1sng - Revision history

OCA at 06:19, 23 August 2023

OCA — Wed, 23 Aug 2023 06:19:09 GMT

←Older revision		Revision as of 06:19, 23 August 2023
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	<StructureSection load='1sng' size='340' side='right'caption='[[1sng]], [[Resolution\|resolution]] 1.76Å' scene=''>		<StructureSection load='1sng' size='340' side='right'caption='[[1sng]], [[Resolution\|resolution]] 1.76Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1sng]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~"thermonospora_fusca"_henssen_1957 "thermonospora~~ fusca~~" henssen 1957~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SNG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1SNG FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1sng]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Thermobifida_fusca Thermobifida fusca]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SNG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1SNG FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.76Å</td></tr>
-	<tr id='~~NonStdRes~~'><td class="sblockLbl"><b>[[~~Non-Standard_Residue~~\|~~NonStd Res~~:]]</b></td><td class="sblockDat"><scene name='pdbligand=CAF:S-DIMETHYLARSINOYL-CYSTEINE'>CAF</scene><~~/td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CAF:S-DIMETHYLARSINOYL-CYSTEINE'>CAF</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	~~<tr id~~='~~related'><td class~~=~~"sblockLbl"><b>[[Related_structure\|Related~~:~~]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;~~'>~~[[1mtp\|1mtp]]~~</~~div~~></td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1sng FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1sng OCA], [https://pdbe.org/1sng PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1sng RCSB], [https://www.ebi.ac.uk/pdbsum/1sng PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1sng ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1sng FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1sng OCA], [https://pdbe.org/1sng PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1sng RCSB], [https://www.ebi.ac.uk/pdbsum/1sng PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1sng ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/Q47NK3_THEFY Q47NK3_THEFY]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Thermonospora fusca henssen 1957]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Bottomley~~, S P~~]]	+	[[Category: Thermobifida fusca]]
-	[[Category: Buckle~~, A M~~]]	+	[[Category: Bottomley SP]]
-	[[Category: Butcher~~, R E~~]]	+	[[Category: Buckle AM]]
-	[[Category: Cabrita~~, L D~~]]	+	[[Category: Butcher RE]]
-	[[Category: Fulton~~, K F~~]]	+	[[Category: Cabrita LD]]
-	[[Category: Irving~~, J A~~]]	+	[[Category: Fulton KF]]
-	[[Category: Lesk~~, A M~~]]	+	[[Category: Irving JA]]
-	[[Category: Reeve, S]]	+	[[Category: Lesk AM]]
-	[[Category: Rossjohn, J]]	+	[[Category: Reeve S]]
-	[[Category: Smith, I]]	+	[[Category: Rossjohn J]]
-	[[Category: Whisstock~~, J C]]~~	+	[[Category: Smith I]]
-	~~[[Category: Hydrolase inhibitor]]~~	+	[[Category: Whisstock JC]]
-	~~[[Category: Native state~~]]	+

OCA at 07:34, 22 September 2021

OCA — Wed, 22 Sep 2021 07:34:40 GMT

←Older revision		Revision as of 07:34, 22 September 2021
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	<StructureSection load='1sng' size='340' side='right'caption='[[1sng]], [[Resolution\|resolution]] 1.76Å' scene=''>		<StructureSection load='1sng' size='340' side='right'caption='[[1sng]], [[Resolution\|resolution]] 1.76Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1sng]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/"thermonospora_fusca"_henssen_1957 "thermonospora fusca" henssen 1957]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SNG OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1SNG FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1sng]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/"thermonospora_fusca"_henssen_1957 "thermonospora fusca" henssen 1957]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SNG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1SNG FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CAF:S-DIMETHYLARSINOYL-CYSTEINE'>CAF</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CAF:S-DIMETHYLARSINOYL-CYSTEINE'>CAF</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1mtp\|1mtp]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1mtp\|1mtp]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1sng FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1sng OCA], [~~http~~://pdbe.org/1sng PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1sng RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1sng PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1sng ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1sng FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1sng OCA], [https://pdbe.org/1sng PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1sng RCSB], [https://www.ebi.ac.uk/pdbsum/1sng PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1sng ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 30:		Line 30:

