1tlk - Revision history

OCA at 08:40, 14 February 2024

OCA — Wed, 14 Feb 2024 08:40:22 GMT

←Older revision		Revision as of 08:40, 14 February 2024
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	<StructureSection load='1tlk' size='340' side='right'caption='[[1tlk]], [[Resolution\|resolution]] 2.80Å' scene=''>		<StructureSection load='1tlk' size='340' side='right'caption='[[1tlk]], [[Resolution\|resolution]] 2.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1tlk]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Melga Melga~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TLK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1TLK FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1tlk]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Meleagris_gallopavo Meleagris gallopavo]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TLK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1TLK FirstGlance]. <br>
-	</td></tr><tr id='~~activity~~'><td class="sblockLbl"><b>~~Activity~~:</b></td><td class="sblockDat"~~><span class~~=~~'plainlinks'~~>[~~https://en.wikipedia.org/wiki/~~[~~Myosin_light-chain~~]~~_kinase [Myosin light-chain~~] ~~kinase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=~~2.~~7.11.18 2.7.11.18] </span>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.8Å</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1tlk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tlk OCA], [https://pdbe.org/1tlk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1tlk RCSB], [https://www.ebi.ac.uk/pdbsum/1tlk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1tlk ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1tlk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tlk OCA], [https://pdbe.org/1tlk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1tlk RCSB], [https://www.ebi.ac.uk/pdbsum/1tlk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1tlk ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/MYLK_MELGA MYLK_MELGA]] Corresponds to the C-terminus of smooth muscle myosin light chain kinase.	+	[https://www.uniprot.org/uniprot/MYLK_MELGA MYLK_MELGA] Corresponds to the C-terminus of smooth muscle myosin light chain kinase.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1tlk ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1tlk ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
-	<div style="background-color:#fffaf0;">
-	== Publication Abstract from PubMed ==
-	The three-dimensional structure of telokin, an acidic protein identical to the C-terminal portion of smooth muscle myosin light chain kinase from turkey gizzard, has been determined at 2.8 A resolution and refined to a crystallographic R-factor of 19.5% for all measured X-ray data from 30 A to 2.8 A. Crystals used in the investigation belonged to the space group P3(2)21, with one molecule per asymmetric unit and unit cell dimensions of a = b = 64.4 A and c = 50.6 A. Telokin contains 154 amino acid residues, 103 of which were visible in the electron density map. The overall molecular fold of telokin consists of seven strands of antiparallel beta-pleated sheet that wrap around to form a barrel. There is also an extended tail of eight amino acid residues at the N terminus that does not participate in beta-sheet formation. The beta-barrel can be simply envisioned as two layers of beta-sheet, nearly parallel to one another, with one layer containing four and the other three beta-strands. This type of beta-barrel, as seen in telokin, was first observed for the CH2 domain of an immunoglobulin fragment Fc. Telokin is an intracellular protein and, as such, does not contain the disulphide linkage between beta-strands B and F normally observed in the immunoglobulin constant domains. It does, however, contain two cysteine amino acid residues (Cys63 and Cys115) that are situated at structurally identical positions to those forming the disulphide linkage in the immunoglobulin constant domain.
-
-	X-ray structure determination of telokin, the C-terminal domain of myosin light chain kinase, at 2.8 A resolution.,Holden HM, Ito M, Hartshorne DJ, Rayment I J Mol Biol. 1992 Oct 5;227(3):840-51. PMID:1404391<ref>PMID:1404391</ref>
-
-	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	</div>
-	<div class="pdbe-citations 1tlk" style="background-color:#fffaf0;"></div>
-	== References ==
-	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Melga~~]]	+	[[Category: Meleagris gallopavo]]
-	[[Category: Holden~~, H M~~]]	+	[[Category: Holden HM]]
-	[[Category: Rayment, I]]	+	[[Category: Rayment I]]
-	~~[[Category: Calmodulin-binding~~]]	+

