1sh1 - Revision history

OCA at 08:31, 1 May 2024

OCA — Wed, 01 May 2024 08:31:54 GMT

←Older revision		Revision as of 08:31, 1 May 2024
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	==SOLUTION STRUCTURE OF NEUROTOXIN I FROM THE SEA ANEMONE STICHODACTYLA HELIANTHUS. A NUCLEAR MAGNETIC RESONANCE, DISTANCE GEOMETRY AND RESTRAINED MOLECULAR DYNAMICS STUDY==		==SOLUTION STRUCTURE OF NEUROTOXIN I FROM THE SEA ANEMONE STICHODACTYLA HELIANTHUS. A NUCLEAR MAGNETIC RESONANCE, DISTANCE GEOMETRY AND RESTRAINED MOLECULAR DYNAMICS STUDY==
-	<StructureSection load='1sh1' size='340' side='right'caption='[[1sh1~~]], [[NMR_Ensembles_of_Models \| 1 NMR models~~]]' scene=''>	+	<StructureSection load='1sh1' size='340' side='right'caption='[[1sh1]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1sh1]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Actinia_helianthus Actinia~~ helianthus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SH1 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=1SH1 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1sh1]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Stichodactyla_helianthus Stichodactyla helianthus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SH1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1SH1 FirstGlance]. <br>
-	</td></tr><tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat">~~[[2sh1\|2sh1]]~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=1sh1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1sh1 OCA], [~~http~~://pdbe.org/1sh1 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1sh1 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1sh1 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1sh1 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1sh1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1sh1 OCA], [https://pdbe.org/1sh1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1sh1 RCSB], [https://www.ebi.ac.uk/pdbsum/1sh1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1sh1 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/~~TXA1_STOHE TXA1_STOHE]~~] Binds specifically to ~~the~~ sodium ~~channel~~ (Nav), thereby delaying ~~its~~ inactivation during signal transduction. ~~Selectively~~ toxic to ~~crustaceans~~.<ref>PMID:~~7913833~~</ref>	+	[https://www.uniprot.org/uniprot/NA21_STIHL NA21_STIHL] Binds specifically to voltage-gated sodium channels (Nav), thereby delaying their inactivation during signal transduction (By similarity). Is highly toxic to crabs (by intrahemocoelic injection) (PubMed:2568126, PubMed:22015268), but without effect upon mice (by intraperitoneal injection) (PubMed:2568126).<ref>PMID:22015268</ref> <ref>PMID:2568126</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1sh1 ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1sh1 ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
-	<div style="background-color:#fffaf0;">
-	== Publication Abstract from PubMed ==
-	The three-dimensional structure of the sea anemone polypeptide Stichodactyla helianthus neurotoxin I in aqueous solution has been determined using distance geometry and restrained molecular dynamics simulations based on NMR data acquired at 500 MHz. A set of 470 nuclear Overhauser enhancement values was measured, of which 216 were used as distance restraints in the structure determination along with 15 dihedral angles derived from coupling constants. After restrained molecular dynamics refinement, the eight structures that best fit the input data form a closely related family. They describe a structure that consists of a core of twisted, four-stranded, antiparallel beta-sheet encompassing residues 1-3, 19-24, 29-34, and 40-47, joined by three loops, two of which are well defined by the NMR data. The third loop, encompassing residues 7-16, is poorly defined by the data and is assumed to undergo conformational averaging in solution. Pairwise root mean square displacement values for the backbone heavy atoms of the eight best structures are 1.3 +/- 0.2A when the poorly defined loop is excluded and 3.6 +/- 1.0A for all backbone atoms. Refinement using restrained molecular dynamics improved the quality of the structures generated by distance geometry calculations with respect to the number of nuclear Overhauser enhancements violated, the size of the total distance violations and the total potential energies of the structures. The family of structures for S. heliathus neurotoxin I is compared with structures of related sea anemone proteins that also bind to the voltage-gated sodium channel.
-
-	Solution structure of neurotoxin I from the sea anemone Stichodactyla helianthus. A nuclear magnetic resonance, distance geometry, and restrained molecular dynamics study.,Fogh RH, Kem WR, Norton RS J Biol Chem. 1990 Aug 5;265(22):13016-28. PMID:1973932<ref>PMID:1973932</ref>
-
-	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	</div>
-	<div class="pdbe-citations 1sh1" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Actinia helianthus]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Fogh, R H~~]]	+	[[Category: Stichodactyla helianthus]]
-	[[Category: ~~Norton, R S~~]]	+	[[Category: Fogh RH]]
-	[[Category: ~~Neurotoxin~~]]	+	[[Category: Norton RS]]