	==See Also==		==See Also==
-	*[[Serpin\|Serpin]]	+	*[[Serpin 3D structures\|Serpin 3D structures]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 14:11, 18 December 2019

OCA — Wed, 18 Dec 2019 14:11:28 GMT

←Older revision		Revision as of 14:11, 18 December 2019
Line 1:		Line 1:

	==Structure of a Thermophilic Serpin in the Native State==		==Structure of a Thermophilic Serpin in the Native State==
-	<StructureSection load='1sng' size='340' side='right' caption='[[1sng]], [[Resolution\|resolution]] 1.76Å' scene=''>	+	<StructureSection load='1sng' size='340' side='right'caption='[[1sng]], [[Resolution\|resolution]] 1.76Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1sng]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"thermonospora_fusca"_henssen_1957 "thermonospora fusca" henssen 1957]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SNG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1SNG FirstGlance]. <br>		<table><tr><td colspan='2'>[[1sng]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"thermonospora_fusca"_henssen_1957 "thermonospora fusca" henssen 1957]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SNG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1SNG FirstGlance]. <br>
Line 36:		Line 36:
	</StructureSection>		</StructureSection>
	[[Category: Thermonospora fusca henssen 1957]]		[[Category: Thermonospora fusca henssen 1957]]
		+	[[Category: Large Structures]]
	[[Category: Bottomley, S P]]		[[Category: Bottomley, S P]]
	[[Category: Buckle, A M]]		[[Category: Buckle, A M]]

OCA at 07:51, 14 March 2018

OCA — Wed, 14 Mar 2018 07:51:59 GMT

←Older revision		Revision as of 07:51, 14 March 2018
Line 1:		Line 1:
		+
	==Structure of a Thermophilic Serpin in the Native State==		==Structure of a Thermophilic Serpin in the Native State==
	<StructureSection load='1sng' size='340' side='right' caption='[[1sng]], [[Resolution\|resolution]] 1.76Å' scene=''>		<StructureSection load='1sng' size='340' side='right' caption='[[1sng]], [[Resolution\|resolution]] 1.76Å' scene=''>
Line 6:		Line 7:
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CAF:S-DIMETHYLARSINOYL-CYSTEINE'>CAF</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CAF:S-DIMETHYLARSINOYL-CYSTEINE'>CAF</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1mtp\|1mtp]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1mtp\|1mtp]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1sng FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1sng OCA], [http://pdbe.org/1sng PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1sng RCSB], [http://www.ebi.ac.uk/pdbsum/1sng PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1sng FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1sng OCA], [http://pdbe.org/1sng PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1sng RCSB], [http://www.ebi.ac.uk/pdbsum/1sng PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1sng ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 12:		Line 13:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/sn/1sng_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/sn/1sng_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 09:57, 9 February 2016

OCA — Tue, 09 Feb 2016 09:57:13 GMT

←Older revision		Revision as of 09:57, 9 February 2016
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	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1sng ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 21:05, 10 September 2015

