1t52 - Revision history

OCA at 10:29, 16 August 2023

OCA — Wed, 16 Aug 2023 10:29:12 GMT

←Older revision		Revision as of 10:29, 16 August 2023
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	==Antibiotic Activity and Structural Analysis of a Scorpion-derived Antimicrobial peptide IsCT and Its Analogs==		==Antibiotic Activity and Structural Analysis of a Scorpion-derived Antimicrobial peptide IsCT and Its Analogs==
-	<StructureSection load='1t52' size='340' side='right'caption='[[1t52~~]], [[NMR_Ensembles_of_Models \| 20 NMR models~~]]' scene=''>	+	<StructureSection load='1t52' size='340' side='right'caption='[[1t52]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1t52]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Opima Opima~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1T52 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1T52 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1t52]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Opisthacanthus_madagascariensis Opisthacanthus madagascariensis]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1T52 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1T52 FirstGlance]. <br>
-	</td></tr><tr id='~~NonStdRes~~'><td class="sblockLbl"><b>[[~~Non-Standard_Residue~~\|~~NonStd Res~~:]]</b></td><td class="sblockDat"~~><scene name~~=~~'pdbligand=NH2:AMINO+GROUP'>NH2</scene~~></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"><~~div style~~='~~overflow~~: ~~auto; max-height: 3em;~~'>~~[[1t51\|1t51]], [[1t54\|1t54]], [[1t55\|1t55]]~~</~~div~~></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1t52 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1t52 OCA], [https://pdbe.org/1t52 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1t52 RCSB], [https://www.ebi.ac.uk/pdbsum/1t52 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1t52 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1t52 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1t52 OCA], [https://pdbe.org/1t52 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1t52 RCSB], [https://www.ebi.ac.uk/pdbsum/1t52 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1t52 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/~~NDB52_OPIMA NDB52_OPIMA~~]~~] Cytotoxic linear peptide IsCT: shows~~ weak hemolytic activity and antibacterial activity against both Gram-positive and Gram-negative bacteria probably by forming pores in the cell membrane. IsCT adopts an amphipathic alpha-helical structure. ~~Cytotoxic linear peptide IsCTf~~: ~~shows~~ neither hemolytic, nor antibacterial activities, probably because it cannot adopt amphipathic alpha-helical structure.	+	[https://www.uniprot.org/uniprot/NDB41_OPIMA NDB41_OPIMA] Shows weak hemolytic activity and antibacterial activity against both Gram-positive and Gram-negative bacteria probably by forming pores in the cell membrane. IsCT adopts an amphipathic alpha-helical structure.<ref>PMID:11520071</ref> Shows neither hemolytic, nor antibacterial activities, probably because it cannot adopt amphipathic alpha-helical structure.<ref>PMID:12054688</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Opima~~]]	+	[[Category: Opisthacanthus madagascariensis]]
-	[[Category: Hahm~~, K S~~]]	+	[[Category: Hahm KS]]
-	[[Category: Kim, K]]	+	[[Category: Kim K]]
-	[[Category: Kim, Y]]	+	[[Category: Kim Y]]
-	[[Category: Lee, K]]	+	[[Category: Lee K]]
-	[[Category: Lim~~, S S~~]]	+	[[Category: Lim SS]]
-	[[Category: Shin~~, S Y]]~~	+	[[Category: Shin SY]]
-	~~[[Category: Antibiotic]]~~	+
-	~~[[Category: Coil-helix~~]]	+

