1tf7 - Revision history

OCA at 08:39, 14 February 2024

OCA — Wed, 14 Feb 2024 08:39:10 GMT

←Older revision		Revision as of 08:39, 14 February 2024
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	<StructureSection load='1tf7' size='340' side='right'caption='[[1tf7]], [[Resolution\|resolution]] 2.80Å' scene=''>		<StructureSection load='1tf7' size='340' side='right'caption='[[1tf7]], [[Resolution\|resolution]] 2.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1tf7]] is a 6 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Synsp Synsp~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TF7 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=1TF7 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1tf7]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Synechococcus_sp. Synechococcus sp.]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TF7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1TF7 FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=ATP:ADENOSINE~~-~~5-TRIPHOSPHATE'>ATP</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.8Å</td></tr>
-	<tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat">~~PCC7942 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode~~=~~Info&srchmode~~=5~~&id=1131 SYNSP])~~</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=1tf7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tf7 OCA], [~~http~~://pdbe.org/1tf7 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1tf7 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1tf7 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1tf7 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1tf7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tf7 OCA], [https://pdbe.org/1tf7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1tf7 RCSB], [https://www.ebi.ac.uk/pdbsum/1tf7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1tf7 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/KAIC_SYNE7 KAIC_SYNE7]] Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction.<ref>PMID:9727980</ref> <ref>PMID:14709675</ref>	+	[https://www.uniprot.org/uniprot/KAIC_SYNE7 KAIC_SYNE7] Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction.<ref>PMID:9727980</ref> <ref>PMID:14709675</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 20:		Line 20:
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1tf7 ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1tf7 ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
-	<div style="background-color:#fffaf0;">
-	== Publication Abstract from PubMed ==
-	Circadian (daily) biological clocks express characteristics that are difficult to explain by known biochemical mechanisms, and will ultimately require characterizing the structures, functions, and interactions of their molecular components. KaiC is an essential circadian protein in cyanobacteria that forms the core of the KaiABC clock protein complex. We report the crystal structure of the KaiC homohexameric complex at 2.8 A resolution. The structure resembles a double doughnut with a central pore that is partially sealed at one end. The crystal structure reveals ATP binding, inter-subunit organization, a scaffold for Kai-protein complex formation, the location of critical KaiC mutations, and evolutionary relationships to other proteins. A key auto-phosphorylation site on KaiC (T432) is identified from the crystal structure, and mutation of this residue abolishes circadian rhythmicity. The crystal structure of KaiC will be essential for understanding this circadian clockwork and for establishing its links to global gene expression.
-
-	Visualizing a circadian clock protein: crystal structure of KaiC and functional insights.,Pattanayek R, Wang J, Mori T, Xu Y, Johnson CH, Egli M Mol Cell. 2004 Aug 13;15(3):375-88. PMID:15304218<ref>PMID:15304218</ref>
-
-	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	</div>
-	<div class="pdbe-citations 1tf7" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
-	*[[Circadian Clock Protein KaiC\|Circadian Clock Protein KaiC]]
	*[[Circadian clock protein 3D structures\|Circadian clock protein 3D structures]]		*[[Circadian clock protein 3D structures\|Circadian clock protein 3D structures]]
	== References ==		== References ==
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	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Synsp~~]]	+	[[Category: Synechococcus sp]]
-	[[Category: Egli, M]]	+	[[Category: Egli M]]
-	[[Category: Johnson~~, C H~~]]	+	[[Category: Johnson CH]]
-	[[Category: Mori, T]]	+	[[Category: Mori T]]
-	[[Category: Pattanayek, R]]	+	[[Category: Pattanayek R]]
-	[[Category: Wang, J]]	+	[[Category: Wang J]]
-	[[Category: Xu, Y]]	+	[[Category: Xu Y]]
-	~~[[Category: Circadian clock protein]]~~	+
-	~~[[Category: Hexamer]]~~	+
-	~~[[Category: Homohexamer~~]]	+