OCA — Thu, 10 Sep 2015 21:05:52 GMT

←Older revision		Revision as of 21:05, 10 September 2015
Line 2:		Line 2:
	<StructureSection load='1sng' size='340' side='right' caption='[[1sng]], [[Resolution\|resolution]] 1.76Å' scene=''>		<StructureSection load='1sng' size='340' side='right' caption='[[1sng]], [[Resolution\|resolution]] 1.76Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1sng]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Thermobifida_fusca Thermobifida~~ fusca]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SNG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1SNG FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1sng]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"thermonospora_fusca"_henssen_1957 "thermonospora fusca" henssen 1957]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SNG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1SNG FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CAF:S-DIMETHYLARSINOYL-CYSTEINE'>CAF</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CAF:S-DIMETHYLARSINOYL-CYSTEINE'>CAF</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1mtp\|1mtp]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1mtp\|1mtp]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1sng FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1sng OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1sng RCSB], [http://www.ebi.ac.uk/pdbsum/1sng PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1sng FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1sng OCA], [http://pdbe.org/1sng PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1sng RCSB], [http://www.ebi.ac.uk/pdbsum/1sng PDBsum]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 26:		Line 26:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1sng" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 33:		Line 34:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Thermobifida~~ fusca]]	+	[[Category: Thermonospora fusca henssen 1957]]
	[[Category: Bottomley, S P]]		[[Category: Bottomley, S P]]
	[[Category: Buckle, A M]]		[[Category: Buckle, A M]]

OCA at 07:15, 6 January 2015

OCA — Tue, 06 Jan 2015 07:15:40 GMT

←Older revision		Revision as of 07:15, 6 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1sng]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Thermobifida_fusca Thermobifida fusca]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SNG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1SNG FirstGlance]. <br>		<table><tr><td colspan='2'>[[1sng]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Thermobifida_fusca Thermobifida fusca]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SNG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1SNG FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CAF:S-DIMETHYLARSINOYL-CYSTEINE'>CAF</scene></td></tr>	+	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CAF:S-DIMETHYLARSINOYL-CYSTEINE'>CAF</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1mtp\|1mtp]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1mtp\|1mtp]]</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1sng FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1sng OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1sng RCSB], [http://www.ebi.ac.uk/pdbsum/1sng PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1sng FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1sng OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1sng RCSB], [http://www.ebi.ac.uk/pdbsum/1sng PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 34:		Line 34:
	</StructureSection>		</StructureSection>
	[[Category: Thermobifida fusca]]		[[Category: Thermobifida fusca]]
-	[[Category: Bottomley, S P.]]	+	[[Category: Bottomley, S P]]
-	[[Category: Buckle, A M.]]	+	[[Category: Buckle, A M]]
-	[[Category: Butcher, R E.]]	+	[[Category: Butcher, R E]]
-	[[Category: Cabrita, L D.]]	+	[[Category: Cabrita, L D]]
-	[[Category: Fulton, K F.]]	+	[[Category: Fulton, K F]]
-	[[Category: Irving, J A.]]	+	[[Category: Irving, J A]]
-	[[Category: Lesk, A M.]]	+	[[Category: Lesk, A M]]
-	[[Category: Reeve, S.]]	+	[[Category: Reeve, S]]
-	[[Category: Rossjohn, J.]]	+	[[Category: Rossjohn, J]]
-	[[Category: Smith, I.]]	+	[[Category: Smith, I]]
-	[[Category: Whisstock, J C.]]	+	[[Category: Whisstock, J C]]
	[[Category: Hydrolase inhibitor]]		[[Category: Hydrolase inhibitor]]
-	[[Category: Native state.]]	+	[[Category: Native state]]

