three distinct crystal forms. The location of this carboxyl-terminal segment appears to interfere with the binding of double-stranded RNA in the active site cleft and may play a role in the initiation of RNA synthesis or mediate interactions with accessory replication proteins.

-	~~{{STRUCTURE_1sh0\| PDB=1sh0 \| SCENE= }}~~	+	Crystal structure of norwalk virus polymerase reveals the carboxyl terminus in the active site cleft.,Ng KK, Pendas-Franco N, Rojo J, Boga JA, Machin A, Alonso JM, Parra F J Biol Chem. 2004 Apr 16;279(16):16638-45. Epub 2004 Feb 5. PMID:14764591<ref>PMID:14764591</ref>

-	~~===Crystal Structure~~ of ~~Norwalk Virus Polymerase (Triclinic)===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_14764591}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[1sh0]] is a 2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Norwalk_virus Norwalk virus]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=1SH0 OCA].~~	+

	==See Also==		==See Also==
	*[[RNA polymerase\|RNA polymerase]]		*[[RNA polymerase\|RNA polymerase]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:014764591<~~/~~ref~~><~~references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Norwalk virus]]		[[Category: Norwalk virus]]
	[[Category: RNA-directed RNA polymerase]]		[[Category: RNA-directed RNA polymerase]]

OCA at 15:06, 20 October 2012

OCA — Sat, 20 Oct 2012 15:06:44 GMT

←Older revision		Revision as of 15:06, 20 October 2012
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	==About this Structure==		==About this Structure==
-	[[1sh0]] is a 2 chain structure ~~of [[RNA polymerase]]~~ with sequence from [http://en.wikipedia.org/wiki/Norwalk_virus Norwalk virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SH0 OCA].	+	[[1sh0]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Norwalk_virus Norwalk virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SH0 OCA].

	==See Also==		==See Also==

OCA: Protected "1sh0" [edit=sysop:move=sysop]

OCA — Thu, 26 Jul 2012 17:19:35 GMT

Protected "1sh0" [edit=sysop:move=sysop]

←Older revision

Revision as of 17:19, 26 July 2012