1t26 - Revision history

OCA at 06:23, 23 August 2023

OCA — Wed, 23 Aug 2023 06:23:38 GMT

←Older revision		Revision as of 06:23, 23 August 2023
Line 3:		Line 3:
	<StructureSection load='1t26' size='340' side='right'caption='[[1t26]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='1t26' size='340' side='right'caption='[[1t26]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1t26]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Plafa Plafa~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1T26 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=1T26 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1t26]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Plasmodium_falciparum Plasmodium falciparum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1T26 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1T26 FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=GBD:4~~-~~HYDROXY-1~~,~~2,5-THIADIAZOLE-3-CARBOXYLIC+ACID'>GBD</scene>, <scene name='pdbligand=NAI:1,4-DIHYDRONICOTINAMIDE+ADENINE+DINUCLEOTIDE'>NAI</scene></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.8Å</td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>~~[[~~Related_structure~~\|~~Related:~~]]~~</b></td><td class="sblockDat"><div style='overflow: auto~~; ~~max-height: 3em;'>[[1ldg\|1ldg]], [[1t24\|1t24]], [[1t25\|1t25]], [[1t2c\|1t2c]], [[1t2d\|1t2d]], [[1t2e\|1t2e]], [[1t2f\|1t2f]]</div>~~</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GBD:4-HYDROXY-1,2,5-THIADIAZOLE-3-CARBOXYLIC+ACID'>GBD</scene>, <scene name='pdbligand=NAI:1,4-DIHYDRONICOTINAMIDE+ADENINE+DINUCLEOTIDE'>NAI</scene></td></tr>
-	<tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat"~~>LDH ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&~~id=~~5833 PLAFA])</td~~><~~/tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1t26 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1t26 OCA], [https://pdbe.org/1t26 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1t26 RCSB], [https://www.ebi.ac.uk/pdbsum/1t26 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1t26 ProSAT]</span></td></tr>
-	~~<tr id~~='~~activity'><td class~~=~~"sblockLbl"><b>Activity~~:~~</b~~></td><~~td class~~=~~"sblockDat"><span class~~=~~'plainlinks'>[http~~:~~//en.wikipedia.org/wiki/L-lactate_dehydrogenase L-lactate dehydrogenase]~~, ~~with EC number [http://www.brenda~~-~~enzymes.info/php/result_flat.php4?ecno=1.1.1.27 1.1.1.27]~~ </~~span~~></td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=1t26 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1t26 OCA], [~~http~~://pdbe.org/1t26 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1t26 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1t26 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1t26 ProSAT]</span></td></tr>	+
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/LDH_PLAFD LDH_PLAFD]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: L-lactate dehydrogenase]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Plafa~~]]	+	[[Category: Plasmodium falciparum]]
-	[[Category: Barros, D]]	+	[[Category: Barros D]]
-	[[Category: Brady~~, R L~~]]	+	[[Category: Brady RL]]
-	[[Category: Cameron, A]]	+	[[Category: Cameron A]]
-	[[Category: Croft~~, S L~~]]	+	[[Category: Croft SL]]
-	[[Category: Easton, A]]	+	[[Category: De Las Heras FG]]
-	[[Category: Gabarro, R]]	+	[[Category: Easton A]]
-	[[Category: Gamo~~, F J~~]]	+	[[Category: Gabarro R]]
-	[[Category: Garcia-Ochoa, S]]	+	[[Category: Gamo FJ]]
-	~~[[Category: Heras, F G.De Las~~]]	+	[[Category: Garcia-Ochoa S]]
-	[[Category: Kendrick, H]]	+	[[Category: Kendrick H]]
-	[[Category: Lavandera~~, J L~~]]	+	[[Category: Lavandera JL]]
-	[[Category: Leon, L]]	+	[[Category: Leon L]]
-	[[Category: Mallo, A]]	+	[[Category: Mallo A]]
-	[[Category: Martin~~, J J~~]]	+	[[Category: Martin JJ]]
-	[[Category: Read, J]]	+	[[Category: Read J]]
-	[[Category: Risco, F]]	+	[[Category: Risco F]]
-	[[Category: Ruiz~~, J R~~]]	+	[[Category: Ruiz JR]]
-	[[Category: Sanz, L]]	+	[[Category: Sanz L]]
-	[[Category: Sessions~~, R B~~]]	+	[[Category: Sessions RB]]
-	[[Category: Tranter, R]]	+	[[Category: Tranter R]]
-	[[Category: Vivas, L]]	+	[[Category: Vivas L]]
-	[[Category: Winter~~, V J]]~~	+	[[Category: Winter VJ]]
-	~~[[Category: Oxidoreductase]]~~	+
-	~~[[Category: Protein-ligand complex~~]]	+

