1t8d - Revision history

OCA at 08:38, 1 May 2024

OCA — Wed, 01 May 2024 08:38:44 GMT

←Older revision		Revision as of 08:38, 1 May 2024
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	==Structure of the C-type lectin domain of CD23==		==Structure of the C-type lectin domain of CD23==
-	<StructureSection load='1t8d' size='340' side='right'caption='[[1t8d~~]], [[NMR_Ensembles_of_Models \| 20 NMR models~~]]' scene=''>	+	<StructureSection load='1t8d' size='340' side='right'caption='[[1t8d]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1t8d]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1T8D OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1T8D FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1t8d]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1T8D OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1T8D FirstGlance]. <br>
-	</td></tr><tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"~~><div style='overflow: auto; max-height: 3em;'>[[1t8c\|1t8c]]</div></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
-	~~<tr~~ id~~='gene'><td class~~="~~sblockLbl~~">~~<b>[[Gene\|Gene:]]</b></td><td class="sblockDat">FCER2, IGEBF ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])~~</td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1t8d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1t8d OCA], [https://pdbe.org/1t8d PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1t8d RCSB], [https://www.ebi.ac.uk/pdbsum/1t8d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1t8d ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1t8d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1t8d OCA], [https://pdbe.org/1t8d PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1t8d RCSB], [https://www.ebi.ac.uk/pdbsum/1t8d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1t8d ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/FCER2_HUMAN FCER2_HUMAN]] Low-affinity receptor for immunoglobulin E (IgE) and CR2/CD21. Has essential roles in the regulation of IgE production and in the differentiation of B-cells (it is a B-cell-specific antigen).	+	[https://www.uniprot.org/uniprot/FCER2_HUMAN FCER2_HUMAN] Low-affinity receptor for immunoglobulin E (IgE) and CR2/CD21. Has essential roles in the regulation of IgE production and in the differentiation of B-cells (it is a B-cell-specific antigen).
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 20:		Line 19:
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1t8d ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1t8d ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
-	<div style="background-color:#fffaf0;">
-	== Publication Abstract from PubMed ==
-	The low-affinity immunoglobulin E (IgE) receptor, CD23 (FcepsilonRII), binds both IgE and CD21 and, through these interactions, regulates the synthesis of IgE, the antibody isotype that mediates the allergic response. We have determined the three-dimensional structure of the C-type lectin domain of CD23 in solution by nuclear magnetic resonance spectroscopy. An analysis of concentration-dependent chemical shift perturbations have allowed us to identify the residues engaged in self-association to the trimeric state, whereas ligand-induced changes have defined the binding sites for IgE and CD21. The results further reveal that CD23 can bind both ligands simultaneously. Despite the C-type lectin domain structure, none of the interactions require calcium. We also find that IgE and CD23 can interact to form high molecular mass multimeric complexes. The interactions that we have described provide a solution to the paradox that CD23 is involved in both up- and down-regulation of IgE and provide a structural basis for the development of inhibitors of allergic disease.
-
-	The structure of human CD23 and its interactions with IgE and CD21.,Hibbert RG, Teriete P, Grundy GJ, Beavil RL, Reljic R, Holers VM, Hannan JP, Sutton BJ, Gould HJ, McDonnell JM J Exp Med. 2005 Sep 19;202(6):751-60. PMID:16172256<ref>PMID:16172256</ref>
-
-	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	</div>
-	<div class="pdbe-citations 1t8d" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
	*[[CD23\|CD23]]		*[[CD23\|CD23]]
-	== References ==
-	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Gould~~, H J~~]]	+	[[Category: Gould HJ]]
-	[[Category: Grundy~~, G J~~]]	+	[[Category: Grundy GJ]]
-	[[Category: Hibbert~~, R G~~]]	+	[[Category: Hibbert RG]]
-	[[Category: McDonnell~~, J M~~]]	+	[[Category: McDonnell JM]]
-	[[Category: Sutton~~, B J~~]]	+	[[Category: Sutton BJ]]
-	[[Category: Teriete, P]]	+	[[Category: Teriete P]]
-	~~[[Category: C-type lectin]]~~	+
-	~~[[Category: Fc receptor]]~~	+
-	~~[[Category: Fcerii]]~~	+
-	~~[[Category: Ige]]~~	+
-	~~[[Category: Immune system~~]]	+

