1t74 - Revision history

OCA at 08:36, 14 February 2024

OCA — Wed, 14 Feb 2024 08:36:55 GMT

←Older revision		Revision as of 08:36, 14 February 2024
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	<StructureSection load='1t74' size='340' side='right'caption='[[1t74]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='1t74' size='340' side='right'caption='[[1t74]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1t74]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Chimpansee_troglodytes Chimpansee~~ troglodytes]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1T74 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=1T74 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1t74]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Pan_troglodytes Pan troglodytes]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1T74 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1T74 FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=DHT:5~~-~~ALPHA-DIHYDROTESTOSTERONE'>DHT</scene>, <scene name='pdbligand=EDO:1~~,2~~-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"><~~div style~~='~~overflow~~: ~~auto; max~~-~~height: 3em;~~'>~~[[1t73\|1t73]], [[1t76\|1t76]], [[1t79\|1t79]], [[1t7f\|1t7f]], [[1t7m\|1t7m]], [[1t7r\|1t7r]], [[1t7t\|1t7t]]~~</~~div~~><~~/td~~></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DHT:5-ALPHA-DIHYDROTESTOSTERONE'>DHT</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	<~~tr id~~='~~gene'><td class~~=~~"sblockLbl"><b>[[Gene\|Gene~~:~~]]</b~~></td>~~<td class="sblockDat">AR, NR3C4 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9598 Chimpansee troglodytes])~~</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1t74 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1t74 OCA], [https://pdbe.org/1t74 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1t74 RCSB], [https://www.ebi.ac.uk/pdbsum/1t74 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1t74 ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=1t74 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1t74 OCA], [~~http~~://pdbe.org/1t74 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1t74 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1t74 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1t74 ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/ANDR_PANTR ANDR_PANTR]] Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins. Transcription activation is down-regulated by NR0B2.Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3 (By similarity).	+	[https://www.uniprot.org/uniprot/ANDR_PANTR ANDR_PANTR] Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins. Transcription activation is down-regulated by NR0B2.Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3 (By similarity).
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1t74 ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1t74 ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
-	<div style="background-color:#fffaf0;">
-	== Publication Abstract from PubMed ==
-	Prostate cancer is a leading killer of men in the industrialized world. Underlying this disease is the aberrant action of the androgen receptor (AR). AR is distinguished from other nuclear receptors in that after hormone binding, it preferentially responds to a specialized set of coactivators bearing aromatic-rich motifs, while responding poorly to coactivators bearing the leucine-rich "NR box" motifs favored by other nuclear receptors. Under normal conditions, interactions with these AR-specific coactivators through aromatic-rich motifs underlie targeted gene transcription. However, during prostate cancer, abnormal association with such coactivators, as well as with coactivators containing canonical leucine-rich motifs, promotes disease progression. To understand the paradox of this unusual selectivity, we have derived a complete set of peptide motifs that interact with AR using phage display. Binding affinities were measured for a selected set of these peptides and their interactions with AR determined by X-ray crystallography. Structures of AR in complex with FxxLF, LxxLL, FxxLW, WxxLF, WxxVW, FxxFF, and FxxYF motifs reveal a changing surface of the AR coactivator binding interface that permits accommodation of both AR-specific aromatic-rich motifs and canonical leucine-rich motifs. Induced fit provides perfect mating of the motifs representing the known family of AR coactivators and suggests a framework for the design of AR coactivator antagonists.
-
-	Recognition and accommodation at the androgen receptor coactivator binding interface.,Hur E, Pfaff SJ, Payne ES, Gron H, Buehrer BM, Fletterick RJ PLoS Biol. 2004 Sep;2(9):E274. Epub 2004 Aug 24. PMID:15328534<ref>PMID:15328534</ref>
-
-	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	</div>
-	<div class="pdbe-citations 1t74" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
	*[[Androgen receptor 3D structures\|Androgen receptor 3D structures]]		*[[Androgen receptor 3D structures\|Androgen receptor 3D structures]]
-	== References ==
-	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Chimpansee troglodytes]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Buehrer~~, B M~~]]	+	[[Category: Pan troglodytes]]
-	[[Category: Fletterick~~, R J~~]]	+	[[Category: Buehrer BM]]
-	[[Category: Gron, H]]	+	[[Category: Fletterick RJ]]
-	[[Category: Hur, E]]	+	[[Category: Gron H]]
-	[[Category: Payne~~, E S~~]]	+	[[Category: Hur E]]
-	[[Category: Pfaff~~, S J]]~~	+	[[Category: Payne ES]]
-	~~[[Category: Af-2]]~~	+	[[Category: Pfaff SJ]]
-	~~[[Category: Alpha-helical sandwich]]~~	+
-	~~[[Category: Androgen]]~~	+
-	~~[[Category: Dht]]~~	+
-	~~[[Category: Hormone-growth factor receptor complex]]~~	+
-	~~[[Category: Ligand binding domain]]~~	+
-	~~[[Category: Nuclear receptor]]~~	+
-	~~[[Category: Testosterone]]~~	+
-	~~[[Category: Transcription factor~~]]	+

