1t6f - Revision history

OCA at 06:26, 23 August 2023

OCA — Wed, 23 Aug 2023 06:26:40 GMT

←Older revision		Revision as of 06:26, 23 August 2023
Line 3:		Line 3:
	<StructureSection load='1t6f' size='340' side='right'caption='[[1t6f]], [[Resolution\|resolution]] 1.47Å' scene=''>		<StructureSection load='1t6f' size='340' side='right'caption='[[1t6f]], [[Resolution\|resolution]] 1.47Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1t6f]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1T6F OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1T6F FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1t6f]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1T6F OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1T6F FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1t6f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1t6f OCA], [https://pdbe.org/1t6f PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1t6f RCSB], [https://www.ebi.ac.uk/pdbsum/1t6f PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1t6f ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.47Å</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1t6f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1t6f OCA], [https://pdbe.org/1t6f PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1t6f RCSB], [https://www.ebi.ac.uk/pdbsum/1t6f PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1t6f ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/GEMI_HUMAN GEMI_HUMAN]] Inhibits DNA replication by preventing the incorporation of MCM complex into pre-replication complex (pre-RC). It is degraded during the mitotic phase of the cell cycle. Its destruction at the metaphase-anaphase transition permits replication in the succeeding cell cycle.<ref>PMID:9635433</ref> <ref>PMID:14993212</ref> <ref>PMID:22615398</ref> Inhibits the transcriptional activity of a subset of Hox proteins, enrolling them in cell proliferative control.<ref>PMID:9635433</ref> <ref>PMID:14993212</ref> <ref>PMID:22615398</ref>	+	[https://www.uniprot.org/uniprot/GEMI_HUMAN GEMI_HUMAN] Inhibits DNA replication by preventing the incorporation of MCM complex into pre-replication complex (pre-RC). It is degraded during the mitotic phase of the cell cycle. Its destruction at the metaphase-anaphase transition permits replication in the succeeding cell cycle.<ref>PMID:9635433</ref> <ref>PMID:14993212</ref> <ref>PMID:22615398</ref> Inhibits the transcriptional activity of a subset of Hox proteins, enrolling them in cell proliferative control.<ref>PMID:9635433</ref> <ref>PMID:14993212</ref> <ref>PMID:22615398</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Auge, M T]]	+	[[Category: Auge M-T]]
-	[[Category: Dumas, C]]	+	[[Category: Dumas C]]
-	[[Category: Guichou, J F]]	+	[[Category: Guichou J-F]]
-	[[Category: Maiorano, D]]	+	[[Category: Maiorano D]]
-	[[Category: Mechali, M]]	+	[[Category: Mechali M]]
-	[[Category: Padilla, A]]	+	[[Category: Padilla A]]
-	[[Category: Thepaut, M]]	+	[[Category: Thepaut M]]
-	~~[[Category: Cell cycle]]~~	+
-	~~[[Category: Coiled-coil~~]]	+

OCA at 09:23, 29 September 2021

OCA — Wed, 29 Sep 2021 09:23:26 GMT

←Older revision		Revision as of 09:23, 29 September 2021
Line 3:		Line 3:
	<StructureSection load='1t6f' size='340' side='right'caption='[[1t6f]], [[Resolution\|resolution]] 1.47Å' scene=''>		<StructureSection load='1t6f' size='340' side='right'caption='[[1t6f]], [[Resolution\|resolution]] 1.47Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1t6f]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1T6F OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1T6F FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1t6f]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1T6F OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1T6F FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1t6f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1t6f OCA], [~~http~~://pdbe.org/1t6f PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1t6f RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1t6f PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1t6f ProSAT]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1t6f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1t6f OCA], [https://pdbe.org/1t6f PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1t6f RCSB], [https://www.ebi.ac.uk/pdbsum/1t6f PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1t6f ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/GEMI_HUMAN GEMI_HUMAN]] Inhibits DNA replication by preventing the incorporation of MCM complex into pre-replication complex (pre-RC). It is degraded during the mitotic phase of the cell cycle. Its destruction at the metaphase-anaphase transition permits replication in the succeeding cell cycle.<ref>PMID:9635433</ref> <ref>PMID:14993212</ref> <ref>PMID:22615398</ref> Inhibits the transcriptional activity of a subset of Hox proteins, enrolling them in cell proliferative control.<ref>PMID:9635433</ref> <ref>PMID:14993212</ref> <ref>PMID:22615398</ref>	+	[[https://www.uniprot.org/uniprot/GEMI_HUMAN GEMI_HUMAN]] Inhibits DNA replication by preventing the incorporation of MCM complex into pre-replication complex (pre-RC). It is degraded during the mitotic phase of the cell cycle. Its destruction at the metaphase-anaphase transition permits replication in the succeeding cell cycle.<ref>PMID:9635433</ref> <ref>PMID:14993212</ref> <ref>PMID:22615398</ref> Inhibits the transcriptional activity of a subset of Hox proteins, enrolling them in cell proliferative control.<ref>PMID:9635433</ref> <ref>PMID:14993212</ref> <ref>PMID:22615398</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 14:10, 18 December 2019

