1t4o - Revision history

OCA at 06:26, 23 August 2023

OCA — Wed, 23 Aug 2023 06:26:03 GMT

←Older revision		Revision as of 06:26, 23 August 2023
Line 3:		Line 3:
	<StructureSection load='1t4o' size='340' side='right'caption='[[1t4o]], [[Resolution\|resolution]] 2.50Å' scene=''>		<StructureSection load='1t4o' size='340' side='right'caption='[[1t4o]], [[Resolution\|resolution]] 2.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1t4o]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Atcc_18824 Atcc 18824~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1T4O OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=1T4O FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1t4o]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1T4O OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1T4O FirstGlance]. <br>
-	</td></tr><tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"~~><div style='overflow: auto; max-height: 3em;'>[[1t4n\|1t4n]]</div></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.5Å</td></tr>
-	~~<tr~~ id~~='gene'><td class~~="~~sblockLbl~~">~~<b>~~[[~~Gene~~\|~~Gene:~~]]~~</b></td><td class="sblockDat">RNT1, YMR239C, YM9408~~.~~01C, YM9959.21 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=~~5&~~id=4932 ATCC 18824])</td></tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1t4o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1t4o OCA], [https://pdbe.org/1t4o PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1t4o RCSB], [https://www.ebi.ac.uk/pdbsum/1t4o PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1t4o ProSAT]</span></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Ribonuclease_III Ribonuclease III], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.26.3 3.1.26.3] </span></td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=1t4o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1t4o OCA], [~~http~~://pdbe.org/1t4o PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1t4o RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1t4o PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1t4o ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/RNT1_YEAST RNT1_YEAST]] DsRNA-specific nuclease that cleaves eukaryotic pre-ribosomal RNA at the U3 snoRNP-dependent A0 site in the 5'-external transcribed spacer (ETS) and in the 3'-ETS. In vitro, cleaves synthetic 5'-ETS RNA A0 site in the absence of snoRNA or other factors. Has an essential growth function in addition to pre-rRNA processing.	+	[https://www.uniprot.org/uniprot/RNT1_YEAST RNT1_YEAST] DsRNA-specific nuclease that cleaves eukaryotic pre-ribosomal RNA at the U3 snoRNP-dependent A0 site in the 5'-external transcribed spacer (ETS) and in the 3'-ETS. In vitro, cleaves synthetic 5'-ETS RNA A0 site in the absence of snoRNA or other factors. Has an essential growth function in addition to pre-rRNA processing.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 33:		Line 31:
	==See Also==		==See Also==
	*[[Ribonuclease 3D structures\|Ribonuclease 3D structures]]		*[[Ribonuclease 3D structures\|Ribonuclease 3D structures]]
-	*[[Temp\|Temp]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Atcc 18824]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Ribonuclease III~~]]	+	[[Category: Saccharomyces cerevisiae]]
-	[[Category: Ares, M]]	+	[[Category: Ares Jr M]]
-	[[Category: Edwards~~, T E~~]]	+	[[Category: Edwards TE]]
-	[[Category: Godin~~, K S~~]]	+	[[Category: Godin KS]]
-	[[Category: Graille, M]]	+	[[Category: Graille M]]
-	[[Category: Leeper~~, T C~~]]	+	[[Category: Leeper TC]]
-	[[Category: Leulliot, N]]	+	[[Category: Leulliot N]]
-	[[Category: Nagel~~, R J~~]]	+	[[Category: Nagel RJ]]
-	[[Category: Quevillon-Cheruel, S]]	+	[[Category: Quevillon-Cheruel S]]
-	[[Category: Rozenkrants, N]]	+	[[Category: Rozenkrants N]]
-	[[Category: Sigurdsson~~, S T]]~~	+	[[Category: Sigurdsson ST]]
-	~~[[Category: Tilbeurgh, H van~~]]	+	[[Category: Varani G]]
-	[[Category: Varani, G]]	+	[[Category: Van Tilbeurgh H]]
-	[[Category: ~~Dsrbd]]~~	+
-	~~[[Category: Hydrolase]]~~	+
-	~~[[Category: Rna-binding]]~~	+
-	~~[[Category: Rnt1p~~]]	+