OCA at 11:44, 24 December 2020

OCA — Thu, 24 Dec 2020 11:44:00 GMT

←Older revision		Revision as of 11:44, 24 December 2020
Line 1:		Line 1:

	==Crystal structure of the androgen receptor ligand binding domain in complex with a WxxLF motif==		==Crystal structure of the androgen receptor ligand binding domain in complex with a WxxLF motif==
-	<StructureSection load='1t74' size='340' side='right' caption='[[1t74]], [[Resolution\|resolution]] 2.00Å' scene=''>	+	<StructureSection load='1t74' size='340' side='right'caption='[[1t74]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1t74]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Chimpansee_troglodytes Chimpansee troglodytes]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1T74 OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1T74 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1t74]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Chimpansee_troglodytes Chimpansee troglodytes]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1T74 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=1T74 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DHT:5-ALPHA-DIHYDROTESTOSTERONE'>DHT</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DHT:5-ALPHA-DIHYDROTESTOSTERONE'>DHT</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1t73\|1t73]], [[1t76\|1t76]], [[1t79\|1t79]], [[1t7f\|1t7f]], [[1t7m\|1t7m]], [[1t7r\|1t7r]], [[1t7t\|1t7t]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1t73\|1t73]], [[1t76\|1t76]], [[1t79\|1t79]], [[1t7f\|1t7f]], [[1t7m\|1t7m]], [[1t7r\|1t7r]], [[1t7t\|1t7t]]</div></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">AR, NR3C4 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9598 Chimpansee troglodytes])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">AR, NR3C4 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9598 Chimpansee troglodytes])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1t74 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1t74 OCA], [http://pdbe.org/1t74 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1t74 RCSB], [http://www.ebi.ac.uk/pdbsum/1t74 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1t74 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=1t74 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1t74 OCA], [http://pdbe.org/1t74 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1t74 RCSB], [http://www.ebi.ac.uk/pdbsum/1t74 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1t74 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 32:		Line 32:

	==See Also==		==See Also==
-	*[[Androgen receptor\|Androgen receptor]]	+	*[[Androgen receptor 3D structures\|Androgen receptor 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 38:		Line 38:
	</StructureSection>		</StructureSection>
	[[Category: Chimpansee troglodytes]]		[[Category: Chimpansee troglodytes]]
		+	[[Category: Large Structures]]
	[[Category: Buehrer, B M]]		[[Category: Buehrer, B M]]
	[[Category: Fletterick, R J]]		[[Category: Fletterick, R J]]

