1sul - Revision history

OCA at 08:33, 14 February 2024

OCA — Wed, 14 Feb 2024 08:33:59 GMT

←Older revision		Revision as of 08:33, 14 February 2024
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	<StructureSection load='1sul' size='340' side='right'caption='[[1sul]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='1sul' size='340' side='right'caption='[[1sul]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1sul]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~"bacillus_globigii"_migula_1900 "bacillus globigii" migula 1900~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SUL OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=1SUL FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1sul]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SUL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1SUL FirstGlance]. <br>
-	</td></tr><tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"~~><div style='overflow: auto; max-height: 3em;'>[[1svi\|1svi]], [[1svw\|1svw]]</div></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2Å</td></tr>
-	~~<tr~~ id~~='gene'><td class~~="~~sblockLbl~~">~~<b>~~[[~~Gene~~\|~~Gene:~~]]~~</b></td><td class="sblockDat">YsxC, ENGB, BSU28190 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info~~&~~srchmode=5&id=1423 "Bacillus globigii" Migula 1900])~~</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1sul FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1sul OCA], [https://pdbe.org/1sul PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1sul RCSB], [https://www.ebi.ac.uk/pdbsum/1sul PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1sul ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=1sul FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1sul OCA], [~~http~~://pdbe.org/1sul PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1sul RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1sul PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1sul ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/ENGB_BACSU ENGB_BACSU]] Necessary for normal cell division and for the maintenance of normal septation (By similarity).[HAMAP-Rule:MF_00321] Binds GTP and GDP.[HAMAP-Rule:MF_00321]	+	[https://www.uniprot.org/uniprot/ENGB_BACSU ENGB_BACSU] Necessary for normal cell division and for the maintenance of normal septation (By similarity).[HAMAP-Rule:MF_00321] Binds GTP and GDP.[HAMAP-Rule:MF_00321]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1sul ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1sul ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
-	<div style="background-color:#fffaf0;">
-	== Publication Abstract from PubMed ==
-	Genetic analysis has suggested that the product of the Bacillus subtilis ysxC gene is essential for survival of the microorganism and hence may represent a target for the development of a novel anti-infective agent. B.subtilis YsxC is a member of the translation factor related class of GTPases and its crystal structure has been determined in an apo form and in complex with GDP and GMPPNP/Mg2+. Analysis of these structures has allowed us to examine the conformational changes that occur during the process of nucleotide binding and GTP hydrolysis. These structural changes particularly affect parts of the switch I and switch II region of YsxC, which become ordered and disordered, respectively in the "closed" or "on" GTP-bound state and disordered and ordered, respectively, in the "open" or "off" GDP-bound conformation. Finally, the binding of the magnesium cation results in subtle shifts of residues in the G3 region, at the start of switch II, which serve to optimize the interaction with a key aspartic acid residue. The structural flexibility observed in YsxC is likely to contribute to the role of the protein, possibly allowing transduction of an essential intracellular signal, which may be mediated via interactions with a conserved patch of surface-exposed, basic residues that lies adjacent to the GTP-binding site.
-
-	Analysis of the open and closed conformations of the GTP-binding protein YsxC from Bacillus subtilis.,Ruzheinikov SN, Das SK, Sedelnikova SE, Baker PJ, Artymiuk PJ, Garcia-Lara J, Foster SJ, Rice DW J Mol Biol. 2004 May 28;339(2):265-78. PMID:15136032<ref>PMID:15136032</ref>
-
-	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	</div>
-	<div class="pdbe-citations 1sul" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
	*[[GTP-binding protein 3D structures\|GTP-binding protein 3D structures]]		*[[GTP-binding protein 3D structures\|GTP-binding protein 3D structures]]
-	== References ==
-	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Bacillus ~~globigii migula 1900~~]]	+	[[Category: Bacillus subtilis]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Artymiuk~~, P J~~]]	+	[[Category: Artymiuk PJ]]
-	[[Category: Baker~~, P J~~]]	+	[[Category: Baker PJ]]
-	[[Category: Das~~, K S~~]]	+	[[Category: Das KS]]
-	[[Category: Foster~~, S J~~]]	+	[[Category: Foster SJ]]
-	[[Category: Garcia-Lara, J]]	+	[[Category: Garcia-Lara J]]
-	[[Category: Rice~~, D W~~]]	+	[[Category: Rice DW]]
-	[[Category: Ruzheinikov~~, S N~~]]	+	[[Category: Ruzheinikov SN]]
-	[[Category: Sedelnikova~~, S E]]~~	+	[[Category: Sedelnikova SE]]
-	~~[[Category: Gtp]]~~	+
-	~~[[Category: Gtp-binding]]~~	+
-	~~[[Category: Gtpase]]~~	+
-	~~[[Category: Hydrolase~~]]	+