OCA at 11:42, 24 December 2020

OCA — Thu, 24 Dec 2020 11:42:25 GMT

←Older revision		Revision as of 11:42, 24 December 2020
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	==Crystal structure of rnt1p dsRBD==		==Crystal structure of rnt1p dsRBD==
-	<StructureSection load='1t4o' size='340' side='right' caption='[[1t4o]], [[Resolution\|resolution]] 2.50Å' scene=''>	+	<StructureSection load='1t4o' size='340' side='right'caption='[[1t4o]], [[Resolution\|resolution]] 2.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1t4o]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_18824 Atcc 18824]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1T4O OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1T4O FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1t4o]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_18824 Atcc 18824]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1T4O OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=1T4O FirstGlance]. <br>
-	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1t4n\|1t4n]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1t4n\|1t4n]]</div></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">RNT1, YMR239C, YM9408.01C, YM9959.21 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 ATCC 18824])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">RNT1, YMR239C, YM9408.01C, YM9959.21 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 ATCC 18824])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Ribonuclease_III Ribonuclease III], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.26.3 3.1.26.3] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Ribonuclease_III Ribonuclease III], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.26.3 3.1.26.3] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1t4o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1t4o OCA], [http://pdbe.org/1t4o PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1t4o RCSB], [http://www.ebi.ac.uk/pdbsum/1t4o PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1t4o ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=1t4o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1t4o OCA], [http://pdbe.org/1t4o PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1t4o RCSB], [http://www.ebi.ac.uk/pdbsum/1t4o PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1t4o ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 32:		Line 32:

	==See Also==		==See Also==
-	*[[Ribonuclease\|Ribonuclease]]	+	*[[Ribonuclease 3D structures\|Ribonuclease 3D structures]]
	*[[Temp\|Temp]]		*[[Temp\|Temp]]
	== References ==		== References ==
Line 39:		Line 39:
	</StructureSection>		</StructureSection>
	[[Category: Atcc 18824]]		[[Category: Atcc 18824]]
		+	[[Category: Large Structures]]
	[[Category: Ribonuclease III]]		[[Category: Ribonuclease III]]
	[[Category: Ares, M]]		[[Category: Ares, M]]

OCA at 07:29, 14 March 2018

OCA — Wed, 14 Mar 2018 07:29:20 GMT

←Older revision		Revision as of 07:29, 14 March 2018
Line 1:		Line 1:
		+
	==Crystal structure of rnt1p dsRBD==		==Crystal structure of rnt1p dsRBD==
	<StructureSection load='1t4o' size='340' side='right' caption='[[1t4o]], [[Resolution\|resolution]] 2.50Å' scene=''>		<StructureSection load='1t4o' size='340' side='right' caption='[[1t4o]], [[Resolution\|resolution]] 2.50Å' scene=''>
Line 6:		Line 7:
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">RNT1, YMR239C, YM9408.01C, YM9959.21 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 ATCC 18824])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">RNT1, YMR239C, YM9408.01C, YM9959.21 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 ATCC 18824])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Ribonuclease_III Ribonuclease III], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.26.3 3.1.26.3] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Ribonuclease_III Ribonuclease III], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.26.3 3.1.26.3] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1t4o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1t4o OCA], [http://pdbe.org/1t4o PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1t4o RCSB], [http://www.ebi.ac.uk/pdbsum/1t4o PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1t4o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1t4o OCA], [http://pdbe.org/1t4o PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1t4o RCSB], [http://www.ebi.ac.uk/pdbsum/1t4o PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1t4o ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 14:		Line 15:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/t4/1t4o_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/t4/1t4o_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 18:21, 9 February 2016

