1tm2 - Revision history

OCA at 08:42, 1 May 2024

OCA — Wed, 01 May 2024 08:42:29 GMT

←Older revision		Revision as of 08:42, 1 May 2024
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	<StructureSection load='1tm2' size='340' side='right'caption='[[1tm2]], [[Resolution\|resolution]] 1.90Å' scene=''>		<StructureSection load='1tm2' size='340' side='right'caption='[[1tm2]], [[Resolution\|resolution]] 1.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1tm2]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Salty Salty~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TM2 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=1TM2 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1tm2]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Salmonella_enterica_subsp._enterica_serovar_Typhimurium_str._LT2 Salmonella enterica subsp. enterica serovar Typhimurium str. LT2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TM2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1TM2 FirstGlance]. <br>
-	</td></tr><tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"~~><div style='overflow: auto; max-height: 3em;'>[[1tjy\|1tjy]], [[1jx6\|1jx6]]</div></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.9Å</td></tr>
-	~~<tr~~ id~~='gene'><td class~~="~~sblockLbl~~">~~<b>~~[[~~Gene~~\|~~Gene:~~]]~~</b></td><td class="sblockDat">LsrB ([http://www~~.~~ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info~~&~~srchmode=5&id=99287 SALTY])~~</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1tm2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tm2 OCA], [https://pdbe.org/1tm2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1tm2 RCSB], [https://www.ebi.ac.uk/pdbsum/1tm2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1tm2 ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=1tm2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tm2 OCA], [~~http~~://pdbe.org/1tm2 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1tm2 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1tm2 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1tm2 ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/~~LSRB_SALTI LSRB_SALTI]~~] Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Binds AI-2 and delivers it to the LsrC and LsrD permeases (~~By similarity~~).	+	[https://www.uniprot.org/uniprot/LSRB_SALTY LSRB_SALTY] Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Binds AI-2 and delivers it to the LsrC and LsrD permeases (Probable).<ref>PMID:11722742</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1tm2 ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1tm2 ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
-	<div style="background-color:#fffaf0;">
-	== Publication Abstract from PubMed ==
-	Bacterial populations use cell-cell communication to coordinate community-wide regulation of processes such as biofilm formation, virulence, and bioluminescence. This phenomenon, termed quorum sensing, is mediated by small molecule signals known as autoinducers. While most autoinducers are species specific, autoinducer-2 (AI-2), first identified in the marine bacterium Vibrio harveyi, is produced and detected by many Gram-negative and Gram-positive bacteria. The crystal structure of the V. harveyi AI-2 signaling molecule bound to its receptor protein revealed an unusual furanosyl borate diester. Here, we present the crystal structure of a second AI-2 signal binding protein, LsrB from Salmonella typhimurium. We find that LsrB binds a chemically distinct form of the AI-2 signal, (2R,4S)-2-methyl-2,3,3,4-tetrahydroxytetrahydrofuran (R-THMF), that lacks boron. Our results demonstrate that two different species of bacteria recognize two different forms of the autoinducer signal, both derived from 4,5-dihydroxy-2,3-pentanedione (DPD), and reveal new sophistication in the chemical lexicon used by bacteria in interspecies signaling.
-
-	Salmonella typhimurium recognizes a chemically distinct form of the bacterial quorum-sensing signal AI-2.,Miller ST, Xavier KB, Campagna SR, Taga ME, Semmelhack MF, Bassler BL, Hughson FM Mol Cell. 2004 Sep 10;15(5):677-87. PMID:15350213<ref>PMID:15350213</ref>
-
-	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	</div>
-	<div class="pdbe-citations 1tm2" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
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	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Salty~~]]	+	[[Category: Salmonella enterica subsp. enterica serovar Typhimurium str. LT2]]
-	[[Category: Bassler~~, B L~~]]	+	[[Category: Bassler BL]]
-	[[Category: Campagna~~, S R~~]]	+	[[Category: Campagna SR]]
-	[[Category: Hughson~~, F M~~]]	+	[[Category: Hughson FM]]
-	[[Category: Miller~~, S T~~]]	+	[[Category: Miller ST]]
-	[[Category: Semmelhack~~, M F~~]]	+	[[Category: Semmelhack MF]]
-	[[Category: Taga~~, M E~~]]	+	[[Category: Taga ME]]
-	[[Category: Xavier~~, K B]]~~	+	[[Category: Xavier KB]]
-	~~[[Category: Periplasmic binding protein]]~~	+
-	~~[[Category: Signaling protein~~]]	+