OCA at 15:39, 27 October 2021

OCA — Wed, 27 Oct 2021 15:39:53 GMT

←Older revision		Revision as of 15:39, 27 October 2021
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	<StructureSection load='1t8d' size='340' side='right'caption='[[1t8d]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='1t8d' size='340' side='right'caption='[[1t8d]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1t8d]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1T8D OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=1T8D FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1t8d]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1T8D OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1T8D FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1t8c\|1t8c]]</div></td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1t8c\|1t8c]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">FCER2, IGEBF ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">FCER2, IGEBF ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=1t8d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1t8d OCA], [~~http~~://pdbe.org/1t8d PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1t8d RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1t8d PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1t8d ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1t8d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1t8d OCA], [https://pdbe.org/1t8d PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1t8d RCSB], [https://www.ebi.ac.uk/pdbsum/1t8d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1t8d ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/FCER2_HUMAN FCER2_HUMAN]] Low-affinity receptor for immunoglobulin E (IgE) and CR2/CD21. Has essential roles in the regulation of IgE production and in the differentiation of B-cells (it is a B-cell-specific antigen).	+	[[https://www.uniprot.org/uniprot/FCER2_HUMAN FCER2_HUMAN]] Low-affinity receptor for immunoglobulin E (IgE) and CR2/CD21. Has essential roles in the regulation of IgE production and in the differentiation of B-cells (it is a B-cell-specific antigen).
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 11:45, 24 December 2020

OCA — Thu, 24 Dec 2020 11:45:33 GMT

←Older revision		Revision as of 11:45, 24 December 2020
Line 1:		Line 1:

	==Structure of the C-type lectin domain of CD23==		==Structure of the C-type lectin domain of CD23==
-	<StructureSection load='1t8d' size='340' side='right' caption='[[1t8d]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>	+	<StructureSection load='1t8d' size='340' side='right'caption='[[1t8d]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1t8d]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1T8D OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1T8D FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1t8d]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1T8D OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=1T8D FirstGlance]. <br>
-	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1t8c\|1t8c]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1t8c\|1t8c]]</div></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">FCER2, IGEBF ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">FCER2, IGEBF ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1t8d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1t8d OCA], [http://pdbe.org/1t8d PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1t8d RCSB], [http://www.ebi.ac.uk/pdbsum/1t8d PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1t8d ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=1t8d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1t8d OCA], [http://pdbe.org/1t8d PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1t8d RCSB], [http://www.ebi.ac.uk/pdbsum/1t8d PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1t8d ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Gould, H J]]		[[Category: Gould, H J]]
	[[Category: Grundy, G J]]		[[Category: Grundy, G J]]

OCA at 07:47, 14 March 2018

OCA — Wed, 14 Mar 2018 07:47:36 GMT

←Older revision		Revision as of 07:47, 14 March 2018
Line 1:		Line 1:
		+
	==Structure of the C-type lectin domain of CD23==		==Structure of the C-type lectin domain of CD23==
	<StructureSection load='1t8d' size='340' side='right' caption='[[1t8d]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='1t8d' size='340' side='right' caption='[[1t8d]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1t8c\|1t8c]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1t8c\|1t8c]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">FCER2, IGEBF ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">FCER2, IGEBF ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1t8d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1t8d OCA], [http://pdbe.org/1t8d PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1t8d RCSB], [http://www.ebi.ac.uk/pdbsum/1t8d PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1t8d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1t8d OCA], [http://pdbe.org/1t8d PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1t8d RCSB], [http://www.ebi.ac.uk/pdbsum/1t8d PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1t8d ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 13:		Line 14:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/t8/1t8d_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/t8/1t8d_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1t8d ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 28:		Line 29:
	</div>		</div>
	<div class="pdbe-citations 1t8d" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 1t8d" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[CD23\|CD23]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 15:22, 11 September 2015