OCA at 11:20, 26 August 2020

OCA — Wed, 26 Aug 2020 11:20:59 GMT

←Older revision		Revision as of 11:20, 26 August 2020
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-	==SOLUTION ~~STRUCUTRE~~ OF NEUROTOXIN I FROM THE SEA ANEMONE STICHODACTYLA HELIANTHUS. A NUCLEAR MAGNETIC RESONANCE, DISTANCE GEOMETRY AND RESTRAINED MOLECULAR DYNAMICS STUDY==	+	==SOLUTION STRUCTURE OF NEUROTOXIN I FROM THE SEA ANEMONE STICHODACTYLA HELIANTHUS. A NUCLEAR MAGNETIC RESONANCE, DISTANCE GEOMETRY AND RESTRAINED MOLECULAR DYNAMICS STUDY==
	<StructureSection load='1sh1' size='340' side='right'caption='[[1sh1]], [[NMR_Ensembles_of_Models \| 1 NMR models]]' scene=''>		<StructureSection load='1sh1' size='340' side='right'caption='[[1sh1]], [[NMR_Ensembles_of_Models \| 1 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1sh1]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Stihl Stihl~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SH1 OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1SH1 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1sh1]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Actinia_helianthus Actinia helianthus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SH1 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=1SH1 FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2sh1\|2sh1]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2sh1\|2sh1]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1sh1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1sh1 OCA], [http://pdbe.org/1sh1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1sh1 RCSB], [http://www.ebi.ac.uk/pdbsum/1sh1 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1sh1 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=1sh1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1sh1 OCA], [http://pdbe.org/1sh1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1sh1 RCSB], [http://www.ebi.ac.uk/pdbsum/1sh1 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1sh1 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Actinia helianthus]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Stihl]]
	[[Category: Fogh, R H]]		[[Category: Fogh, R H]]
	[[Category: Norton, R S]]		[[Category: Norton, R S]]
	[[Category: Neurotoxin]]		[[Category: Neurotoxin]]

OCA at 11:07, 4 December 2019

OCA — Wed, 04 Dec 2019 11:07:17 GMT

←Older revision		Revision as of 11:07, 4 December 2019
Line 1:		Line 1:

	==SOLUTION STRUCUTRE OF NEUROTOXIN I FROM THE SEA ANEMONE STICHODACTYLA HELIANTHUS. A NUCLEAR MAGNETIC RESONANCE, DISTANCE GEOMETRY AND RESTRAINED MOLECULAR DYNAMICS STUDY==		==SOLUTION STRUCUTRE OF NEUROTOXIN I FROM THE SEA ANEMONE STICHODACTYLA HELIANTHUS. A NUCLEAR MAGNETIC RESONANCE, DISTANCE GEOMETRY AND RESTRAINED MOLECULAR DYNAMICS STUDY==
-	<StructureSection load='1sh1' size='340' side='right' caption='[[1sh1]], [[NMR_Ensembles_of_Models \| 1 NMR models]]' scene=''>	+	<StructureSection load='1sh1' size='340' side='right'caption='[[1sh1]], [[NMR_Ensembles_of_Models \| 1 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1sh1]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Stihl Stihl]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SH1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1SH1 FirstGlance]. <br>		<table><tr><td colspan='2'>[[1sh1]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Stihl Stihl]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SH1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1SH1 FirstGlance]. <br>
Line 13:		Line 13:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/sh/1sh1_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/sh/1sh1_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 32:		Line 32:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Stihl]]		[[Category: Stihl]]
	[[Category: Fogh, R H]]		[[Category: Fogh, R H]]
	[[Category: Norton, R S]]		[[Category: Norton, R S]]
	[[Category: Neurotoxin]]		[[Category: Neurotoxin]]

OCA at 06:57, 29 November 2017

OCA — Wed, 29 Nov 2017 06:57:00 GMT

←Older revision		Revision as of 06:57, 29 November 2017
Line 1:		Line 1:
		+
	==SOLUTION STRUCUTRE OF NEUROTOXIN I FROM THE SEA ANEMONE STICHODACTYLA HELIANTHUS. A NUCLEAR MAGNETIC RESONANCE, DISTANCE GEOMETRY AND RESTRAINED MOLECULAR DYNAMICS STUDY==		==SOLUTION STRUCUTRE OF NEUROTOXIN I FROM THE SEA ANEMONE STICHODACTYLA HELIANTHUS. A NUCLEAR MAGNETIC RESONANCE, DISTANCE GEOMETRY AND RESTRAINED MOLECULAR DYNAMICS STUDY==
	<StructureSection load='1sh1' size='340' side='right' caption='[[1sh1]], [[NMR_Ensembles_of_Models \| 1 NMR models]]' scene=''>		<StructureSection load='1sh1' size='340' side='right' caption='[[1sh1]], [[NMR_Ensembles_of_Models \| 1 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1sh1]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Carribean_sea_anemone Carribean sea anemone~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SH1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1SH1 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1sh1]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Stihl Stihl]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SH1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1SH1 FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2sh1\|2sh1]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2sh1\|2sh1]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1sh1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1sh1 OCA], [http://pdbe.org/1sh1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1sh1 RCSB], [http://www.ebi.ac.uk/pdbsum/1sh1 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1sh1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1sh1 OCA], [http://pdbe.org/1sh1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1sh1 RCSB], [http://www.ebi.ac.uk/pdbsum/1sh1 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1sh1 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Carribean sea anemone~~]]	+	[[Category: Stihl]]
	[[Category: Fogh, R H]]		[[Category: Fogh, R H]]
	[[Category: Norton, R S]]		[[Category: Norton, R S]]
	[[Category: Neurotoxin]]		[[Category: Neurotoxin]]

