1t4z - Revision history

OCA at 06:35, 1 May 2024

OCA — Wed, 01 May 2024 06:35:17 GMT

←Older revision		Revision as of 06:35, 1 May 2024
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	==Solution structure of the N-terminal domain of Synechococcus elongatus SasA (25-structures ensemble)==		==Solution structure of the N-terminal domain of Synechococcus elongatus SasA (25-structures ensemble)==
-	<StructureSection load='1t4z' size='340' side='right'caption='[[1t4z~~]], [[NMR_Ensembles_of_Models \| 25 NMR models~~]]' scene=''>	+	<StructureSection load='1t4z' size='340' side='right'caption='[[1t4z]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1t4z]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Anacystis_nidulans_r2 Anacystis nidulans r2~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1T4Z OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=1T4Z FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1t4z]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Synechococcus_elongatus_PCC_7942_=_FACHB-805 Synechococcus elongatus PCC 7942 = FACHB-805]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1T4Z OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1T4Z FirstGlance]. <br>
-	</td></tr><tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"~~><div style='overflow: auto; max-height: 3em;'>[[1t4y\|1t4y]]</div></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
-	~~<tr~~ id~~='gene'><td class~~="~~sblockLbl~~">~~<b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SASA, SARS ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1140 Anacystis nidulans R2])~~</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1t4z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1t4z OCA], [https://pdbe.org/1t4z PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1t4z RCSB], [https://www.ebi.ac.uk/pdbsum/1t4z PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1t4z ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=1t4z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1t4z OCA], [~~http~~://pdbe.org/1t4z PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1t4z RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1t4z PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1t4z ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/SASA_SYNE7 SASA_SYNE7]] May be involved in signal transduction. Participates in the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria, via its interaction with KaiC. Required for robustness of the circadian rhythm of gene expression and is involved in clock outputs.<ref>PMID:10786837</ref>	+	[https://www.uniprot.org/uniprot/SASA_SYNE7 SASA_SYNE7] May be involved in signal transduction. Participates in the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria, via its interaction with KaiC. Required for robustness of the circadian rhythm of gene expression and is involved in clock outputs.<ref>PMID:10786837</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 20:		Line 19:
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1t4z ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1t4z ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
-	<div style="background-color:#fffaf0;">
-	== Publication Abstract from PubMed ==
-	Circadian oscillators are endogenous biological systems that generate the approximately 24 hour temporal pattern of biological processes and confer a reproductive fitness advantage to their hosts. The cyanobacterial clock is the simplest known and the only clock system for which structural information for core component proteins, in this case KaiA, KaiB and KaiC, is available. SasA, a clock-associated histidine kinase, is necessary for robustness of the circadian rhythm of gene expression and implicated in clock output. The N-terminal domain of SasA (N-SasA) interacts directly with KaiC and likely functions as the sensory domain controlling the SasA histidine kinase activity. N-SasA and KaiB share significant sequence similarity and, thus, it has been proposed that they would be structurally similar and may even compete for KaiC binding. Here, we report the NMR structure of N-SasA and show it to be different from that of KaiB. The structural comparisons provide no clear details to suggest competition of SasA and KaiB for KaiC binding. N-SasA adopts a canonical thioredoxin fold but lacks the catalytic cysteine residues. A patch of conserved, solvent-exposed residues is found near the canonical thioredoxin active site. We suggest that this surface is used by N-SasA for protein-protein interactions. Our analysis suggests that the structural differences between N-SasA and KaiB are the result of only a few critical amino acid substitutions.
-
-	Structure of the N-terminal domain of the circadian clock-associated histidine kinase SasA.,Vakonakis I, Klewer DA, Williams SB, Golden SS, LiWang AC J Mol Biol. 2004 Sep 3;342(1):9-17. PMID:15313603<ref>PMID:15313603</ref>
-
-	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	</div>
-	<div class="pdbe-citations 1t4z" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Anacystis nidulans r2]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Klewer, D A~~]]	+	[[Category: Synechococcus elongatus PCC 7942 = FACHB-805]]
-	[[Category: ~~LiWang, A C~~]]	+	[[Category: Klewer DA]]
-	[[Category: ~~Vakonakis, I~~]]	+	[[Category: LiWang AC]]
-	[[Category: ~~Alpha/beta protein]]~~	+	[[Category: Vakonakis I]]
-	~~[[Category: Thioredoxin fold]]~~	+
-	~~[[Category: Transferase~~]]	+

