1t2p - Revision history

OCA at 06:24, 23 August 2023

OCA — Wed, 23 Aug 2023 06:24:29 GMT

←Older revision		Revision as of 06:24, 23 August 2023
Line 3:		Line 3:
	<StructureSection load='1t2p' size='340' side='right'caption='[[1t2p]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='1t2p' size='340' side='right'caption='[[1t2p]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1t2p]] is a 3 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~"micrococcus_aureus"_(rosenbach_1884)_zopf_1885 "micrococcus~~ aureus~~" (rosenbach 1884) zopf 1885~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1T2P OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=1T2P FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1t2p]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1T2P OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1T2P FirstGlance]. <br>
-	</td></tr><tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"~~><div style='overflow: auto; max-height: 3em;'>[[1t2o\|1t2o]], [[1t2w\|1t2w]]</div></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2Å</td></tr>
-	~~<tr~~ id~~='gene'><td class~~="~~sblockLbl~~">~~<b>~~[[~~Gene~~\|~~Gene:~~]]~~</b></td><td class="sblockDat">srt ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info~~&~~srchmode=5&id=1280 "Micrococcus aureus" (Rosenbach 1884) Zopf 1885])~~</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1t2p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1t2p OCA], [https://pdbe.org/1t2p PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1t2p RCSB], [https://www.ebi.ac.uk/pdbsum/1t2p PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1t2p ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=1t2p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1t2p OCA], [~~http~~://pdbe.org/1t2p PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1t2p RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1t2p PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1t2p ProSAT]</span></td></tr>	+
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/Q9S446_STAAU Q9S446_STAAU]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Bice~~, T W~~]]	+	[[Category: Staphylococcus aureus]]
-	[[Category: Narayana~~, S V~~]]	+	[[Category: Bice TW]]
-	[[Category: Schneewind, O]]	+	[[Category: Narayana SV]]
-	[[Category: Ton-That, H]]	+	[[Category: Schneewind O]]
-	[[Category: Zong, Y]]	+	[[Category: Ton-That H]]
-	~~[[Category: Beta barrel]]~~	+	[[Category: Zong Y]]
-	~~[[Category: Hydrolase]]~~	+
-	~~[[Category: Sortase]]~~	+
-	~~[[Category: Transpeptidase~~]]	+

OCA at 11:40, 24 December 2020

OCA — Thu, 24 Dec 2020 11:40:26 GMT

←Older revision		Revision as of 11:40, 24 December 2020
Line 1:		Line 1:

	==Crystal structure of Sortase A from Staphylococcus aureus==		==Crystal structure of Sortase A from Staphylococcus aureus==
-	<StructureSection load='1t2p' size='340' side='right' caption='[[1t2p]], [[Resolution\|resolution]] 2.00Å' scene=''>	+	<StructureSection load='1t2p' size='340' side='right'caption='[[1t2p]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1t2p]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/"micrococcus_aureus"_(rosenbach_1884)_zopf_1885 "micrococcus aureus" (rosenbach 1884) zopf 1885]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1T2P OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1T2P FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1t2p]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/"micrococcus_aureus"_(rosenbach_1884)_zopf_1885 "micrococcus aureus" (rosenbach 1884) zopf 1885]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1T2P OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=1T2P FirstGlance]. <br>
-	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1t2o\|1t2o]], [[1t2w\|1t2w]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1t2o\|1t2o]], [[1t2w\|1t2w]]</div></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">srt ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1280 "Micrococcus aureus" (Rosenbach 1884) Zopf 1885])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">srt ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1280 "Micrococcus aureus" (Rosenbach 1884) Zopf 1885])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1t2p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1t2p OCA], [http://pdbe.org/1t2p PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1t2p RCSB], [http://www.ebi.ac.uk/pdbsum/1t2p PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1t2p ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=1t2p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1t2p OCA], [http://pdbe.org/1t2p PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1t2p RCSB], [http://www.ebi.ac.uk/pdbsum/1t2p PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1t2p ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 31:		Line 31:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Bice, T W]]		[[Category: Bice, T W]]
	[[Category: Narayana, S V]]		[[Category: Narayana, S V]]

OCA at 07:38, 14 March 2018

OCA — Wed, 14 Mar 2018 07:38:15 GMT

←Older revision		Revision as of 07:38, 14 March 2018
Line 1:		Line 1:
		+
	==Crystal structure of Sortase A from Staphylococcus aureus==		==Crystal structure of Sortase A from Staphylococcus aureus==
	<StructureSection load='1t2p' size='340' side='right' caption='[[1t2p]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='1t2p' size='340' side='right' caption='[[1t2p]], [[Resolution\|resolution]] 2.00Å' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1t2o\|1t2o]], [[1t2w\|1t2w]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1t2o\|1t2o]], [[1t2w\|1t2w]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">srt ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1280 "Micrococcus aureus" (Rosenbach 1884) Zopf 1885])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">srt ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1280 "Micrococcus aureus" (Rosenbach 1884) Zopf 1885])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1t2p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1t2p OCA], [http://pdbe.org/1t2p PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1t2p RCSB], [http://www.ebi.ac.uk/pdbsum/1t2p PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1t2p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1t2p OCA], [http://pdbe.org/1t2p PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1t2p RCSB], [http://www.ebi.ac.uk/pdbsum/1t2p PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1t2p ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 11:		Line 12:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/t2/1t2p_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/t2/1t2p_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 07:34, 8 February 2016