OCA at 12:09, 7 February 2016

OCA — Sun, 07 Feb 2016 12:09:30 GMT

←Older revision		Revision as of 12:09, 7 February 2016
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	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1sh1 ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 01:22, 10 September 2015

OCA — Thu, 10 Sep 2015 01:22:25 GMT

←Older revision		Revision as of 01:22, 10 September 2015
Line 2:		Line 2:
	<StructureSection load='1sh1' size='340' side='right' caption='[[1sh1]], [[NMR_Ensembles_of_Models \| 1 NMR models]]' scene=''>		<StructureSection load='1sh1' size='340' side='right' caption='[[1sh1]], [[NMR_Ensembles_of_Models \| 1 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1sh1]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Stichodactyla_helianthus Stichodactyla helianthus~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SH1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1SH1 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1sh1]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Carribean_sea_anemone Carribean sea anemone]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SH1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1SH1 FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2sh1\|2sh1]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2sh1\|2sh1]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1sh1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1sh1 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1sh1 RCSB], [http://www.ebi.ac.uk/pdbsum/1sh1 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1sh1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1sh1 OCA], [http://pdbe.org/1sh1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1sh1 RCSB], [http://www.ebi.ac.uk/pdbsum/1sh1 PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 26:		Line 26:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1sh1" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Stichodactyla helianthus~~]]	+	[[Category: Carribean sea anemone]]
	[[Category: Fogh, R H]]		[[Category: Fogh, R H]]
	[[Category: Norton, R S]]		[[Category: Norton, R S]]
	[[Category: Neurotoxin]]		[[Category: Neurotoxin]]

OCA at 14:58, 24 December 2014

OCA — Wed, 24 Dec 2014 14:58:13 GMT

←Older revision		Revision as of 14:58, 24 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1sh1]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Stichodactyla_helianthus Stichodactyla helianthus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SH1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1SH1 FirstGlance]. <br>		<table><tr><td colspan='2'>[[1sh1]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Stichodactyla_helianthus Stichodactyla helianthus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SH1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1SH1 FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2sh1\|2sh1]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2sh1\|2sh1]]</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1sh1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1sh1 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1sh1 RCSB], [http://www.ebi.ac.uk/pdbsum/1sh1 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1sh1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1sh1 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1sh1 RCSB], [http://www.ebi.ac.uk/pdbsum/1sh1 PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/TXA1_STOHE TXA1_STOHE]] Binds specifically to the sodium channel (Nav), thereby delaying its inactivation during signal transduction. Selectively toxic to crustaceans.<ref>PMID:7913833</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	</StructureSection>		</StructureSection>
	[[Category: Stichodactyla helianthus]]		[[Category: Stichodactyla helianthus]]
-	[[Category: Fogh, R H.]]	+	[[Category: Fogh, R H]]
-	[[Category: Norton, R S.]]	+	[[Category: Norton, R S]]
	[[Category: Neurotoxin]]		[[Category: Neurotoxin]]

