1t93 - Revision history

OCA at 06:27, 23 August 2023

OCA — Wed, 23 Aug 2023 06:27:43 GMT

←Older revision		Revision as of 06:27, 23 August 2023
Line 3:		Line 3:
	<StructureSection load='1t93' size='340' side='right'caption='[[1t93]], [[Resolution\|resolution]] 1.62Å' scene=''>		<StructureSection load='1t93' size='340' side='right'caption='[[1t93]], [[Resolution\|resolution]] 1.62Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1t93]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Strco Strco~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1T93 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1T93 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1t93]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptomyces_coelicolor_A3(2) Streptomyces coelicolor A3(2)]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1T93 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1T93 FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=FLV:FLAVIOLIN'>FLV</scene>~~, ~~<scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.62Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"><~~div style~~='~~overflow~~: ~~auto; max-height: 3em;~~'>~~[[1s1f\|1s1f]]~~, ~~[[1se6\|1se6]]~~</~~div~~></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FLV:FLAVIOLIN'>FLV</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1t93 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1t93 OCA], [https://pdbe.org/1t93 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1t93 RCSB], [https://www.ebi.ac.uk/pdbsum/1t93 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1t93 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1t93 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1t93 OCA], [https://pdbe.org/1t93 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1t93 RCSB], [https://www.ebi.ac.uk/pdbsum/1t93 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1t93 ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/C1582_STRCO C1582_STRCO] Catalyze oxidative C-C coupling reaction to polymerize flaviolin and form highly conjugated pigments which protect the soil bacterium from deleterious effects of UV irradiation (three isomers of biflaviolin and one triflaviolin).<ref>PMID:15659395</ref> <ref>PMID:16239228</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	~~[[Category: Strco]]~~	+	[[Category: Sundaramoorthy M]]
-	[[Category: Sundaramoorthy, M]]	+	[[Category: Waterman MR]]
-	[[Category: Waterman~~, M R~~]]	+	[[Category: Zhao B]]
-	[[Category: Zhao, B]]	+
-	~~[[Category: Cyp158a2]]~~	+
-	~~[[Category: Cytochrome p450 oxidoreductase]]~~	+
-	~~[[Category: Molecular mechanism]]~~	+
-	~~[[Category: Oxidoreductase]]~~	+
-	~~[[Category: Streptomyce]]~~	+
-	~~[[Category: Substrate recognition~~]]	+

OCA at 09:24, 29 September 2021

OCA — Wed, 29 Sep 2021 09:24:13 GMT

←Older revision		Revision as of 09:24, 29 September 2021
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	<StructureSection load='1t93' size='340' side='right'caption='[[1t93]], [[Resolution\|resolution]] 1.62Å' scene=''>		<StructureSection load='1t93' size='340' side='right'caption='[[1t93]], [[Resolution\|resolution]] 1.62Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1t93]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Strco Strco]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1T93 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1T93 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1t93]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Strco Strco]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1T93 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1T93 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FLV:FLAVIOLIN'>FLV</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FLV:FLAVIOLIN'>FLV</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1s1f\|1s1f]], [[1se6\|1se6]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1s1f\|1s1f]], [[1se6\|1se6]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1t93 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1t93 OCA], [~~http~~://pdbe.org/1t93 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1t93 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1t93 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1t93 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1t93 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1t93 OCA], [https://pdbe.org/1t93 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1t93 RCSB], [https://www.ebi.ac.uk/pdbsum/1t93 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1t93 ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==

OCA at 14:14, 18 December 2019

OCA — Wed, 18 Dec 2019 14:14:18 GMT

←Older revision		Revision as of 14:14, 18 December 2019
Line 1:		Line 1:

	==Evidence for Multiple Substrate Recognition and Molecular Mechanism of C-C reaction by Cytochrome P450 CYP158A2 from Streptomyces Coelicolor A3(2)==		==Evidence for Multiple Substrate Recognition and Molecular Mechanism of C-C reaction by Cytochrome P450 CYP158A2 from Streptomyces Coelicolor A3(2)==
-	<StructureSection load='1t93' size='340' side='right' caption='[[1t93]], [[Resolution\|resolution]] 1.62Å' scene=''>	+	<StructureSection load='1t93' size='340' side='right'caption='[[1t93]], [[Resolution\|resolution]] 1.62Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1t93]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Strco Strco]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1T93 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1T93 FirstGlance]. <br>		<table><tr><td colspan='2'>[[1t93]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Strco Strco]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1T93 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1T93 FirstGlance]. <br>
Line 31:		Line 31:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Strco]]		[[Category: Strco]]
	[[Category: Sundaramoorthy, M]]		[[Category: Sundaramoorthy, M]]

OCA at 07:54, 14 March 2018

OCA — Wed, 14 Mar 2018 07:54:28 GMT

←Older revision		Revision as of 07:54, 14 March 2018
Line 1:		Line 1:
		+
	==Evidence for Multiple Substrate Recognition and Molecular Mechanism of C-C reaction by Cytochrome P450 CYP158A2 from Streptomyces Coelicolor A3(2)==		==Evidence for Multiple Substrate Recognition and Molecular Mechanism of C-C reaction by Cytochrome P450 CYP158A2 from Streptomyces Coelicolor A3(2)==
	<StructureSection load='1t93' size='340' side='right' caption='[[1t93]], [[Resolution\|resolution]] 1.62Å' scene=''>		<StructureSection load='1t93' size='340' side='right' caption='[[1t93]], [[Resolution\|resolution]] 1.62Å' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FLV:FLAVIOLIN'>FLV</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FLV:FLAVIOLIN'>FLV</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1s1f\|1s1f]], [[1se6\|1se6]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1s1f\|1s1f]], [[1se6\|1se6]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1t93 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1t93 OCA], [http://pdbe.org/1t93 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1t93 RCSB], [http://www.ebi.ac.uk/pdbsum/1t93 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1t93 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1t93 OCA], [http://pdbe.org/1t93 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1t93 RCSB], [http://www.ebi.ac.uk/pdbsum/1t93 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1t93 ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 11:		Line 12:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/t9/1t93_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/t9/1t93_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1t93 ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 17:00, 11 September 2015

OCA — Fri, 11 Sep 2015 17:00:27 GMT

←Older revision		Revision as of 17:00, 11 September 2015
Line 2:		Line 2:
	<StructureSection load='1t93' size='340' side='right' caption='[[1t93]], [[Resolution\|resolution]] 1.62Å' scene=''>		<StructureSection load='1t93' size='340' side='right' caption='[[1t93]], [[Resolution\|resolution]] 1.62Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1t93]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Streptomyces_coelicolor Streptomyces coelicolor~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1T93 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1T93 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1t93]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Strco Strco]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1T93 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1T93 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FLV:FLAVIOLIN'>FLV</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FLV:FLAVIOLIN'>FLV</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1s1f\|1s1f]], [[1se6\|1se6]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1s1f\|1s1f]], [[1se6\|1se6]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1t93 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1t93 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1t93 RCSB], [http://www.ebi.ac.uk/pdbsum/1t93 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1t93 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1t93 OCA], [http://pdbe.org/1t93 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1t93 RCSB], [http://www.ebi.ac.uk/pdbsum/1t93 PDBsum]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 25:		Line 25:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1t93" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Streptomyces coelicolor~~]]	+	[[Category: Strco]]
	[[Category: Sundaramoorthy, M]]		[[Category: Sundaramoorthy, M]]
	[[Category: Waterman, M R]]		[[Category: Waterman, M R]]