OCA — Wed, 18 Dec 2019 14:10:27 GMT

←Older revision		Revision as of 14:10, 18 December 2019
Line 1:		Line 1:

	==Crystal Structure of the Coiled-coil Dimerization Motif of Geminin==		==Crystal Structure of the Coiled-coil Dimerization Motif of Geminin==
-	<StructureSection load='1t6f' size='340' side='right' caption='[[1t6f]], [[Resolution\|resolution]] 1.47Å' scene=''>	+	<StructureSection load='1t6f' size='340' side='right'caption='[[1t6f]], [[Resolution\|resolution]] 1.47Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1t6f]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1T6F OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1T6F FirstGlance]. <br>		<table><tr><td colspan='2'>[[1t6f]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1T6F OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1T6F FirstGlance]. <br>
Line 31:		Line 31:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Auge, M T]]		[[Category: Auge, M T]]
	[[Category: Dumas, C]]		[[Category: Dumas, C]]

OCA at 07:50, 14 March 2018

OCA — Wed, 14 Mar 2018 07:50:57 GMT

←Older revision		Revision as of 07:50, 14 March 2018
Line 1:		Line 1:
		+
	==Crystal Structure of the Coiled-coil Dimerization Motif of Geminin==		==Crystal Structure of the Coiled-coil Dimerization Motif of Geminin==
	<StructureSection load='1t6f' size='340' side='right' caption='[[1t6f]], [[Resolution\|resolution]] 1.47Å' scene=''>		<StructureSection load='1t6f' size='340' side='right' caption='[[1t6f]], [[Resolution\|resolution]] 1.47Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1t6f]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1T6F OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1T6F FirstGlance]. <br>		<table><tr><td colspan='2'>[[1t6f]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1T6F OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1T6F FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1t6f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1t6f OCA], [http://pdbe.org/1t6f PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1t6f RCSB], [http://www.ebi.ac.uk/pdbsum/1t6f PDBsum]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1t6f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1t6f OCA], [http://pdbe.org/1t6f PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1t6f RCSB], [http://www.ebi.ac.uk/pdbsum/1t6f PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1t6f ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 11:		Line 12:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/t6/1t6f_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/t6/1t6f_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1t6f ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 13:08, 11 September 2015

OCA — Fri, 11 Sep 2015 13:08:00 GMT

←Older revision		Revision as of 13:08, 11 September 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1t6f]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1T6F OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1T6F FirstGlance]. <br>		<table><tr><td colspan='2'>[[1t6f]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1T6F OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1T6F FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1t6f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1t6f OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1t6f RCSB], [http://www.ebi.ac.uk/pdbsum/1t6f PDBsum]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1t6f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1t6f OCA], [http://pdbe.org/1t6f PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1t6f RCSB], [http://www.ebi.ac.uk/pdbsum/1t6f PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 25:		Line 25:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1t6f" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 16:51, 25 December 2014

OCA — Thu, 25 Dec 2014 16:51:52 GMT

←Older revision		Revision as of 16:51, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1t6f]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1T6F OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1T6F FirstGlance]. <br>		<table><tr><td colspan='2'>[[1t6f]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1T6F OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1T6F FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1t6f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1t6f OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1t6f RCSB], [http://www.ebi.ac.uk/pdbsum/1t6f PDBsum]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1t6f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1t6f OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1t6f RCSB], [http://www.ebi.ac.uk/pdbsum/1t6f PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/GEMI_HUMAN GEMI_HUMAN]] Inhibits DNA replication by preventing the incorporation of MCM complex into pre-replication complex (pre-RC). It is degraded during the mitotic phase of the cell cycle. Its destruction at the metaphase-anaphase transition permits replication in the succeeding cell cycle.<ref>PMID:9635433</ref> <ref>PMID:14993212</ref> <ref>PMID:22615398</ref> Inhibits the transcriptional activity of a subset of Hox proteins, enrolling them in cell proliferative control.<ref>PMID:9635433</ref> <ref>PMID:14993212</ref> <ref>PMID:22615398</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 27:		Line 29:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Auge, M T.]]	+	[[Category: Auge, M T]]
-	[[Category: Dumas, C.]]	+	[[Category: Dumas, C]]
-	[[Category: Guichou, J F.]]	+	[[Category: Guichou, J F]]
-	[[Category: Maiorano, D.]]	+	[[Category: Maiorano, D]]
-	[[Category: Mechali, M.]]	+	[[Category: Mechali, M]]
-	[[Category: Padilla, A.]]	+	[[Category: Padilla, A]]
-	[[Category: Thepaut, M.]]	+	[[Category: Thepaut, M]]
	[[Category: Cell cycle]]		[[Category: Cell cycle]]
	[[Category: Coiled-coil]]		[[Category: Coiled-coil]]

