1tcj - Revision history

OCA at 06:03, 5 July 2023

OCA — Wed, 05 Jul 2023 06:03:38 GMT

←Older revision		Revision as of 06:03, 5 July 2023
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	==STRUCTURE-ACTIVITY RELATIONSHIPS OF MU-CONOTOXIN GIIIA: STRUCTURE DETERMINATION OF ACTIVE AND INACTIVE SODIUM CHANNEL BLOCKER PEPTIDES BY NMR AND SIMULATED ANNEALING CALCULATIONS==		==STRUCTURE-ACTIVITY RELATIONSHIPS OF MU-CONOTOXIN GIIIA: STRUCTURE DETERMINATION OF ACTIVE AND INACTIVE SODIUM CHANNEL BLOCKER PEPTIDES BY NMR AND SIMULATED ANNEALING CALCULATIONS==
-	<StructureSection load='1tcj' size='340' side='right'caption='[[1tcj~~]], [[NMR_Ensembles_of_Models \| 10 NMR models~~]]' scene=''>	+	<StructureSection load='1tcj' size='340' side='right'caption='[[1tcj]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1tcj]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Conge Conge~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TCJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1TCJ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1tcj]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Conus_geographus Conus geographus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TCJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1TCJ FirstGlance]. <br>
-	</td></tr><tr id='~~NonStdRes~~'><td class="sblockLbl"><b>[[~~Non-Standard_Residue~~\|~~NonStd Res~~:]]</b></td><td class="sblockDat"~~><scene name~~=~~'pdbligand=HYP:4-HYDROXYPROLINE'>HYP</scene>, <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene~~></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"><~~div style~~='~~overflow~~: ~~auto; max~~-~~height~~: ~~3em;~~'>~~[[1tcg\|1tcg]]~~</~~div~~></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HYP:4-HYDROXYPROLINE'>HYP</scene>, <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1tcj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tcj OCA], [https://pdbe.org/1tcj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1tcj RCSB], [https://www.ebi.ac.uk/pdbsum/1tcj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1tcj ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1tcj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tcj OCA], [https://pdbe.org/1tcj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1tcj RCSB], [https://www.ebi.ac.uk/pdbsum/1tcj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1tcj ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/CM3A_CONGE CM3A_CONGE]] Mu-conotoxins block voltage-gated sodium channels (Nav). This toxin potently blocks Nav1.4/SCN4A. It also moderately blocks rNav1.1/SCN1A, rNav1.2/SCN2A, and mNav1.6/SCN8A. The inhibition is reversible. Induces paralysis in vertebrates.<ref>PMID:18950653</ref> <ref>PMID:21652775</ref> <ref>PMID:2410412</ref>	+	[https://www.uniprot.org/uniprot/CM3A_CONGE CM3A_CONGE] Mu-conotoxins block voltage-gated sodium channels (Nav). This toxin potently blocks Nav1.4/SCN4A. It also moderately blocks rNav1.1/SCN1A, rNav1.2/SCN2A, and mNav1.6/SCN8A. The inhibition is reversible. Induces paralysis in vertebrates.<ref>PMID:18950653</ref> <ref>PMID:21652775</ref> <ref>PMID:2410412</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 23:		Line 23:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Conge~~]]	+	[[Category: Conus geographus]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Inagaki, F]]	+	[[Category: Inagaki F]]
-	[[Category: Kohda, D]]	+	[[Category: Kohda D]]
-	[[Category: Lancelin, J M]]	+	[[Category: Lancelin J-M]]
-	[[Category: Wakamatsu, K]]	+	[[Category: Wakamatsu K]]
-	~~[[Category: Neurotoxin~~]]	+

