1t28 - Revision history

OCA at 09:25, 6 December 2023

OCA — Wed, 06 Dec 2023 09:25:32 GMT

←Older revision		Revision as of 09:25, 6 December 2023
Line 1:		Line 1:

	==High resolution structure of a picornaviral internal cis-acting replication element==		==High resolution structure of a picornaviral internal cis-acting replication element==
-	<StructureSection load='1t28' size='340' side='right'caption='[[1t28~~]], [[NMR_Ensembles_of_Models \| 1 NMR models~~]]' scene=''>	+	<StructureSection load='1t28' size='340' side='right'caption='[[1t28]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1t28]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1T28 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1T28 FirstGlance]. <br>		<table><tr><td colspan='2'>[[1t28]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1T28 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1T28 FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1t28 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1t28 OCA], [https://pdbe.org/1t28 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1t28 RCSB], [https://www.ebi.ac.uk/pdbsum/1t28 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1t28 ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1t28 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1t28 OCA], [https://pdbe.org/1t28 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1t28 RCSB], [https://www.ebi.ac.uk/pdbsum/1t28 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1t28 ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 20:		Line 21:
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Gorenstein~~, D G~~]]	+	[[Category: Gorenstein DG]]
-	[[Category: Kaluarachchi, K]]	+	[[Category: Kaluarachchi K]]
-	[[Category: Lemon~~, S M~~]]	+	[[Category: Lemon SM]]
-	[[Category: Reynbrand, R]]	+	[[Category: Reynbrand R]]
-	[[Category: Thiviyanathan, V]]	+	[[Category: Thiviyanathan V]]
-	[[Category: Yang, Y]]	+	[[Category: Yang Y]]
-	~~[[Category: Cre]]~~	+
-	~~[[Category: Picornavirus]]~~	+
-	~~[[Category: Rhino virus]]~~	+
-	~~[[Category: Rna]]~~	+
-	~~[[Category: Stem loop~~]]	+

OCA at 07:40, 22 September 2021

OCA — Wed, 22 Sep 2021 07:40:43 GMT

←Older revision		Revision as of 07:40, 22 September 2021
Line 3:		Line 3:
	<StructureSection load='1t28' size='340' side='right'caption='[[1t28]], [[NMR_Ensembles_of_Models \| 1 NMR models]]' scene=''>		<StructureSection load='1t28' size='340' side='right'caption='[[1t28]], [[NMR_Ensembles_of_Models \| 1 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1t28]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1T28 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1T28 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1t28]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1T28 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1T28 FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1t28 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1t28 OCA], [~~http~~://pdbe.org/1t28 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1t28 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1t28 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1t28 ProSAT]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1t28 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1t28 OCA], [https://pdbe.org/1t28 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1t28 RCSB], [https://www.ebi.ac.uk/pdbsum/1t28 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1t28 ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 14:03, 18 December 2019

OCA — Wed, 18 Dec 2019 14:03:33 GMT

←Older revision		Revision as of 14:03, 18 December 2019
Line 1:		Line 1:

	==High resolution structure of a picornaviral internal cis-acting replication element==		==High resolution structure of a picornaviral internal cis-acting replication element==
-	<StructureSection load='1t28' size='340' side='right' caption='[[1t28]], [[NMR_Ensembles_of_Models \| 1 NMR models]]' scene=''>	+	<StructureSection load='1t28' size='340' side='right'caption='[[1t28]], [[NMR_Ensembles_of_Models \| 1 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1t28]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1T28 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1T28 FirstGlance]. <br>		<table><tr><td colspan='2'>[[1t28]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1T28 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1T28 FirstGlance]. <br>
Line 19:		Line 19:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Gorenstein, D G]]		[[Category: Gorenstein, D G]]
	[[Category: Kaluarachchi, K]]		[[Category: Kaluarachchi, K]]

OCA at 07:45, 14 March 2018

OCA — Wed, 14 Mar 2018 07:45:52 GMT

←Older revision		Revision as of 07:45, 14 March 2018
Line 1:		Line 1:
		+
	==High resolution structure of a picornaviral internal cis-acting replication element==		==High resolution structure of a picornaviral internal cis-acting replication element==
	<StructureSection load='1t28' size='340' side='right' caption='[[1t28]], [[NMR_Ensembles_of_Models \| 1 NMR models]]' scene=''>		<StructureSection load='1t28' size='340' side='right' caption='[[1t28]], [[NMR_Ensembles_of_Models \| 1 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1t28]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1T28 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1T28 FirstGlance]. <br>		<table><tr><td colspan='2'>[[1t28]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1T28 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1T28 FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1t28 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1t28 OCA], [http://pdbe.org/1t28 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1t28 RCSB], [http://www.ebi.ac.uk/pdbsum/1t28 PDBsum]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1t28 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1t28 OCA], [http://pdbe.org/1t28 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1t28 RCSB], [http://www.ebi.ac.uk/pdbsum/1t28 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1t28 ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 20:11, 10 September 2015