OCA at 07:41, 22 September 2021

OCA — Wed, 22 Sep 2021 07:41:25 GMT

←Older revision		Revision as of 07:41, 22 September 2021
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	<StructureSection load='1t52' size='340' side='right'caption='[[1t52]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='1t52' size='340' side='right'caption='[[1t52]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1t52]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Opima Opima]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1T52 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1T52 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1t52]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Opima Opima]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1T52 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1T52 FirstGlance]. <br>
	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1t51\|1t51]], [[1t54\|1t54]], [[1t55\|1t55]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1t51\|1t51]], [[1t54\|1t54]], [[1t55\|1t55]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1t52 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1t52 OCA], [~~http~~://pdbe.org/1t52 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1t52 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1t52 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1t52 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1t52 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1t52 OCA], [https://pdbe.org/1t52 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1t52 RCSB], [https://www.ebi.ac.uk/pdbsum/1t52 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1t52 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/NDB52_OPIMA NDB52_OPIMA]] Cytotoxic linear peptide IsCT: shows weak hemolytic activity and antibacterial activity against both Gram-positive and Gram-negative bacteria probably by forming pores in the cell membrane. IsCT adopts an amphipathic alpha-helical structure. Cytotoxic linear peptide IsCTf: shows neither hemolytic, nor antibacterial activities, probably because it cannot adopt amphipathic alpha-helical structure.	+	[[https://www.uniprot.org/uniprot/NDB52_OPIMA NDB52_OPIMA]] Cytotoxic linear peptide IsCT: shows weak hemolytic activity and antibacterial activity against both Gram-positive and Gram-negative bacteria probably by forming pores in the cell membrane. IsCT adopts an amphipathic alpha-helical structure. Cytotoxic linear peptide IsCTf: shows neither hemolytic, nor antibacterial activities, probably because it cannot adopt amphipathic alpha-helical structure.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 14:02, 18 December 2019

OCA — Wed, 18 Dec 2019 14:02:22 GMT

←Older revision		Revision as of 14:02, 18 December 2019
Line 1:		Line 1:

	==Antibiotic Activity and Structural Analysis of a Scorpion-derived Antimicrobial peptide IsCT and Its Analogs==		==Antibiotic Activity and Structural Analysis of a Scorpion-derived Antimicrobial peptide IsCT and Its Analogs==
-	<StructureSection load='1t52' size='340' side='right' caption='[[1t52]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>	+	<StructureSection load='1t52' size='340' side='right'caption='[[1t52]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1t52]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Opima Opima]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1T52 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1T52 FirstGlance]. <br>		<table><tr><td colspan='2'>[[1t52]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Opima Opima]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1T52 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1T52 FirstGlance]. <br>
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Opima]]		[[Category: Opima]]
	[[Category: Hahm, K S]]		[[Category: Hahm, K S]]

OCA at 07:44, 14 March 2018

OCA — Wed, 14 Mar 2018 07:44:43 GMT

←Older revision		Revision as of 07:44, 14 March 2018
Line 1:		Line 1:
		+
	==Antibiotic Activity and Structural Analysis of a Scorpion-derived Antimicrobial peptide IsCT and Its Analogs==		==Antibiotic Activity and Structural Analysis of a Scorpion-derived Antimicrobial peptide IsCT and Its Analogs==
	<StructureSection load='1t52' size='340' side='right' caption='[[1t52]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='1t52' size='340' side='right' caption='[[1t52]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1t51\|1t51]], [[1t54\|1t54]], [[1t55\|1t55]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1t51\|1t51]], [[1t54\|1t54]], [[1t55\|1t55]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1t52 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1t52 OCA], [http://pdbe.org/1t52 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1t52 RCSB], [http://www.ebi.ac.uk/pdbsum/1t52 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1t52 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1t52 OCA], [http://pdbe.org/1t52 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1t52 RCSB], [http://www.ebi.ac.uk/pdbsum/1t52 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1t52 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==

OCA at 08:31, 11 September 2015

OCA — Fri, 11 Sep 2015 08:31:15 GMT

←Older revision		Revision as of 08:31, 11 September 2015
Line 2:		Line 2:
	<StructureSection load='1t52' size='340' side='right' caption='[[1t52]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='1t52' size='340' side='right' caption='[[1t52]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1t52]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Opisthacanthus_madagascariensis Opisthacanthus madagascariensis~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1T52 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1T52 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1t52]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Opima Opima]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1T52 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1T52 FirstGlance]. <br>
	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1t51\|1t51]], [[1t54\|1t54]], [[1t55\|1t55]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1t51\|1t51]], [[1t54\|1t54]], [[1t55\|1t55]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1t52 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1t52 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1t52 RCSB], [http://www.ebi.ac.uk/pdbsum/1t52 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1t52 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1t52 OCA], [http://pdbe.org/1t52 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1t52 RCSB], [http://www.ebi.ac.uk/pdbsum/1t52 PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[http://www.uniprot.org/uniprot/~~TXT1_OPIMA TXT1_OPIMA~~]] Cytotoxic linear peptide IsCT: shows weak hemolytic activity and antibacterial activity against both Gram-positive and Gram-negative bacteria probably by forming pores in the cell membrane. IsCT adopts an amphipathic alpha-helical structure. Cytotoxic linear peptide IsCTf: shows neither hemolytic, nor antibacterial activities, probably because it cannot adopt amphipathic alpha-helical structure.	+	[[http://www.uniprot.org/uniprot/NDB52_OPIMA NDB52_OPIMA]] Cytotoxic linear peptide IsCT: shows weak hemolytic activity and antibacterial activity against both Gram-positive and Gram-negative bacteria probably by forming pores in the cell membrane. IsCT adopts an amphipathic alpha-helical structure. Cytotoxic linear peptide IsCTf: shows neither hemolytic, nor antibacterial activities, probably because it cannot adopt amphipathic alpha-helical structure.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1t52" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Opisthacanthus madagascariensis~~]]	+	[[Category: Opima]]
	[[Category: Hahm, K S]]		[[Category: Hahm, K S]]
	[[Category: Kim, K]]		[[Category: Kim, K]]