OCA at 11:39, 24 December 2020

OCA — Thu, 24 Dec 2020 11:39:44 GMT

←Older revision		Revision as of 11:39, 24 December 2020
Line 1:		Line 1:

	==Plasmodium falciparum lactate dehydrogenase complexed with NADH and 4-hydroxy-1,2,5-thiadiazole-3-carboxylic acid==		==Plasmodium falciparum lactate dehydrogenase complexed with NADH and 4-hydroxy-1,2,5-thiadiazole-3-carboxylic acid==
-	<StructureSection load='1t26' size='340' side='right' caption='[[1t26]], [[Resolution\|resolution]] 1.80Å' scene=''>	+	<StructureSection load='1t26' size='340' side='right'caption='[[1t26]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1t26]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Plafa Plafa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1T26 OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1T26 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1t26]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Plafa Plafa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1T26 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=1T26 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GBD:4-HYDROXY-1,2,5-THIADIAZOLE-3-CARBOXYLIC+ACID'>GBD</scene>, <scene name='pdbligand=NAI:1,4-DIHYDRONICOTINAMIDE+ADENINE+DINUCLEOTIDE'>NAI</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GBD:4-HYDROXY-1,2,5-THIADIAZOLE-3-CARBOXYLIC+ACID'>GBD</scene>, <scene name='pdbligand=NAI:1,4-DIHYDRONICOTINAMIDE+ADENINE+DINUCLEOTIDE'>NAI</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1ldg\|1ldg]], [[1t24\|1t24]], [[1t25\|1t25]], [[1t2c\|1t2c]], [[1t2d\|1t2d]], [[1t2e\|1t2e]], [[1t2f\|1t2f]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1ldg\|1ldg]], [[1t24\|1t24]], [[1t25\|1t25]], [[1t2c\|1t2c]], [[1t2d\|1t2d]], [[1t2e\|1t2e]], [[1t2f\|1t2f]]</div></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">LDH ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5833 PLAFA])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">LDH ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5833 PLAFA])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/L-lactate_dehydrogenase L-lactate dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.27 1.1.1.27] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/L-lactate_dehydrogenase L-lactate dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.27 1.1.1.27] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1t26 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1t26 OCA], [http://pdbe.org/1t26 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1t26 RCSB], [http://www.ebi.ac.uk/pdbsum/1t26 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1t26 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=1t26 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1t26 OCA], [http://pdbe.org/1t26 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1t26 RCSB], [http://www.ebi.ac.uk/pdbsum/1t26 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1t26 ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 31:		Line 31:

	==See Also==		==See Also==
-	*[[Lactate ~~Dehydrogenase~~\|Lactate ~~Dehydrogenase~~]]	+	*[[Lactate dehydrogenase 3D structures\|Lactate dehydrogenase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 37:		Line 37:
	</StructureSection>		</StructureSection>
	[[Category: L-lactate dehydrogenase]]		[[Category: L-lactate dehydrogenase]]
		+	[[Category: Large Structures]]
	[[Category: Plafa]]		[[Category: Plafa]]
	[[Category: Barros, D]]		[[Category: Barros, D]]