OCA at 23:28, 28 September 2014

OCA — Sun, 28 Sep 2014 23:28:41 GMT

←Older revision		Revision as of 23:28, 28 September 2014
Line 1:		Line 1:
-	[[~~Image:~~1sng.~~png~~\|~~left~~\|200px]]	+	==Structure of a Thermophilic Serpin in the Native State==
		+	<StructureSection load='1sng' size='340' side='right' caption='[[1sng]], [[Resolution\|resolution]] 1.76Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1sng]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Thermobifida_fusca Thermobifida fusca]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SNG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1SNG FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CAF:S-DIMETHYLARSINOYL-CYSTEINE'>CAF</scene></td></tr>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1mtp\|1mtp]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1sng FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1sng OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1sng RCSB], [http://www.ebi.ac.uk/pdbsum/1sng PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/sn/1sng_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Serpins fold into a native metastable state and utilize a complex conformational change to inhibit target proteases. An undesirable result of this conformational flexibility is that most inhibitory serpins are heat sensitive, forming inactive polymers at elevated temperatures. However, the prokaryote serpin, thermopin, from Thermobifida fusca is able to function in a heated environment. We have determined the 1.8 A x-ray crystal structure of thermopin in the native, inhibitory conformation. A structural comparison with the previously determined 1.5 A structure of cleaved thermopin provides detailed insight into the complex mechanism of conformational change in serpins. Flexibility in the shutter region and electrostatic interactions at the top of the A beta-sheet (the breach) involving the C-terminal tail, a unique structural feature of thermopin, are postulated to be important for controlling inhibitory activity and triggering conformational change, respectively, in the native state. Here we have discussed the structural basis of how this serpin reconciles the thermodynamic instability necessary for function with the stability required to withstand elevated temperatures.

-	~~{{STRUCTURE_1sng\| PDB=1sng \| SCENE= }}~~	+	The high resolution crystal structure of a native thermostable serpin reveals the complex mechanism underpinning the stressed to relaxed transition.,Fulton KF, Buckle AM, Cabrita LD, Irving JA, Butcher RE, Smith I, Reeve S, Lesk AM, Bottomley SP, Rossjohn J, Whisstock JC J Biol Chem. 2005 Mar 4;280(9):8435-42. Epub 2004 Dec 7. PMID:15590653<ref>PMID:15590653</ref>

-	~~===Structure~~ of ~~a Thermophilic Serpin in~~ the ~~Native State===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_15590653}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[1sng]] is a 1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Thermobifida_fusca Thermobifida fusca]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=1SNG OCA].~~	+

	==See Also==		==See Also==
	*[[Serpin\|Serpin]]		*[[Serpin\|Serpin]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:015590653<~~/~~ref~~><~~references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Thermobifida fusca]]		[[Category: Thermobifida fusca]]
	[[Category: Bottomley, S P.]]		[[Category: Bottomley, S P.]]

OCA: Protected "1sng" [edit=sysop:move=sysop]

OCA — Sat, 20 Oct 2012 13:29:34 GMT

Protected "1sng" [edit=sysop:move=sysop]

←Older revision

Revision as of 13:29, 20 October 2012

OCA at 13:29, 20 October 2012

OCA — Sat, 20 Oct 2012 13:29:33 GMT

←Older revision		Revision as of 13:29, 20 October 2012
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-	{{Seed}}
	[[Image:1sng.png\|left\|200px]]		[[Image:1sng.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_1sng", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_1sng\| PDB=1sng \| SCENE= }}		{{STRUCTURE_1sng\| PDB=1sng \| SCENE= }}

	===Structure of a Thermophilic Serpin in the Native State===		===Structure of a Thermophilic Serpin in the Native State===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_15590653}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 15590653 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_15590653}}		{{ABSTRACT_PUBMED_15590653}}

	==About this Structure==		==About this Structure==
-	~~1SNG~~ is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Thermobifida_fusca Thermobifida fusca]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SNG OCA].	+	[[1sng]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Thermobifida_fusca Thermobifida fusca]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SNG OCA].
		+
		+	==See Also==
		+	*[[Serpin\|Serpin]]

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~15590653~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:015590653</ref><references group="xtra"/>
	[[Category: Thermobifida fusca]]		[[Category: Thermobifida fusca]]
	[[Category: Bottomley, S P.]]		[[Category: Bottomley, S P.]]
Line 36:		Line 27:
	[[Category: Smith, I.]]		[[Category: Smith, I.]]
	[[Category: Whisstock, J C.]]		[[Category: Whisstock, J C.]]
		+	[[Category: Hydrolase inhibitor]]
	[[Category: Native state.]]		[[Category: Native state.]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 08:57:20 2009''