OCA at 13:54, 25 December 2014

OCA — Thu, 25 Dec 2014 13:54:16 GMT

←Older revision		Revision as of 13:54, 25 December 2014
Line 7:		Line 7:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1t52 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1t52 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1t52 RCSB], [http://www.ebi.ac.uk/pdbsum/1t52 PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1t52 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1t52 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1t52 RCSB], [http://www.ebi.ac.uk/pdbsum/1t52 PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/TXT1_OPIMA TXT1_OPIMA]] Cytotoxic linear peptide IsCT: shows weak hemolytic activity and antibacterial activity against both Gram-positive and Gram-negative bacteria probably by forming pores in the cell membrane. IsCT adopts an amphipathic alpha-helical structure. Cytotoxic linear peptide IsCTf: shows neither hemolytic, nor antibacterial activities, probably because it cannot adopt amphipathic alpha-helical structure.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 06:19, 22 December 2014

OCA — Mon, 22 Dec 2014 06:19:33 GMT

←Older revision		Revision as of 06:19, 22 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1t52]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Opisthacanthus_madagascariensis Opisthacanthus madagascariensis]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1T52 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1T52 FirstGlance]. <br>		<table><tr><td colspan='2'>[[1t52]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Opisthacanthus_madagascariensis Opisthacanthus madagascariensis]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1T52 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1T52 FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>	+	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1t51\|1t51]], [[1t54\|1t54]], [[1t55\|1t55]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1t51\|1t51]], [[1t54\|1t54]], [[1t55\|1t55]]</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1t52 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1t52 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1t52 RCSB], [http://www.ebi.ac.uk/pdbsum/1t52 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1t52 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1t52 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1t52 RCSB], [http://www.ebi.ac.uk/pdbsum/1t52 PDBsum]</span></td></tr>
-	<table>	+	</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 20:		Line 20:
	</StructureSection>		</StructureSection>
	[[Category: Opisthacanthus madagascariensis]]		[[Category: Opisthacanthus madagascariensis]]
-	[[Category: Hahm, K S.]]	+	[[Category: Hahm, K S]]
-	[[Category: Kim, K.]]	+	[[Category: Kim, K]]
-	[[Category: Kim, Y.]]	+	[[Category: Kim, Y]]
-	[[Category: Lee, K.]]	+	[[Category: Lee, K]]
-	[[Category: Lim, S S.]]	+	[[Category: Lim, S S]]
-	[[Category: Shin, S Y.]]	+	[[Category: Shin, S Y]]
	[[Category: Antibiotic]]		[[Category: Antibiotic]]
	[[Category: Coil-helix]]		[[Category: Coil-helix]]

OCA at 06:59, 9 June 2014

OCA — Mon, 09 Jun 2014 06:59:14 GMT

←Older revision		Revision as of 06:59, 9 June 2014
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-	[[~~Image:~~1t52.~~png~~\|~~left~~\|~~200px~~]]	+	==Antibiotic Activity and Structural Analysis of a Scorpion-derived Antimicrobial peptide IsCT and Its Analogs==
		+	<StructureSection load='1t52' size='340' side='right' caption='[[1t52]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1t52]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Opisthacanthus_madagascariensis Opisthacanthus madagascariensis]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1T52 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1T52 FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1t51\|1t51]], [[1t54\|1t54]], [[1t55\|1t55]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1t52 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1t52 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1t52 RCSB], [http://www.ebi.ac.uk/pdbsum/1t52 PDBsum]</span></td></tr>
		+	<table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	IsCT is a non-cell-selective antimicrobial peptide isolated from the scorpion Opisthacanthus madagascariensis that has potent cytolytic activity against both mammalian and bacterial cells. To investigate the structure-activity relationships of IsCT and to design novel peptide antibiotics with bacterial cell selectivity, we synthesized several analogs of IsCT and determined their three-dimensional structures in solution by 2D-NMR spectroscopy. IsCT has a linear alpha-helical structure from Gly3 to Phe13, and [K7]-IsCT has a linear alpha-helical structure from Leu2 to Phe13. [K7, P8, K11]-IsCT, which has a bend in its middle region, exhibited the highest antibacterial activity without hemolytic activity, suggesting that its proline-induced bend is an important determinant of this selectivity. Tryptophan fluorescence showed that the high selectivity of [K7, P8, K11]-IsCT toward bacterial cells is closely correlated with its highly selective interaction with negatively charged phospholipids. Its potent activity against antibiotic-resistant bacteria suggests that [K7, P8, K11]-IsCT may serve as a promising lead candidate in the development of new peptide antibiotics.