OCA at 11:50, 24 December 2020

OCA — Thu, 24 Dec 2020 11:50:38 GMT

←Older revision		Revision as of 11:50, 24 December 2020
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	==Crystal Structure of Circadian Clock Protein KaiC==		==Crystal Structure of Circadian Clock Protein KaiC==
-	<StructureSection load='1tf7' size='340' side='right' caption='[[1tf7]], [[Resolution\|resolution]] 2.80Å' scene=''>	+	<StructureSection load='1tf7' size='340' side='right'caption='[[1tf7]], [[Resolution\|resolution]] 2.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1tf7]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Synsp Synsp]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TF7 OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1TF7 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1tf7]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Synsp Synsp]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TF7 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=1TF7 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PCC7942 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1131 SYNSP])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PCC7942 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1131 SYNSP])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1tf7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tf7 OCA], [http://pdbe.org/1tf7 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1tf7 RCSB], [http://www.ebi.ac.uk/pdbsum/1tf7 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1tf7 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=1tf7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tf7 OCA], [http://pdbe.org/1tf7 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1tf7 RCSB], [http://www.ebi.ac.uk/pdbsum/1tf7 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1tf7 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 32:		Line 32:
	==See Also==		==See Also==
	*[[Circadian Clock Protein KaiC\|Circadian Clock Protein KaiC]]		*[[Circadian Clock Protein KaiC\|Circadian Clock Protein KaiC]]
-	*[[Circadian clock protein\|Circadian clock protein]]	+	*[[Circadian clock protein 3D structures\|Circadian clock protein 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Synsp]]		[[Category: Synsp]]
	[[Category: Egli, M]]		[[Category: Egli, M]]

OCA at 07:24, 14 March 2018

OCA — Wed, 14 Mar 2018 07:24:32 GMT

←Older revision		Revision as of 07:24, 14 March 2018
Line 1:		Line 1:
		+
	==Crystal Structure of Circadian Clock Protein KaiC==		==Crystal Structure of Circadian Clock Protein KaiC==
	<StructureSection load='1tf7' size='340' side='right' caption='[[1tf7]], [[Resolution\|resolution]] 2.80Å' scene=''>		<StructureSection load='1tf7' size='340' side='right' caption='[[1tf7]], [[Resolution\|resolution]] 2.80Å' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PCC7942 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1131 SYNSP])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PCC7942 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1131 SYNSP])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1tf7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tf7 OCA], [http://pdbe.org/1tf7 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1tf7 RCSB], [http://www.ebi.ac.uk/pdbsum/1tf7 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1tf7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tf7 OCA], [http://pdbe.org/1tf7 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1tf7 RCSB], [http://www.ebi.ac.uk/pdbsum/1tf7 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1tf7 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 13:		Line 14:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/tf/1tf7_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/tf/1tf7_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 23:10, 9 February 2016

OCA — Tue, 09 Feb 2016 23:10:10 GMT

←Older revision		Revision as of 23:10, 9 February 2016
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	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1tf7 ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 02:58, 11 September 2015

OCA — Fri, 11 Sep 2015 02:58:29 GMT

←Older revision		Revision as of 02:58, 11 September 2015
Line 2:		Line 2:
	<StructureSection load='1tf7' size='340' side='right' caption='[[1tf7]], [[Resolution\|resolution]] 2.80Å' scene=''>		<StructureSection load='1tf7' size='340' side='right' caption='[[1tf7]], [[Resolution\|resolution]] 2.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1tf7]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Synechococcus_sp. Synechococcus sp.~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TF7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1TF7 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1tf7]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Synsp Synsp]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TF7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1TF7 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PCC7942 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1131 ~~Synechococcus sp.~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PCC7942 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1131 SYNSP])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1tf7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tf7 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1tf7 RCSB], [http://www.ebi.ac.uk/pdbsum/1tf7 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1tf7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tf7 OCA], [http://pdbe.org/1tf7 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1tf7 RCSB], [http://www.ebi.ac.uk/pdbsum/1tf7 PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 27:		Line 27:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1tf7" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 35:		Line 36:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Synechococcus sp~~]]	+	[[Category: Synsp]]
	[[Category: Egli, M]]		[[Category: Egli, M]]
	[[Category: Johnson, C H]]		[[Category: Johnson, C H]]

