1tg6 - Revision history

OCA at 06:29, 23 August 2023

OCA — Wed, 23 Aug 2023 06:29:48 GMT

←Older revision		Revision as of 06:29, 23 August 2023
Line 3:		Line 3:
	<StructureSection load='1tg6' size='340' side='right'caption='[[1tg6]], [[Resolution\|resolution]] 2.10Å' scene=''>		<StructureSection load='1tg6' size='340' side='right'caption='[[1tg6]], [[Resolution\|resolution]] 2.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1tg6]] is a 7 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TG6 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=1TG6 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1tg6]] is a 7 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TG6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1TG6 FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=DIO:1,4~~-~~DIETHYLENE+DIOXIDE'>DIO</scene>~~, ~~<scene name='pdbligand=EDO:~~1~~,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=FME:N-FORMYLMETHIONINE'>FME</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.1Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"><~~div style~~='~~overflow~~: ~~auto; max~~-~~height: 3em;~~'>~~[[1tyf\|1tyf]]~~</~~div~~><~~/td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DIO:1,4-DIETHYLENE+DIOXIDE'>DIO</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=FME:N-FORMYLMETHIONINE'>FME</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
-	~~<tr id~~='~~gene'><td class~~=~~"sblockLbl"><b>[[Gene\|Gene~~:~~]]</b~~></td><~~td class~~=~~"sblockDat">CLPP ([http~~:~~//www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td~~></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1tg6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tg6 OCA], [https://pdbe.org/1tg6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1tg6 RCSB], [https://www.ebi.ac.uk/pdbsum/1tg6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1tg6 ProSAT]</span></td></tr>
-	<~~tr id~~='~~activity'><td class~~=~~"sblockLbl"><b>Activity~~:~~</b></td><td class="sblockDat"><span class='plainlinks~~'>~~[http://en.wikipedia.org/wiki/Endopeptidase_Clp Endopeptidase Clp], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.92 3.4.21.92]~~ </~~span~~></td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=1tg6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tg6 OCA], [~~http~~://pdbe.org/1tg6 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1tg6 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1tg6 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1tg6 ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/CLPP_HUMAN CLPP_HUMAN]] Clp cleaves peptides in various proteins in a process that requires ATP hydrolysis. Clp may be responsible for a fairly general and central housekeeping function rather than for the degradation of specific substrates.	+	[https://www.uniprot.org/uniprot/CLPP_HUMAN CLPP_HUMAN] Clp cleaves peptides in various proteins in a process that requires ATP hydrolysis. Clp may be responsible for a fairly general and central housekeeping function rather than for the degradation of specific substrates.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 34:		Line 32:
	==See Also==		==See Also==
	*[[Clp protease 3D structures\|Clp protease 3D structures]]		*[[Clp protease 3D structures\|Clp protease 3D structures]]
-	*[[Retractions and Fraud\|Retractions and Fraud]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Endopeptidase Clp]]~~	+	[[Category: Homo sapiens]]
-	~~[[Category: Human~~]]	+
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Ahvazi, B]]	+	[[Category: Ahvazi B]]
-	[[Category: Kang~~, S G~~]]	+	[[Category: Kang SG]]
-	[[Category: Maurizi~~, M R~~]]	+	[[Category: Maurizi MR]]
-	[[Category: Mueser, T]]	+	[[Category: Mueser T]]
-	[[Category: Thompson, M]]	+	[[Category: Thompson M]]
-	~~[[Category: Atp-dependent protease]]~~	+
-	~~[[Category: Clp/hsp 100]]~~	+
-	~~[[Category: Hydrolase]]~~	+
-	~~[[Category: Mitochondrial clpp~~]]	+

OCA at 11:51, 24 December 2020

OCA — Thu, 24 Dec 2020 11:51:19 GMT

←Older revision		Revision as of 11:51, 24 December 2020
Line 1:		Line 1:
-	<table cellpadding='5'><tr><td style='background-color: yellow;border:2px solid black;font-size:150%;'>
-	WARNING: This structure was flagged as problematic. For additional information see '''2014, October:''' at [[Retractions and Fraud]].</td></tr></table>