OCA at 07:35, 14 March 2018

OCA — Wed, 14 Mar 2018 07:35:33 GMT

←Older revision		Revision as of 07:35, 14 March 2018
Line 1:		Line 1:
		+
	==Plasmodium falciparum lactate dehydrogenase complexed with NADH and 4-hydroxy-1,2,5-thiadiazole-3-carboxylic acid==		==Plasmodium falciparum lactate dehydrogenase complexed with NADH and 4-hydroxy-1,2,5-thiadiazole-3-carboxylic acid==
	<StructureSection load='1t26' size='340' side='right' caption='[[1t26]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='1t26' size='340' side='right' caption='[[1t26]], [[Resolution\|resolution]] 1.80Å' scene=''>
Line 7:		Line 8:
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">LDH ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5833 PLAFA])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">LDH ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5833 PLAFA])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/L-lactate_dehydrogenase L-lactate dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.27 1.1.1.27] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/L-lactate_dehydrogenase L-lactate dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.27 1.1.1.27] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1t26 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1t26 OCA], [http://pdbe.org/1t26 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1t26 RCSB], [http://www.ebi.ac.uk/pdbsum/1t26 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1t26 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1t26 OCA], [http://pdbe.org/1t26 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1t26 RCSB], [http://www.ebi.ac.uk/pdbsum/1t26 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1t26 ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 13:		Line 14:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/t2/1t26_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/t2/1t26_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 07:32, 9 February 2016

OCA — Tue, 09 Feb 2016 07:32:32 GMT

←Older revision		Revision as of 07:32, 9 February 2016
Line 17:		Line 17:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1t26 ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 20:00, 10 September 2015

OCA — Thu, 10 Sep 2015 20:00:40 GMT

←Older revision		Revision as of 20:00, 10 September 2015
Line 2:		Line 2:
	<StructureSection load='1t26' size='340' side='right' caption='[[1t26]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='1t26' size='340' side='right' caption='[[1t26]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1t26]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Plasmodium_falciparum Plasmodium falciparum~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1T26 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1T26 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1t26]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Plafa Plafa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1T26 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1T26 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GBD:4-HYDROXY-1,2,5-THIADIAZOLE-3-CARBOXYLIC+ACID'>GBD</scene>, <scene name='pdbligand=NAI:1,4-DIHYDRONICOTINAMIDE+ADENINE+DINUCLEOTIDE'>NAI</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GBD:4-HYDROXY-1,2,5-THIADIAZOLE-3-CARBOXYLIC+ACID'>GBD</scene>, <scene name='pdbligand=NAI:1,4-DIHYDRONICOTINAMIDE+ADENINE+DINUCLEOTIDE'>NAI</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1ldg\|1ldg]], [[1t24\|1t24]], [[1t25\|1t25]], [[1t2c\|1t2c]], [[1t2d\|1t2d]], [[1t2e\|1t2e]], [[1t2f\|1t2f]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1ldg\|1ldg]], [[1t24\|1t24]], [[1t25\|1t25]], [[1t2c\|1t2c]], [[1t2d\|1t2d]], [[1t2e\|1t2e]], [[1t2f\|1t2f]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">LDH ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5833 ~~Plasmodium falciparum~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">LDH ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5833 PLAFA])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/L-lactate_dehydrogenase L-lactate dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.27 1.1.1.27] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/L-lactate_dehydrogenase L-lactate dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.27 1.1.1.27] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1t26 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1t26 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1t26 RCSB], [http://www.ebi.ac.uk/pdbsum/1t26 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1t26 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1t26 OCA], [http://pdbe.org/1t26 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1t26 RCSB], [http://www.ebi.ac.uk/pdbsum/1t26 PDBsum]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 27:		Line 27:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1t26" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 35:		Line 36:
	</StructureSection>		</StructureSection>
	[[Category: L-lactate dehydrogenase]]		[[Category: L-lactate dehydrogenase]]
-	[[Category: ~~Plasmodium falciparum~~]]	+	[[Category: Plafa]]
	[[Category: Barros, D]]		[[Category: Barros, D]]
	[[Category: Brady, R L]]		[[Category: Brady, R L]]