OCA — Thu, 10 Sep 2015 20:11:31 GMT

←Older revision		Revision as of 20:11, 10 September 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1t28]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1T28 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1T28 FirstGlance]. <br>		<table><tr><td colspan='2'>[[1t28]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1T28 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1T28 FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1t28 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1t28 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1t28 RCSB], [http://www.ebi.ac.uk/pdbsum/1t28 PDBsum]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1t28 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1t28 OCA], [http://pdbe.org/1t28 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1t28 RCSB], [http://www.ebi.ac.uk/pdbsum/1t28 PDBsum]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 13:		Line 13:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1t28" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 06:22, 22 December 2014

OCA — Mon, 22 Dec 2014 06:22:08 GMT

←Older revision		Revision as of 06:22, 22 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1t28]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1T28 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1T28 FirstGlance]. <br>		<table><tr><td colspan='2'>[[1t28]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1T28 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1T28 FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1t28 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1t28 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1t28 RCSB], [http://www.ebi.ac.uk/pdbsum/1t28 PDBsum]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1t28 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1t28 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1t28 RCSB], [http://www.ebi.ac.uk/pdbsum/1t28 PDBsum]</span></td></tr>
-	<table>	+	</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 17:		Line 17:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Gorenstein, D G.]]	+	[[Category: Gorenstein, D G]]
-	[[Category: Kaluarachchi, K.]]	+	[[Category: Kaluarachchi, K]]
-	[[Category: Lemon, S M.]]	+	[[Category: Lemon, S M]]
-	[[Category: Reynbrand, R.]]	+	[[Category: Reynbrand, R]]
-	[[Category: Thiviyanathan, V.]]	+	[[Category: Thiviyanathan, V]]
-	[[Category: Yang, Y.]]	+	[[Category: Yang, Y]]
	[[Category: Cre]]		[[Category: Cre]]
	[[Category: Picornavirus]]		[[Category: Picornavirus]]

OCA at 07:00, 9 June 2014

OCA — Mon, 09 Jun 2014 07:00:07 GMT

←Older revision		Revision as of 07:00, 9 June 2014
Line 1:		Line 1:
-	[[~~Image~~:1t28.~~png\|left\|200px~~]]	+	==High resolution structure of a picornaviral internal cis-acting replication element==
		+	<StructureSection load='1t28' size='340' side='right' caption='[[1t28]], [[NMR_Ensembles_of_Models \| 1 NMR models]]' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1t28]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1T28 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1T28 FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1t28 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1t28 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1t28 RCSB], [http://www.ebi.ac.uk/pdbsum/1t28 PDBsum]</span></td></tr>
		+	<table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Picornaviruses constitute a medically important family of RNA viruses in which genome replication critically depends on a small RNA element, the cis-acting replication element (cre), that templates 3D(pol) polymerase-catalyzed uridylylation of the protein primer for RNA synthesis, VPg. We report the solution structure of the 33-nt cre of human rhinovirus 14 under solution conditions optimal for uridylylation in vitro. The cre adopts a stem-loop conformation with an extended duplex stem supporting a novel 14-nt loop that derives stability from base-stacking interactions. Base-pair interactions are absent within the loop, and base substitutions within the loop that favor such interactions are detrimental to viral RNA replication. Conserved adenosines in the 5' loop sequence that participate in a slide-back mechanism of VPg-pUpU synthesis are oriented to the inside of the loop but are available for base templating during uridylation. The structure explains why substitutions of the 3' loop nucleotides have little impact on conformation of the critical 5' loop bases and accounts for wide variation in the sequences of cres from different enteroviruses and rhinoviruses.

-	~~{{STRUCTURE_1t28\| PDB=1t28 \| SCENE= }}~~	+	High-resolution structure of a picornaviral internal cis-acting RNA replication element (cre).,Thiviyanathan V, Yang Y, Kaluarachchi K, Rijnbrand R, Gorenstein DG, Lemon SM Proc Natl Acad Sci U S A. 2004 Aug 24;101(34):12688-93. Epub 2004 Aug 16. PMID:15314212<ref>PMID:15314212</ref>

-	~~===High resolution structure~~ of ~~a picornaviral internal cis-acting replication element===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_15314212}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[1t28]] is a 1 chain structure~~. ~~Full experimental information is available from [http://oca~~.~~weizmann~~.~~ac.il~~/~~oca-bin/ocashort?id=1T28 OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:015314212<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Gorenstein, D G.]]		[[Category: Gorenstein, D G.]]
	[[Category: Kaluarachchi, K.]]		[[Category: Kaluarachchi, K.]]