OCA at 09:25, 29 September 2021

OCA — Wed, 29 Sep 2021 09:25:43 GMT

←Older revision		Revision as of 09:25, 29 September 2021
Line 3:		Line 3:
	<StructureSection load='1tcj' size='340' side='right'caption='[[1tcj]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>		<StructureSection load='1tcj' size='340' side='right'caption='[[1tcj]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1tcj]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Conge Conge]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TCJ OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1TCJ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1tcj]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Conge Conge]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TCJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1TCJ FirstGlance]. <br>
	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=HYP:4-HYDROXYPROLINE'>HYP</scene>, <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=HYP:4-HYDROXYPROLINE'>HYP</scene>, <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1tcg\|1tcg]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1tcg\|1tcg]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1tcj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tcj OCA], [~~http~~://pdbe.org/1tcj PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1tcj RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1tcj PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1tcj ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1tcj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tcj OCA], [https://pdbe.org/1tcj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1tcj RCSB], [https://www.ebi.ac.uk/pdbsum/1tcj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1tcj ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/CM3A_CONGE CM3A_CONGE]] Mu-conotoxins block voltage-gated sodium channels (Nav). This toxin potently blocks Nav1.4/SCN4A. It also moderately blocks rNav1.1/SCN1A, rNav1.2/SCN2A, and mNav1.6/SCN8A. The inhibition is reversible. Induces paralysis in vertebrates.<ref>PMID:18950653</ref> <ref>PMID:21652775</ref> <ref>PMID:2410412</ref>	+	[[https://www.uniprot.org/uniprot/CM3A_CONGE CM3A_CONGE]] Mu-conotoxins block voltage-gated sodium channels (Nav). This toxin potently blocks Nav1.4/SCN4A. It also moderately blocks rNav1.1/SCN1A, rNav1.2/SCN2A, and mNav1.6/SCN8A. The inhibition is reversible. Induces paralysis in vertebrates.<ref>PMID:18950653</ref> <ref>PMID:21652775</ref> <ref>PMID:2410412</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 11:49, 4 December 2019

OCA — Wed, 04 Dec 2019 11:49:32 GMT

←Older revision		Revision as of 11:49, 4 December 2019
Line 1:		Line 1:

	==STRUCTURE-ACTIVITY RELATIONSHIPS OF MU-CONOTOXIN GIIIA: STRUCTURE DETERMINATION OF ACTIVE AND INACTIVE SODIUM CHANNEL BLOCKER PEPTIDES BY NMR AND SIMULATED ANNEALING CALCULATIONS==		==STRUCTURE-ACTIVITY RELATIONSHIPS OF MU-CONOTOXIN GIIIA: STRUCTURE DETERMINATION OF ACTIVE AND INACTIVE SODIUM CHANNEL BLOCKER PEPTIDES BY NMR AND SIMULATED ANNEALING CALCULATIONS==
-	<StructureSection load='1tcj' size='340' side='right' caption='[[1tcj]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>	+	<StructureSection load='1tcj' size='340' side='right'caption='[[1tcj]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1tcj]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Conge Conge]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TCJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1TCJ FirstGlance]. <br>		<table><tr><td colspan='2'>[[1tcj]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Conge Conge]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TCJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1TCJ FirstGlance]. <br>
Line 24:		Line 24:
	</StructureSection>		</StructureSection>
	[[Category: Conge]]		[[Category: Conge]]
		+	[[Category: Large Structures]]
	[[Category: Inagaki, F]]		[[Category: Inagaki, F]]
	[[Category: Kohda, D]]		[[Category: Kohda, D]]

OCA at 06:58, 29 November 2017

OCA — Wed, 29 Nov 2017 06:58:36 GMT

←Older revision		Revision as of 06:58, 29 November 2017
Line 1:		Line 1:
		+
	==STRUCTURE-ACTIVITY RELATIONSHIPS OF MU-CONOTOXIN GIIIA: STRUCTURE DETERMINATION OF ACTIVE AND INACTIVE SODIUM CHANNEL BLOCKER PEPTIDES BY NMR AND SIMULATED ANNEALING CALCULATIONS==		==STRUCTURE-ACTIVITY RELATIONSHIPS OF MU-CONOTOXIN GIIIA: STRUCTURE DETERMINATION OF ACTIVE AND INACTIVE SODIUM CHANNEL BLOCKER PEPTIDES BY NMR AND SIMULATED ANNEALING CALCULATIONS==
	<StructureSection load='1tcj' size='340' side='right' caption='[[1tcj]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>		<StructureSection load='1tcj' size='340' side='right' caption='[[1tcj]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=HYP:4-HYDROXYPROLINE'>HYP</scene>, <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=HYP:4-HYDROXYPROLINE'>HYP</scene>, <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1tcg\|1tcg]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1tcg\|1tcg]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1tcj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tcj OCA], [http://pdbe.org/1tcj PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1tcj RCSB], [http://www.ebi.ac.uk/pdbsum/1tcj PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1tcj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tcj OCA], [http://pdbe.org/1tcj PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1tcj RCSB], [http://www.ebi.ac.uk/pdbsum/1tcj PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1tcj ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==