OCA at 11:42, 24 December 2020

OCA — Thu, 24 Dec 2020 11:42:46 GMT

←Older revision		Revision as of 11:42, 24 December 2020
Line 1:		Line 1:

	==Solution structure of the N-terminal domain of Synechococcus elongatus SasA (25-structures ensemble)==		==Solution structure of the N-terminal domain of Synechococcus elongatus SasA (25-structures ensemble)==
-	<StructureSection load='1t4z' size='340' side='right' caption='[[1t4z]], [[NMR_Ensembles_of_Models \| 25 NMR models]]' scene=''>	+	<StructureSection load='1t4z' size='340' side='right'caption='[[1t4z]], [[NMR_Ensembles_of_Models \| 25 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1t4z]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Anacystis_nidulans_r2 Anacystis nidulans r2]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1T4Z OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1T4Z FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1t4z]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Anacystis_nidulans_r2 Anacystis nidulans r2]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1T4Z OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=1T4Z FirstGlance]. <br>
-	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1t4y\|1t4y]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1t4y\|1t4y]]</div></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SASA, SARS ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1140 Anacystis nidulans R2])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SASA, SARS ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1140 Anacystis nidulans R2])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1t4z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1t4z OCA], [http://pdbe.org/1t4z PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1t4z RCSB], [http://www.ebi.ac.uk/pdbsum/1t4z PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1t4z ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=1t4z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1t4z OCA], [http://pdbe.org/1t4z PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1t4z RCSB], [http://www.ebi.ac.uk/pdbsum/1t4z PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1t4z ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	</StructureSection>		</StructureSection>
	[[Category: Anacystis nidulans r2]]		[[Category: Anacystis nidulans r2]]
		+	[[Category: Large Structures]]
	[[Category: Klewer, D A]]		[[Category: Klewer, D A]]
	[[Category: LiWang, A C]]		[[Category: LiWang, A C]]

OCA at 07:44, 14 March 2018

OCA — Wed, 14 Mar 2018 07:44:18 GMT

←Older revision		Revision as of 07:44, 14 March 2018
Line 1:		Line 1:
		+
	==Solution structure of the N-terminal domain of Synechococcus elongatus SasA (25-structures ensemble)==		==Solution structure of the N-terminal domain of Synechococcus elongatus SasA (25-structures ensemble)==
	<StructureSection load='1t4z' size='340' side='right' caption='[[1t4z]], [[NMR_Ensembles_of_Models \| 25 NMR models]]' scene=''>		<StructureSection load='1t4z' size='340' side='right' caption='[[1t4z]], [[NMR_Ensembles_of_Models \| 25 NMR models]]' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1t4y\|1t4y]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1t4y\|1t4y]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SASA, SARS ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1140 Anacystis nidulans R2])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SASA, SARS ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1140 Anacystis nidulans R2])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1t4z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1t4z OCA], [http://pdbe.org/1t4z PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1t4z RCSB], [http://www.ebi.ac.uk/pdbsum/1t4z PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1t4z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1t4z OCA], [http://pdbe.org/1t4z PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1t4z RCSB], [http://www.ebi.ac.uk/pdbsum/1t4z PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1t4z ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 13:		Line 14:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/t4/1t4z_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/t4/1t4z_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 15:05, 9 February 2016

OCA — Tue, 09 Feb 2016 15:05:53 GMT

←Older revision		Revision as of 15:05, 9 February 2016
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	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1t4z ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 23:25, 10 September 2015

OCA — Thu, 10 Sep 2015 23:25:03 GMT

←Older revision		Revision as of 23:25, 10 September 2015
Line 2:		Line 2:
	<StructureSection load='1t4z' size='340' side='right' caption='[[1t4z]], [[NMR_Ensembles_of_Models \| 25 NMR models]]' scene=''>		<StructureSection load='1t4z' size='340' side='right' caption='[[1t4z]], [[NMR_Ensembles_of_Models \| 25 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1t4z]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Synechococcus_elongatus_pcc_7942 Synechococcus elongatus pcc 7942~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1T4Z OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1T4Z FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1t4z]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Anacystis_nidulans_r2 Anacystis nidulans r2]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1T4Z OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1T4Z FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1t4y\|1t4y]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1t4y\|1t4y]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SASA, SARS ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1140 ~~Synechococcus elongatus PCC 7942~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SASA, SARS ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1140 Anacystis nidulans R2])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1t4z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1t4z OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1t4z RCSB], [http://www.ebi.ac.uk/pdbsum/1t4z PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1t4z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1t4z OCA], [http://pdbe.org/1t4z PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1t4z RCSB], [http://www.ebi.ac.uk/pdbsum/1t4z PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1t4z" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Synechococcus elongatus pcc 7942~~]]	+	[[Category: Anacystis nidulans r2]]
	[[Category: Klewer, D A]]		[[Category: Klewer, D A]]
	[[Category: LiWang, A C]]		[[Category: LiWang, A C]]

