1tbp - Revision history

OCA at 08:38, 14 February 2024

OCA — Wed, 14 Feb 2024 08:38:23 GMT

←Older revision		Revision as of 08:38, 14 February 2024
Line 3:		Line 3:
	<StructureSection load='1tbp' size='340' side='right'caption='[[1tbp]], [[Resolution\|resolution]] 2.60Å' scene=''>		<StructureSection load='1tbp' size='340' side='right'caption='[[1tbp]], [[Resolution\|resolution]] 2.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1tbp]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Atcc_18824 Atcc 18824~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TBP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1TBP FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1tbp]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TBP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1TBP FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1tbp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tbp OCA], [https://pdbe.org/1tbp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1tbp RCSB], [https://www.ebi.ac.uk/pdbsum/1tbp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1tbp ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.6Å</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1tbp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tbp OCA], [https://pdbe.org/1tbp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1tbp RCSB], [https://www.ebi.ac.uk/pdbsum/1tbp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1tbp ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/TBP_YEAST TBP_YEAST]] General transcription factor that functions at the core of the DNA-binding general transcription factor complex TFIID. Binding of TFIID to a promoter (with or without TATA element) is the initial step in preinitiation complex (PIC) formation. TFIID plays a key role in the regulation of gene expression by RNA polymerase II through different activities such as transcription activator interaction, core promoter recognition and selectivity, TFIIA and TFIIB interaction, chromatin modification (histone acetylation by TAF1), facilitation of DNA opening and initiation of transcription.<ref>PMID:9618449</ref> <ref>PMID:12138208</ref> <ref>PMID:12516863</ref>	+	[https://www.uniprot.org/uniprot/TBP_YEAST TBP_YEAST] General transcription factor that functions at the core of the DNA-binding general transcription factor complex TFIID. Binding of TFIID to a promoter (with or without TATA element) is the initial step in preinitiation complex (PIC) formation. TFIID plays a key role in the regulation of gene expression by RNA polymerase II through different activities such as transcription activator interaction, core promoter recognition and selectivity, TFIIA and TFIIB interaction, chromatin modification (histone acetylation by TAF1), facilitation of DNA opening and initiation of transcription.<ref>PMID:9618449</ref> <ref>PMID:12138208</ref> <ref>PMID:12516863</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 18:		Line 19:
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1tbp ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1tbp ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
-	<div style="background-color:#fffaf0;">
-	== Publication Abstract from PubMed ==
-	The C-terminal 179-aa region of yeast (Saccharomyces cerevisiae) TATA-binding protein (TBP), phylogenetically conserved and sufficient for many functions, formed crystals diffracting to 1.7-A resolution. The structure of the protein, determined by molecular replacement with coordinates from Arabidopsis TBP and refined to 2.6 A, differed from that in Arabidopsis slightly by an angle of about 12 degrees between two structurally nearly identical subdomains, indicative of a degree of conformational flexibility. A model for TBP-DNA interaction is proposed with the following important features: the long dimension of the protein follows the trajectory of the minor groove; two rows of basic residues conserved between the subdomains lie along the edges of the protein in proximity to the DNA phosphates; a band of hydrophobic residues runs down the middle of the groove; and amino acid residues whose mutation alters specificity for the second base of the TATA sequence are juxtaposed to that base.
-
-	Crystal structure of yeast TATA-binding protein and model for interaction with DNA.,Chasman DI, Flaherty KM, Sharp PA, Kornberg RD Proc Natl Acad Sci U S A. 1993 Sep 1;90(17):8174-8. PMID:8367480<ref>PMID:8367480</ref>
-
-	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	</div>
-	<div class="pdbe-citations 1tbp" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 34:		Line 26:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Atcc 18824]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Chasman, D I~~]]	+	[[Category: Saccharomyces cerevisiae]]
-	[[Category: ~~Flaherty, K M~~]]	+	[[Category: Chasman DI]]
-	[[Category: ~~Kornberg, R D~~]]	+	[[Category: Flaherty KM]]
-	[[Category: ~~Sharp, P A~~]]	+	[[Category: Kornberg RD]]
-	[[Category: ~~Binding protein~~]]	+	[[Category: Sharp PA]]