OCA at 07:54, 14 March 2018

OCA — Wed, 14 Mar 2018 07:54:04 GMT

←Older revision		Revision as of 07:54, 14 March 2018
Line 1:		Line 1:
		+
	==Crystal structure of the androgen receptor ligand binding domain in complex with a WxxLF motif==		==Crystal structure of the androgen receptor ligand binding domain in complex with a WxxLF motif==
	<StructureSection load='1t74' size='340' side='right' caption='[[1t74]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='1t74' size='340' side='right' caption='[[1t74]], [[Resolution\|resolution]] 2.00Å' scene=''>
Line 6:		Line 7:
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1t73\|1t73]], [[1t76\|1t76]], [[1t79\|1t79]], [[1t7f\|1t7f]], [[1t7m\|1t7m]], [[1t7r\|1t7r]], [[1t7t\|1t7t]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1t73\|1t73]], [[1t76\|1t76]], [[1t79\|1t79]], [[1t7f\|1t7f]], [[1t7m\|1t7m]], [[1t7r\|1t7r]], [[1t7t\|1t7t]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">AR, NR3C4 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9598 Chimpansee troglodytes])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">AR, NR3C4 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9598 Chimpansee troglodytes])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1t74 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1t74 OCA], [http://pdbe.org/1t74 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1t74 RCSB], [http://www.ebi.ac.uk/pdbsum/1t74 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1t74 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1t74 OCA], [http://pdbe.org/1t74 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1t74 RCSB], [http://www.ebi.ac.uk/pdbsum/1t74 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1t74 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 14:		Line 15:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/t7/1t74_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/t7/1t74_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 03:00, 8 February 2016

OCA — Mon, 08 Feb 2016 03:00:40 GMT

←Older revision		Revision as of 03:00, 8 February 2016
Line 18:		Line 18:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1t74 ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 07:14, 10 September 2015

OCA — Thu, 10 Sep 2015 07:14:05 GMT

←Older revision		Revision as of 07:14, 10 September 2015
Line 2:		Line 2:
	<StructureSection load='1t74' size='340' side='right' caption='[[1t74]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='1t74' size='340' side='right' caption='[[1t74]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1t74]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Pan_troglodytes Pan~~ troglodytes]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1T74 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1T74 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1t74]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Chimpansee_troglodytes Chimpansee troglodytes]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1T74 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1T74 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DHT:5-ALPHA-DIHYDROTESTOSTERONE'>DHT</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DHT:5-ALPHA-DIHYDROTESTOSTERONE'>DHT</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1t73\|1t73]], [[1t76\|1t76]], [[1t79\|1t79]], [[1t7f\|1t7f]], [[1t7m\|1t7m]], [[1t7r\|1t7r]], [[1t7t\|1t7t]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1t73\|1t73]], [[1t76\|1t76]], [[1t79\|1t79]], [[1t7f\|1t7f]], [[1t7m\|1t7m]], [[1t7r\|1t7r]], [[1t7t\|1t7t]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">AR, NR3C4 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9598 ~~Pan~~ troglodytes])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">AR, NR3C4 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9598 Chimpansee troglodytes])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1t74 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1t74 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1t74 RCSB], [http://www.ebi.ac.uk/pdbsum/1t74 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1t74 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1t74 OCA], [http://pdbe.org/1t74 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1t74 RCSB], [http://www.ebi.ac.uk/pdbsum/1t74 PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1t74" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 35:		Line 36:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Pan~~ troglodytes]]	+	[[Category: Chimpansee troglodytes]]
	[[Category: Buehrer, B M]]		[[Category: Buehrer, B M]]
	[[Category: Fletterick, R J]]		[[Category: Fletterick, R J]]

OCA at 20:05, 24 December 2014

OCA — Wed, 24 Dec 2014 20:05:58 GMT

←Older revision		Revision as of 20:05, 24 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1t74]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Pan_troglodytes Pan troglodytes]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1T74 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1T74 FirstGlance]. <br>		<table><tr><td colspan='2'>[[1t74]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Pan_troglodytes Pan troglodytes]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1T74 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1T74 FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DHT:5-ALPHA-DIHYDROTESTOSTERONE'>DHT</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DHT:5-ALPHA-DIHYDROTESTOSTERONE'>DHT</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1t73\|1t73]], [[1t76\|1t76]], [[1t79\|1t79]], [[1t7f\|1t7f]], [[1t7m\|1t7m]], [[1t7r\|1t7r]], [[1t7t\|1t7t]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1t73\|1t73]], [[1t76\|1t76]], [[1t79\|1t79]], [[1t7f\|1t7f]], [[1t7m\|1t7m]], [[1t7r\|1t7r]], [[1t7t\|1t7t]]</td></tr>
-	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">AR, NR3C4 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9598 Pan troglodytes])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">AR, NR3C4 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9598 Pan troglodytes])</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1t74 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1t74 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1t74 RCSB], [http://www.ebi.ac.uk/pdbsum/1t74 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1t74 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1t74 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1t74 RCSB], [http://www.ebi.ac.uk/pdbsum/1t74 PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/ANDR_PANTR ANDR_PANTR]] Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins. Transcription activation is down-regulated by NR0B2.Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3 (By similarity).
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 34:		Line 36:
	</StructureSection>		</StructureSection>
	[[Category: Pan troglodytes]]		[[Category: Pan troglodytes]]
-	[[Category: Buehrer, B M.]]	+	[[Category: Buehrer, B M]]
-	[[Category: Fletterick, R J.]]	+	[[Category: Fletterick, R J]]
-	[[Category: Gron, H.]]	+	[[Category: Gron, H]]
-	[[Category: Hur, E.]]	+	[[Category: Hur, E]]
-	[[Category: Payne, E S.]]	+	[[Category: Payne, E S]]
-	[[Category: Pfaff, S J.]]	+	[[Category: Pfaff, S J]]
	[[Category: Af-2]]		[[Category: Af-2]]
	[[Category: Alpha-helical sandwich]]		[[Category: Alpha-helical sandwich]]