OCA at 07:18, 6 January 2015

OCA — Tue, 06 Jan 2015 07:18:04 GMT

←Older revision		Revision as of 07:18, 6 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1t93]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Streptomyces_coelicolor Streptomyces coelicolor]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1T93 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1T93 FirstGlance]. <br>		<table><tr><td colspan='2'>[[1t93]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Streptomyces_coelicolor Streptomyces coelicolor]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1T93 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1T93 FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FLV:FLAVIOLIN'>FLV</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FLV:FLAVIOLIN'>FLV</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1s1f\|1s1f]], [[1se6\|1se6]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1s1f\|1s1f]], [[1se6\|1se6]]</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1t93 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1t93 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1t93 RCSB], [http://www.ebi.ac.uk/pdbsum/1t93 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1t93 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1t93 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1t93 RCSB], [http://www.ebi.ac.uk/pdbsum/1t93 PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 30:		Line 30:
	</StructureSection>		</StructureSection>
	[[Category: Streptomyces coelicolor]]		[[Category: Streptomyces coelicolor]]
-	[[Category: Sundaramoorthy, M.]]	+	[[Category: Sundaramoorthy, M]]
-	[[Category: Waterman, M R.]]	+	[[Category: Waterman, M R]]
-	[[Category: Zhao, B.]]	+	[[Category: Zhao, B]]
	[[Category: Cyp158a2]]		[[Category: Cyp158a2]]
	[[Category: Cytochrome p450 oxidoreductase]]		[[Category: Cytochrome p450 oxidoreductase]]

OCA at 18:40, 29 September 2014

OCA — Mon, 29 Sep 2014 18:40:25 GMT

←Older revision		Revision as of 18:40, 29 September 2014
Line 1:		Line 1:
-	[[~~Image:~~1t93.~~png~~\|~~left~~\|200px]]	+	==Evidence for Multiple Substrate Recognition and Molecular Mechanism of C-C reaction by Cytochrome P450 CYP158A2 from Streptomyces Coelicolor A3(2)==
		+	<StructureSection load='1t93' size='340' side='right' caption='[[1t93]], [[Resolution\|resolution]] 1.62Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1t93]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Streptomyces_coelicolor Streptomyces coelicolor]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1T93 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1T93 FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FLV:FLAVIOLIN'>FLV</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1s1f\|1s1f]], [[1se6\|1se6]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1t93 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1t93 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1t93 RCSB], [http://www.ebi.ac.uk/pdbsum/1t93 PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/t9/1t93_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Cytochrome P450 158A2 (CYP158A2) is encoded within a three-gene operon (sco1206-sco1208) in the prototypic soil bacterium Streptomyces coelicolor A3(2). This operon is widely conserved among streptomycetes. CYP158A2 has been suggested to produce polymers of flaviolin, a pigment that may protect microbes from UV radiation, in combination with the adjacent rppA gene, which encodes the type III polyketide synthase, 1,3,6,8-tetrahydroxynaphthalene synthase. Following cloning, expression, and purification of this cytochrome P450, we have shown that it can produce dimer and trimer products from the substrate flaviolin and that the structures of two of the dimeric products were established using mass spectrometry and multiple NMR methods. A comparison of the x-ray structures of ligand-free (1.75 angstroms) and flaviolin-bound (1.62 angstroms) forms of CYP158A2 demonstrates a major conformational change upon ligand binding that closes the entry into the active site, partly due to repositioning of the F and G helices. Particularly interesting is the presence of two molecules of flaviolin in the closed active site. The flaviolin molecules form a quasi-planar three-molecule stack including the heme of CYP158A2, suggesting that oxidative C-C coupling of these phenolic molecules leads to the production of flaviolin dimers.

-	~~{{STRUCTURE_1t93\| PDB=1t93 \| SCENE= }}~~	+	Binding of two flaviolin substrate molecules, oxidative coupling, and crystal structure of Streptomyces coelicolor A3(2) cytochrome P450 158A2.,Zhao B, Guengerich FP, Bellamine A, Lamb DC, Izumikawa M, Lei L, Podust LM, Sundaramoorthy M, Kalaitzis JA, Reddy LM, Kelly SL, Moore BS, Stec D, Voehler M, Falck JR, Shimada T, Waterman MR J Biol Chem. 2005 Mar 25;280(12):11599-607. Epub 2005 Jan 19. PMID:15659395<ref>PMID:15659395</ref>

-	~~===Evidence for Multiple Substrate Recognition and Molecular Mechanism~~ of ~~C-C reaction by Cytochrome P450 CYP158A2 from Streptomyces Coelicolor A3(2)===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_15659395}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[1t93]] is a 1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Streptomyces_coelicolor Streptomyces coelicolor]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=1T93 OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:015659395<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Streptomyces coelicolor]]		[[Category: Streptomyces coelicolor]]
	[[Category: Sundaramoorthy, M.]]		[[Category: Sundaramoorthy, M.]]