OCA at 07:51, 6 January 2015

OCA — Tue, 06 Jan 2015 07:51:11 GMT

←Older revision		Revision as of 07:51, 6 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1t26]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Plasmodium_falciparum Plasmodium falciparum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1T26 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1T26 FirstGlance]. <br>		<table><tr><td colspan='2'>[[1t26]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Plasmodium_falciparum Plasmodium falciparum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1T26 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1T26 FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GBD:4-HYDROXY-1,2,5-THIADIAZOLE-3-CARBOXYLIC+ACID'>GBD</scene>, <scene name='pdbligand=NAI:1,4-DIHYDRONICOTINAMIDE+ADENINE+DINUCLEOTIDE'>NAI</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GBD:4-HYDROXY-1,2,5-THIADIAZOLE-3-CARBOXYLIC+ACID'>GBD</scene>, <scene name='pdbligand=NAI:1,4-DIHYDRONICOTINAMIDE+ADENINE+DINUCLEOTIDE'>NAI</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1ldg\|1ldg]], [[1t24\|1t24]], [[1t25\|1t25]], [[1t2c\|1t2c]], [[1t2d\|1t2d]], [[1t2e\|1t2e]], [[1t2f\|1t2f]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1ldg\|1ldg]], [[1t24\|1t24]], [[1t25\|1t25]], [[1t2c\|1t2c]], [[1t2d\|1t2d]], [[1t2e\|1t2e]], [[1t2f\|1t2f]]</td></tr>
-	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">LDH ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5833 Plasmodium falciparum])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">LDH ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5833 Plasmodium falciparum])</td></tr>
-	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/L-lactate_dehydrogenase L-lactate dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.27 1.1.1.27] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/L-lactate_dehydrogenase L-lactate dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.27 1.1.1.27] </span></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1t26 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1t26 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1t26 RCSB], [http://www.ebi.ac.uk/pdbsum/1t26 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1t26 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1t26 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1t26 RCSB], [http://www.ebi.ac.uk/pdbsum/1t26 PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 36:		Line 36:
	[[Category: L-lactate dehydrogenase]]		[[Category: L-lactate dehydrogenase]]
	[[Category: Plasmodium falciparum]]		[[Category: Plasmodium falciparum]]
-	[[Category: Barros, D.]]	+	[[Category: Barros, D]]
-	[[Category: Brady, R L.]]	+	[[Category: Brady, R L]]
-	[[Category: Cameron, A.]]	+	[[Category: Cameron, A]]
-	[[Category: Croft, S L.]]	+	[[Category: Croft, S L]]
-	[[Category: Easton, A.]]	+	[[Category: Easton, A]]
-	[[Category: Gabarro, R.]]	+	[[Category: Gabarro, R]]
-	[[Category: Gamo, F J.]]	+	[[Category: Gamo, F J]]
-	[[Category: Garcia-Ochoa, S.]]	+	[[Category: Garcia-Ochoa, S]]
-	[[Category: Heras, F G.De Las.]]	+	[[Category: Heras, F G.De Las]]
-	[[Category: Kendrick, H.]]	+	[[Category: Kendrick, H]]
-	[[Category: Lavandera, J L.]]	+	[[Category: Lavandera, J L]]
-	[[Category: Leon, L.]]	+	[[Category: Leon, L]]
-	[[Category: Mallo, A.]]	+	[[Category: Mallo, A]]
-	[[Category: Martin, J J.]]	+	[[Category: Martin, J J]]
-	[[Category: Read, J.]]	+	[[Category: Read, J]]
-	[[Category: Risco, F.]]	+	[[Category: Risco, F]]
-	[[Category: Ruiz, J R.]]	+	[[Category: Ruiz, J R]]
-	[[Category: Sanz, L.]]	+	[[Category: Sanz, L]]
-	[[Category: Sessions, R B.]]	+	[[Category: Sessions, R B]]
-	[[Category: Tranter, R.]]	+	[[Category: Tranter, R]]
-	[[Category: Vivas, L.]]	+	[[Category: Vivas, L]]
-	[[Category: Winter, V J.]]	+	[[Category: Winter, V J]]
	[[Category: Oxidoreductase]]		[[Category: Oxidoreductase]]
	[[Category: Protein-ligand complex]]		[[Category: Protein-ligand complex]]