	==Crystallography and mutagenesis point to an essential role for the N-terminus of human mitochondrial ClpP==		==Crystallography and mutagenesis point to an essential role for the N-terminus of human mitochondrial ClpP==
-	<StructureSection load='1tg6' size='340' side='right' caption='[[1tg6]], [[Resolution\|resolution]] 2.10Å' scene=''>	+	<StructureSection load='1tg6' size='340' side='right'caption='[[1tg6]], [[Resolution\|resolution]] 2.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1tg6]] is a 7 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TG6 OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1TG6 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1tg6]] is a 7 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TG6 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=1TG6 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DIO:1,4-DIETHYLENE+DIOXIDE'>DIO</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=FME:N-FORMYLMETHIONINE'>FME</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DIO:1,4-DIETHYLENE+DIOXIDE'>DIO</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=FME:N-FORMYLMETHIONINE'>FME</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1tyf\|1tyf]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1tyf\|1tyf]]</div></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CLPP ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CLPP ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Endopeptidase_Clp Endopeptidase Clp], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.92 3.4.21.92] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Endopeptidase_Clp Endopeptidase Clp], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.92 3.4.21.92] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1tg6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tg6 OCA], [http://pdbe.org/1tg6 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1tg6 RCSB], [http://www.ebi.ac.uk/pdbsum/1tg6 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1tg6 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=1tg6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tg6 OCA], [http://pdbe.org/1tg6 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1tg6 RCSB], [http://www.ebi.ac.uk/pdbsum/1tg6 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1tg6 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 35:		Line 33:

	==See Also==		==See Also==
-	*[[Clp ~~Protease~~\|Clp ~~Protease~~]]	+	*[[Clp protease 3D structures\|Clp protease 3D structures]]
	*[[Retractions and Fraud\|Retractions and Fraud]]		*[[Retractions and Fraud\|Retractions and Fraud]]
	== References ==		== References ==
Line 43:		Line 41:
	[[Category: Endopeptidase Clp]]		[[Category: Endopeptidase Clp]]
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Ahvazi, B]]		[[Category: Ahvazi, B]]
	[[Category: Kang, S G]]		[[Category: Kang, S G]]

OCA at 16:32, 4 April 2018

OCA — Wed, 04 Apr 2018 16:32:58 GMT

←Older revision		Revision as of 16:32, 4 April 2018
Line 1:		Line 1:
		+	<table cellpadding='5'><tr><td style='background-color: yellow;border:2px solid black;font-size:150%;'>
		+	WARNING: This structure was flagged as problematic. For additional information see '''2014, October:''' at [[Retractions and Fraud]].</td></tr></table>

	==Crystallography and mutagenesis point to an essential role for the N-terminus of human mitochondrial ClpP==		==Crystallography and mutagenesis point to an essential role for the N-terminus of human mitochondrial ClpP==
Line 33:		Line 35:

	==See Also==		==See Also==
		+	*[[Clp Protease\|Clp Protease]]
	*[[Retractions and Fraud\|Retractions and Fraud]]		*[[Retractions and Fraud\|Retractions and Fraud]]
	== References ==		== References ==

OCA at 06:32, 31 January 2018

OCA — Wed, 31 Jan 2018 06:32:06 GMT

←Older revision		Revision as of 06:32, 31 January 2018
Line 1:		Line 1:
-	<table cellpadding='5'><tr><td style='background-color: yellow;border:2px solid black;font-size:150%;'>
-	WARNING: This structure was flagged as problematic. For additional information see '''2014, October:''' at [[Retractions and Fraud]].</td></tr></table>

	==Crystallography and mutagenesis point to an essential role for the N-terminus of human mitochondrial ClpP==		==Crystallography and mutagenesis point to an essential role for the N-terminus of human mitochondrial ClpP==
	<StructureSection load='1tg6' size='340' side='right' caption='[[1tg6]], [[Resolution\|resolution]] 2.10Å' scene=''>		<StructureSection load='1tg6' size='340' side='right' caption='[[1tg6]], [[Resolution\|resolution]] 2.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1tg6]] is a 7 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TG6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1TG6 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1tg6]] is a 7 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TG6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1TG6 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DIO:1,4-DIETHYLENE+DIOXIDE'>DIO</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=FME:N-FORMYLMETHIONINE'>FME</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DIO:1,4-DIETHYLENE+DIOXIDE'>DIO</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=FME:N-FORMYLMETHIONINE'>FME</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1tyf\|1tyf]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1tyf\|1tyf]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CLPP ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Endopeptidase_Clp Endopeptidase Clp], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.92 3.4.21.92] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Endopeptidase_Clp Endopeptidase Clp], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.92 3.4.21.92] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1tg6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tg6 OCA], [http://pdbe.org/1tg6 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1tg6 RCSB], [http://www.ebi.ac.uk/pdbsum/1tg6 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1tg6 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1tg6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tg6 OCA], [http://pdbe.org/1tg6 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1tg6 RCSB], [http://www.ebi.ac.uk/pdbsum/1tg6 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1tg6 ProSAT]</span></td></tr>
Line 17:		Line 16:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/tg/1tg6_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/tg/1tg6_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 34:		Line 33:

	==See Also==		==See Also==
-	*[[Clp Protease\|Clp Protease]]
	*[[Retractions and Fraud\|Retractions and Fraud]]		*[[Retractions and Fraud\|Retractions and Fraud]]
	== References ==		== References ==
Line 41:		Line 39:
	</StructureSection>		</StructureSection>
	[[Category: Endopeptidase Clp]]		[[Category: Endopeptidase Clp]]
		+	[[Category: Human]]
	[[Category: Ahvazi, B]]		[[Category: Ahvazi, B]]
	[[Category: Kang, S G]]		[[Category: Kang, S G]]

OCA at 11:59, 23 March 2017

OCA — Thu, 23 Mar 2017 11:59:16 GMT

←Older revision		Revision as of 11:59, 23 March 2017
Line 1:		Line 1:
		+	<table cellpadding='5'><tr><td style='background-color: yellow;border:2px solid black;font-size:150%;'>
		+	WARNING: This structure was flagged as problematic. For additional information see '''2014, October:''' at [[Retractions and Fraud]].</td></tr></table>

	==Crystallography and mutagenesis point to an essential role for the N-terminus of human mitochondrial ClpP==		==Crystallography and mutagenesis point to an essential role for the N-terminus of human mitochondrial ClpP==

OCA at 18:40, 10 December 2016

OCA — Sat, 10 Dec 2016 18:40:35 GMT

←Older revision		Revision as of 18:40, 10 December 2016
Line 1:		Line 1:
		+
	==Crystallography and mutagenesis point to an essential role for the N-terminus of human mitochondrial ClpP==		==Crystallography and mutagenesis point to an essential role for the N-terminus of human mitochondrial ClpP==
	<StructureSection load='1tg6' size='340' side='right' caption='[[1tg6]], [[Resolution\|resolution]] 2.10Å' scene=''>		<StructureSection load='1tg6' size='340' side='right' caption='[[1tg6]], [[Resolution\|resolution]] 2.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1tg6]] is a 7 chain structure ~~with sequence from [http://en.wikipedia.org/wiki/Human Human]~~. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TG6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1TG6 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1tg6]] is a 7 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TG6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1TG6 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DIO:1,4-DIETHYLENE+DIOXIDE'>DIO</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=FME:N-FORMYLMETHIONINE'>FME</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DIO:1,4-DIETHYLENE+DIOXIDE'>DIO</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=FME:N-FORMYLMETHIONINE'>FME</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1tyf\|1tyf]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1tyf\|1tyf]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CLPP ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Endopeptidase_Clp Endopeptidase Clp], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.92 3.4.21.92] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Endopeptidase_Clp Endopeptidase Clp], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.92 3.4.21.92] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1tg6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tg6 OCA], [http://pdbe.org/1tg6 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1tg6 RCSB], [http://www.ebi.ac.uk/pdbsum/1tg6 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1tg6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tg6 OCA], [http://pdbe.org/1tg6 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1tg6 RCSB], [http://www.ebi.ac.uk/pdbsum/1tg6 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1tg6 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 19:		Line 19:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1tg6 ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 39:		Line 39:
	</StructureSection>		</StructureSection>
	[[Category: Endopeptidase Clp]]		[[Category: Endopeptidase Clp]]
-	[[Category: Human]]
	[[Category: Ahvazi, B]]		[[Category: Ahvazi, B]]
	[[Category: Kang, S G]]		[[Category: Kang, S G]]