OCA — Tue, 09 Feb 2016 18:21:50 GMT

←Older revision		Revision as of 18:21, 9 February 2016
Line 18:		Line 18:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1t4o ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 00:50, 11 September 2015

OCA — Fri, 11 Sep 2015 00:50:09 GMT

←Older revision		Revision as of 00:50, 11 September 2015
Line 2:		Line 2:
	<StructureSection load='1t4o' size='340' side='right' caption='[[1t4o]], [[Resolution\|resolution]] 2.50Å' scene=''>		<StructureSection load='1t4o' size='340' side='right' caption='[[1t4o]], [[Resolution\|resolution]] 2.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1t4o]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Saccharomyces_cerevisiae Saccharomyces cerevisiae~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1T4O OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1T4O FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1t4o]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_18824 Atcc 18824]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1T4O OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1T4O FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1t4n\|1t4n]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1t4n\|1t4n]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">RNT1, YMR239C, YM9408.01C, YM9959.21 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 ~~Saccharomyces cerevisiae~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">RNT1, YMR239C, YM9408.01C, YM9959.21 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 ATCC 18824])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Ribonuclease_III Ribonuclease III], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.26.3 3.1.26.3] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Ribonuclease_III Ribonuclease III], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.26.3 3.1.26.3] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1t4o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1t4o OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1t4o RCSB], [http://www.ebi.ac.uk/pdbsum/1t4o PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1t4o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1t4o OCA], [http://pdbe.org/1t4o PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1t4o RCSB], [http://www.ebi.ac.uk/pdbsum/1t4o PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 28:		Line 28:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1t4o" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
	*[[Ribonuclease\|Ribonuclease]]		*[[Ribonuclease\|Ribonuclease]]
	*[[Temp\|Temp]]		*[[Temp\|Temp]]
-	*[[User:Jaime.Prilusky/Test/tree\|User:Jaime.Prilusky/Test/tree]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Atcc 18824]]
	[[Category: Ribonuclease III]]		[[Category: Ribonuclease III]]
-	[[Category: Saccharomyces cerevisiae]]
	[[Category: Ares, M]]		[[Category: Ares, M]]
	[[Category: Edwards, T E]]		[[Category: Edwards, T E]]