OCA at 11:34, 24 December 2020

OCA — Thu, 24 Dec 2020 11:34:26 GMT

←Older revision		Revision as of 11:34, 24 December 2020
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	==Crystal Structure of the apo-YsxC==		==Crystal Structure of the apo-YsxC==
-	<StructureSection load='1sul' size='340' side='right' caption='[[1sul]], [[Resolution\|resolution]] 2.00Å' scene=''>	+	<StructureSection load='1sul' size='340' side='right'caption='[[1sul]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1sul]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_globigii"_migula_1900 "bacillus globigii" migula 1900]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SUL OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1SUL FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1sul]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_globigii"_migula_1900 "bacillus globigii" migula 1900]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SUL OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=1SUL FirstGlance]. <br>
-	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1svi\|1svi]], [[1svw\|1svw]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1svi\|1svi]], [[1svw\|1svw]]</div></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">YsxC, ENGB, BSU28190 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1423 "Bacillus globigii" Migula 1900])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">YsxC, ENGB, BSU28190 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1423 "Bacillus globigii" Migula 1900])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1sul FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1sul OCA], [http://pdbe.org/1sul PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1sul RCSB], [http://www.ebi.ac.uk/pdbsum/1sul PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1sul ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=1sul FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1sul OCA], [http://pdbe.org/1sul PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1sul RCSB], [http://www.ebi.ac.uk/pdbsum/1sul PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1sul ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/su/1sul_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/su/1sul_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 29:		Line 29:
	</div>		</div>
	<div class="pdbe-citations 1sul" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 1sul" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[GTP-binding protein 3D structures\|GTP-binding protein 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
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	</StructureSection>		</StructureSection>
	[[Category: Bacillus globigii migula 1900]]		[[Category: Bacillus globigii migula 1900]]
		+	[[Category: Large Structures]]
	[[Category: Artymiuk, P J]]		[[Category: Artymiuk, P J]]
	[[Category: Baker, P J]]		[[Category: Baker, P J]]

OCA at 08:36, 12 October 2017

OCA — Thu, 12 Oct 2017 08:36:59 GMT

←Older revision		Revision as of 08:36, 12 October 2017
Line 1:		Line 1:
		+
	==Crystal Structure of the apo-YsxC==		==Crystal Structure of the apo-YsxC==
	<StructureSection load='1sul' size='340' side='right' caption='[[1sul]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='1sul' size='340' side='right' caption='[[1sul]], [[Resolution\|resolution]] 2.00Å' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1svi\|1svi]], [[1svw\|1svw]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1svi\|1svi]], [[1svw\|1svw]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">YsxC, ENGB, BSU28190 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1423 "Bacillus globigii" Migula 1900])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">YsxC, ENGB, BSU28190 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1423 "Bacillus globigii" Migula 1900])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1sul FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1sul OCA], [http://pdbe.org/1sul PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1sul RCSB], [http://www.ebi.ac.uk/pdbsum/1sul PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1sul FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1sul OCA], [http://pdbe.org/1sul PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1sul RCSB], [http://www.ebi.ac.uk/pdbsum/1sul PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1sul ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	</div>		</div>
	<div class="pdbe-citations 1sul" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 1sul" style="background-color:#fffaf0;"></div>
-
-	==See Also==
-	*[[GTP-binding protein\|GTP-binding protein]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 05:59, 9 February 2016

OCA — Tue, 09 Feb 2016 05:59:10 GMT

←Older revision		Revision as of 05:59, 9 February 2016
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	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1sul ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 19:18, 10 September 2015