OCA at 22:19, 11 September 2015

OCA — Fri, 11 Sep 2015 22:19:44 GMT

←Older revision		Revision as of 22:19, 11 September 2015
Line 2:		Line 2:
	<StructureSection load='1tg6' size='340' side='right' caption='[[1tg6]], [[Resolution\|resolution]] 2.10Å' scene=''>		<StructureSection load='1tg6' size='340' side='right' caption='[[1tg6]], [[Resolution\|resolution]] 2.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1tg6]] is a 7 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TG6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1TG6 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1tg6]] is a 7 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TG6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1TG6 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DIO:1,4-DIETHYLENE+DIOXIDE'>DIO</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=FME:N-FORMYLMETHIONINE'>FME</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DIO:1,4-DIETHYLENE+DIOXIDE'>DIO</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=FME:N-FORMYLMETHIONINE'>FME</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1tyf\|1tyf]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1tyf\|1tyf]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CLPP ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CLPP ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Endopeptidase_Clp Endopeptidase Clp], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.92 3.4.21.92] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Endopeptidase_Clp Endopeptidase Clp], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.92 3.4.21.92] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1tg6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tg6 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1tg6 RCSB], [http://www.ebi.ac.uk/pdbsum/1tg6 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1tg6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tg6 OCA], [http://pdbe.org/1tg6 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1tg6 RCSB], [http://www.ebi.ac.uk/pdbsum/1tg6 PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 29:		Line 29:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1tg6" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 38:		Line 39:
	</StructureSection>		</StructureSection>
	[[Category: Endopeptidase Clp]]		[[Category: Endopeptidase Clp]]
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Ahvazi, B]]		[[Category: Ahvazi, B]]
	[[Category: Kang, S G]]		[[Category: Kang, S G]]

OCA at 20:15, 25 December 2014

OCA — Thu, 25 Dec 2014 20:15:16 GMT

←Older revision		Revision as of 20:15, 25 December 2014
Line 1:		Line 1:
-	<table cellpadding='5'><tr><td style='background-color: yellow;border:2px solid black;font-size:150%;'>
-	WARNING: This structure was flagged as problematic. For additional information see '''2014, October:''' at [[Retractions and Fraud]].</td></tr></table>
	==Crystallography and mutagenesis point to an essential role for the N-terminus of human mitochondrial ClpP==		==Crystallography and mutagenesis point to an essential role for the N-terminus of human mitochondrial ClpP==
	<StructureSection load='1tg6' size='340' side='right' caption='[[1tg6]], [[Resolution\|resolution]] 2.10Å' scene=''>		<StructureSection load='1tg6' size='340' side='right' caption='[[1tg6]], [[Resolution\|resolution]] 2.10Å' scene=''>
Line 11:		Line 9:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1tg6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tg6 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1tg6 RCSB], [http://www.ebi.ac.uk/pdbsum/1tg6 PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1tg6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tg6 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1tg6 RCSB], [http://www.ebi.ac.uk/pdbsum/1tg6 PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/CLPP_HUMAN CLPP_HUMAN]] Clp cleaves peptides in various proteins in a process that requires ATP hydrolysis. Clp may be responsible for a fairly general and central housekeeping function rather than for the degradation of specific substrates.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 08:18, 18 November 2014

OCA — Tue, 18 Nov 2014 08:18:25 GMT

←Older revision		Revision as of 08:18, 18 November 2014
Line 1:		Line 1:
		+	<table cellpadding='5'><tr><td style='background-color: yellow;border:2px solid black;font-size:150%;'>
		+	WARNING: This structure was flagged as problematic. For additional information see '''2014, October:''' at [[Retractions and Fraud]].</td></tr></table>
	==Crystallography and mutagenesis point to an essential role for the N-terminus of human mitochondrial ClpP==		==Crystallography and mutagenesis point to an essential role for the N-terminus of human mitochondrial ClpP==
	<StructureSection load='1tg6' size='340' side='right' caption='[[1tg6]], [[Resolution\|resolution]] 2.10Å' scene=''>		<StructureSection load='1tg6' size='340' side='right' caption='[[1tg6]], [[Resolution\|resolution]] 2.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1tg6]] is a 7 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TG6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1TG6 FirstGlance]. <br>		<table><tr><td colspan='2'>[[1tg6]] is a 7 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TG6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1TG6 FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DIO:1,4-DIETHYLENE+DIOXIDE'>DIO</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=FME:N-FORMYLMETHIONINE'>FME</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DIO:1,4-DIETHYLENE+DIOXIDE'>DIO</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=FME:N-FORMYLMETHIONINE'>FME</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1tyf\|1tyf]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1tyf\|1tyf]]</td></tr>
-	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CLPP ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CLPP ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
-	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Endopeptidase_Clp Endopeptidase Clp], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.92 3.4.21.92] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Endopeptidase_Clp Endopeptidase Clp], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.92 3.4.21.92] </span></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1tg6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tg6 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1tg6 RCSB], [http://www.ebi.ac.uk/pdbsum/1tg6 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1tg6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tg6 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1tg6 RCSB], [http://www.ebi.ac.uk/pdbsum/1tg6 PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 30:		Line 32:
	==See Also==		==See Also==
	*[[Clp Protease\|Clp Protease]]		*[[Clp Protease\|Clp Protease]]
		+	*[[Retractions and Fraud\|Retractions and Fraud]]
	== References ==		== References ==
	<references/>		<references/>
Line 36:		Line 39:
	[[Category: Endopeptidase Clp]]		[[Category: Endopeptidase Clp]]
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Ahvazi, B.]]	+	[[Category: Ahvazi, B]]
-	[[Category: Kang, S G.]]	+	[[Category: Kang, S G]]
-	[[Category: Maurizi, M R.]]	+	[[Category: Maurizi, M R]]
-	[[Category: Mueser, T.]]	+	[[Category: Mueser, T]]
-	[[Category: Thompson, M.]]	+	[[Category: Thompson, M]]
	[[Category: Atp-dependent protease]]		[[Category: Atp-dependent protease]]
	[[Category: Clp/hsp 100]]		[[Category: Clp/hsp 100]]
	[[Category: Hydrolase]]		[[Category: Hydrolase]]
	[[Category: Mitochondrial clpp]]		[[Category: Mitochondrial clpp]]

