1tmi - Revision history

OCA at 08:40, 14 February 2024

OCA — Wed, 14 Feb 2024 08:40:32 GMT

←Older revision		Revision as of 08:40, 14 February 2024
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	<StructureSection load='1tmi' size='340' side='right'caption='[[1tmi]], [[Resolution\|resolution]] 1.70Å' scene=''>		<StructureSection load='1tmi' size='340' side='right'caption='[[1tmi]], [[Resolution\|resolution]] 1.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1tmi]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Atcc_43589 Atcc 43589~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TMI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1TMI FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1tmi]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Thermotoga_maritima Thermotoga maritima]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TMI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1TMI FirstGlance]. <br>
-	</td></tr><tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"~~><div style='overflow: auto; max-height: 3em;'>[[1tlu\|1tlu]]</div></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.7Å</td></tr>
-	~~<tr~~ id~~='gene'><td class~~="~~sblockLbl~~">~~<b>~~[[~~Gene~~\|~~Gene:~~]]~~</b></td><td class="sblockDat">SPEH, TM0655 ([https://www~~.~~ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info~~&~~srchmode=5&id=2336 ATCC 43589])</td></tr>~~	+
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Adenosylmethionine_decarboxylase Adenosylmethionine decarboxylase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.1.1.50 4.1.1.50] </span></td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1tmi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tmi OCA], [https://pdbe.org/1tmi PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1tmi RCSB], [https://www.ebi.ac.uk/pdbsum/1tmi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1tmi ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1tmi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tmi OCA], [https://pdbe.org/1tmi PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1tmi RCSB], [https://www.ebi.ac.uk/pdbsum/1tmi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1tmi ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/SPEH_THEMA SPEH_THEMA]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1tmi ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1tmi ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
-	<div style="background-color:#fffaf0;">
-	== Publication Abstract from PubMed ==
-	S-adenosylmethionine decarboxylase (AdoMetDC) is a critical regulatory enzyme of the polyamine biosynthetic pathway and belongs to a small class of pyruvoyl-dependent amino acid decarboxylases. Structural elucidation of the prokaryotic AdoMetDC is of substantial interest in order to determine the relationship between the eukaryotic and prokaryotic forms of the enzyme. Although both forms utilize pyruvoyl groups, there is no detectable sequence similarity except at the site of pyruvoyl group formation. The x-ray structure of the Thermatoga maritima AdoMetDC proenzyme reveals a dimeric protein fold that is remarkably similar to the eukaryotic AdoMetDC protomer, suggesting an evolutionary link between the two forms of the enzyme. Three key active site residues (Ser55, His68, and Cys83) involved in substrate binding, catalysis or proenzyme processing that were identified in the human and potato AdoMet-DCs are structurally conserved in the T. maritima AdoMetDC despite very limited primary sequence identity. The role of Ser55, His68, and Cys83 in the self-processing reaction was investigated through site-directed mutagenesis. A homology model for the Escherichia coli AdoMetDC was generated based on the structures of the T. maritima and human AdoMetDCs.
-
-	Evolutionary links as revealed by the structure of Thermotoga maritima S-adenosylmethionine decarboxylase.,Toms AV, Kinsland C, McCloskey DE, Pegg AE, Ealick SE J Biol Chem. 2004 Aug 6;279(32):33837-46. Epub 2004 May 18. PMID:15150268<ref>PMID:15150268</ref>
-
-	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	</div>
-	<div class="pdbe-citations 1tmi" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
	*[[SAM decarboxylase\|SAM decarboxylase]]		*[[SAM decarboxylase\|SAM decarboxylase]]
-	== References ==
-	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Adenosylmethionine decarboxylase]]
-	[[Category: Atcc 43589]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Ealick, S E~~]]	+	[[Category: Thermotoga maritima]]
-	[[Category: ~~Kinsland, C~~]]	+	[[Category: Ealick SE]]
-	[[Category: ~~McCloskey, D E~~]]	+	[[Category: Kinsland C]]
-	[[Category: ~~Pegg, A E~~]]	+	[[Category: McCloskey DE]]
-	[[Category: ~~Toms, A V~~]]	+	[[Category: Pegg AE]]
-	[[Category: ~~Lyase]]~~	+	[[Category: Toms AV]]
-	~~[[Category: Two-layer alpha beta-sandwich~~]]	+