OCA at 09:29, 29 September 2021

OCA — Wed, 29 Sep 2021 09:29:17 GMT

←Older revision		Revision as of 09:29, 29 September 2021
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	<StructureSection load='1tlk' size='340' side='right'caption='[[1tlk]], [[Resolution\|resolution]] 2.80Å' scene=''>		<StructureSection load='1tlk' size='340' side='right'caption='[[1tlk]], [[Resolution\|resolution]] 2.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1tlk]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Melga Melga]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TLK OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1TLK FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1tlk]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Melga Melga]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TLK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1TLK FirstGlance]. <br>
-	</td></tr><tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/[Myosin_light-chain]_kinase [Myosin light-chain] kinase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.18 2.7.11.18] </span></td></tr>	+	</td></tr><tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/[Myosin_light-chain]_kinase [Myosin light-chain] kinase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.18 2.7.11.18] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1tlk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tlk OCA], [~~http~~://pdbe.org/1tlk PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1tlk RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1tlk PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1tlk ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1tlk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tlk OCA], [https://pdbe.org/1tlk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1tlk RCSB], [https://www.ebi.ac.uk/pdbsum/1tlk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1tlk ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/MYLK_MELGA MYLK_MELGA]] Corresponds to the C-terminus of smooth muscle myosin light chain kinase.	+	[[https://www.uniprot.org/uniprot/MYLK_MELGA MYLK_MELGA]] Corresponds to the C-terminus of smooth muscle myosin light chain kinase.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 11:17, 4 December 2019

OCA — Wed, 04 Dec 2019 11:17:59 GMT

←Older revision		Revision as of 11:17, 4 December 2019
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	==X-RAY STRUCTURE DETERMINATION OF TELOKIN, THE C-TERMINAL DOMAIN OF MYOSIN LIGHT CHAIN KINASE, AT 2.8 ANGSTROMS RESOLUTION==		==X-RAY STRUCTURE DETERMINATION OF TELOKIN, THE C-TERMINAL DOMAIN OF MYOSIN LIGHT CHAIN KINASE, AT 2.8 ANGSTROMS RESOLUTION==
-	<StructureSection load='1tlk' size='340' side='right' caption='[[1tlk]], [[Resolution\|resolution]] 2.80Å' scene=''>	+	<StructureSection load='1tlk' size='340' side='right'caption='[[1tlk]], [[Resolution\|resolution]] 2.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1tlk]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Melga Melga]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TLK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1TLK FirstGlance]. <br>		<table><tr><td colspan='2'>[[1tlk]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Melga Melga]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TLK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1TLK FirstGlance]. <br>
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	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/tl/1tlk_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/tl/1tlk_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 32:		Line 32:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Melga]]		[[Category: Melga]]
	[[Category: Holden, H M]]		[[Category: Holden, H M]]
	[[Category: Rayment, I]]		[[Category: Rayment, I]]
	[[Category: Calmodulin-binding]]		[[Category: Calmodulin-binding]]

OCA at 06:59, 29 November 2017

OCA — Wed, 29 Nov 2017 06:59:06 GMT

←Older revision		Revision as of 06:59, 29 November 2017
Line 1:		Line 1:
		+
	==X-RAY STRUCTURE DETERMINATION OF TELOKIN, THE C-TERMINAL DOMAIN OF MYOSIN LIGHT CHAIN KINASE, AT 2.8 ANGSTROMS RESOLUTION==		==X-RAY STRUCTURE DETERMINATION OF TELOKIN, THE C-TERMINAL DOMAIN OF MYOSIN LIGHT CHAIN KINASE, AT 2.8 ANGSTROMS RESOLUTION==
	<StructureSection load='1tlk' size='340' side='right' caption='[[1tlk]], [[Resolution\|resolution]] 2.80Å' scene=''>		<StructureSection load='1tlk' size='340' side='right' caption='[[1tlk]], [[Resolution\|resolution]] 2.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1tlk]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Common_turkey Common turkey~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TLK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1TLK FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1tlk]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Melga Melga]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TLK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1TLK FirstGlance]. <br>
	</td></tr><tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/[Myosin_light-chain]_kinase [Myosin light-chain] kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.18 2.7.11.18] </span></td></tr>		</td></tr><tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/[Myosin_light-chain]_kinase [Myosin light-chain] kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.18 2.7.11.18] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1tlk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tlk OCA], [http://pdbe.org/1tlk PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1tlk RCSB], [http://www.ebi.ac.uk/pdbsum/1tlk PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1tlk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tlk OCA], [http://pdbe.org/1tlk PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1tlk RCSB], [http://www.ebi.ac.uk/pdbsum/1tlk PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1tlk ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1tlk ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Common turkey~~]]	+	[[Category: Melga]]
	[[Category: Holden, H M]]		[[Category: Holden, H M]]
	[[Category: Rayment, I]]		[[Category: Rayment, I]]
	[[Category: Calmodulin-binding]]		[[Category: Calmodulin-binding]]