OCA at 21:10, 28 September 2014

OCA — Sun, 28 Sep 2014 21:10:50 GMT

←Older revision		Revision as of 21:10, 28 September 2014
Line 1:		Line 1:
-	[[~~Image:~~1tg6.~~png~~\|~~left~~\|200px]]	+	==Crystallography and mutagenesis point to an essential role for the N-terminus of human mitochondrial ClpP==
		+	<StructureSection load='1tg6' size='340' side='right' caption='[[1tg6]], [[Resolution\|resolution]] 2.10Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1tg6]] is a 7 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TG6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1TG6 FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DIO:1,4-DIETHYLENE+DIOXIDE'>DIO</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=FME:N-FORMYLMETHIONINE'>FME</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1tyf\|1tyf]]</td></tr>
		+	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CLPP ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
		+	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Endopeptidase_Clp Endopeptidase Clp], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.92 3.4.21.92] </span></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1tg6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tg6 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1tg6 RCSB], [http://www.ebi.ac.uk/pdbsum/1tg6 PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/tg/1tg6_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	We have determined a 2.1 A crystal structure for human mitochondrial ClpP (hClpP), the proteolytic component of the ATP-dependent ClpXP protease. HClpP has a structure similar to that of the bacterial enzyme, with the proteolytic active sites sequestered within an aqueous chamber formed by face-to-face assembly of the two heptameric rings. The hydrophobic N-terminal peptides of the subunits are bound within the narrow (12 A) axial channel, positioned to interact with unfolded substrates translocated there by the associated ClpX chaperone. Mutation or deletion of these residues causes a drastic decrease in ClpX-mediated protein and peptide degradation. Residues 8-16 form a mobile loop that extends above the ring surface and is also required for activity. The 28 amino acid C-terminal domain, a unique feature of mammalian ClpP proteins, lies on the periphery of the ring, with its proximal portion forming a loop that extends out from the ring surface. Residues at the start of the C-terminal domain impinge on subunit interfaces within the ring and affect heptamer assembly and stability. We propose that the N-terminal peptide of ClpP is a structural component of the substrate translocation channel and may play an important functional role as well.

-	~~{{STRUCTURE_1tg6\| PDB=1tg6 \| SCENE= }}~~	+	Crystallography and mutagenesis point to an essential role for the N-terminus of human mitochondrial ClpP.,Kang SG, Maurizi MR, Thompson M, Mueser T, Ahvazi B J Struct Biol. 2004 Dec;148(3):338-52. PMID:15522782<ref>PMID:15522782</ref>

-	~~===Crystallography and mutagenesis point to an essential role for~~ the ~~N-terminus of human mitochondrial ClpP===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_15522782}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[1tg6]] is a 7 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Homo_sapiens Homo sapiens]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=1TG6 OCA].~~	+

	==See Also==		==See Also==
	*[[Clp Protease\|Clp Protease]]		*[[Clp Protease\|Clp Protease]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:015522782<~~/~~ref~~><~~references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Endopeptidase Clp]]		[[Category: Endopeptidase Clp]]
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]