OCA at 07:35, 25 December 2014

OCA — Thu, 25 Dec 2014 07:35:19 GMT

←Older revision		Revision as of 07:35, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1t4z]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Synechococcus_elongatus_pcc_7942 Synechococcus elongatus pcc 7942]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1T4Z OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1T4Z FirstGlance]. <br>		<table><tr><td colspan='2'>[[1t4z]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Synechococcus_elongatus_pcc_7942 Synechococcus elongatus pcc 7942]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1T4Z OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1T4Z FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1t4y\|1t4y]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1t4y\|1t4y]]</td></tr>
-	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SASA, SARS ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1140 Synechococcus elongatus PCC 7942])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SASA, SARS ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1140 Synechococcus elongatus PCC 7942])</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1t4z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1t4z OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1t4z RCSB], [http://www.ebi.ac.uk/pdbsum/1t4z PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1t4z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1t4z OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1t4z RCSB], [http://www.ebi.ac.uk/pdbsum/1t4z PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/SASA_SYNE7 SASA_SYNE7]] May be involved in signal transduction. Participates in the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria, via its interaction with KaiC. Required for robustness of the circadian rhythm of gene expression and is involved in clock outputs.<ref>PMID:10786837</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	</StructureSection>		</StructureSection>
	[[Category: Synechococcus elongatus pcc 7942]]		[[Category: Synechococcus elongatus pcc 7942]]
-	[[Category: Klewer, D A.]]	+	[[Category: Klewer, D A]]
-	[[Category: LiWang, A C.]]	+	[[Category: LiWang, A C]]
-	[[Category: Vakonakis, I.]]	+	[[Category: Vakonakis, I]]
	[[Category: Alpha/beta protein]]		[[Category: Alpha/beta protein]]
	[[Category: Thioredoxin fold]]		[[Category: Thioredoxin fold]]
	[[Category: Transferase]]		[[Category: Transferase]]

OCA at 19:03, 29 September 2014

OCA — Mon, 29 Sep 2014 19:03:53 GMT

←Older revision		Revision as of 19:03, 29 September 2014
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-	[[~~Image:~~1t4z.~~png~~\|~~left~~\|200px]]	+	==Solution structure of the N-terminal domain of Synechococcus elongatus SasA (25-structures ensemble)==
		+	<StructureSection load='1t4z' size='340' side='right' caption='[[1t4z]], [[NMR_Ensembles_of_Models \| 25 NMR models]]' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1t4z]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Synechococcus_elongatus_pcc_7942 Synechococcus elongatus pcc 7942]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1T4Z OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1T4Z FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1t4y\|1t4y]]</td></tr>
		+	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SASA, SARS ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1140 Synechococcus elongatus PCC 7942])</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1t4z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1t4z OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1t4z RCSB], [http://www.ebi.ac.uk/pdbsum/1t4z PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/t4/1t4z_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Circadian oscillators are endogenous biological systems that generate the approximately 24 hour temporal pattern of biological processes and confer a reproductive fitness advantage to their hosts. The cyanobacterial clock is the simplest known and the only clock system for which structural information for core component proteins, in this case KaiA, KaiB and KaiC, is available. SasA, a clock-associated histidine kinase, is necessary for robustness of the circadian rhythm of gene expression and implicated in clock output. The N-terminal domain of SasA (N-SasA) interacts directly with KaiC and likely functions as the sensory domain controlling the SasA histidine kinase activity. N-SasA and KaiB share significant sequence similarity and, thus, it has been proposed that they would be structurally similar and may even compete for KaiC binding. Here, we report the NMR structure of N-SasA and show it to be different from that of KaiB. The structural comparisons provide no clear details to suggest competition of SasA and KaiB for KaiC binding. N-SasA adopts a canonical thioredoxin fold but lacks the catalytic cysteine residues. A patch of conserved, solvent-exposed residues is found near the canonical thioredoxin active site. We suggest that this surface is used by N-SasA for protein-protein interactions. Our analysis suggests that the structural differences between N-SasA and KaiB are the result of only a few critical amino acid substitutions.