OCA at 22:46, 28 September 2014

OCA — Sun, 28 Sep 2014 22:46:22 GMT

←Older revision		Revision as of 22:46, 28 September 2014
Line 1:		Line 1:
-	[[~~Image:~~1t26.~~png~~\|~~left~~\|200px]]	+	==Plasmodium falciparum lactate dehydrogenase complexed with NADH and 4-hydroxy-1,2,5-thiadiazole-3-carboxylic acid==
		+	<StructureSection load='1t26' size='340' side='right' caption='[[1t26]], [[Resolution\|resolution]] 1.80Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1t26]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Plasmodium_falciparum Plasmodium falciparum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1T26 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1T26 FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GBD:4-HYDROXY-1,2,5-THIADIAZOLE-3-CARBOXYLIC+ACID'>GBD</scene>, <scene name='pdbligand=NAI:1,4-DIHYDRONICOTINAMIDE+ADENINE+DINUCLEOTIDE'>NAI</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1ldg\|1ldg]], [[1t24\|1t24]], [[1t25\|1t25]], [[1t2c\|1t2c]], [[1t2d\|1t2d]], [[1t2e\|1t2e]], [[1t2f\|1t2f]]</td></tr>
		+	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">LDH ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5833 Plasmodium falciparum])</td></tr>
		+	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/L-lactate_dehydrogenase L-lactate dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.27 1.1.1.27] </span></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1t26 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1t26 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1t26 RCSB], [http://www.ebi.ac.uk/pdbsum/1t26 PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/t2/1t26_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Plasmodium falciparum, the causative agent of malaria, relies extensively on glycolysis coupled with homolactic fermentation during its blood-borne stages for energy production. Selective inhibitors of the parasite lactate dehydrogenase (LDH), central to NAD(+) regeneration, therefore potentially provide a route to new antimalarial drugs directed against a novel molecular target. A series of heterocyclic, azole-based compounds are described that preferentially inhibit P. falciparum LDH at sub-micromolar concentrations, typically at concentrations about 100-fold lower than required for human lactate dehydrogenase inhibition. Crystal structures show these competitive inhibitors form a network of interactions with amino acids within the active site of the enzyme, stacking alongside the nicotinamide ring of the NAD(+) cofactor. These compounds display modest activity against parasitized erythrocytes, including parasite strains with known resistance to existing anti-malarials and against Plasmodium berghei in BALB/c mice. Initial toxicity data suggest the azole derivatives have generally low cytotoxicity, and preliminary pharmoco-kinetic data show favorable bioavailability and circulation times. These encouraging results suggest that further enhancement of these structures may yield candidates suitable for consideration as new therapeutics for the treatment of malaria. In combination these studies also provide strong support for the validity of targeting the Plasmodium glycolytic pathway and, in particular, LDH in the search for novel anti-malarials.