OCA at 20:36, 29 September 2014

OCA — Mon, 29 Sep 2014 20:36:22 GMT

←Older revision		Revision as of 20:36, 29 September 2014
Line 1:		Line 1:
-	[[~~Image:~~1t74.~~png~~\|~~left~~\|200px]]	+	==Crystal structure of the androgen receptor ligand binding domain in complex with a WxxLF motif==
		+	<StructureSection load='1t74' size='340' side='right' caption='[[1t74]], [[Resolution\|resolution]] 2.00Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1t74]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Pan_troglodytes Pan troglodytes]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1T74 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1T74 FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DHT:5-ALPHA-DIHYDROTESTOSTERONE'>DHT</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1t73\|1t73]], [[1t76\|1t76]], [[1t79\|1t79]], [[1t7f\|1t7f]], [[1t7m\|1t7m]], [[1t7r\|1t7r]], [[1t7t\|1t7t]]</td></tr>
		+	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">AR, NR3C4 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9598 Pan troglodytes])</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1t74 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1t74 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1t74 RCSB], [http://www.ebi.ac.uk/pdbsum/1t74 PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/t7/1t74_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Prostate cancer is a leading killer of men in the industrialized world. Underlying this disease is the aberrant action of the androgen receptor (AR). AR is distinguished from other nuclear receptors in that after hormone binding, it preferentially responds to a specialized set of coactivators bearing aromatic-rich motifs, while responding poorly to coactivators bearing the leucine-rich "NR box" motifs favored by other nuclear receptors. Under normal conditions, interactions with these AR-specific coactivators through aromatic-rich motifs underlie targeted gene transcription. However, during prostate cancer, abnormal association with such coactivators, as well as with coactivators containing canonical leucine-rich motifs, promotes disease progression. To understand the paradox of this unusual selectivity, we have derived a complete set of peptide motifs that interact with AR using phage display. Binding affinities were measured for a selected set of these peptides and their interactions with AR determined by X-ray crystallography. Structures of AR in complex with FxxLF, LxxLL, FxxLW, WxxLF, WxxVW, FxxFF, and FxxYF motifs reveal a changing surface of the AR coactivator binding interface that permits accommodation of both AR-specific aromatic-rich motifs and canonical leucine-rich motifs. Induced fit provides perfect mating of the motifs representing the known family of AR coactivators and suggests a framework for the design of AR coactivator antagonists.

-	~~{{STRUCTURE_1t74\| PDB=1t74 \| SCENE= }}~~	+	Recognition and accommodation at the androgen receptor coactivator binding interface.,Hur E, Pfaff SJ, Payne ES, Gron H, Buehrer BM, Fletterick RJ PLoS Biol. 2004 Sep;2(9):E274. Epub 2004 Aug 24. PMID:15328534<ref>PMID:15328534</ref>

-	~~===Crystal structure~~ of the ~~androgen receptor ligand binding domain in complex with a WxxLF motif===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>

-	~~{{ABSTRACT_PUBMED_15328534}}~~	+	==See Also==
-		+	*[[Androgen receptor\|Androgen receptor]]
-	==~~About this Structure~~==	+	== References ==
-	[[~~1t74~~]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Pan_troglodytes Pan troglodytes]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1T74 OCA].	+	<references/>
-		+	__TOC__
-	==~~Reference~~==	+	</StructureSection>
-	<~~ref group="xtra">PMID:015328534<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Pan troglodytes]]		[[Category: Pan troglodytes]]
	[[Category: Buehrer, B M.]]		[[Category: Buehrer, B M.]]