OCA at 15:42, 27 October 2021

OCA — Wed, 27 Oct 2021 15:42:28 GMT

←Older revision		Revision as of 15:42, 27 October 2021
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	<StructureSection load='1tmi' size='340' side='right'caption='[[1tmi]], [[Resolution\|resolution]] 1.70Å' scene=''>		<StructureSection load='1tmi' size='340' side='right'caption='[[1tmi]], [[Resolution\|resolution]] 1.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1tmi]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Atcc_43589 Atcc 43589]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TMI OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=1TMI FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1tmi]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Atcc_43589 Atcc 43589]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TMI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1TMI FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1tlu\|1tlu]]</div></td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1tlu\|1tlu]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SPEH, TM0655 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=2336 ATCC 43589])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SPEH, TM0655 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=2336 ATCC 43589])</td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Adenosylmethionine_decarboxylase Adenosylmethionine decarboxylase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.1.1.50 4.1.1.50] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Adenosylmethionine_decarboxylase Adenosylmethionine decarboxylase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.1.1.50 4.1.1.50] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=1tmi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tmi OCA], [~~http~~://pdbe.org/1tmi PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1tmi RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1tmi PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1tmi ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1tmi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tmi OCA], [https://pdbe.org/1tmi PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1tmi RCSB], [https://www.ebi.ac.uk/pdbsum/1tmi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1tmi ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==

OCA at 11:55, 24 December 2020

OCA — Thu, 24 Dec 2020 11:55:51 GMT

←Older revision		Revision as of 11:55, 24 December 2020
Line 1:		Line 1:

	==Structure of Thermotoga maritima S63A non-processing mutant S-adenosylmethionine decarboxylase==		==Structure of Thermotoga maritima S63A non-processing mutant S-adenosylmethionine decarboxylase==
-	<StructureSection load='1tmi' size='340' side='right' caption='[[1tmi]], [[Resolution\|resolution]] 1.70Å' scene=''>	+	<StructureSection load='1tmi' size='340' side='right'caption='[[1tmi]], [[Resolution\|resolution]] 1.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1tmi]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_43589 Atcc 43589]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TMI OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1TMI FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1tmi]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_43589 Atcc 43589]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TMI OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=1TMI FirstGlance]. <br>
-	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1tlu\|1tlu]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1tlu\|1tlu]]</div></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SPEH, TM0655 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=2336 ATCC 43589])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SPEH, TM0655 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=2336 ATCC 43589])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Adenosylmethionine_decarboxylase Adenosylmethionine decarboxylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.1.1.50 4.1.1.50] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Adenosylmethionine_decarboxylase Adenosylmethionine decarboxylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.1.1.50 4.1.1.50] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1tmi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tmi OCA], [http://pdbe.org/1tmi PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1tmi RCSB], [http://www.ebi.ac.uk/pdbsum/1tmi PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1tmi ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=1tmi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tmi OCA], [http://pdbe.org/1tmi PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1tmi RCSB], [http://www.ebi.ac.uk/pdbsum/1tmi PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1tmi ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
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	[[Category: Adenosylmethionine decarboxylase]]		[[Category: Adenosylmethionine decarboxylase]]
	[[Category: Atcc 43589]]		[[Category: Atcc 43589]]
		+	[[Category: Large Structures]]
	[[Category: Ealick, S E]]		[[Category: Ealick, S E]]
	[[Category: Kinsland, C]]		[[Category: Kinsland, C]]

OCA at 09:04, 21 March 2018

OCA — Wed, 21 Mar 2018 09:04:41 GMT

←Older revision		Revision as of 09:04, 21 March 2018
Line 1:		Line 1:
		+
	==Structure of Thermotoga maritima S63A non-processing mutant S-adenosylmethionine decarboxylase==		==Structure of Thermotoga maritima S63A non-processing mutant S-adenosylmethionine decarboxylase==
	<StructureSection load='1tmi' size='340' side='right' caption='[[1tmi]], [[Resolution\|resolution]] 1.70Å' scene=''>		<StructureSection load='1tmi' size='340' side='right' caption='[[1tmi]], [[Resolution\|resolution]] 1.70Å' scene=''>
Line 6:		Line 7:
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SPEH, TM0655 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=2336 ATCC 43589])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SPEH, TM0655 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=2336 ATCC 43589])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Adenosylmethionine_decarboxylase Adenosylmethionine decarboxylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.1.1.50 4.1.1.50] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Adenosylmethionine_decarboxylase Adenosylmethionine decarboxylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.1.1.50 4.1.1.50] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1tmi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tmi OCA], [http://pdbe.org/1tmi PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1tmi RCSB], [http://www.ebi.ac.uk/pdbsum/1tmi PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1tmi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tmi OCA], [http://pdbe.org/1tmi PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1tmi RCSB], [http://www.ebi.ac.uk/pdbsum/1tmi PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1tmi ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 12:		Line 13:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/tm/1tmi_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/tm/1tmi_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 27:		Line 28:
	</div>		</div>
	<div class="pdbe-citations 1tmi" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 1tmi" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[SAM decarboxylase\|SAM decarboxylase]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 15:56, 7 February 2016