OCA — Thu, 10 Sep 2015 19:18:50 GMT

←Older revision		Revision as of 19:18, 10 September 2015
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	<StructureSection load='1sul' size='340' side='right' caption='[[1sul]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='1sul' size='340' side='right' caption='[[1sul]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1sul]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Bacillus_subtilis Bacillus subtilis~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SUL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1SUL FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1sul]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_globigii"_migula_1900 "bacillus globigii" migula 1900]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SUL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1SUL FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1svi\|1svi]], [[1svw\|1svw]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1svi\|1svi]], [[1svw\|1svw]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">YsxC, ENGB, BSU28190 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1423 Bacillus ~~subtilis~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">YsxC, ENGB, BSU28190 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1423 "Bacillus globigii" Migula 1900])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1sul FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1sul OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1sul RCSB], [http://www.ebi.ac.uk/pdbsum/1sul PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1sul FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1sul OCA], [http://pdbe.org/1sul PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1sul RCSB], [http://www.ebi.ac.uk/pdbsum/1sul PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1sul" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 34:		Line 35:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Bacillus ~~subtilis~~]]	+	[[Category: Bacillus globigii migula 1900]]
	[[Category: Artymiuk, P J]]		[[Category: Artymiuk, P J]]
	[[Category: Baker, P J]]		[[Category: Baker, P J]]

OCA at 04:53, 25 December 2014

OCA — Thu, 25 Dec 2014 04:53:35 GMT

←Older revision		Revision as of 04:53, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1sul]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SUL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1SUL FirstGlance]. <br>		<table><tr><td colspan='2'>[[1sul]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SUL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1SUL FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1svi\|1svi]], [[1svw\|1svw]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1svi\|1svi]], [[1svw\|1svw]]</td></tr>
-	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">YsxC, ENGB, BSU28190 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1423 Bacillus subtilis])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">YsxC, ENGB, BSU28190 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1423 Bacillus subtilis])</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1sul FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1sul OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1sul RCSB], [http://www.ebi.ac.uk/pdbsum/1sul PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1sul FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1sul OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1sul RCSB], [http://www.ebi.ac.uk/pdbsum/1sul PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/ENGB_BACSU ENGB_BACSU]] Necessary for normal cell division and for the maintenance of normal septation (By similarity).[HAMAP-Rule:MF_00321] Binds GTP and GDP.[HAMAP-Rule:MF_00321]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	</StructureSection>		</StructureSection>
	[[Category: Bacillus subtilis]]		[[Category: Bacillus subtilis]]
-	[[Category: Artymiuk, P J.]]	+	[[Category: Artymiuk, P J]]
-	[[Category: Baker, P J.]]	+	[[Category: Baker, P J]]
-	[[Category: Das, K S.]]	+	[[Category: Das, K S]]
-	[[Category: Foster, S J.]]	+	[[Category: Foster, S J]]
-	[[Category: Garcia-Lara, J.]]	+	[[Category: Garcia-Lara, J]]
-	[[Category: Rice, D W.]]	+	[[Category: Rice, D W]]
-	[[Category: Ruzheinikov, S N.]]	+	[[Category: Ruzheinikov, S N]]
-	[[Category: Sedelnikova, S E.]]	+	[[Category: Sedelnikova, S E]]
	[[Category: Gtp]]		[[Category: Gtp]]
	[[Category: Gtp-binding]]		[[Category: Gtp-binding]]
	[[Category: Gtpase]]		[[Category: Gtpase]]
	[[Category: Hydrolase]]		[[Category: Hydrolase]]