OCA at 11:55, 24 December 2020

OCA — Thu, 24 Dec 2020 11:55:33 GMT

←Older revision		Revision as of 11:55, 24 December 2020
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	==Crystal Structure of the apo form of the Salmonella typhimurium AI-2 receptor LsrB==		==Crystal Structure of the apo form of the Salmonella typhimurium AI-2 receptor LsrB==
-	<StructureSection load='1tm2' size='340' side='right' caption='[[1tm2]], [[Resolution\|resolution]] 1.90Å' scene=''>	+	<StructureSection load='1tm2' size='340' side='right'caption='[[1tm2]], [[Resolution\|resolution]] 1.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1tm2]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Salty Salty]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TM2 OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1TM2 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1tm2]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Salty Salty]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TM2 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=1TM2 FirstGlance]. <br>
-	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1tjy\|1tjy]], [[1jx6\|1jx6]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1tjy\|1tjy]], [[1jx6\|1jx6]]</div></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">LsrB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=99287 SALTY])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">LsrB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=99287 SALTY])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1tm2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tm2 OCA], [http://pdbe.org/1tm2 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1tm2 RCSB], [http://www.ebi.ac.uk/pdbsum/1tm2 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1tm2 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=1tm2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tm2 OCA], [http://pdbe.org/1tm2 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1tm2 RCSB], [http://www.ebi.ac.uk/pdbsum/1tm2 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1tm2 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Salty]]		[[Category: Salty]]
	[[Category: Bassler, B L]]		[[Category: Bassler, B L]]

OCA at 06:32, 31 January 2018

OCA — Wed, 31 Jan 2018 06:32:39 GMT

←Older revision		Revision as of 06:32, 31 January 2018
Line 1:		Line 1:
		+
	==Crystal Structure of the apo form of the Salmonella typhimurium AI-2 receptor LsrB==		==Crystal Structure of the apo form of the Salmonella typhimurium AI-2 receptor LsrB==
	<StructureSection load='1tm2' size='340' side='right' caption='[[1tm2]], [[Resolution\|resolution]] 1.90Å' scene=''>		<StructureSection load='1tm2' size='340' side='right' caption='[[1tm2]], [[Resolution\|resolution]] 1.90Å' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1tjy\|1tjy]], [[1jx6\|1jx6]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1tjy\|1tjy]], [[1jx6\|1jx6]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">LsrB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=99287 SALTY])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">LsrB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=99287 SALTY])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1tm2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tm2 OCA], [http://pdbe.org/1tm2 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1tm2 RCSB], [http://www.ebi.ac.uk/pdbsum/1tm2 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1tm2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tm2 OCA], [http://pdbe.org/1tm2 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1tm2 RCSB], [http://www.ebi.ac.uk/pdbsum/1tm2 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1tm2 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/tm/1tm2_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/tm/1tm2_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 18:06, 9 February 2016

OCA — Tue, 09 Feb 2016 18:06:42 GMT

←Older revision		Revision as of 18:06, 9 February 2016
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	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1tm2 ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 00:43, 11 September 2015

OCA — Fri, 11 Sep 2015 00:43:05 GMT

←Older revision		Revision as of 00:43, 11 September 2015
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	<StructureSection load='1tm2' size='340' side='right' caption='[[1tm2]], [[Resolution\|resolution]] 1.90Å' scene=''>		<StructureSection load='1tm2' size='340' side='right' caption='[[1tm2]], [[Resolution\|resolution]] 1.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1tm2]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Salmonella_enterica_subsp._enterica_serovar_typhimurium Salmonella enterica subsp. enterica serovar typhimurium~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TM2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1TM2 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1tm2]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Salty Salty]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TM2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1TM2 FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1tjy\|1tjy]], [[1jx6\|1jx6]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1tjy\|1tjy]], [[1jx6\|1jx6]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">LsrB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=~~90371 Salmonella enterica subsp. enterica serovar Typhimurium~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">LsrB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=99287 SALTY])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1tm2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tm2 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1tm2 RCSB], [http://www.ebi.ac.uk/pdbsum/1tm2 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1tm2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tm2 OCA], [http://pdbe.org/1tm2 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1tm2 RCSB], [http://www.ebi.ac.uk/pdbsum/1tm2 PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/LSRB_SALTI LSRB_SALTI]] Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Binds AI-2 and delivers it to the LsrC and LsrD permeases (By similarity).
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1tm2" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Salmonella enterica subsp. enterica serovar typhimurium~~]]	+	[[Category: Salty]]
	[[Category: Bassler, B L]]		[[Category: Bassler, B L]]
	[[Category: Campagna, S R]]		[[Category: Campagna, S R]]

