1skg - Revision history

OCA at 07:26, 25 October 2023

OCA — Wed, 25 Oct 2023 07:26:14 GMT

←Older revision		Revision as of 07:26, 25 October 2023
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	<StructureSection load='1skg' size='340' side='right'caption='[[1skg]], [[Resolution\|resolution]] 1.21Å' scene=''>		<StructureSection load='1skg' size='340' side='right'caption='[[1skg]], [[Resolution\|resolution]] 1.21Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1skg]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Daboia_pulchella~~ Daboia pulchella]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SKG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1SKG FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1skg]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Daboia_russelii_pulchella Daboia russelii pulchella]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SKG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1SKG FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=MOH:METHANOL'>MOH</scene>~~, ~~<scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.21Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"><~~div style~~='~~overflow~~: ~~auto; max-height: 3em;~~'>~~[[1fb2\|1fb2]]~~</~~div~~><~~/td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MOH:METHANOL'>MOH</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	~~<tr id~~='~~activity'><td class~~=~~"sblockLbl"><b>Activity~~:~~</b></td><td class="sblockDat"><span class='plainlinks~~'>~~[https://en.wikipedia.org/wiki/Phospholipase_A(2) Phospholipase A(2)], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.4 3.1.1.4]~~ </~~span~~></td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1skg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1skg OCA], [https://pdbe.org/1skg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1skg RCSB], [https://www.ebi.ac.uk/pdbsum/1skg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1skg ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1skg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1skg OCA], [https://pdbe.org/1skg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1skg RCSB], [https://www.ebi.ac.uk/pdbsum/1skg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1skg ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/PA2B8_DABRR PA2B8_DABRR] Snake venom phospholipase A2 (PLA2) that shows weak neurotoxicity and medium anticoagulant effects by binding to factor Xa (F10) and inhibiting the prothrombinase activity (IC(50) is 130 nM) (PubMed:18062812). It also damages vital organs such as lung, liver and kidney, displays edema-inducing activities when injected into the foot pads of mice and induces necrosis of muscle cells when injected into the thigh muscle. Has a low enzymatic activity. PLA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides.<ref>PMID:18062812</ref> <ref>PMID:2115497</ref> <ref>PMID:8835338</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	==See Also==		==See Also==
	*[[Phospholipase A2 3D structures\|Phospholipase A2 3D structures]]		*[[Phospholipase A2 3D structures\|Phospholipase A2 3D structures]]
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Daboia pulchella]]	+	[[Category: Daboia russelii pulchella]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Betzel, C]]	+	[[Category: Betzel C]]
-	[[Category: Dey, S]]	+	[[Category: Dey S]]
-	[[Category: Ethayathulla~~, A S~~]]	+	[[Category: Ethayathulla AS]]
-	[[Category: Makker, J]]	+	[[Category: Makker J]]
-	[[Category: Perbandt, M]]	+	[[Category: Perbandt M]]
-	[[Category: Sharma, S]]	+	[[Category: Sharma S]]
-	[[Category: Singh, N]]	+	[[Category: Singh N]]
-	[[Category: Singh~~, T P]]~~	+	[[Category: Singh TP]]
-	~~[[Category: Hydrolase]]~~	+
-	~~[[Category: Phospholipase a2]]~~	+
-	~~[[Category: Rational drug design]]~~	+
-	~~[[Category: Vafrs complex~~]]	+

OCA at 09:01, 21 April 2021

OCA — Wed, 21 Apr 2021 09:01:40 GMT

←Older revision		Revision as of 09:01, 21 April 2021
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	<StructureSection load='1skg' size='340' side='right'caption='[[1skg]], [[Resolution\|resolution]] 1.21Å' scene=''>		<StructureSection load='1skg' size='340' side='right'caption='[[1skg]], [[Resolution\|resolution]] 1.21Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1skg]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Daboia_pulchella Daboia pulchella]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SKG OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1SKG FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1skg]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Daboia_pulchella Daboia pulchella]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SKG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1SKG FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MOH:METHANOL'>MOH</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MOH:METHANOL'>MOH</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1fb2\|1fb2]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1fb2\|1fb2]]</div></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Phospholipase_A(2) Phospholipase A(2)], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.4 3.1.1.4] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Phospholipase_A(2) Phospholipase A(2)], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.4 3.1.1.4] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1skg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1skg OCA], [~~http~~://pdbe.org/1skg PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1skg RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1skg PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1skg ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1skg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1skg OCA], [https://pdbe.org/1skg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1skg RCSB], [https://www.ebi.ac.uk/pdbsum/1skg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1skg ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
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	==See Also==		==See Also==
-	*[[Phospholipase A2\|Phospholipase A2]]	+	*[[Phospholipase A2 3D structures\|Phospholipase A2 3D structures]]
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 13:29, 17 July 2019