OCA — Fri, 11 Sep 2015 15:22:15 GMT

←Older revision		Revision as of 15:22, 11 September 2015
Line 2:		Line 2:
	<StructureSection load='1t8d' size='340' side='right' caption='[[1t8d]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='1t8d' size='340' side='right' caption='[[1t8d]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1t8d]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1T8D OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1T8D FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1t8d]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1T8D OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1T8D FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1t8c\|1t8c]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1t8c\|1t8c]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">FCER2, IGEBF ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">FCER2, IGEBF ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1t8d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1t8d OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1t8d RCSB], [http://www.ebi.ac.uk/pdbsum/1t8d PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1t8d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1t8d OCA], [http://pdbe.org/1t8d PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1t8d RCSB], [http://www.ebi.ac.uk/pdbsum/1t8d PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 27:		Line 27:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1t8d" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Gould, H J]]		[[Category: Gould, H J]]
	[[Category: Grundy, G J]]		[[Category: Grundy, G J]]

OCA at 18:19, 25 December 2014

OCA — Thu, 25 Dec 2014 18:19:57 GMT

←Older revision		Revision as of 18:19, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1t8d]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1T8D OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1T8D FirstGlance]. <br>		<table><tr><td colspan='2'>[[1t8d]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1T8D OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1T8D FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1t8c\|1t8c]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1t8c\|1t8c]]</td></tr>
-	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">FCER2, IGEBF ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">FCER2, IGEBF ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1t8d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1t8d OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1t8d RCSB], [http://www.ebi.ac.uk/pdbsum/1t8d PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1t8d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1t8d OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1t8d RCSB], [http://www.ebi.ac.uk/pdbsum/1t8d PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/FCER2_HUMAN FCER2_HUMAN]] Low-affinity receptor for immunoglobulin E (IgE) and CR2/CD21. Has essential roles in the regulation of IgE production and in the differentiation of B-cells (it is a B-cell-specific antigen).
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 30:		Line 32:
	</StructureSection>		</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Gould, H J.]]	+	[[Category: Gould, H J]]
-	[[Category: Grundy, G J.]]	+	[[Category: Grundy, G J]]
-	[[Category: Hibbert, R G.]]	+	[[Category: Hibbert, R G]]
-	[[Category: McDonnell, J M.]]	+	[[Category: McDonnell, J M]]
-	[[Category: Sutton, B J.]]	+	[[Category: Sutton, B J]]
-	[[Category: Teriete, P.]]	+	[[Category: Teriete, P]]
	[[Category: C-type lectin]]		[[Category: C-type lectin]]
	[[Category: Fc receptor]]		[[Category: Fc receptor]]

OCA at 21:29, 29 September 2014

OCA — Mon, 29 Sep 2014 21:29:09 GMT

←Older revision		Revision as of 21:29, 29 September 2014
Line 1:		Line 1:
-	[[~~Image:~~1t8d.~~png~~\|~~left~~\|200px]]	+	==Structure of the C-type lectin domain of CD23==
		+	<StructureSection load='1t8d' size='340' side='right' caption='[[1t8d]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1t8d]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1T8D OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1T8D FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1t8c\|1t8c]]</td></tr>
		+	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">FCER2, IGEBF ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1t8d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1t8d OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1t8d RCSB], [http://www.ebi.ac.uk/pdbsum/1t8d PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/t8/1t8d_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The low-affinity immunoglobulin E (IgE) receptor, CD23 (FcepsilonRII), binds both IgE and CD21 and, through these interactions, regulates the synthesis of IgE, the antibody isotype that mediates the allergic response. We have determined the three-dimensional structure of the C-type lectin domain of CD23 in solution by nuclear magnetic resonance spectroscopy. An analysis of concentration-dependent chemical shift perturbations have allowed us to identify the residues engaged in self-association to the trimeric state, whereas ligand-induced changes have defined the binding sites for IgE and CD21. The results further reveal that CD23 can bind both ligands simultaneously. Despite the C-type lectin domain structure, none of the interactions require calcium. We also find that IgE and CD23 can interact to form high molecular mass multimeric complexes. The interactions that we have described provide a solution to the paradox that CD23 is involved in both up- and down-regulation of IgE and provide a structural basis for the development of inhibitors of allergic disease.