OCA — Mon, 08 Feb 2016 07:34:07 GMT

←Older revision		Revision as of 07:34, 8 February 2016
Line 15:		Line 15:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1t2p ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 09:17, 10 September 2015

OCA — Thu, 10 Sep 2015 09:17:53 GMT

←Older revision		Revision as of 09:17, 10 September 2015
Line 2:		Line 2:
	<StructureSection load='1t2p' size='340' side='right' caption='[[1t2p]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='1t2p' size='340' side='right' caption='[[1t2p]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1t2p]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Staphylococcus_aureus Staphylococcus~~ aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1T2P OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1T2P FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1t2p]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/"micrococcus_aureus"_(rosenbach_1884)_zopf_1885 "micrococcus aureus" (rosenbach 1884) zopf 1885]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1T2P OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1T2P FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1t2o\|1t2o]], [[1t2w\|1t2w]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1t2o\|1t2o]], [[1t2w\|1t2w]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">srt ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1280 ~~Staphylococcus~~ aureus])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">srt ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1280 "Micrococcus aureus" (Rosenbach 1884) Zopf 1885])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1t2p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1t2p OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1t2p RCSB], [http://www.ebi.ac.uk/pdbsum/1t2p PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1t2p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1t2p OCA], [http://pdbe.org/1t2p PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1t2p RCSB], [http://www.ebi.ac.uk/pdbsum/1t2p PDBsum]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1t2p" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Staphylococcus aureus]]
	[[Category: Bice, T W]]		[[Category: Bice, T W]]
	[[Category: Narayana, S V]]		[[Category: Narayana, S V]]

OCA at 07:54, 6 January 2015

OCA — Tue, 06 Jan 2015 07:54:56 GMT

←Older revision		Revision as of 07:54, 6 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1t2p]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1T2P OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1T2P FirstGlance]. <br>		<table><tr><td colspan='2'>[[1t2p]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1T2P OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1T2P FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1t2o\|1t2o]], [[1t2w\|1t2w]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1t2o\|1t2o]], [[1t2w\|1t2w]]</td></tr>
-	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">srt ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1280 Staphylococcus aureus])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">srt ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1280 Staphylococcus aureus])</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1t2p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1t2p OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1t2p RCSB], [http://www.ebi.ac.uk/pdbsum/1t2p PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1t2p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1t2p OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1t2p RCSB], [http://www.ebi.ac.uk/pdbsum/1t2p PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 30:		Line 30:
	</StructureSection>		</StructureSection>
	[[Category: Staphylococcus aureus]]		[[Category: Staphylococcus aureus]]
-	[[Category: Bice, T W.]]	+	[[Category: Bice, T W]]
-	[[Category: Narayana, S V.]]	+	[[Category: Narayana, S V]]
-	[[Category: Schneewind, O.]]	+	[[Category: Schneewind, O]]
-	[[Category: Ton-That, H.]]	+	[[Category: Ton-That, H]]
-	[[Category: Zong, Y.]]	+	[[Category: Zong, Y]]
	[[Category: Beta barrel]]		[[Category: Beta barrel]]
	[[Category: Hydrolase]]		[[Category: Hydrolase]]
	[[Category: Sortase]]		[[Category: Sortase]]
	[[Category: Transpeptidase]]		[[Category: Transpeptidase]]

OCA at 21:50, 29 September 2014

OCA — Mon, 29 Sep 2014 21:50:40 GMT

←Older revision		Revision as of 21:50, 29 September 2014
Line 1:		Line 1:
-	[[~~Image:~~1t2p.~~png~~\|~~left~~\|200px]]	+	==Crystal structure of Sortase A from Staphylococcus aureus==
		+	<StructureSection load='1t2p' size='340' side='right' caption='[[1t2p]], [[Resolution\|resolution]] 2.00Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1t2p]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1T2P OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1T2P FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1t2o\|1t2o]], [[1t2w\|1t2w]]</td></tr>
		+	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">srt ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1280 Staphylococcus aureus])</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1t2p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1t2p OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1t2p RCSB], [http://www.ebi.ac.uk/pdbsum/1t2p PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/t2/1t2p_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The cell wall envelope of staphylococci and other Gram-positive pathogens is coated with surface proteins that interact with human host tissues. Surface proteins of Staphylococcus aureus are covalently linked to the cell wall envelope by a mechanism requiring C-terminal sorting signals with an LPXTG motif. Sortase (SrtA) cleaves surface proteins between the threonine (T) and the glycine (G) of the LPXTG motif and catalyzes the formation of an amide bond between threonine at the C-terminal end of polypeptides and cell wall cross-bridges. The active site architecture and catalytic mechanism of sortase A has hitherto not been revealed. Here we present the crystal structures of native SrtA, of an active site mutant of SrtA, and of the mutant SrtA complexed with its substrate LPETG peptide and describe the substrate binding pocket of the enzyme. Highly conserved proline (P) and threonine (T) residues of the LPXTG motif are held in position by hydrophobic contacts, whereas the glutamic acid residue (E) at the X position points out into the solvent. The scissile T-G peptide bond is positioned between the active site Cys(184) and Arg(197) residues and at a greater distance from the imidazolium side chain of His(120). All three residues, His(120), Cys(184), and Arg(197), are conserved in sortase enzymes from Gram-positive bacteria. Comparison of the active sites of S. aureus sortase A and sortase B provides insight into substrate specificity and suggests a universal sortase-catalyzed mechanism of bacterial surface protein anchoring in Gram-positive bacteria.