OCA at 20:04, 29 September 2014

OCA — Mon, 29 Sep 2014 20:04:49 GMT

←Older revision		Revision as of 20:04, 29 September 2014
Line 1:		Line 1:
-	[[~~Image~~:1t6f.~~png\|left~~\|200px]]	+	==Crystal Structure of the Coiled-coil Dimerization Motif of Geminin==
		+	<StructureSection load='1t6f' size='340' side='right' caption='[[1t6f]], [[Resolution\|resolution]] 1.47Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1t6f]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1T6F OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1T6F FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1t6f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1t6f OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1t6f RCSB], [http://www.ebi.ac.uk/pdbsum/1t6f PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/t6/1t6f_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	We have determined the crystal structure of the coiled-coil domain of human geminin, a DNA synthesis inhibitor in higher eukaryotes. We show that a peptide encompassing the five heptad repeats of the geminin leucine zipper (LZ) domain is a dimeric parallel coiled coil characterized by a unique pattern of internal polar residues and a negatively charged surface that may target the basic domain of interacting partners. We show that the LZ domain itself is not sufficient to inhibit DNA synthesis but upstream and downstream residues are required. Analysis of a functional form of geminin by density sedimentation indicates an oligomeric structure. X-ray solution scattering experiments performed on a non-functional form of geminin having upstream basic residues and the LZ domain show a tetramer structure. Altogether, these results give a consistent identification and mapping of geminin interacting regions onto structurally important domains. They also suggest that oligomerization properties of geminin may be implicated in its inhibitory activity of DNA synthesis.

-	~~{{STRUCTURE_1t6f\| PDB=1t6f \| SCENE= }}~~	+	Crystal structure of the coiled-coil dimerization motif of geminin: structural and functional insights on DNA replication regulation.,Thepaut M, Maiorano D, Guichou JF, Auge MT, Dumas C, Mechali M, Padilla A J Mol Biol. 2004 Sep 3;342(1):275-87. PMID:15313623<ref>PMID:15313623</ref>

-	~~===Crystal Structure~~ of the ~~Coiled-coil Dimerization Motif of Geminin===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_15313623}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[1t6f]] is a 2 chain structure~~. ~~Full crystallographic information is available from [http://oca~~.~~weizmann~~.~~ac.il~~/~~oca-bin/ocashort?id=1T6F OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:015313623<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Auge, M T.]]		[[Category: Auge, M T.]]
	[[Category: Dumas, C.]]		[[Category: Dumas, C.]]

OCA: Protected "1t6f" [edit=sysop:move=sysop]

OCA — Sat, 05 Jan 2013 13:35:53 GMT

Protected "1t6f" [edit=sysop:move=sysop]

←Older revision

Revision as of 13:35, 5 January 2013

OCA at 13:35, 5 January 2013

OCA — Sat, 05 Jan 2013 13:35:51 GMT

←Older revision		Revision as of 13:35, 5 January 2013
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	[[Image:1t6f.png\|left\|200px]]		[[Image:1t6f.png\|left\|200px]]

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	{{STRUCTURE_1t6f\| PDB=1t6f \| SCENE= }}		{{STRUCTURE_1t6f\| PDB=1t6f \| SCENE= }}

	===Crystal Structure of the Coiled-coil Dimerization Motif of Geminin===		===Crystal Structure of the Coiled-coil Dimerization Motif of Geminin===

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	{{ABSTRACT_PUBMED_15313623}}		{{ABSTRACT_PUBMED_15313623}}

	==About this Structure==		==About this Structure==
-	~~1T6F~~ is a 2 ~~chains~~ structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1T6F OCA].	+	[[1t6f]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1T6F OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~15313623~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:015313623</ref><references group="xtra"/>
	[[Category: Auge, M T.]]		[[Category: Auge, M T.]]
	[[Category: Dumas, C.]]		[[Category: Dumas, C.]]
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	[[Category: Padilla, A.]]		[[Category: Padilla, A.]]
	[[Category: Thepaut, M.]]		[[Category: Thepaut, M.]]
		+	[[Category: Cell cycle]]
	[[Category: Coiled-coil]]		[[Category: Coiled-coil]]
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OCA at 20:16, 17 February 2009

OCA — Tue, 17 Feb 2009 20:16:39 GMT

←Older revision		Revision as of 20:16, 17 February 2009
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	==About this Structure==		==About this Structure==
-	1T6F is a ~~[[Single protein]]~~ structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1T6F OCA].	+	1T6F is a 2 chains structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1T6F OCA].

	==Reference==		==Reference==
-	Crystal structure of the coiled-coil dimerization motif of geminin: structural and functional insights on DNA replication regulation., Thepaut M, Maiorano D, Guichou JF, Auge MT, Dumas C, Mechali M, Padilla A, J Mol Biol. 2004 Sep 3;342(1):275-87. PMID:~~[http:~~//~~www.ncbi.nlm.nih.gov/pubmed/15313623 15313623]~~	+	<ref group="xtra">PMID:15313623</ref><references group="xtra"/>
-	~~[[Category: Single protein]]~~	+
	[[Category: Auge, M T.]]		[[Category: Auge, M T.]]
	[[Category: Dumas, C.]]		[[Category: Dumas, C.]]
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	[[Category: Coiled-coil]]		[[Category: Coiled-coil]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue ~~Jul 29 06~~:32:~~47 2008~~''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 22:16:37 2009''