OCA at 09:25, 29 September 2021

OCA — Wed, 29 Sep 2021 09:25:09 GMT

←Older revision		Revision as of 09:25, 29 September 2021
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	<StructureSection load='1tbp' size='340' side='right'caption='[[1tbp]], [[Resolution\|resolution]] 2.60Å' scene=''>		<StructureSection load='1tbp' size='340' side='right'caption='[[1tbp]], [[Resolution\|resolution]] 2.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1tbp]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Atcc_18824 Atcc 18824]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TBP OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1TBP FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1tbp]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Atcc_18824 Atcc 18824]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TBP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1TBP FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1tbp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tbp OCA], [~~http~~://pdbe.org/1tbp PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1tbp RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1tbp PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1tbp ProSAT]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1tbp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tbp OCA], [https://pdbe.org/1tbp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1tbp RCSB], [https://www.ebi.ac.uk/pdbsum/1tbp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1tbp ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/TBP_YEAST TBP_YEAST]] General transcription factor that functions at the core of the DNA-binding general transcription factor complex TFIID. Binding of TFIID to a promoter (with or without TATA element) is the initial step in preinitiation complex (PIC) formation. TFIID plays a key role in the regulation of gene expression by RNA polymerase II through different activities such as transcription activator interaction, core promoter recognition and selectivity, TFIIA and TFIIB interaction, chromatin modification (histone acetylation by TAF1), facilitation of DNA opening and initiation of transcription.<ref>PMID:9618449</ref> <ref>PMID:12138208</ref> <ref>PMID:12516863</ref>	+	[[https://www.uniprot.org/uniprot/TBP_YEAST TBP_YEAST]] General transcription factor that functions at the core of the DNA-binding general transcription factor complex TFIID. Binding of TFIID to a promoter (with or without TATA element) is the initial step in preinitiation complex (PIC) formation. TFIID plays a key role in the regulation of gene expression by RNA polymerase II through different activities such as transcription activator interaction, core promoter recognition and selectivity, TFIIA and TFIIB interaction, chromatin modification (histone acetylation by TAF1), facilitation of DNA opening and initiation of transcription.<ref>PMID:9618449</ref> <ref>PMID:12138208</ref> <ref>PMID:12516863</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 29:		Line 29:

	==See Also==		==See Also==
-	*[[TATA-~~Binding Protein~~\|TATA-~~Binding Protein~~]]	+	*[[TATA-binding protein 3D structures\|TATA-binding protein 3D structures]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 13:52, 18 December 2019

OCA — Wed, 18 Dec 2019 13:52:50 GMT

←Older revision		Revision as of 13:52, 18 December 2019
Line 1:		Line 1:

	==CRYSTAL STRUCTURE OF YEAST TATA-BINDING PROTEIN AND MODEL FOR INTERACTION WITH DNA==		==CRYSTAL STRUCTURE OF YEAST TATA-BINDING PROTEIN AND MODEL FOR INTERACTION WITH DNA==
-	<StructureSection load='1tbp' size='340' side='right' caption='[[1tbp]], [[Resolution\|resolution]] 2.60Å' scene=''>	+	<StructureSection load='1tbp' size='340' side='right'caption='[[1tbp]], [[Resolution\|resolution]] 2.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1tbp]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_18824 Atcc 18824]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TBP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1TBP FirstGlance]. <br>		<table><tr><td colspan='2'>[[1tbp]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_18824 Atcc 18824]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TBP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1TBP FirstGlance]. <br>
Line 35:		Line 35:
	</StructureSection>		</StructureSection>
	[[Category: Atcc 18824]]		[[Category: Atcc 18824]]
		+	[[Category: Large Structures]]
	[[Category: Chasman, D I]]		[[Category: Chasman, D I]]
	[[Category: Flaherty, K M]]		[[Category: Flaherty, K M]]