OCA at 10:09, 25 December 2014

OCA — Thu, 25 Dec 2014 10:09:07 GMT

←Older revision		Revision as of 10:09, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1tf7]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Synechococcus_sp. Synechococcus sp.]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TF7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1TF7 FirstGlance]. <br>		<table><tr><td colspan='2'>[[1tf7]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Synechococcus_sp. Synechococcus sp.]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TF7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1TF7 FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PCC7942 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1131 Synechococcus sp.])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PCC7942 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1131 Synechococcus sp.])</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1tf7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tf7 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1tf7 RCSB], [http://www.ebi.ac.uk/pdbsum/1tf7 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1tf7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tf7 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1tf7 RCSB], [http://www.ebi.ac.uk/pdbsum/1tf7 PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/KAIC_SYNE7 KAIC_SYNE7]] Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction.<ref>PMID:9727980</ref> <ref>PMID:14709675</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 33:		Line 35:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Synechococcus sp.]]	+	[[Category: Synechococcus sp]]
-	[[Category: Egli, M.]]	+	[[Category: Egli, M]]
-	[[Category: Johnson, C H.]]	+	[[Category: Johnson, C H]]
-	[[Category: Mori, T.]]	+	[[Category: Mori, T]]
-	[[Category: Pattanayek, R.]]	+	[[Category: Pattanayek, R]]
-	[[Category: Wang, J.]]	+	[[Category: Wang, J]]
-	[[Category: Xu, Y.]]	+	[[Category: Xu, Y]]
	[[Category: Circadian clock protein]]		[[Category: Circadian clock protein]]
	[[Category: Hexamer]]		[[Category: Hexamer]]
	[[Category: Homohexamer]]		[[Category: Homohexamer]]

OCA at 21:15, 29 September 2014

OCA — Mon, 29 Sep 2014 21:15:03 GMT

←Older revision		Revision as of 21:15, 29 September 2014
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-	~~{{STRUCTURE_1tf7~~\| ~~PDB~~=1tf7 \| ~~SCENE~~= }}	+	==Crystal Structure of Circadian Clock Protein KaiC==
-	===~~Crystal Structure~~ of ~~Circadian Clock Protein KaiC~~===	+	<StructureSection load='1tf7' size='340' side='right' caption='[[1tf7]], [[Resolution\|resolution]] 2.80Å' scene=''>
-	~~{{ABSTRACT_PUBMED_15304218}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1tf7]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Synechococcus_sp. Synechococcus sp.]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TF7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1TF7 FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PCC7942 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1131 Synechococcus sp.])</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1tf7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tf7 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1tf7 RCSB], [http://www.ebi.ac.uk/pdbsum/1tf7 PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/tf/1tf7_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Circadian (daily) biological clocks express characteristics that are difficult to explain by known biochemical mechanisms, and will ultimately require characterizing the structures, functions, and interactions of their molecular components. KaiC is an essential circadian protein in cyanobacteria that forms the core of the KaiABC clock protein complex. We report the crystal structure of the KaiC homohexameric complex at 2.8 A resolution. The structure resembles a double doughnut with a central pore that is partially sealed at one end. The crystal structure reveals ATP binding, inter-subunit organization, a scaffold for Kai-protein complex formation, the location of critical KaiC mutations, and evolutionary relationships to other proteins. A key auto-phosphorylation site on KaiC (T432) is identified from the crystal structure, and mutation of this residue abolishes circadian rhythmicity. The crystal structure of KaiC will be essential for understanding this circadian clockwork and for establishing its links to global gene expression.