-	~~{{STRUCTURE_1t4z\| PDB=1t4z \| SCENE= }}~~	+	Structure of the N-terminal domain of the circadian clock-associated histidine kinase SasA.,Vakonakis I, Klewer DA, Williams SB, Golden SS, LiWang AC J Mol Biol. 2004 Sep 3;342(1):9-17. PMID:15313603<ref>PMID:15313603</ref>

-	~~===Solution structure~~ of the ~~N-terminal domain of Synechococcus elongatus SasA (25-structures ensemble)===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_15313603}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[1t4z]] is a 1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Synechococcus_elongatus_pcc_7942 Synechococcus elongatus pcc 7942]~~. ~~Full experimental information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=1T4Z OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:015313603<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Synechococcus elongatus pcc 7942]]		[[Category: Synechococcus elongatus pcc 7942]]
	[[Category: Klewer, D A.]]		[[Category: Klewer, D A.]]

OCA: Protected "1t4z" [edit=sysop:move=sysop]

OCA — Sat, 05 Jan 2013 11:55:08 GMT

Protected "1t4z" [edit=sysop:move=sysop]

←Older revision

Revision as of 11:55, 5 January 2013

OCA at 11:55, 5 January 2013

OCA — Sat, 05 Jan 2013 11:55:05 GMT

←Older revision		Revision as of 11:55, 5 January 2013
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-	{{Seed}}
	[[Image:1t4z.png\|left\|200px]]		[[Image:1t4z.png\|left\|200px]]

-	<!--
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	{{STRUCTURE_1t4z\| PDB=1t4z \| SCENE= }}		{{STRUCTURE_1t4z\| PDB=1t4z \| SCENE= }}

	===Solution structure of the N-terminal domain of Synechococcus elongatus SasA (25-structures ensemble)===		===Solution structure of the N-terminal domain of Synechococcus elongatus SasA (25-structures ensemble)===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_15313603}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 15313603 is the PubMed ID number.
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	{{ABSTRACT_PUBMED_15313603}}		{{ABSTRACT_PUBMED_15313603}}

	==About this Structure==		==About this Structure==
-	~~1T4Z~~ is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/~~Synechococcus_elongatus~~ Synechococcus elongatus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1T4Z OCA].	+	[[1t4z]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Synechococcus_elongatus_pcc_7942 Synechococcus elongatus pcc 7942]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1T4Z OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~15313603~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:015313603</ref><references group="xtra"/>
-	[[Category: Synechococcus elongatus]]	+	[[Category: Synechococcus elongatus pcc 7942]]
	[[Category: Klewer, D A.]]		[[Category: Klewer, D A.]]
	[[Category: LiWang, A C.]]		[[Category: LiWang, A C.]]
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	[[Category: Alpha/beta protein]]		[[Category: Alpha/beta protein]]
	[[Category: Thioredoxin fold]]		[[Category: Thioredoxin fold]]
-		+	[[Category: Transferase]]
-	~~''Page seeded by~~ [~~http~~:~~//oca.weizmann.ac.il/oca OCA~~ ] ~~on Tue Feb 17 10:41:59 2009''~~	+

OCA at 08:42, 17 February 2009

OCA — Tue, 17 Feb 2009 08:42:00 GMT

←Older revision		Revision as of 08:42, 17 February 2009
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	==About this Structure==		==About this Structure==
-	1T4Z is a ~~[[Single protein]]~~ structure of sequence from [http://en.wikipedia.org/wiki/Synechococcus_elongatus Synechococcus elongatus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1T4Z OCA].	+	1T4Z is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Synechococcus_elongatus Synechococcus elongatus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1T4Z OCA].

	==Reference==		==Reference==
-	~~Structure of the N-terminal domain of the circadian clock-associated histidine kinase SasA., Vakonakis I, Klewer DA, Williams SB, Golden SS, LiWang AC, J Mol Biol. 2004 Sep 3;342(1):9-17.~~ PMID:~~[http:~~//~~www.ncbi.nlm.nih.gov/pubmed/15313603 15313603]~~	+	<ref group="xtra">PMID:15313603</ref><references group="xtra"/>
-	~~[[Category: Single protein]]~~	+
	[[Category: Synechococcus elongatus]]		[[Category: Synechococcus elongatus]]
	[[Category: Klewer, D A.]]		[[Category: Klewer, D A.]]
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	[[Category: Thioredoxin fold]]		[[Category: Thioredoxin fold]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Mon Jul 28 14~~:37:~~18 2008~~''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 10:41:59 2009''