OCA at 13:13, 6 January 2015

OCA — Tue, 06 Jan 2015 13:13:46 GMT

←Older revision		Revision as of 13:13, 6 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1tm2]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Salmonella_enterica_subsp._enterica_serovar_typhimurium Salmonella enterica subsp. enterica serovar typhimurium]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TM2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1TM2 FirstGlance]. <br>		<table><tr><td colspan='2'>[[1tm2]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Salmonella_enterica_subsp._enterica_serovar_typhimurium Salmonella enterica subsp. enterica serovar typhimurium]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TM2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1TM2 FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1tjy\|1tjy]], [[1jx6\|1jx6]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1tjy\|1tjy]], [[1jx6\|1jx6]]</td></tr>
-	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">LsrB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=90371 Salmonella enterica subsp. enterica serovar Typhimurium])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">LsrB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=90371 Salmonella enterica subsp. enterica serovar Typhimurium])</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1tm2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tm2 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1tm2 RCSB], [http://www.ebi.ac.uk/pdbsum/1tm2 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1tm2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tm2 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1tm2 RCSB], [http://www.ebi.ac.uk/pdbsum/1tm2 PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	</StructureSection>		</StructureSection>
	[[Category: Salmonella enterica subsp. enterica serovar typhimurium]]		[[Category: Salmonella enterica subsp. enterica serovar typhimurium]]
-	[[Category: Bassler, B L.]]	+	[[Category: Bassler, B L]]
-	[[Category: Campagna, S R.]]	+	[[Category: Campagna, S R]]
-	[[Category: Hughson, F M.]]	+	[[Category: Hughson, F M]]
-	[[Category: Miller, S T.]]	+	[[Category: Miller, S T]]
-	[[Category: Semmelhack, M F.]]	+	[[Category: Semmelhack, M F]]
-	[[Category: Taga, M E.]]	+	[[Category: Taga, M E]]
-	[[Category: Xavier, K B.]]	+	[[Category: Xavier, K B]]
	[[Category: Periplasmic binding protein]]		[[Category: Periplasmic binding protein]]
	[[Category: Signaling protein]]		[[Category: Signaling protein]]

OCA at 19:47, 29 September 2014

OCA — Mon, 29 Sep 2014 19:47:16 GMT

←Older revision		Revision as of 19:47, 29 September 2014
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-	[[~~Image:~~1tm2.~~png~~\|~~left~~\|200px]]	+	==Crystal Structure of the apo form of the Salmonella typhimurium AI-2 receptor LsrB==
		+	<StructureSection load='1tm2' size='340' side='right' caption='[[1tm2]], [[Resolution\|resolution]] 1.90Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1tm2]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Salmonella_enterica_subsp._enterica_serovar_typhimurium Salmonella enterica subsp. enterica serovar typhimurium]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TM2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1TM2 FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1tjy\|1tjy]], [[1jx6\|1jx6]]</td></tr>
		+	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">LsrB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=90371 Salmonella enterica subsp. enterica serovar Typhimurium])</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1tm2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tm2 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1tm2 RCSB], [http://www.ebi.ac.uk/pdbsum/1tm2 PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/tm/1tm2_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Bacterial populations use cell-cell communication to coordinate community-wide regulation of processes such as biofilm formation, virulence, and bioluminescence. This phenomenon, termed quorum sensing, is mediated by small molecule signals known as autoinducers. While most autoinducers are species specific, autoinducer-2 (AI-2), first identified in the marine bacterium Vibrio harveyi, is produced and detected by many Gram-negative and Gram-positive bacteria. The crystal structure of the V. harveyi AI-2 signaling molecule bound to its receptor protein revealed an unusual furanosyl borate diester. Here, we present the crystal structure of a second AI-2 signal binding protein, LsrB from Salmonella typhimurium. We find that LsrB binds a chemically distinct form of the AI-2 signal, (2R,4S)-2-methyl-2,3,3,4-tetrahydroxytetrahydrofuran (R-THMF), that lacks boron. Our results demonstrate that two different species of bacteria recognize two different forms of the autoinducer signal, both derived from 4,5-dihydroxy-2,3-pentanedione (DPD), and reveal new sophistication in the chemical lexicon used by bacteria in interspecies signaling.