OCA at 14:34, 10 September 2015

OCA — Thu, 10 Sep 2015 14:34:32 GMT

←Older revision		Revision as of 14:34, 10 September 2015
Line 2:		Line 2:
	<StructureSection load='1tcj' size='340' side='right' caption='[[1tcj]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>		<StructureSection load='1tcj' size='340' side='right' caption='[[1tcj]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1tcj]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Conus_geographus Conus geographus~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TCJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1TCJ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1tcj]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Conge Conge]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TCJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1TCJ FirstGlance]. <br>
	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=HYP:4-HYDROXYPROLINE'>HYP</scene>, <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=HYP:4-HYDROXYPROLINE'>HYP</scene>, <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1tcg\|1tcg]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1tcg\|1tcg]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1tcj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tcj OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1tcj RCSB], [http://www.ebi.ac.uk/pdbsum/1tcj PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1tcj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tcj OCA], [http://pdbe.org/1tcj PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1tcj RCSB], [http://www.ebi.ac.uk/pdbsum/1tcj PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[http://www.uniprot.org/uniprot/~~CXM3A_CONGE CXM3A_CONGE~~]] Mu-conotoxins block voltage-gated sodium channels (Nav). This toxin potently blocks Nav1.4/SCN4A. It also moderately blocks rNav1.1/SCN1A, rNav1.2/SCN2A, and mNav1.6/SCN8A. The inhibition is reversible. Induces paralysis in vertebrates.<ref>PMID:~~2410412~~</ref> <ref>PMID:~~18950653~~</ref> <ref>PMID:~~21652775~~</ref>	+	[[http://www.uniprot.org/uniprot/CM3A_CONGE CM3A_CONGE]] Mu-conotoxins block voltage-gated sodium channels (Nav). This toxin potently blocks Nav1.4/SCN4A. It also moderately blocks rNav1.1/SCN1A, rNav1.2/SCN2A, and mNav1.6/SCN8A. The inhibition is reversible. Induces paralysis in vertebrates.<ref>PMID:18950653</ref> <ref>PMID:21652775</ref> <ref>PMID:2410412</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 17:		Line 17:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1tcj" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Conus geographus~~]]	+	[[Category: Conge]]
	[[Category: Inagaki, F]]		[[Category: Inagaki, F]]
	[[Category: Kohda, D]]		[[Category: Kohda, D]]

OCA at 01:34, 25 December 2014

OCA — Thu, 25 Dec 2014 01:34:19 GMT

←Older revision		Revision as of 01:34, 25 December 2014
Line 7:		Line 7:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1tcj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tcj OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1tcj RCSB], [http://www.ebi.ac.uk/pdbsum/1tcj PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1tcj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tcj OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1tcj RCSB], [http://www.ebi.ac.uk/pdbsum/1tcj PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/CXM3A_CONGE CXM3A_CONGE]] Mu-conotoxins block voltage-gated sodium channels (Nav). This toxin potently blocks Nav1.4/SCN4A. It also moderately blocks rNav1.1/SCN1A, rNav1.2/SCN2A, and mNav1.6/SCN8A. The inhibition is reversible. Induces paralysis in vertebrates.<ref>PMID:2410412</ref> <ref>PMID:18950653</ref> <ref>PMID:21652775</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 06:48, 22 December 2014

OCA — Mon, 22 Dec 2014 06:48:57 GMT

←Older revision		Revision as of 06:48, 22 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1tcj]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Conus_geographus Conus geographus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TCJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1TCJ FirstGlance]. <br>		<table><tr><td colspan='2'>[[1tcj]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Conus_geographus Conus geographus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TCJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1TCJ FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=HYP:4-HYDROXYPROLINE'>HYP</scene>, <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>	+	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=HYP:4-HYDROXYPROLINE'>HYP</scene>, <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1tcg\|1tcg]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1tcg\|1tcg]]</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1tcj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tcj OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1tcj RCSB], [http://www.ebi.ac.uk/pdbsum/1tcj PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1tcj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tcj OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1tcj RCSB], [http://www.ebi.ac.uk/pdbsum/1tcj PDBsum]</span></td></tr>
-	<table>	+	</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 20:		Line 20:
	</StructureSection>		</StructureSection>
	[[Category: Conus geographus]]		[[Category: Conus geographus]]
-	[[Category: Inagaki, F.]]	+	[[Category: Inagaki, F]]
-	[[Category: Kohda, D.]]	+	[[Category: Kohda, D]]
-	[[Category: Lancelin, J M.]]	+	[[Category: Lancelin, J M]]
-	[[Category: Wakamatsu, K.]]	+	[[Category: Wakamatsu, K]]
	[[Category: Neurotoxin]]		[[Category: Neurotoxin]]