OCA at 09:07, 11 September 2015

OCA — Fri, 11 Sep 2015 09:07:17 GMT

←Older revision		Revision as of 09:07, 11 September 2015
Line 2:		Line 2:
	<StructureSection load='1tlk' size='340' side='right' caption='[[1tlk]], [[Resolution\|resolution]] 2.80Å' scene=''>		<StructureSection load='1tlk' size='340' side='right' caption='[[1tlk]], [[Resolution\|resolution]] 2.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1tlk]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Meleagris_gallopavo Meleagris gallopavo~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TLK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1TLK FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1tlk]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Common_turkey Common turkey]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TLK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1TLK FirstGlance]. <br>
	</td></tr><tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/[Myosin_light-chain]_kinase [Myosin light-chain] kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.18 2.7.11.18] </span></td></tr>		</td></tr><tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/[Myosin_light-chain]_kinase [Myosin light-chain] kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.18 2.7.11.18] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1tlk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tlk OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1tlk RCSB], [http://www.ebi.ac.uk/pdbsum/1tlk PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1tlk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tlk OCA], [http://pdbe.org/1tlk PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1tlk RCSB], [http://www.ebi.ac.uk/pdbsum/1tlk PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1tlk" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Meleagris gallopavo~~]]	+	[[Category: Common turkey]]
	[[Category: Holden, H M]]		[[Category: Holden, H M]]
	[[Category: Rayment, I]]		[[Category: Rayment, I]]
	[[Category: Calmodulin-binding]]		[[Category: Calmodulin-binding]]

OCA at 14:15, 25 December 2014

OCA — Thu, 25 Dec 2014 14:15:52 GMT

←Older revision		Revision as of 14:15, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1tlk]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Meleagris_gallopavo Meleagris gallopavo]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TLK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1TLK FirstGlance]. <br>		<table><tr><td colspan='2'>[[1tlk]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Meleagris_gallopavo Meleagris gallopavo]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TLK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1TLK FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/[Myosin_light-chain]_kinase [Myosin light-chain] kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.18 2.7.11.18] </span></td></tr>	+	</td></tr><tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/[Myosin_light-chain]_kinase [Myosin light-chain] kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.18 2.7.11.18] </span></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1tlk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tlk OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1tlk RCSB], [http://www.ebi.ac.uk/pdbsum/1tlk PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1tlk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tlk OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1tlk RCSB], [http://www.ebi.ac.uk/pdbsum/1tlk PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/MYLK_MELGA MYLK_MELGA]] Corresponds to the C-terminus of smooth muscle myosin light chain kinase.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	</StructureSection>		</StructureSection>
	[[Category: Meleagris gallopavo]]		[[Category: Meleagris gallopavo]]
-	[[Category: Holden, H M.]]	+	[[Category: Holden, H M]]
-	[[Category: Rayment, I.]]	+	[[Category: Rayment, I]]
	[[Category: Calmodulin-binding]]		[[Category: Calmodulin-binding]]

OCA at 21:21, 29 September 2014

OCA — Mon, 29 Sep 2014 21:21:22 GMT

←Older revision		Revision as of 21:21, 29 September 2014
Line 1:		Line 1:
-	[[~~Image~~:1tlk.~~png\|left~~\|200px]]	+	==X-RAY STRUCTURE DETERMINATION OF TELOKIN, THE C-TERMINAL DOMAIN OF MYOSIN LIGHT CHAIN KINASE, AT 2.8 ANGSTROMS RESOLUTION==
		+	<StructureSection load='1tlk' size='340' side='right' caption='[[1tlk]], [[Resolution\|resolution]] 2.80Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1tlk]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Meleagris_gallopavo Meleagris gallopavo]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TLK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1TLK FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/[Myosin_light-chain]_kinase [Myosin light-chain] kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.18 2.7.11.18] </span></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1tlk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tlk OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1tlk RCSB], [http://www.ebi.ac.uk/pdbsum/1tlk PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/tl/1tlk_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The three-dimensional structure of telokin, an acidic protein identical to the C-terminal portion of smooth muscle myosin light chain kinase from turkey gizzard, has been determined at 2.8 A resolution and refined to a crystallographic R-factor of 19.5% for all measured X-ray data from 30 A to 2.8 A. Crystals used in the investigation belonged to the space group P3(2)21, with one molecule per asymmetric unit and unit cell dimensions of a = b = 64.4 A and c = 50.6 A. Telokin contains 154 amino acid residues, 103 of which were visible in the electron density map. The overall molecular fold of telokin consists of seven strands of antiparallel beta-pleated sheet that wrap around to form a barrel. There is also an extended tail of eight amino acid residues at the N terminus that does not participate in beta-sheet formation. The beta-barrel can be simply envisioned as two layers of beta-sheet, nearly parallel to one another, with one layer containing four and the other three beta-strands. This type of beta-barrel, as seen in telokin, was first observed for the CH2 domain of an immunoglobulin fragment Fc. Telokin is an intracellular protein and, as such, does not contain the disulphide linkage between beta-strands B and F normally observed in the immunoglobulin constant domains. It does, however, contain two cysteine amino acid residues (Cys63 and Cys115) that are situated at structurally identical positions to those forming the disulphide linkage in the immunoglobulin constant domain.