OCA — Wed, 17 Jul 2019 13:29:30 GMT

←Older revision		Revision as of 13:29, 17 July 2019
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	==Structure-based rational drug design: Crystal structure of the complex formed between Phospholipase A2 and a pentapeptide Val-Ala-Phe-Arg-Ser==		==Structure-based rational drug design: Crystal structure of the complex formed between Phospholipase A2 and a pentapeptide Val-Ala-Phe-Arg-Ser==
-	<StructureSection load='1skg' size='340' side='right' caption='[[1skg]], [[Resolution\|resolution]] 1.21Å' scene=''>	+	<StructureSection load='1skg' size='340' side='right'caption='[[1skg]], [[Resolution\|resolution]] 1.21Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1skg]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Daboia_pulchella Daboia pulchella]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SKG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1SKG FirstGlance]. <br>		<table><tr><td colspan='2'>[[1skg]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Daboia_pulchella Daboia pulchella]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SKG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1SKG FirstGlance]. <br>
Line 13:		Line 13:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/sk/1skg_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/sk/1skg_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 25:		Line 25:
	</StructureSection>		</StructureSection>
	[[Category: Daboia pulchella]]		[[Category: Daboia pulchella]]
		+	[[Category: Large Structures]]
	[[Category: Betzel, C]]		[[Category: Betzel, C]]
	[[Category: Dey, S]]		[[Category: Dey, S]]

OCA at 16:11, 12 October 2017

OCA — Thu, 12 Oct 2017 16:11:28 GMT

←Older revision		Revision as of 16:11, 12 October 2017
Line 1:		Line 1:
		+
	==Structure-based rational drug design: Crystal structure of the complex formed between Phospholipase A2 and a pentapeptide Val-Ala-Phe-Arg-Ser==		==Structure-based rational drug design: Crystal structure of the complex formed between Phospholipase A2 and a pentapeptide Val-Ala-Phe-Arg-Ser==
	<StructureSection load='1skg' size='340' side='right' caption='[[1skg]], [[Resolution\|resolution]] 1.21Å' scene=''>		<StructureSection load='1skg' size='340' side='right' caption='[[1skg]], [[Resolution\|resolution]] 1.21Å' scene=''>
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	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1fb2\|1fb2]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1fb2\|1fb2]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Phospholipase_A(2) Phospholipase A(2)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.4 3.1.1.4] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Phospholipase_A(2) Phospholipase A(2)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.4 3.1.1.4] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1skg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1skg OCA], [http://pdbe.org/1skg PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1skg RCSB], [http://www.ebi.ac.uk/pdbsum/1skg PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1skg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1skg OCA], [http://pdbe.org/1skg PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1skg RCSB], [http://www.ebi.ac.uk/pdbsum/1skg PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1skg ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==

OCA at 15:18, 8 February 2016

OCA — Mon, 08 Feb 2016 15:18:14 GMT

←Older revision		Revision as of 15:18, 8 February 2016
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	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1skg ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>

OCA at 12:52, 10 September 2015

OCA — Thu, 10 Sep 2015 12:52:53 GMT

←Older revision		Revision as of 12:52, 10 September 2015
Line 2:		Line 2:
	<StructureSection load='1skg' size='340' side='right' caption='[[1skg]], [[Resolution\|resolution]] 1.21Å' scene=''>		<StructureSection load='1skg' size='340' side='right' caption='[[1skg]], [[Resolution\|resolution]] 1.21Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1skg]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Daboia_russellii_pulchella~~ Daboia ~~russellii~~ pulchella]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SKG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1SKG FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1skg]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Daboia_pulchella Daboia pulchella]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SKG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1SKG FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MOH:METHANOL'>MOH</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MOH:METHANOL'>MOH</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1fb2\|1fb2]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1fb2\|1fb2]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Phospholipase_A(2) Phospholipase A(2)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.4 3.1.1.4] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Phospholipase_A(2) Phospholipase A(2)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.4 3.1.1.4] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1skg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1skg OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1skg RCSB], [http://www.ebi.ac.uk/pdbsum/1skg PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1skg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1skg OCA], [http://pdbe.org/1skg PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1skg RCSB], [http://www.ebi.ac.uk/pdbsum/1skg PDBsum]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Daboia ~~russellii~~ pulchella]]	+	[[Category: Daboia pulchella]]
	[[Category: Betzel, C]]		[[Category: Betzel, C]]
	[[Category: Dey, S]]		[[Category: Dey, S]]