OCA at 08:38, 25 December 2014

OCA — Thu, 25 Dec 2014 08:38:15 GMT

←Older revision		Revision as of 08:38, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1t4o]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1T4O OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1T4O FirstGlance]. <br>		<table><tr><td colspan='2'>[[1t4o]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1T4O OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1T4O FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1t4n\|1t4n]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1t4n\|1t4n]]</td></tr>
-	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">RNT1, YMR239C, YM9408.01C, YM9959.21 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 Saccharomyces cerevisiae])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">RNT1, YMR239C, YM9408.01C, YM9959.21 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 Saccharomyces cerevisiae])</td></tr>
-	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Ribonuclease_III Ribonuclease III], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.26.3 3.1.26.3] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Ribonuclease_III Ribonuclease III], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.26.3 3.1.26.3] </span></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1t4o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1t4o OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1t4o RCSB], [http://www.ebi.ac.uk/pdbsum/1t4o PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1t4o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1t4o OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1t4o RCSB], [http://www.ebi.ac.uk/pdbsum/1t4o PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/RNT1_YEAST RNT1_YEAST]] DsRNA-specific nuclease that cleaves eukaryotic pre-ribosomal RNA at the U3 snoRNP-dependent A0 site in the 5'-external transcribed spacer (ETS) and in the 3'-ETS. In vitro, cleaves synthetic 5'-ETS RNA A0 site in the absence of snoRNA or other factors. Has an essential growth function in addition to pre-rRNA processing.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 29:		Line 31:
	==See Also==		==See Also==
	*[[Ribonuclease\|Ribonuclease]]		*[[Ribonuclease\|Ribonuclease]]
		+	*[[Temp\|Temp]]
		+	*[[User:Jaime.Prilusky/Test/tree\|User:Jaime.Prilusky/Test/tree]]
	== References ==		== References ==
	<references/>		<references/>
Line 35:		Line 39:
	[[Category: Ribonuclease III]]		[[Category: Ribonuclease III]]
	[[Category: Saccharomyces cerevisiae]]		[[Category: Saccharomyces cerevisiae]]
-	[[Category: Ares, M.]]	+	[[Category: Ares, M]]
-	[[Category: Edwards, T E.]]	+	[[Category: Edwards, T E]]
-	[[Category: Godin, K S.]]	+	[[Category: Godin, K S]]
-	[[Category: Graille, M.]]	+	[[Category: Graille, M]]
-	[[Category: Leeper, T C.]]	+	[[Category: Leeper, T C]]
-	[[Category: Leulliot, N.]]	+	[[Category: Leulliot, N]]
-	[[Category: Nagel, R J.]]	+	[[Category: Nagel, R J]]
-	[[Category: Quevillon-Cheruel, S.]]	+	[[Category: Quevillon-Cheruel, S]]
-	[[Category: Rozenkrants, N.]]	+	[[Category: Rozenkrants, N]]
-	[[Category: Sigurdsson, S T.]]	+	[[Category: Sigurdsson, S T]]
-	[[Category: Tilbeurgh, H van.]]	+	[[Category: Tilbeurgh, H van]]
-	[[Category: Varani, G.]]	+	[[Category: Varani, G]]
	[[Category: Dsrbd]]		[[Category: Dsrbd]]
	[[Category: Hydrolase]]		[[Category: Hydrolase]]
	[[Category: Rna-binding]]		[[Category: Rna-binding]]
	[[Category: Rnt1p]]		[[Category: Rnt1p]]

OCA at 21:33, 28 September 2014

OCA — Sun, 28 Sep 2014 21:33:33 GMT

←Older revision		Revision as of 21:33, 28 September 2014
Line 1:		Line 1:
-	[[~~Image:~~1t4o.~~png~~\|~~left~~\|200px]]	+	==Crystal structure of rnt1p dsRBD==
		+	<StructureSection load='1t4o' size='340' side='right' caption='[[1t4o]], [[Resolution\|resolution]] 2.50Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1t4o]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1T4O OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1T4O FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1t4n\|1t4n]]</td></tr>
		+	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">RNT1, YMR239C, YM9408.01C, YM9959.21 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 Saccharomyces cerevisiae])</td></tr>
		+	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Ribonuclease_III Ribonuclease III], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.26.3 3.1.26.3] </span></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1t4o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1t4o OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1t4o RCSB], [http://www.ebi.ac.uk/pdbsum/1t4o PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/t4/1t4o_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Rnt1 endoribonuclease, the yeast homolog of RNAse III, plays an important role in the maturation of a diverse set of RNAs. The enzymatic activity requires a conserved catalytic domain, while RNA binding requires the double-stranded RNA-binding domain (dsRBD) at the C-terminus of the protein. While bacterial RNAse III enzymes cleave double-stranded RNA, Rnt1p specifically cleaves RNAs that possess short irregular stem-loops containing 12-14 base pairs interrupted by internal loops and bulges and capped by conserved AGNN tetraloops. Consistent with this substrate specificity, the isolated Rnt1p dsRBD and the 30-40 amino acids that follow bind to AGNN-containing stem-loops preferentially in vitro. In order to understand how Rnt1p recognizes its cognate processing sites, we have defined its minimal RNA-binding domain and determined its structure by solution NMR spectroscopy and X-ray crystallography. We observe a new carboxy-terminal helix following a canonical dsRBD structure. Removal of this helix reduces binding to Rnt1p substrates. The results suggest that this helix allows the Rnt1p dsRBD to bind to short RNA stem-loops by modulating the conformation of helix alpha1, a key RNA-recognition element of the dsRBD.