OCA: Protected "1tcj" [edit=sysop:move=sysop]

OCA — Mon, 09 Jun 2014 07:10:54 GMT

Protected "1tcj" [edit=sysop:move=sysop]

←Older revision

Revision as of 07:10, 9 June 2014

OCA at 07:10, 9 June 2014

OCA — Mon, 09 Jun 2014 07:10:52 GMT

←Older revision		Revision as of 07:10, 9 June 2014
Line 1:		Line 1:
-	~~{{Seed}}~~	+	==STRUCTURE-ACTIVITY RELATIONSHIPS OF MU-CONOTOXIN GIIIA: STRUCTURE DETERMINATION OF ACTIVE AND INACTIVE SODIUM CHANNEL BLOCKER PEPTIDES BY NMR AND SIMULATED ANNEALING CALCULATIONS==
-	[[~~Image:~~1tcj.~~png~~\|~~left~~\|~~200px~~]]	+	<StructureSection load='1tcj' size='340' side='right' caption='[[1tcj]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1tcj]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Conus_geographus Conus geographus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TCJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1TCJ FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=HYP:4-HYDROXYPROLINE'>HYP</scene>, <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1tcg\|1tcg]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1tcj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tcj OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1tcj RCSB], [http://www.ebi.ac.uk/pdbsum/1tcj PDBsum]</span></td></tr>
		+	<table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	A synthetic replacement study of the amino acid residues of mu-conotoxin GIIIA, a peptide blocker for muscle sodium channels, has recently shown that the conformation formed by three disulfide bridges and the molecular basicity, especially the one around the Arg13 residue, are important for blocking activity. In the present study, we determined the three-dimensional structure of an inactive analog, [Ala13]mu-conotoxin GIIIA, and refined that of the native toxin by NMR spectroscopy combined with simulated annealing calculations. The atomic root-mean-square difference of the mutant from the native conotoxin was 0.62 A for the backbone atoms (N, C alpha, C') of all residues except for the two terminal residues. The observation that the replacement of Arg13 by Ala13 does not significantly change the molecular conformation suggests that the loss of activity is not due to the conformational change but to the direct interaction of the essential Arg13 residue with the sodium channel molecules. In the determined structure, important residues for the activity, Arg13, Lys16, Hyp(hydroxyproline)17, and Arg19, are clustered on one side of the molecule, an observation which suggests that this face of the molecule associates with the receptor site of sodium channels. The hydroxyl group of Hyp17 is suggested to interact with the channel site with which the essential hydroxyl groups of tetrodotoxin and saxitoxin interact.

-	<!--	+	Structure-activity relationships of mu-conotoxin GIIIA: structure determination of active and inactive sodium channel blocker peptides by NMR and simulated annealing calculations.,Wakamatsu K, Kohda D, Hatanaka H, Lancelin JM, Ishida Y, Oya M, Nakamura H, Inagaki F, Sato K Biochemistry. 1992 Dec 22;31(50):12577-84. PMID:1335283<ref>PMID:1335283</ref>
-	~~The line below this paragraph~~, ~~containing "STRUCTURE_1tcj"~~, ~~creates the "Structure Box" on the page~~.	+
-	~~You may change the PDB parameter~~ (~~which sets the PDB file loaded into the applet~~)	+
-	~~or the SCENE parameter (which sets the initial scene displayed when the page is loaded),~~	+
-	~~or leave the SCENE parameter empty for the default display.~~	+
-	-->	+
-	~~{{STRUCTURE_1tcj\| PDB=1tcj \| SCENE= }}~~	+