OCA at 08:15, 6 January 2015

OCA — Tue, 06 Jan 2015 08:15:50 GMT

←Older revision		Revision as of 08:15, 6 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1skg]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Daboia_russellii_pulchella Daboia russellii pulchella]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SKG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1SKG FirstGlance]. <br>		<table><tr><td colspan='2'>[[1skg]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Daboia_russellii_pulchella Daboia russellii pulchella]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SKG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1SKG FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MOH:METHANOL'>MOH</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MOH:METHANOL'>MOH</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1fb2\|1fb2]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1fb2\|1fb2]]</td></tr>
-	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Phospholipase_A(2) Phospholipase A(2)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.4 3.1.1.4] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Phospholipase_A(2) Phospholipase A(2)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.4 3.1.1.4] </span></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1skg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1skg OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1skg RCSB], [http://www.ebi.ac.uk/pdbsum/1skg PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1skg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1skg OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1skg RCSB], [http://www.ebi.ac.uk/pdbsum/1skg PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 24:		Line 24:
	</StructureSection>		</StructureSection>
	[[Category: Daboia russellii pulchella]]		[[Category: Daboia russellii pulchella]]
-	[[Category: Betzel, C.]]	+	[[Category: Betzel, C]]
-	[[Category: Dey, S.]]	+	[[Category: Dey, S]]
-	[[Category: Ethayathulla, A S.]]	+	[[Category: Ethayathulla, A S]]
-	[[Category: Makker, J.]]	+	[[Category: Makker, J]]
-	[[Category: Perbandt, M.]]	+	[[Category: Perbandt, M]]
-	[[Category: Sharma, S.]]	+	[[Category: Sharma, S]]
-	[[Category: Singh, N.]]	+	[[Category: Singh, N]]
-	[[Category: Singh, T P.]]	+	[[Category: Singh, T P]]
	[[Category: Hydrolase]]		[[Category: Hydrolase]]
	[[Category: Phospholipase a2]]		[[Category: Phospholipase a2]]
	[[Category: Rational drug design]]		[[Category: Rational drug design]]
	[[Category: Vafrs complex]]		[[Category: Vafrs complex]]

OCA at 21:57, 28 September 2014

OCA — Sun, 28 Sep 2014 21:57:49 GMT

←Older revision		Revision as of 21:57, 28 September 2014
Line 1:		Line 1:
-	~~[[Image:1skg.png\|left\|200px]]~~	+	==Structure-based rational drug design: Crystal structure of the complex formed between Phospholipase A2 and a pentapeptide Val-Ala-Phe-Arg-Ser==
-		+	<StructureSection load='1skg' size='340' side='right' caption='[[1skg]], [[Resolution\|resolution]] 1.21Å' scene=''>
-	~~{{STRUCTURE_1skg\| PDB=1skg \| SCENE= }}~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[1skg]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Daboia_russellii_pulchella Daboia russellii pulchella]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SKG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1SKG FirstGlance]. <br>
-	===Structure-based rational drug design: Crystal structure of the complex formed between Phospholipase A2 and a pentapeptide Val-Ala-Phe-Arg-Ser===	+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MOH:METHANOL'>MOH</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene><br>
-		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1fb2\|1fb2]]</td></tr>
-		+	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Phospholipase_A(2) Phospholipase A(2)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.4 3.1.1.4] </span></td></tr>
-	==~~About this Structure~~==	+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1skg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1skg OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1skg RCSB], [http://www.ebi.ac.uk/pdbsum/1skg PDBsum]</span></td></tr>
-	[[1skg]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Daboia_russellii_pulchella Daboia russellii pulchella]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SKG OCA].	+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/sk/1skg_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>

	==See Also==		==See Also==
	*[[Phospholipase A2\|Phospholipase A2]]		*[[Phospholipase A2\|Phospholipase A2]]
		+	__TOC__
		+	</StructureSection>
	[[Category: Daboia russellii pulchella]]		[[Category: Daboia russellii pulchella]]
	[[Category: Betzel, C.]]		[[Category: Betzel, C.]]

OCA at 10:35, 20 October 2012

OCA — Sat, 20 Oct 2012 10:35:01 GMT

←Older revision		Revision as of 10:35, 20 October 2012
Line 7:		Line 7:

	==About this Structure==		==About this Structure==
-	[[1skg]] is a 2 chain structure ~~of [[Phospholipase A2]]~~ with sequence from [http://en.wikipedia.org/wiki/Daboia_russellii_pulchella Daboia russellii pulchella]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SKG OCA].	+	[[1skg]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Daboia_russellii_pulchella Daboia russellii pulchella]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SKG OCA].

	==See Also==		==See Also==

OCA: Protected "1skg" [edit=sysop:move=sysop]

OCA — Thu, 26 Jul 2012 02:36:17 GMT

Protected "1skg" [edit=sysop:move=sysop]

←Older revision

Revision as of 02:36, 26 July 2012