OCA at 07:37, 14 March 2018

OCA — Wed, 14 Mar 2018 07:37:27 GMT

←Older revision		Revision as of 07:37, 14 March 2018
Line 1:		Line 1:
		+
	==CRYSTAL STRUCTURE OF YEAST TATA-BINDING PROTEIN AND MODEL FOR INTERACTION WITH DNA==		==CRYSTAL STRUCTURE OF YEAST TATA-BINDING PROTEIN AND MODEL FOR INTERACTION WITH DNA==
	<StructureSection load='1tbp' size='340' side='right' caption='[[1tbp]], [[Resolution\|resolution]] 2.60Å' scene=''>		<StructureSection load='1tbp' size='340' side='right' caption='[[1tbp]], [[Resolution\|resolution]] 2.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1tbp]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_18824 Atcc 18824]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TBP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1TBP FirstGlance]. <br>		<table><tr><td colspan='2'>[[1tbp]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_18824 Atcc 18824]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TBP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1TBP FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1tbp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tbp OCA], [http://pdbe.org/1tbp PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1tbp RCSB], [http://www.ebi.ac.uk/pdbsum/1tbp PDBsum]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1tbp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tbp OCA], [http://pdbe.org/1tbp PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1tbp RCSB], [http://www.ebi.ac.uk/pdbsum/1tbp PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1tbp ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 11:		Line 12:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/tb/1tbp_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/tb/1tbp_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1tbp ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 13:40, 11 September 2015

OCA — Fri, 11 Sep 2015 13:40:44 GMT

←Older revision		Revision as of 13:40, 11 September 2015
Line 2:		Line 2:
	<StructureSection load='1tbp' size='340' side='right' caption='[[1tbp]], [[Resolution\|resolution]] 2.60Å' scene=''>		<StructureSection load='1tbp' size='340' side='right' caption='[[1tbp]], [[Resolution\|resolution]] 2.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1tbp]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Saccharomyces_cerevisiae Saccharomyces cerevisiae~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TBP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1TBP FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1tbp]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_18824 Atcc 18824]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TBP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1TBP FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1tbp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tbp OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1tbp RCSB], [http://www.ebi.ac.uk/pdbsum/1tbp PDBsum]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1tbp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tbp OCA], [http://pdbe.org/1tbp PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1tbp RCSB], [http://www.ebi.ac.uk/pdbsum/1tbp PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 25:		Line 25:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1tbp" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 32:		Line 33:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Saccharomyces cerevisiae~~]]	+	[[Category: Atcc 18824]]
	[[Category: Chasman, D I]]		[[Category: Chasman, D I]]
	[[Category: Flaherty, K M]]		[[Category: Flaherty, K M]]

OCA at 17:12, 25 December 2014

OCA — Thu, 25 Dec 2014 17:12:41 GMT

←Older revision		Revision as of 17:12, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1tbp]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TBP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1TBP FirstGlance]. <br>		<table><tr><td colspan='2'>[[1tbp]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TBP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1TBP FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1tbp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tbp OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1tbp RCSB], [http://www.ebi.ac.uk/pdbsum/1tbp PDBsum]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1tbp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tbp OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1tbp RCSB], [http://www.ebi.ac.uk/pdbsum/1tbp PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/TBP_YEAST TBP_YEAST]] General transcription factor that functions at the core of the DNA-binding general transcription factor complex TFIID. Binding of TFIID to a promoter (with or without TATA element) is the initial step in preinitiation complex (PIC) formation. TFIID plays a key role in the regulation of gene expression by RNA polymerase II through different activities such as transcription activator interaction, core promoter recognition and selectivity, TFIIA and TFIIB interaction, chromatin modification (histone acetylation by TAF1), facilitation of DNA opening and initiation of transcription.<ref>PMID:9618449</ref> <ref>PMID:12138208</ref> <ref>PMID:12516863</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 31:		Line 33:
	</StructureSection>		</StructureSection>
	[[Category: Saccharomyces cerevisiae]]		[[Category: Saccharomyces cerevisiae]]
-	[[Category: Chasman, D I.]]	+	[[Category: Chasman, D I]]
-	[[Category: Flaherty, K M.]]	+	[[Category: Flaherty, K M]]
-	[[Category: Kornberg, R D.]]	+	[[Category: Kornberg, R D]]
-	[[Category: Sharp, P A.]]	+	[[Category: Sharp, P A]]
	[[Category: Binding protein]]		[[Category: Binding protein]]