OCA at 16:16, 29 September 2014

OCA — Mon, 29 Sep 2014 16:16:15 GMT

←Older revision		Revision as of 16:16, 29 September 2014
Line 1:		Line 1:
-	[[~~Image:~~1sh1.~~png~~\|~~left~~\|200px]]	+	==SOLUTION STRUCUTRE OF NEUROTOXIN I FROM THE SEA ANEMONE STICHODACTYLA HELIANTHUS. A NUCLEAR MAGNETIC RESONANCE, DISTANCE GEOMETRY AND RESTRAINED MOLECULAR DYNAMICS STUDY==
		+	<StructureSection load='1sh1' size='340' side='right' caption='[[1sh1]], [[NMR_Ensembles_of_Models \| 1 NMR models]]' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1sh1]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Stichodactyla_helianthus Stichodactyla helianthus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SH1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1SH1 FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2sh1\|2sh1]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1sh1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1sh1 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1sh1 RCSB], [http://www.ebi.ac.uk/pdbsum/1sh1 PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/sh/1sh1_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The three-dimensional structure of the sea anemone polypeptide Stichodactyla helianthus neurotoxin I in aqueous solution has been determined using distance geometry and restrained molecular dynamics simulations based on NMR data acquired at 500 MHz. A set of 470 nuclear Overhauser enhancement values was measured, of which 216 were used as distance restraints in the structure determination along with 15 dihedral angles derived from coupling constants. After restrained molecular dynamics refinement, the eight structures that best fit the input data form a closely related family. They describe a structure that consists of a core of twisted, four-stranded, antiparallel beta-sheet encompassing residues 1-3, 19-24, 29-34, and 40-47, joined by three loops, two of which are well defined by the NMR data. The third loop, encompassing residues 7-16, is poorly defined by the data and is assumed to undergo conformational averaging in solution. Pairwise root mean square displacement values for the backbone heavy atoms of the eight best structures are 1.3 +/- 0.2A when the poorly defined loop is excluded and 3.6 +/- 1.0A for all backbone atoms. Refinement using restrained molecular dynamics improved the quality of the structures generated by distance geometry calculations with respect to the number of nuclear Overhauser enhancements violated, the size of the total distance violations and the total potential energies of the structures. The family of structures for S. heliathus neurotoxin I is compared with structures of related sea anemone proteins that also bind to the voltage-gated sodium channel.

-	~~{{STRUCTURE_1sh1\| PDB=1sh1 \| SCENE= }}~~	+	Solution structure of neurotoxin I from the sea anemone Stichodactyla helianthus. A nuclear magnetic resonance, distance geometry, and restrained molecular dynamics study.,Fogh RH, Kem WR, Norton RS J Biol Chem. 1990 Aug 5;265(22):13016-28. PMID:1973932<ref>PMID:1973932</ref>

-	~~===SOLUTION STRUCUTRE OF NEUROTOXIN I FROM THE SEA ANEMONE STICHODACTYLA HELIANTHUS. A NUCLEAR MAGNETIC RESONANCE~~, ~~DISTANCE GEOMETRY AND RESTRAINED MOLECULAR DYNAMICS STUDY===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_1973932}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[1sh1]] is~~ a ~~1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Stichodactyla_helianthus Stichodactyla helianthus]~~. ~~Full experimental information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=1SH1 OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:001973932<~~/~~ref~~><~~ref group="xtra">PMID:015267926</ref><references group="xtra"~~/>	+
	[[Category: Stichodactyla helianthus]]		[[Category: Stichodactyla helianthus]]
	[[Category: Fogh, R H.]]		[[Category: Fogh, R H.]]
	[[Category: Norton, R S.]]		[[Category: Norton, R S.]]
	[[Category: Neurotoxin]]		[[Category: Neurotoxin]]

OCA: Protected "1sh1" [edit=sysop:move=sysop]

OCA — Fri, 04 Jan 2013 09:57:37 GMT

Protected "1sh1" [edit=sysop:move=sysop]

←Older revision

Revision as of 09:57, 4 January 2013

OCA at 09:57, 4 January 2013

OCA — Fri, 04 Jan 2013 09:57:35 GMT

←Older revision		Revision as of 09:57, 4 January 2013
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-	{{Seed}}
	[[Image:1sh1.png\|left\|200px]]		[[Image:1sh1.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_1sh1", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_1sh1\| PDB=1sh1 \| SCENE= }}		{{STRUCTURE_1sh1\| PDB=1sh1 \| SCENE= }}

	===SOLUTION STRUCUTRE OF NEUROTOXIN I FROM THE SEA ANEMONE STICHODACTYLA HELIANTHUS. A NUCLEAR MAGNETIC RESONANCE, DISTANCE GEOMETRY AND RESTRAINED MOLECULAR DYNAMICS STUDY===		===SOLUTION STRUCUTRE OF NEUROTOXIN I FROM THE SEA ANEMONE STICHODACTYLA HELIANTHUS. A NUCLEAR MAGNETIC RESONANCE, DISTANCE GEOMETRY AND RESTRAINED MOLECULAR DYNAMICS STUDY===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_1973932}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 1973932 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_1973932}}		{{ABSTRACT_PUBMED_1973932}}

	==About this Structure==		==About this Structure==
-	~~1SH1~~ is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Stichodactyla_helianthus Stichodactyla helianthus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SH1 OCA].	+	[[1sh1]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Stichodactyla_helianthus Stichodactyla helianthus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SH1 OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~1973932~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:001973932</ref><ref group="xtra">PMID:015267926</ref><references group="xtra"/>
	[[Category: Stichodactyla helianthus]]		[[Category: Stichodactyla helianthus]]
	[[Category: Fogh, R H.]]		[[Category: Fogh, R H.]]
	[[Category: Norton, R S.]]		[[Category: Norton, R S.]]
	[[Category: Neurotoxin]]		[[Category: Neurotoxin]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 13:42:29 2009''