-	~~{{STRUCTURE_1tm2\| PDB=1tm2 \| SCENE= }}~~	+	Salmonella typhimurium recognizes a chemically distinct form of the bacterial quorum-sensing signal AI-2.,Miller ST, Xavier KB, Campagna SR, Taga ME, Semmelhack MF, Bassler BL, Hughson FM Mol Cell. 2004 Sep 10;15(5):677-87. PMID:15350213<ref>PMID:15350213</ref>

-	~~===Crystal Structure~~ of the ~~apo form of the Salmonella typhimurium AI-2 receptor LsrB===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_15350213}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[1tm2]] is a 1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Salmonella_enterica_subsp~~.~~_enterica_serovar_typhimurium Salmonella enterica subsp. enterica serovar typhimurium]. Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=1TM2 OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:015350213<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Salmonella enterica subsp. enterica serovar typhimurium]]		[[Category: Salmonella enterica subsp. enterica serovar typhimurium]]
	[[Category: Bassler, B L.]]		[[Category: Bassler, B L.]]

OCA: Protected "1tm2" [edit=sysop:move=sysop]

OCA — Sat, 05 Jan 2013 13:05:32 GMT

Protected "1tm2" [edit=sysop:move=sysop]

←Older revision

Revision as of 13:05, 5 January 2013

OCA at 13:05, 5 January 2013

OCA — Sat, 05 Jan 2013 13:05:28 GMT

←Older revision		Revision as of 13:05, 5 January 2013
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-	{{Seed}}
	[[Image:1tm2.png\|left\|200px]]		[[Image:1tm2.png\|left\|200px]]

-	<!--
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	{{STRUCTURE_1tm2\| PDB=1tm2 \| SCENE= }}		{{STRUCTURE_1tm2\| PDB=1tm2 \| SCENE= }}

	===Crystal Structure of the apo form of the Salmonella typhimurium AI-2 receptor LsrB===		===Crystal Structure of the apo form of the Salmonella typhimurium AI-2 receptor LsrB===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_15350213}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 15350213 is the PubMed ID number.
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	{{ABSTRACT_PUBMED_15350213}}		{{ABSTRACT_PUBMED_15350213}}

	==About this Structure==		==About this Structure==
-	~~1TM2~~ is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/~~Salmonella_typhimurium_lt2~~ Salmonella typhimurium ~~lt2~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TM2 OCA].	+	[[1tm2]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Salmonella_enterica_subsp._enterica_serovar_typhimurium Salmonella enterica subsp. enterica serovar typhimurium]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TM2 OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~15350213~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:015350213</ref><references group="xtra"/>
-	[[Category: Salmonella typhimurium ~~lt2~~]]	+	[[Category: Salmonella enterica subsp. enterica serovar typhimurium]]
	[[Category: Bassler, B L.]]		[[Category: Bassler, B L.]]
	[[Category: Campagna, S R.]]		[[Category: Campagna, S R.]]
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	[[Category: Xavier, K B.]]		[[Category: Xavier, K B.]]
	[[Category: Periplasmic binding protein]]		[[Category: Periplasmic binding protein]]
-		+	[[Category: Signaling protein]]
-	~~''Page seeded by~~ [~~http~~:~~//oca.weizmann.ac.il/oca OCA~~ ] ~~on Tue Feb 17 11:41:17 2009''~~	+

OCA at 09:41, 17 February 2009

OCA — Tue, 17 Feb 2009 09:41:18 GMT

←Older revision		Revision as of 09:41, 17 February 2009
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	==About this Structure==		==About this Structure==
-	1TM2 is a ~~[[Single protein]]~~ structure of sequence from [http://en.wikipedia.org/wiki/Salmonella_typhimurium_lt2 Salmonella typhimurium lt2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TM2 OCA].	+	1TM2 is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Salmonella_typhimurium_lt2 Salmonella typhimurium lt2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TM2 OCA].

	==Reference==		==Reference==
-	Salmonella typhimurium recognizes a chemically distinct form of the bacterial quorum-sensing signal AI-2., Miller ST, Xavier KB, Campagna SR, Taga ME, Semmelhack MF, Bassler BL, Hughson FM, Mol Cell. 2004 Sep 10;15(5):677-87. PMID:~~[http:~~//~~www.ncbi.nlm.nih.gov/pubmed/15350213 15350213]~~	+	<ref group="xtra">PMID:15350213</ref><references group="xtra"/>
	[[Category: Salmonella typhimurium lt2]]		[[Category: Salmonella typhimurium lt2]]
-	[[Category: Single protein]]
	[[Category: Bassler, B L.]]		[[Category: Bassler, B L.]]
	[[Category: Campagna, S R.]]		[[Category: Campagna, S R.]]
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	[[Category: Periplasmic binding protein]]		[[Category: Periplasmic binding protein]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Mon Jul 28 15~~:50:~~24 2008~~''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 11:41:17 2009''