-	~~==About this Structure==~~	+	Visualizing a circadian clock protein: crystal structure of KaiC and functional insights.,Pattanayek R, Wang J, Mori T, Xu Y, Johnson CH, Egli M Mol Cell. 2004 Aug 13;15(3):375-88. PMID:15304218<ref>PMID:15304218</ref>
-	~~[[1tf7]] is~~ a ~~6 chain~~ structure ~~with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Synechococcus_sp~~. ~~Synechococcus sp.]. Full crystallographic information is available from [http~~://~~oca~~.~~weizmann~~.ac.il/~~oca-bin/ocashort?id=1TF7 OCA].~~	+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>

	==See Also==		==See Also==
	*[[Circadian Clock Protein KaiC\|Circadian Clock Protein KaiC]]		*[[Circadian Clock Protein KaiC\|Circadian Clock Protein KaiC]]
-		+	*[[Circadian clock protein\|Circadian clock protein]]
-	==~~Reference~~==	+	== References ==
-	<~~ref group="xtra">PMID:015304218<~~/~~ref~~><~~ref group="xtra">PMID:016628225</ref><references group="xtra"~~/>	+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Synechococcus sp.]]		[[Category: Synechococcus sp.]]
	[[Category: Egli, M.]]		[[Category: Egli, M.]]

OCA at 10:13, 11 March 2013

OCA — Mon, 11 Mar 2013 10:13:40 GMT

←Older revision		Revision as of 10:13, 11 March 2013
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-	[[Image:1tf7.png\|left\|200px]]
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	{{STRUCTURE_1tf7\| PDB=1tf7 \| SCENE= }}		{{STRUCTURE_1tf7\| PDB=1tf7 \| SCENE= }}
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	===Crystal Structure of Circadian Clock Protein KaiC===		===Crystal Structure of Circadian Clock Protein KaiC===
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	{{ABSTRACT_PUBMED_15304218}}		{{ABSTRACT_PUBMED_15304218}}

OCA: Protected "1tf7" [edit=sysop:move=sysop]

OCA — Sat, 05 Jan 2013 12:21:06 GMT

Protected "1tf7" [edit=sysop:move=sysop]

←Older revision

Revision as of 12:21, 5 January 2013

OCA at 12:21, 5 January 2013

OCA — Sat, 05 Jan 2013 12:21:04 GMT

←Older revision		Revision as of 12:21, 5 January 2013
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-	{{Seed}}
	[[Image:1tf7.png\|left\|200px]]		[[Image:1tf7.png\|left\|200px]]

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	{{STRUCTURE_1tf7\| PDB=1tf7 \| SCENE= }}		{{STRUCTURE_1tf7\| PDB=1tf7 \| SCENE= }}

	===Crystal Structure of Circadian Clock Protein KaiC===		===Crystal Structure of Circadian Clock Protein KaiC===

-
-	<!--
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	{{ABSTRACT_PUBMED_15304218}}		{{ABSTRACT_PUBMED_15304218}}

	==About this Structure==		==About this Structure==
-	~~1TF7~~ is a 6 ~~chains~~ structure ~~of sequences~~ from [http://en.wikipedia.org/wiki/Synechococcus_sp. Synechococcus sp.]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TF7 OCA].	+	[[1tf7]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Synechococcus_sp. Synechococcus sp.]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TF7 OCA].
		+
		+	==See Also==
		+	*[[Circadian Clock Protein KaiC\|Circadian Clock Protein KaiC]]

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~15304218~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:015304218</ref><ref group="xtra">PMID:016628225</ref><references group="xtra"/>
	[[Category: Synechococcus sp.]]		[[Category: Synechococcus sp.]]
	[[Category: Egli, M.]]		[[Category: Egli, M.]]
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	[[Category: Wang, J.]]		[[Category: Wang, J.]]
	[[Category: Xu, Y.]]		[[Category: Xu, Y.]]
		+	[[Category: Circadian clock protein]]
	[[Category: Hexamer]]		[[Category: Hexamer]]
	[[Category: Homohexamer]]		[[Category: Homohexamer]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 13:29:10 2009''