OCA at 22:18, 28 September 2014

OCA — Sun, 28 Sep 2014 22:18:48 GMT

←Older revision		Revision as of 22:18, 28 September 2014
Line 1:		Line 1:
-	[[~~Image~~:1tbp.~~png\|left~~\|200px]]	+	==CRYSTAL STRUCTURE OF YEAST TATA-BINDING PROTEIN AND MODEL FOR INTERACTION WITH DNA==
		+	<StructureSection load='1tbp' size='340' side='right' caption='[[1tbp]], [[Resolution\|resolution]] 2.60Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1tbp]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TBP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1TBP FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1tbp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tbp OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1tbp RCSB], [http://www.ebi.ac.uk/pdbsum/1tbp PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/tb/1tbp_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The C-terminal 179-aa region of yeast (Saccharomyces cerevisiae) TATA-binding protein (TBP), phylogenetically conserved and sufficient for many functions, formed crystals diffracting to 1.7-A resolution. The structure of the protein, determined by molecular replacement with coordinates from Arabidopsis TBP and refined to 2.6 A, differed from that in Arabidopsis slightly by an angle of about 12 degrees between two structurally nearly identical subdomains, indicative of a degree of conformational flexibility. A model for TBP-DNA interaction is proposed with the following important features: the long dimension of the protein follows the trajectory of the minor groove; two rows of basic residues conserved between the subdomains lie along the edges of the protein in proximity to the DNA phosphates; a band of hydrophobic residues runs down the middle of the groove; and amino acid residues whose mutation alters specificity for the second base of the TATA sequence are juxtaposed to that base.

-	~~{{STRUCTURE_1tbp\| PDB=1tbp \| SCENE= }}~~	+	Crystal structure of yeast TATA-binding protein and model for interaction with DNA.,Chasman DI, Flaherty KM, Sharp PA, Kornberg RD Proc Natl Acad Sci U S A. 1993 Sep 1;90(17):8174-8. PMID:8367480<ref>PMID:8367480</ref>

-	~~===CRYSTAL STRUCTURE OF YEAST TATA-BINDING PROTEIN AND MODEL FOR INTERACTION WITH DNA===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_8367480}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[1tbp]] is~~ a ~~2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=1TBP OCA].~~	+

	==See Also==		==See Also==
	*[[TATA-Binding Protein\|TATA-Binding Protein]]		*[[TATA-Binding Protein\|TATA-Binding Protein]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:008367480<~~/~~ref~~><~~references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Saccharomyces cerevisiae]]		[[Category: Saccharomyces cerevisiae]]
	[[Category: Chasman, D I.]]		[[Category: Chasman, D I.]]

OCA at 19:19, 20 October 2012

OCA — Sat, 20 Oct 2012 19:19:13 GMT

←Older revision		Revision as of 19:19, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[1tbp]] is a 2 chain structure ~~of [[TATA-Binding Protein]]~~ with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TBP OCA].	+	[[1tbp]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TBP OCA].

	==See Also==		==See Also==
Line 14:		Line 14:

	==Reference==		==Reference==
-	<ref group="xtra">PMID:008367480~~</ref><ref group="xtra">PMID:012215419~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:008367480</ref><references group="xtra"/>
	[[Category: Saccharomyces cerevisiae]]		[[Category: Saccharomyces cerevisiae]]
	[[Category: Chasman, D I.]]		[[Category: Chasman, D I.]]

OCA at 06:57, 27 July 2012

OCA — Fri, 27 Jul 2012 06:57:49 GMT

←Older revision		Revision as of 06:57, 27 July 2012
Line 1:		Line 1:
	[[Image:1tbp.png\|left\|200px]]		[[Image:1tbp.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_1tbp", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_1tbp\| PDB=1tbp \| SCENE= }}		{{STRUCTURE_1tbp\| PDB=1tbp \| SCENE= }}

	===CRYSTAL STRUCTURE OF YEAST TATA-BINDING PROTEIN AND MODEL FOR INTERACTION WITH DNA===		===CRYSTAL STRUCTURE OF YEAST TATA-BINDING PROTEIN AND MODEL FOR INTERACTION WITH DNA===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_8367480}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 8367480 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_8367480}}		{{ABSTRACT_PUBMED_8367480}}

Line 22:		Line 11:

	==See Also==		==See Also==
-	*[[TATA-Binding Protein]]	+	*[[TATA-Binding Protein\|TATA-Binding Protein]]

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~8367480~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:008367480</ref><ref group="xtra">PMID:012215419</ref><references group="xtra"/>
	[[Category: Saccharomyces cerevisiae]]		[[Category: Saccharomyces cerevisiae]]
	[[Category: Chasman, D I.]]		[[Category: Chasman, D I.]]

OCA: Protected "1tbp" [edit=sysop:move=sysop]

OCA — Sun, 26 Dec 2010 23:55:12 GMT

Protected "1tbp" [edit=sysop:move=sysop]

←Older revision

Revision as of 23:55, 26 December 2010