OCA at 22:20, 28 September 2014

OCA — Sun, 28 Sep 2014 22:20:25 GMT

←Older revision		Revision as of 22:20, 28 September 2014
Line 1:		Line 1:
-	[[~~Image:~~1sul.~~png~~\|~~left~~\|200px]]	+	==Crystal Structure of the apo-YsxC==
		+	<StructureSection load='1sul' size='340' side='right' caption='[[1sul]], [[Resolution\|resolution]] 2.00Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1sul]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SUL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1SUL FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1svi\|1svi]], [[1svw\|1svw]]</td></tr>
		+	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">YsxC, ENGB, BSU28190 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1423 Bacillus subtilis])</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1sul FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1sul OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1sul RCSB], [http://www.ebi.ac.uk/pdbsum/1sul PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/su/1sul_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Genetic analysis has suggested that the product of the Bacillus subtilis ysxC gene is essential for survival of the microorganism and hence may represent a target for the development of a novel anti-infective agent. B.subtilis YsxC is a member of the translation factor related class of GTPases and its crystal structure has been determined in an apo form and in complex with GDP and GMPPNP/Mg2+. Analysis of these structures has allowed us to examine the conformational changes that occur during the process of nucleotide binding and GTP hydrolysis. These structural changes particularly affect parts of the switch I and switch II region of YsxC, which become ordered and disordered, respectively in the "closed" or "on" GTP-bound state and disordered and ordered, respectively, in the "open" or "off" GDP-bound conformation. Finally, the binding of the magnesium cation results in subtle shifts of residues in the G3 region, at the start of switch II, which serve to optimize the interaction with a key aspartic acid residue. The structural flexibility observed in YsxC is likely to contribute to the role of the protein, possibly allowing transduction of an essential intracellular signal, which may be mediated via interactions with a conserved patch of surface-exposed, basic residues that lies adjacent to the GTP-binding site.

-	~~{{STRUCTURE_1sul\| PDB=1sul \| SCENE= }}~~	+	Analysis of the open and closed conformations of the GTP-binding protein YsxC from Bacillus subtilis.,Ruzheinikov SN, Das SK, Sedelnikova SE, Baker PJ, Artymiuk PJ, Garcia-Lara J, Foster SJ, Rice DW J Mol Biol. 2004 May 28;339(2):265-78. PMID:15136032<ref>PMID:15136032</ref>

-	~~===Crystal Structure~~ of the ~~apo-YsxC===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_15136032}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[1sul]] is a 2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Bacillus_subtilis Bacillus subtilis]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=1SUL OCA].~~	+

	==See Also==		==See Also==
	*[[GTP-binding protein\|GTP-binding protein]]		*[[GTP-binding protein\|GTP-binding protein]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:015136032<~~/~~ref~~><~~references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Bacillus subtilis]]		[[Category: Bacillus subtilis]]
	[[Category: Artymiuk, P J.]]		[[Category: Artymiuk, P J.]]

OCA at 12:53, 20 October 2012

OCA — Sat, 20 Oct 2012 12:53:11 GMT

←Older revision		Revision as of 12:53, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[1sul]] is a 2 chain structure ~~of [[GTP-binding protein]]~~ with sequence from [http://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SUL OCA].	+	[[1sul]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SUL OCA].

	==See Also==		==See Also==

OCA: Protected "1sul" [edit=sysop:move=sysop]

OCA — Thu, 26 Jul 2012 10:12:50 GMT

Protected "1sul" [edit=sysop:move=sysop]

←Older revision

Revision as of 10:12, 26 July 2012

OCA at 10:12, 26 July 2012

OCA — Thu, 26 Jul 2012 10:12:48 GMT

←Older revision		Revision as of 10:12, 26 July 2012
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-	{{Seed}}
	[[Image:1sul.png\|left\|200px]]		[[Image:1sul.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_1sul", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_1sul\| PDB=1sul \| SCENE= }}		{{STRUCTURE_1sul\| PDB=1sul \| SCENE= }}

	===Crystal Structure of the apo-YsxC===		===Crystal Structure of the apo-YsxC===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_15136032}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 15136032 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_15136032}}		{{ABSTRACT_PUBMED_15136032}}

	==About this Structure==		==About this Structure==
-	~~1SUL~~ is a 2 ~~chains~~ structure of ~~sequences~~ from [http://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SUL OCA].	+	[[1sul]] is a 2 chain structure of [[GTP-binding protein]] with sequence from [http://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SUL OCA].
		+
		+	==See Also==
		+	*[[GTP-binding protein\|GTP-binding protein]]

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~15136032~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:015136032</ref><references group="xtra"/>
	[[Category: Bacillus subtilis]]		[[Category: Bacillus subtilis]]
	[[Category: Artymiuk, P J.]]		[[Category: Artymiuk, P J.]]
Line 36:		Line 27:
	[[Category: Gtp-binding]]		[[Category: Gtp-binding]]
	[[Category: Gtpase]]		[[Category: Gtpase]]
-		+	[[Category: Hydrolase]]
-	~~''Page seeded by~~ [~~http~~:~~//oca.weizmann.ac.il/oca OCA~~ ] ~~on Tue Feb 17 07:01:59 2009''~~	+