-	~~{{STRUCTURE_1t26\| PDB=1t26 \| SCENE= }}~~	+	Identification and activity of a series of azole-based compounds with lactate dehydrogenase-directed anti-malarial activity.,Cameron A, Read J, Tranter R, Winter VJ, Sessions RB, Brady RL, Vivas L, Easton A, Kendrick H, Croft SL, Barros D, Lavandera JL, Martin JJ, Risco F, Garcia-Ochoa S, Gamo FJ, Sanz L, Leon L, Ruiz JR, Gabarro R, Mallo A, Gomez de las Heras F J Biol Chem. 2004 Jul 23;279(30):31429-39. Epub 2004 Apr 26. PMID:15117937<ref>PMID:15117937</ref>

-	~~===Plasmodium falciparum lactate dehydrogenase complexed with NADH and 4-hydroxy-1~~,~~2,5-thiadiazole-3-carboxylic acid===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_15117937}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[1t26]] is~~ a ~~1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Plasmodium_falciparum Plasmodium falciparum]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=1T26 OCA].~~	+

	==See Also==		==See Also==
	*[[Lactate Dehydrogenase\|Lactate Dehydrogenase]]		*[[Lactate Dehydrogenase\|Lactate Dehydrogenase]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:015117937<~~/~~ref~~><~~references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: L-lactate dehydrogenase]]		[[Category: L-lactate dehydrogenase]]
	[[Category: Plasmodium falciparum]]		[[Category: Plasmodium falciparum]]

OCA at 13:07, 20 October 2012

OCA — Sat, 20 Oct 2012 13:07:46 GMT

←Older revision		Revision as of 13:07, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[1t26]] is a 1 chain structure ~~of [[Lactate Dehydrogenase]]~~ with sequence from [http://en.wikipedia.org/wiki/Plasmodium_falciparum Plasmodium falciparum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1T26 OCA].	+	[[1t26]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Plasmodium_falciparum Plasmodium falciparum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1T26 OCA].

	==See Also==		==See Also==

OCA: Protected "1t26" [edit=sysop:move=sysop]

OCA — Thu, 26 Jul 2012 10:59:22 GMT

Protected "1t26" [edit=sysop:move=sysop]

←Older revision

Revision as of 10:59, 26 July 2012

OCA at 10:59, 26 July 2012

OCA — Thu, 26 Jul 2012 10:59:20 GMT

←Older revision		Revision as of 10:59, 26 July 2012
Line 1:		Line 1:
-	{{Seed}}
	[[Image:1t26.png\|left\|200px]]		[[Image:1t26.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_1t26", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_1t26\| PDB=1t26 \| SCENE= }}		{{STRUCTURE_1t26\| PDB=1t26 \| SCENE= }}

	===Plasmodium falciparum lactate dehydrogenase complexed with NADH and 4-hydroxy-1,2,5-thiadiazole-3-carboxylic acid===		===Plasmodium falciparum lactate dehydrogenase complexed with NADH and 4-hydroxy-1,2,5-thiadiazole-3-carboxylic acid===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_15117937}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 15117937 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_15117937}}		{{ABSTRACT_PUBMED_15117937}}

	==About this Structure==		==About this Structure==
-	~~1T26~~ is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Plasmodium_falciparum Plasmodium falciparum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1T26 OCA].	+	[[1t26]] is a 1 chain structure of [[Lactate Dehydrogenase]] with sequence from [http://en.wikipedia.org/wiki/Plasmodium_falciparum Plasmodium falciparum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1T26 OCA].
		+
		+	==See Also==
		+	*[[Lactate Dehydrogenase\|Lactate Dehydrogenase]]

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~15117937~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:015117937</ref><references group="xtra"/>
	[[Category: L-lactate dehydrogenase]]		[[Category: L-lactate dehydrogenase]]
	[[Category: Plasmodium falciparum]]		[[Category: Plasmodium falciparum]]
Line 48:		Line 39:
	[[Category: Vivas, L.]]		[[Category: Vivas, L.]]
	[[Category: Winter, V J.]]		[[Category: Winter, V J.]]
		+	[[Category: Oxidoreductase]]
	[[Category: Protein-ligand complex]]		[[Category: Protein-ligand complex]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 07:59:52 2009''