OCA — Sun, 07 Feb 2016 15:56:26 GMT

←Older revision		Revision as of 15:56, 7 February 2016
Line 16:		Line 16:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1tmi ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 02:59, 10 September 2015

OCA — Thu, 10 Sep 2015 02:59:27 GMT

←Older revision		Revision as of 02:59, 10 September 2015
Line 2:		Line 2:
	<StructureSection load='1tmi' size='340' side='right' caption='[[1tmi]], [[Resolution\|resolution]] 1.70Å' scene=''>		<StructureSection load='1tmi' size='340' side='right' caption='[[1tmi]], [[Resolution\|resolution]] 1.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1tmi]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Thermotoga_maritima Thermotoga maritima~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TMI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1TMI FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1tmi]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_43589 Atcc 43589]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TMI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1TMI FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1tlu\|1tlu]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1tlu\|1tlu]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SPEH, TM0655 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=2336 ~~Thermotoga maritima~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SPEH, TM0655 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=2336 ATCC 43589])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Adenosylmethionine_decarboxylase Adenosylmethionine decarboxylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.1.1.50 4.1.1.50] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Adenosylmethionine_decarboxylase Adenosylmethionine decarboxylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.1.1.50 4.1.1.50] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1tmi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tmi OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1tmi RCSB], [http://www.ebi.ac.uk/pdbsum/1tmi PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1tmi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tmi OCA], [http://pdbe.org/1tmi PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1tmi RCSB], [http://www.ebi.ac.uk/pdbsum/1tmi PDBsum]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 26:		Line 26:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1tmi" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
Line 31:		Line 32:
	</StructureSection>		</StructureSection>
	[[Category: Adenosylmethionine decarboxylase]]		[[Category: Adenosylmethionine decarboxylase]]
-	[[Category: ~~Thermotoga maritima~~]]	+	[[Category: Atcc 43589]]
	[[Category: Ealick, S E]]		[[Category: Ealick, S E]]
	[[Category: Kinsland, C]]		[[Category: Kinsland, C]]

OCA at 16:27, 24 December 2014

OCA — Wed, 24 Dec 2014 16:27:43 GMT

←Older revision		Revision as of 16:27, 24 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1tmi]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Thermotoga_maritima Thermotoga maritima]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TMI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1TMI FirstGlance]. <br>		<table><tr><td colspan='2'>[[1tmi]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Thermotoga_maritima Thermotoga maritima]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TMI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1TMI FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1tlu\|1tlu]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1tlu\|1tlu]]</td></tr>
-	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SPEH, TM0655 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=2336 Thermotoga maritima])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SPEH, TM0655 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=2336 Thermotoga maritima])</td></tr>
-	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Adenosylmethionine_decarboxylase Adenosylmethionine decarboxylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.1.1.50 4.1.1.50] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Adenosylmethionine_decarboxylase Adenosylmethionine decarboxylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.1.1.50 4.1.1.50] </span></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1tmi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tmi OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1tmi RCSB], [http://www.ebi.ac.uk/pdbsum/1tmi PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1tmi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tmi OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1tmi RCSB], [http://www.ebi.ac.uk/pdbsum/1tmi PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 32:		Line 32:
	[[Category: Adenosylmethionine decarboxylase]]		[[Category: Adenosylmethionine decarboxylase]]
	[[Category: Thermotoga maritima]]		[[Category: Thermotoga maritima]]
-	[[Category: Ealick, S E.]]	+	[[Category: Ealick, S E]]
-	[[Category: Kinsland, C.]]	+	[[Category: Kinsland, C]]
-	[[Category: McCloskey, D E.]]	+	[[Category: McCloskey, D E]]
-	[[Category: Pegg, A E.]]	+	[[Category: Pegg, A E]]
-	[[Category: Toms, A V.]]	+	[[Category: Toms, A V]]
	[[Category: Lyase]]		[[Category: Lyase]]
	[[Category: Two-layer alpha beta-sandwich]]		[[Category: Two-layer alpha beta-sandwich]]