-	~~===STRUCTURE-ACTIVITY RELATIONSHIPS OF MU-CONOTOXIN GIIIA: STRUCTURE DETERMINATION OF ACTIVE AND INACTIVE SODIUM CHANNEL BLOCKER PEPTIDES BY NMR AND SIMULATED ANNEALING CALCULATIONS===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-		+	== References ==
-	~~<!--~~	+	<references/>
-	~~The line below this paragraph~~, ~~{{ABSTRACT_PUBMED_1335283}}, adds~~ the ~~Publication Abstract to the page~~	+	__TOC__
-	~~(as it appears on PubMed at http://www~~.~~pubmed~~.~~gov), where 1335283 is the PubMed ID number~~.	+	</StructureSection>
-	-->	+
-	~~{{ABSTRACT_PUBMED_1335283}}~~	+
-		+
-	==~~About this Structure~~==	+
-	~~1TCJ is a [[Single protein]] structure of sequence from [http:~~/~~/en.wikipedia.org/wiki/Conus_geographus Conus geographus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TCJ OCA].~~	+
-		+
-	~~==Reference==~~	+
-	Structure-activity relationships of mu-conotoxin GIIIA: structure determination of active and inactive sodium channel blocker peptides by NMR and simulated annealing calculations., Wakamatsu K, Kohda D, Hatanaka H, Lancelin JM, Ishida Y, Oya M, Nakamura H, Inagaki F, Sato K, Biochemistry. 1992 Dec 22;31(50):12577-84. PMID:[http:/~~/www.ncbi.nlm.nih.gov/pubmed/1335283 1335283]~~	+
	[[Category: Conus geographus]]		[[Category: Conus geographus]]
-	[[Category: Single protein]]
	[[Category: Inagaki, F.]]		[[Category: Inagaki, F.]]
	[[Category: Kohda, D.]]		[[Category: Kohda, D.]]
Line 31:		Line 25:
	[[Category: Wakamatsu, K.]]		[[Category: Wakamatsu, K.]]
	[[Category: Neurotoxin]]		[[Category: Neurotoxin]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 06:02:04 2008''

OCA at 03:02, 28 July 2008

OCA — Mon, 28 Jul 2008 03:02:11 GMT

←Older revision		Revision as of 03:02, 28 July 2008
Line 1:		Line 1:
-	[[Image:1tcj.~~jpg~~\|left\|200px]]	+	{{Seed}}
		+	[[Image:1tcj.png\|left\|200px]]

	<!--		<!--
Line 9:		Line 10:
	{{STRUCTURE_1tcj\| PDB=1tcj \| SCENE= }}		{{STRUCTURE_1tcj\| PDB=1tcj \| SCENE= }}

-	~~'''~~STRUCTURE-ACTIVITY RELATIONSHIPS OF MU-CONOTOXIN GIIIA: STRUCTURE DETERMINATION OF ACTIVE AND INACTIVE SODIUM CHANNEL BLOCKER PEPTIDES BY NMR AND SIMULATED ANNEALING CALCULATIONS~~'''~~	+	===STRUCTURE-ACTIVITY RELATIONSHIPS OF MU-CONOTOXIN GIIIA: STRUCTURE DETERMINATION OF ACTIVE AND INACTIVE SODIUM CHANNEL BLOCKER PEPTIDES BY NMR AND SIMULATED ANNEALING CALCULATIONS===


-	~~==Overview==~~	+	<!--
-	~~A synthetic replacement study of the amino acid residues of mu~~-conotoxin GIIIA, a peptide blocker for muscle sodium channels, has recently shown that the conformation formed by three disulfide bridges and the molecular basicity, especially the one around the Arg13 residue, are important for blocking activity. In the present study, we determined the three-~~dimensional structure of an inactive analog, [Ala13]mu-conotoxin GIIIA, and refined that of the native toxin by NMR spectroscopy combined with simulated annealing calculations.~~ The ~~atomic root-mean-square difference of the mutant from the native conotoxin was 0.62 A for the backbone atoms (N~~, ~~C alpha~~, ~~C') of all residues except for~~ the ~~two terminal residues. The observation that the replacement of Arg13 by Ala13 does not significantly change the molecular conformation suggests that the loss of activity is not due~~ to the ~~conformational change but to the direct interaction of the essential Arg13 residue with the sodium channel molecules~~. ~~In the determined structure, important residues for the activity, Arg13, Lys16, Hyp(hydroxyproline~~)17, ~~and Arg19, are clustered on one side of the molecule, an observation which suggests that this face of the molecule associates with the receptor site of sodium channels. The hydroxyl group of Hyp17~~ is ~~suggested to interact with~~ the ~~channel site with which the essential hydroxyl groups of tetrodotoxin and saxitoxin interact~~.	+	The line below this paragraph, {{ABSTRACT_PUBMED_1335283}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 1335283 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_1335283}}

	==About this Structure==		==About this Structure==
-	1TCJ is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Conus_geographus Conus geographus]. Full ~~crystallographic~~ information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TCJ OCA].	+	1TCJ is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Conus_geographus Conus geographus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TCJ OCA].

	==Reference==		==Reference==
Line 27:		Line 31:
	[[Category: Wakamatsu, K.]]		[[Category: Wakamatsu, K.]]
	[[Category: Neurotoxin]]		[[Category: Neurotoxin]]
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Sat May 3 09~~:47:49 2008''	+
		+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 06:02:04 2008''