-	~~{{STRUCTURE_1t2p\| PDB=1t2p \| SCENE= }}~~	+	Crystal structures of Staphylococcus aureus sortase A and its substrate complex.,Zong Y, Bice TW, Ton-That H, Schneewind O, Narayana SV J Biol Chem. 2004 Jul 23;279(30):31383-9. Epub 2004 Apr 26. PMID:15117963<ref>PMID:15117963</ref>

-	~~===Crystal structure~~ of ~~Sortase A from Staphylococcus aureus===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_15117963}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[1t2p]] is a 3 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Staphylococcus_aureus Staphylococcus aureus]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=1T2P OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:015117963<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Staphylococcus aureus]]		[[Category: Staphylococcus aureus]]
	[[Category: Bice, T W.]]		[[Category: Bice, T W.]]

OCA: Protected "1t2p" [edit=sysop:move=sysop]

OCA — Sat, 05 Jan 2013 13:22:32 GMT

Protected "1t2p" [edit=sysop:move=sysop]

←Older revision

Revision as of 13:22, 5 January 2013

OCA at 13:22, 5 January 2013

OCA — Sat, 05 Jan 2013 13:22:29 GMT

←Older revision		Revision as of 13:22, 5 January 2013
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-	{{Seed}}
	[[Image:1t2p.png\|left\|200px]]		[[Image:1t2p.png\|left\|200px]]

-	<!--
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	{{STRUCTURE_1t2p\| PDB=1t2p \| SCENE= }}		{{STRUCTURE_1t2p\| PDB=1t2p \| SCENE= }}

	===Crystal structure of Sortase A from Staphylococcus aureus===		===Crystal structure of Sortase A from Staphylococcus aureus===

-
-	<!--
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	{{ABSTRACT_PUBMED_15117963}}		{{ABSTRACT_PUBMED_15117963}}

	==About this Structure==		==About this Structure==
-	~~1T2P~~ is a 3 ~~chains~~ structure ~~of sequences~~ from [http://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1T2P OCA].	+	[[1t2p]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1T2P OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~15117963~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:015117963</ref><references group="xtra"/>
	[[Category: Staphylococcus aureus]]		[[Category: Staphylococcus aureus]]
	[[Category: Bice, T W.]]		[[Category: Bice, T W.]]
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	[[Category: Zong, Y.]]		[[Category: Zong, Y.]]
	[[Category: Beta barrel]]		[[Category: Beta barrel]]
		+	[[Category: Hydrolase]]
	[[Category: Sortase]]		[[Category: Sortase]]
	[[Category: Transpeptidase]]		[[Category: Transpeptidase]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 20:13:50 2009''

OCA at 18:13, 16 February 2009

OCA — Mon, 16 Feb 2009 18:13:52 GMT

←Older revision		Revision as of 18:13, 16 February 2009
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	==About this Structure==		==About this Structure==
-	1T2P is a ~~[[Single protein]]~~ structure of ~~sequence~~ from [http://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1T2P OCA].	+	1T2P is a 3 chains structure of sequences from [http://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1T2P OCA].

	==Reference==		==Reference==
-	~~Crystal structures of Staphylococcus aureus sortase A and its substrate complex., Zong Y, Bice TW, Ton-That H, Schneewind O, Narayana SV, J Biol Chem. 2004 Jul 23;279(30):31383-9. Epub 2004 Apr 26.~~ PMID:~~[http:~~//~~www.ncbi.nlm.nih.gov/pubmed/15117963 15117963]~~	+	<ref group="xtra">PMID:15117963</ref><references group="xtra"/>
-	~~[[Category: Single protein]]~~	+
	[[Category: Staphylococcus aureus]]		[[Category: Staphylococcus aureus]]
	[[Category: Bice, T W.]]		[[Category: Bice, T W.]]
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	[[Category: Transpeptidase]]		[[Category: Transpeptidase]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon ~~Jul 28 00~~:22:~~15 2008~~''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 20:13:50 2009''