OCA: Protected "1t93" [edit=sysop:move=sysop]

OCA — Sat, 05 Jan 2013 11:23:23 GMT

Protected "1t93" [edit=sysop:move=sysop]

←Older revision

Revision as of 11:23, 5 January 2013

OCA at 11:23, 5 January 2013

OCA — Sat, 05 Jan 2013 11:23:21 GMT

←Older revision		Revision as of 11:23, 5 January 2013
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-	{{Seed}}
	[[Image:1t93.png\|left\|200px]]		[[Image:1t93.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_1t93", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_1t93\| PDB=1t93 \| SCENE= }}		{{STRUCTURE_1t93\| PDB=1t93 \| SCENE= }}

	===Evidence for Multiple Substrate Recognition and Molecular Mechanism of C-C reaction by Cytochrome P450 CYP158A2 from Streptomyces Coelicolor A3(2)===		===Evidence for Multiple Substrate Recognition and Molecular Mechanism of C-C reaction by Cytochrome P450 CYP158A2 from Streptomyces Coelicolor A3(2)===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_15659395}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 15659395 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_15659395}}		{{ABSTRACT_PUBMED_15659395}}

	==About this Structure==		==About this Structure==
-	~~1T93~~ is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Streptomyces_coelicolor Streptomyces coelicolor]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1T93 OCA].	+	[[1t93]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Streptomyces_coelicolor Streptomyces coelicolor]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1T93 OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~15659395~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:015659395</ref><references group="xtra"/>
	[[Category: Streptomyces coelicolor]]		[[Category: Streptomyces coelicolor]]
	[[Category: Sundaramoorthy, M.]]		[[Category: Sundaramoorthy, M.]]
Line 31:		Line 19:
	[[Category: Cytochrome p450 oxidoreductase]]		[[Category: Cytochrome p450 oxidoreductase]]
	[[Category: Molecular mechanism]]		[[Category: Molecular mechanism]]
		+	[[Category: Oxidoreductase]]
	[[Category: Streptomyce]]		[[Category: Streptomyce]]
	[[Category: Substrate recognition]]		[[Category: Substrate recognition]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 18 04:18:20 2009''

OCA at 02:18, 18 February 2009

OCA — Wed, 18 Feb 2009 02:18:22 GMT

←Older revision		Revision as of 02:18, 18 February 2009
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	==About this Structure==		==About this Structure==
-	1T93 is a ~~[[Single protein]]~~ structure of sequence from [http://en.wikipedia.org/wiki/Streptomyces_coelicolor Streptomyces coelicolor]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1T93 OCA].	+	1T93 is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Streptomyces_coelicolor Streptomyces coelicolor]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1T93 OCA].

	==Reference==		==Reference==
-	Binding of two flaviolin substrate molecules, oxidative coupling, and crystal structure of Streptomyces coelicolor A3(2) cytochrome P450 158A2., Zhao B, Guengerich FP, Bellamine A, Lamb DC, Izumikawa M, Lei L, Podust LM, Sundaramoorthy M, Kalaitzis JA, Reddy LM, Kelly SL, Moore BS, Stec D, Voehler M, Falck JR, Shimada T, Waterman MR, J Biol Chem. 2005 Mar 25;280(12):11599-607. Epub 2005 Jan 19. PMID:~~[http:~~//~~www.ncbi.nlm.nih.gov/pubmed/15659395 15659395]~~	+	<ref group="xtra">PMID:15659395</ref><references group="xtra"/>
-	~~[[Category: Single protein]]~~	+
	[[Category: Streptomyces coelicolor]]		[[Category: Streptomyces coelicolor]]
	[[Category: Sundaramoorthy, M.]]		[[Category: Sundaramoorthy, M.]]
Line 35:		Line 34:
	[[Category: Substrate recognition]]		[[Category: Substrate recognition]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Tue Jul 29 10~~:55:~~46 2008~~''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 18 04:18:20 2009''