-	~~{{STRUCTURE_1tlk\| PDB=1tlk \| SCENE= }}~~	+	X-ray structure determination of telokin, the C-terminal domain of myosin light chain kinase, at 2.8 A resolution.,Holden HM, Ito M, Hartshorne DJ, Rayment I J Mol Biol. 1992 Oct 5;227(3):840-51. PMID:1404391<ref>PMID:1404391</ref>

-	~~===X-RAY STRUCTURE DETERMINATION OF TELOKIN~~, ~~THE C-TERMINAL DOMAIN OF MYOSIN LIGHT CHAIN KINASE, AT 2.8 ANGSTROMS RESOLUTION===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_1404391}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[1tlk]] is~~ a ~~1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Meleagris_gallopavo Meleagris gallopavo]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=1TLK OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:001404391<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Meleagris gallopavo]]		[[Category: Meleagris gallopavo]]
	[[Category: Holden, H M.]]		[[Category: Holden, H M.]]
	[[Category: Rayment, I.]]		[[Category: Rayment, I.]]
	[[Category: Calmodulin-binding]]		[[Category: Calmodulin-binding]]

OCA: Protected "1tlk" [edit=sysop:move=sysop]

OCA — Sat, 05 Jan 2013 12:32:11 GMT

Protected "1tlk" [edit=sysop:move=sysop]

←Older revision

Revision as of 12:32, 5 January 2013

OCA at 12:32, 5 January 2013

OCA — Sat, 05 Jan 2013 12:32:09 GMT

←Older revision		Revision as of 12:32, 5 January 2013
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-	{{Seed}}
	[[Image:1tlk.png\|left\|200px]]		[[Image:1tlk.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_1tlk", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_1tlk\| PDB=1tlk \| SCENE= }}		{{STRUCTURE_1tlk\| PDB=1tlk \| SCENE= }}

	===X-RAY STRUCTURE DETERMINATION OF TELOKIN, THE C-TERMINAL DOMAIN OF MYOSIN LIGHT CHAIN KINASE, AT 2.8 ANGSTROMS RESOLUTION===		===X-RAY STRUCTURE DETERMINATION OF TELOKIN, THE C-TERMINAL DOMAIN OF MYOSIN LIGHT CHAIN KINASE, AT 2.8 ANGSTROMS RESOLUTION===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_1404391}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 1404391 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_1404391}}		{{ABSTRACT_PUBMED_1404391}}

	==About this Structure==		==About this Structure==
-	~~1TLK~~ is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Meleagris_gallopavo Meleagris gallopavo]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TLK OCA].	+	[[1tlk]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Meleagris_gallopavo Meleagris gallopavo]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TLK OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~1404391~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:001404391</ref><references group="xtra"/>
	[[Category: Meleagris gallopavo]]		[[Category: Meleagris gallopavo]]
	[[Category: Holden, H M.]]		[[Category: Holden, H M.]]
	[[Category: Rayment, I.]]		[[Category: Rayment, I.]]
	[[Category: Calmodulin-binding]]		[[Category: Calmodulin-binding]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 18:26:44 2009''

OCA at 16:26, 17 February 2009

OCA — Tue, 17 Feb 2009 16:26:47 GMT

←Older revision		Revision as of 16:26, 17 February 2009
Line 20:		Line 20:

	==About this Structure==		==About this Structure==
-	1TLK is a ~~[[Single protein]]~~ structure of sequence from [http://en.wikipedia.org/wiki/Meleagris_gallopavo Meleagris gallopavo]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TLK OCA].	+	1TLK is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Meleagris_gallopavo Meleagris gallopavo]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TLK OCA].

	==Reference==		==Reference==
-	~~X-ray structure determination of telokin, the C-terminal domain of myosin light chain kinase, at 2.8 A resolution., Holden HM, Ito M, Hartshorne DJ, Rayment I, J Mol Biol. 1992 Oct 5;227(3):840-51.~~ PMID:~~[http:~~//~~www.ncbi.nlm.nih.gov/pubmed/1404391 1404391]~~	+	<ref group="xtra">PMID:1404391</ref><references group="xtra"/>
	[[Category: Meleagris gallopavo]]		[[Category: Meleagris gallopavo]]
-	[[Category: Single protein]]
	[[Category: Holden, H M.]]		[[Category: Holden, H M.]]
	[[Category: Rayment, I.]]		[[Category: Rayment, I.]]
	[[Category: Calmodulin-binding]]		[[Category: Calmodulin-binding]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue ~~Jul 29 02~~:24:~~31 2008~~''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 18:26:44 2009''