-	~~{{STRUCTURE_1t8d\| PDB=1t8d \| SCENE= }}~~	+	The structure of human CD23 and its interactions with IgE and CD21.,Hibbert RG, Teriete P, Grundy GJ, Beavil RL, Reljic R, Holers VM, Hannan JP, Sutton BJ, Gould HJ, McDonnell JM J Exp Med. 2005 Sep 19;202(6):751-60. PMID:16172256<ref>PMID:16172256</ref>

-	~~===Structure~~ of the ~~C-type lectin domain of CD23===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_16172256}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[1t8d]] is a 1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Homo_sapiens Homo sapiens]~~. ~~Full experimental information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=1T8D OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:016172256<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Gould, H J.]]		[[Category: Gould, H J.]]

OCA: Protected "1t8d" [edit=sysop:move=sysop]

OCA — Sat, 05 Jan 2013 12:45:29 GMT

Protected "1t8d" [edit=sysop:move=sysop]

←Older revision

Revision as of 12:45, 5 January 2013

OCA at 12:45, 5 January 2013

OCA — Sat, 05 Jan 2013 12:45:27 GMT

←Older revision		Revision as of 12:45, 5 January 2013
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-	{{Seed}}
	[[Image:1t8d.png\|left\|200px]]		[[Image:1t8d.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_1t8d", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_1t8d\| PDB=1t8d \| SCENE= }}		{{STRUCTURE_1t8d\| PDB=1t8d \| SCENE= }}

	===Structure of the C-type lectin domain of CD23===		===Structure of the C-type lectin domain of CD23===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_16172256}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 16172256 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_16172256}}		{{ABSTRACT_PUBMED_16172256}}

	==About this Structure==		==About this Structure==
-	~~1T8D~~ is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1T8D OCA].	+	[[1t8d]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1T8D OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~16172256~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:016172256</ref><references group="xtra"/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Gould, H J.]]		[[Category: Gould, H J.]]
Line 35:		Line 23:
	[[Category: Fcerii]]		[[Category: Fcerii]]
	[[Category: Ige]]		[[Category: Ige]]
-		+	[[Category: Immune system]]
-	~~''Page seeded by~~ [~~http~~:~~//oca.weizmann.ac.il/oca OCA~~ ] ~~on Wed Feb 18 01:59:10 2009''~~	+

OCA at 23:59, 17 February 2009

OCA — Tue, 17 Feb 2009 23:59:11 GMT

←Older revision		Revision as of 23:59, 17 February 2009
Line 20:		Line 20:

	==About this Structure==		==About this Structure==
-	1T8D is a ~~[[Single protein]]~~ structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1T8D OCA].	+	1T8D is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1T8D OCA].

	==Reference==		==Reference==
-	The structure of human CD23 and its interactions with IgE and CD21., Hibbert RG, Teriete P, Grundy GJ, Beavil RL, Reljic R, Holers VM, Hannan JP, Sutton BJ, Gould HJ, McDonnell JM, J Exp Med. 2005 Sep 19;202(6):751-60. PMID:~~[http:~~//~~www.ncbi.nlm.nih.gov/pubmed/16172256 16172256]~~	+	<ref group="xtra">PMID:16172256</ref><references group="xtra"/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Single protein]]
	[[Category: Gould, H J.]]		[[Category: Gould, H J.]]
	[[Category: Grundy, G J.]]		[[Category: Grundy, G J.]]
Line 37:		Line 36:
	[[Category: Ige]]		[[Category: Ige]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Tue Jul 29 08~~:50:~~53 2008~~''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 18 01:59:10 2009''