OCA: Protected "1t28" [edit=sysop:move=sysop]

OCA — Tue, 14 Aug 2012 18:23:13 GMT

Protected "1t28" [edit=sysop:move=sysop]

←Older revision

Revision as of 18:23, 14 August 2012

OCA at 18:23, 14 August 2012

OCA — Tue, 14 Aug 2012 18:23:11 GMT

←Older revision		Revision as of 18:23, 14 August 2012
Line 1:		Line 1:
-	{{Seed}}
	[[Image:1t28.png\|left\|200px]]		[[Image:1t28.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_1t28", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_1t28\| PDB=1t28 \| SCENE= }}		{{STRUCTURE_1t28\| PDB=1t28 \| SCENE= }}

	===High resolution structure of a picornaviral internal cis-acting replication element===		===High resolution structure of a picornaviral internal cis-acting replication element===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_15314212}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 15314212 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_15314212}}		{{ABSTRACT_PUBMED_15314212}}

	==About this Structure==		==About this Structure==
-	Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1T28 OCA].	+	[[1t28]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1T28 OCA].

	==Reference==		==Reference==
-	High-resolution structure of a picornaviral internal cis-acting RNA replication element (cre)., Thiviyanathan V, Yang Y, Kaluarachchi K, Rijnbrand R, Gorenstein DG, Lemon SM, Proc Natl Acad Sci U S A. 2004 Aug 24;101(34):12688-93. Epub 2004 Aug 16. PMID:~~[http://www.ncbi.nlm.nih.gov~~/~~pubmed~~/~~15314212 15314212]~~	+	<ref group="xtra">PMID:015314212</ref><references group="xtra"/>
	[[Category: Gorenstein, D G.]]		[[Category: Gorenstein, D G.]]
	[[Category: Kaluarachchi, K.]]		[[Category: Kaluarachchi, K.]]
Line 33:		Line 21:
	[[Category: Picornavirus]]		[[Category: Picornavirus]]
	[[Category: Rhino virus]]		[[Category: Rhino virus]]
		+	[[Category: Rna]]
	[[Category: Stem loop]]		[[Category: Stem loop]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 11:32:37 2008''

OCA at 08:32, 28 July 2008

OCA — Mon, 28 Jul 2008 08:32:38 GMT

←Older revision		Revision as of 08:32, 28 July 2008
Line 1:		Line 1:
-	[[Image:1t28.~~gif~~\|left\|200px]]	+	{{Seed}}
		+	[[Image:1t28.png\|left\|200px]]

	<!--		<!--
Line 9:		Line 10:
	{{STRUCTURE_1t28\| PDB=1t28 \| SCENE= }}		{{STRUCTURE_1t28\| PDB=1t28 \| SCENE= }}

-	~~'''~~High resolution structure of a picornaviral internal cis-acting replication element~~'''~~	+	===High resolution structure of a picornaviral internal cis-acting replication element===


-	~~==Overview==~~	+	<!--
-	~~Picornaviruses constitute a medically important family of RNA viruses in which genome replication critically depends on a small RNA element~~, ~~the cis-acting replication element (cre)~~, ~~that templates 3D(pol) polymerase-catalyzed uridylylation of~~ the ~~protein primer for RNA synthesis, VPg. We report~~ the ~~solution structure of the 33-nt cre of human rhinovirus 14 under solution conditions optimal for uridylylation in vitro~~. ~~The cre adopts a stem-loop conformation with an extended duplex stem supporting a novel 14-nt loop that derives stability from base-stacking interactions~~. ~~Base-pair interactions are absent within the loop~~, ~~and base substitutions within~~ the ~~loop that favor such interactions are detrimental to viral RNA replication~~. ~~Conserved adenosines in the 5' loop sequence that participate in a slide~~-~~back mechanism of VPg~~-pUpU synthesis are oriented to the inside of the loop but are available for base templating during uridylation. The structure explains why substitutions of the 3' loop nucleotides have little impact on conformation of the critical 5' loop bases and accounts for wide variation in the sequences of cres from different enteroviruses and rhinoviruses.	+	The line below this paragraph, {{ABSTRACT_PUBMED_15314212}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 15314212 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_15314212}}

	==About this Structure==		==About this Structure==
-	Full ~~crystallographic~~ information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1T28 OCA].	+	Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1T28 OCA].

	==Reference==		==Reference==
Line 30:		Line 34:
	[[Category: Rhino virus]]		[[Category: Rhino virus]]
	[[Category: Stem loop]]		[[Category: Stem loop]]
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Sat May 3 09~~:25:12 2008''	+
		+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 11:32:37 2008''