-	~~{{STRUCTURE_1t52\| PDB=1t52 \| SCENE= }}~~	+	Antibiotic activity and structural analysis of the scorpion-derived antimicrobial peptide IsCT and its analogs.,Lee K, Shin SY, Kim K, Lim SS, Hahm KS, Kim Y Biochem Biophys Res Commun. 2004 Oct 15;323(2):712-9. PMID:15369808<ref>PMID:15369808</ref>

-	~~===Antibiotic Activity and Structural Analysis~~ of ~~a Scorpion-derived Antimicrobial peptide IsCT and Its Analogs===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_15369808}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[1t52]] is a 1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Opisthacanthus_madagascariensis Opisthacanthus madagascariensis]~~. ~~Full experimental information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=1T52 OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:015369808<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Opisthacanthus madagascariensis]]		[[Category: Opisthacanthus madagascariensis]]
	[[Category: Hahm, K S.]]		[[Category: Hahm, K S.]]

OCA: Protected "1t52" [edit=sysop:move=sysop]

OCA — Tue, 14 Aug 2012 18:17:26 GMT

Protected "1t52" [edit=sysop:move=sysop]

←Older revision

Revision as of 18:17, 14 August 2012

OCA at 18:17, 14 August 2012

OCA — Tue, 14 Aug 2012 18:17:25 GMT

←Older revision		Revision as of 18:17, 14 August 2012
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-	{{Seed}}
	[[Image:1t52.png\|left\|200px]]		[[Image:1t52.png\|left\|200px]]

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	{{STRUCTURE_1t52\| PDB=1t52 \| SCENE= }}		{{STRUCTURE_1t52\| PDB=1t52 \| SCENE= }}

	===Antibiotic Activity and Structural Analysis of a Scorpion-derived Antimicrobial peptide IsCT and Its Analogs===		===Antibiotic Activity and Structural Analysis of a Scorpion-derived Antimicrobial peptide IsCT and Its Analogs===

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	{{ABSTRACT_PUBMED_15369808}}		{{ABSTRACT_PUBMED_15369808}}

	==About this Structure==		==About this Structure==
-	~~1T52 is a~~ [[~~Single protein~~]] structure of sequence from [http://en.wikipedia.org/wiki/Opisthacanthus_madagascariensis Opisthacanthus madagascariensis]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1T52 OCA].	+	[[1t52]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Opisthacanthus_madagascariensis Opisthacanthus madagascariensis]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1T52 OCA].

	==Reference==		==Reference==
-	Antibiotic activity and structural analysis of the scorpion-derived antimicrobial peptide IsCT and its analogs., Lee K, Shin SY, Kim K, Lim SS, Hahm KS, Kim Y, Biochem Biophys Res Commun. 2004 Oct 15;323(2):712-9. PMID:~~[http://www.ncbi.nlm.nih.gov~~/~~pubmed~~/~~15369808 15369808]~~	+	<ref group="xtra">PMID:015369808</ref><references group="xtra"/>
	[[Category: Opisthacanthus madagascariensis]]		[[Category: Opisthacanthus madagascariensis]]
-	[[Category: Single protein]]
	[[Category: Hahm, K S.]]		[[Category: Hahm, K S.]]
	[[Category: Kim, K.]]		[[Category: Kim, K.]]
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	[[Category: Lim, S S.]]		[[Category: Lim, S S.]]
	[[Category: Shin, S Y.]]		[[Category: Shin, S Y.]]
		+	[[Category: Antibiotic]]
	[[Category: Coil-helix]]		[[Category: Coil-helix]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 01:11:47 2008''