OCA at 21:41, 29 September 2014

OCA — Mon, 29 Sep 2014 21:41:05 GMT

←Older revision		Revision as of 21:41, 29 September 2014
Line 1:		Line 1:
-	[[~~Image:~~1tmi.~~png~~\|~~left~~\|200px]]	+	==Structure of Thermotoga maritima S63A non-processing mutant S-adenosylmethionine decarboxylase==
		+	<StructureSection load='1tmi' size='340' side='right' caption='[[1tmi]], [[Resolution\|resolution]] 1.70Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1tmi]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Thermotoga_maritima Thermotoga maritima]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TMI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1TMI FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1tlu\|1tlu]]</td></tr>
		+	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SPEH, TM0655 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=2336 Thermotoga maritima])</td></tr>
		+	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Adenosylmethionine_decarboxylase Adenosylmethionine decarboxylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.1.1.50 4.1.1.50] </span></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1tmi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tmi OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1tmi RCSB], [http://www.ebi.ac.uk/pdbsum/1tmi PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/tm/1tmi_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	S-adenosylmethionine decarboxylase (AdoMetDC) is a critical regulatory enzyme of the polyamine biosynthetic pathway and belongs to a small class of pyruvoyl-dependent amino acid decarboxylases. Structural elucidation of the prokaryotic AdoMetDC is of substantial interest in order to determine the relationship between the eukaryotic and prokaryotic forms of the enzyme. Although both forms utilize pyruvoyl groups, there is no detectable sequence similarity except at the site of pyruvoyl group formation. The x-ray structure of the Thermatoga maritima AdoMetDC proenzyme reveals a dimeric protein fold that is remarkably similar to the eukaryotic AdoMetDC protomer, suggesting an evolutionary link between the two forms of the enzyme. Three key active site residues (Ser55, His68, and Cys83) involved in substrate binding, catalysis or proenzyme processing that were identified in the human and potato AdoMet-DCs are structurally conserved in the T. maritima AdoMetDC despite very limited primary sequence identity. The role of Ser55, His68, and Cys83 in the self-processing reaction was investigated through site-directed mutagenesis. A homology model for the Escherichia coli AdoMetDC was generated based on the structures of the T. maritima and human AdoMetDCs.

-	~~{{STRUCTURE_1tmi\| PDB=1tmi \| SCENE= }}~~	+	Evolutionary links as revealed by the structure of Thermotoga maritima S-adenosylmethionine decarboxylase.,Toms AV, Kinsland C, McCloskey DE, Pegg AE, Ealick SE J Biol Chem. 2004 Aug 6;279(32):33837-46. Epub 2004 May 18. PMID:15150268<ref>PMID:15150268</ref>

-	~~===Structure~~ of ~~Thermotoga maritima S63A non-processing mutant~~ S~~-adenosylmethionine decarboxylase===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_15150268}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[1tmi]] is a 2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org~~/~~wiki/Thermotoga_maritima Thermotoga maritima]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TMI OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:015150268<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Adenosylmethionine decarboxylase]]		[[Category: Adenosylmethionine decarboxylase]]
	[[Category: Thermotoga maritima]]		[[Category: Thermotoga maritima]]

OCA: Protected "1tmi" [edit=sysop:move=sysop]

OCA — Sat, 05 Jan 2013 13:05:14 GMT

Protected "1tmi" [edit=sysop:move=sysop]

←Older revision

Revision as of 13:05, 5 January 2013

OCA at 13:05, 5 January 2013

OCA — Sat, 05 Jan 2013 13:05:12 GMT

←Older revision		Revision as of 13:05, 5 January 2013
Line 1:		Line 1:
-	{{Seed}}
	[[Image:1tmi.png\|left\|200px]]		[[Image:1tmi.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_1tmi", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_1tmi\| PDB=1tmi \| SCENE= }}		{{STRUCTURE_1tmi\| PDB=1tmi \| SCENE= }}

	===Structure of Thermotoga maritima S63A non-processing mutant S-adenosylmethionine decarboxylase===		===Structure of Thermotoga maritima S63A non-processing mutant S-adenosylmethionine decarboxylase===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_15150268}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 15150268 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_15150268}}		{{ABSTRACT_PUBMED_15150268}}

	==About this Structure==		==About this Structure==
-	~~1TMI~~ is a 2 ~~chains~~ structure ~~of sequences~~ from [http://en.wikipedia.org/wiki/Thermotoga_maritima Thermotoga maritima]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TMI OCA].	+	[[1tmi]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Thermotoga_maritima Thermotoga maritima]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TMI OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~15150268~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:015150268</ref><references group="xtra"/>
	[[Category: Adenosylmethionine decarboxylase]]		[[Category: Adenosylmethionine decarboxylase]]
	[[Category: Thermotoga maritima]]		[[Category: Thermotoga maritima]]
Line 31:		Line 19:
	[[Category: Pegg, A E.]]		[[Category: Pegg, A E.]]
	[[Category: Toms, A V.]]		[[Category: Toms, A V.]]
		+	[[Category: Lyase]]
	[[Category: Two-layer alpha beta-sandwich]]		[[Category: Two-layer alpha beta-sandwich]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 14:55:54 2009''