OCA: Protected "1t74" [edit=sysop:move=sysop]

OCA — Sat, 05 Jan 2013 11:22:56 GMT

Protected "1t74" [edit=sysop:move=sysop]

←Older revision

Revision as of 11:22, 5 January 2013

OCA at 11:22, 5 January 2013

OCA — Sat, 05 Jan 2013 11:22:53 GMT

←Older revision		Revision as of 11:22, 5 January 2013
Line 1:		Line 1:
-	{{Seed}}
	[[Image:1t74.png\|left\|200px]]		[[Image:1t74.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_1t74", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
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	{{STRUCTURE_1t74\| PDB=1t74 \| SCENE= }}		{{STRUCTURE_1t74\| PDB=1t74 \| SCENE= }}

	===Crystal structure of the androgen receptor ligand binding domain in complex with a WxxLF motif===		===Crystal structure of the androgen receptor ligand binding domain in complex with a WxxLF motif===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_15328534}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 15328534 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_15328534}}		{{ABSTRACT_PUBMED_15328534}}

	==About this Structure==		==About this Structure==
-	~~1T74~~ is a 2 ~~chains~~ structure ~~of sequences~~ from [http://en.wikipedia.org/wiki/Pan_troglodytes Pan troglodytes]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1T74 OCA].	+	[[1t74]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Pan_troglodytes Pan troglodytes]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1T74 OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~15328534~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:015328534</ref><references group="xtra"/>
	[[Category: Pan troglodytes]]		[[Category: Pan troglodytes]]
	[[Category: Buehrer, B M.]]		[[Category: Buehrer, B M.]]
Line 35:		Line 23:
	[[Category: Androgen]]		[[Category: Androgen]]
	[[Category: Dht]]		[[Category: Dht]]
		+	[[Category: Hormone-growth factor receptor complex]]
	[[Category: Ligand binding domain]]		[[Category: Ligand binding domain]]
	[[Category: Nuclear receptor]]		[[Category: Nuclear receptor]]
	[[Category: Testosterone]]		[[Category: Testosterone]]
	[[Category: Transcription factor]]		[[Category: Transcription factor]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 18:19:14 2009''

OCA at 16:19, 16 February 2009

OCA — Mon, 16 Feb 2009 16:19:14 GMT

←Older revision		Revision as of 16:19, 16 February 2009
Line 20:		Line 20:

	==About this Structure==		==About this Structure==
-	1T74 is a ~~[[Single protein]]~~ structure of ~~sequence~~ from [http://en.wikipedia.org/wiki/Pan_troglodytes Pan troglodytes]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1T74 OCA].	+	1T74 is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Pan_troglodytes Pan troglodytes]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1T74 OCA].

	==Reference==		==Reference==
-	~~Recognition and accommodation at the androgen receptor coactivator binding interface., Hur E, Pfaff SJ, Payne ES, Gron H, Buehrer BM, Fletterick RJ, PLoS Biol. 2004 Sep;2(9):E274. Epub 2004 Aug 24.~~ PMID:~~[http:~~//~~www.ncbi.nlm.nih.gov/pubmed/15328534 15328534]~~	+	<ref group="xtra">PMID:15328534</ref><references group="xtra"/>
	[[Category: Pan troglodytes]]		[[Category: Pan troglodytes]]
-	[[Category: Single protein]]
	[[Category: Buehrer, B M.]]		[[Category: Buehrer, B M.]]
	[[Category: Fletterick, R J.]]		[[Category: Fletterick, R J.]]
Line 41:		Line 40:
	[[Category: Transcription factor]]		[[Category: Transcription factor]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Sun Jul 27 22~~:05:~~25 2008~~''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 18:19:14 2009''