-	~~{{STRUCTURE_1t4o\| PDB=1t4o \| SCENE= }}~~	+	A new alpha-helical extension promotes RNA binding by the dsRBD of Rnt1p RNAse III.,Leulliot N, Quevillon-Cheruel S, Graille M, van Tilbeurgh H, Leeper TC, Godin KS, Edwards TE, Sigurdsson ST, Rozenkrants N, Nagel RJ, Ares M, Varani G EMBO J. 2004 Jul 7;23(13):2468-77. Epub 2004 Jun 10. PMID:15192703<ref>PMID:15192703</ref>

-	~~===Crystal structure~~ of ~~rnt1p dsRBD===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_15192703}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[1t4o]] is a 2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=1T4O OCA].~~	+

	==See Also==		==See Also==
	*[[Ribonuclease\|Ribonuclease]]		*[[Ribonuclease\|Ribonuclease]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:015192703<~~/~~ref~~><~~references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Ribonuclease III]]		[[Category: Ribonuclease III]]
	[[Category: Saccharomyces cerevisiae]]		[[Category: Saccharomyces cerevisiae]]

OCA at 14:43, 20 October 2012

OCA — Sat, 20 Oct 2012 14:43:07 GMT

←Older revision

Revision as of 14:43, 20 October 2012

OCA: Protected "1t4o" [edit=sysop:move=sysop]

OCA — Thu, 26 Jul 2012 16:01:30 GMT

Protected "1t4o" [edit=sysop:move=sysop]

←Older revision

Revision as of 16:01, 26 July 2012

OCA at 16:01, 26 July 2012

OCA — Thu, 26 Jul 2012 16:01:29 GMT

←Older revision		Revision as of 16:01, 26 July 2012
Line 1:		Line 1:
-	{{Seed}}
	[[Image:1t4o.png\|left\|200px]]		[[Image:1t4o.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_1t4o", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_1t4o\| PDB=1t4o \| SCENE= }}		{{STRUCTURE_1t4o\| PDB=1t4o \| SCENE= }}

	===Crystal structure of rnt1p dsRBD===		===Crystal structure of rnt1p dsRBD===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_15192703}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 15192703 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_15192703}}		{{ABSTRACT_PUBMED_15192703}}

	==About this Structure==		==About this Structure==
-	~~1T4O~~ is a 2 ~~chains~~ structure of ~~sequences~~ from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1T4O OCA].	+	[[1t4o]] is a 2 chain structure of [[Ribonuclease]] with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1T4O OCA].
		+
		+	==See Also==
		+	*[[Ribonuclease\|Ribonuclease]]

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~15192703~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:015192703</ref><references group="xtra"/>
	[[Category: Ribonuclease III]]		[[Category: Ribonuclease III]]
	[[Category: Saccharomyces cerevisiae]]		[[Category: Saccharomyces cerevisiae]]
		+	[[Category: Ares, M.]]
	[[Category: Edwards, T E.]]		[[Category: Edwards, T E.]]
	[[Category: Godin, K S.]]		[[Category: Godin, K S.]]
	[[Category: Graille, M.]]		[[Category: Graille, M.]]
-	[[Category: Jr., M Ares.]]
	[[Category: Leeper, T C.]]		[[Category: Leeper, T C.]]
	[[Category: Leulliot, N.]]		[[Category: Leulliot, N.]]
Line 39:		Line 30:
	[[Category: Varani, G.]]		[[Category: Varani, G.]]
	[[Category: Dsrbd]]		[[Category: Dsrbd]]
		+	[[Category: Hydrolase]]
	[[Category: Rna-binding]]		[[Category: Rna-binding]]
	[[Category: Rnt1p]]		[[Category: Rnt1p]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 11:46:48 2009''