1tq9 - Revision history

OCA at 07:27, 25 October 2023

OCA — Wed, 25 Oct 2023 07:27:51 GMT

←Older revision		Revision as of 07:27, 25 October 2023
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1tq9]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TQ9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1TQ9 FirstGlance]. <br>		<table><tr><td colspan='2'>[[1tq9]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TQ9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1TQ9 FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=CPA:2-DEOXYCYTIDINE~~-2~~-DEOXYADENOSINE-3,5-MONOPHOSPHATE'>CPA</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2Å</td></tr>
-	<tr id='~~NonStdRes~~'><td class="sblockLbl"><b>[[~~Non-Standard_Residue~~\|~~NonStd Res~~:]]</b></td><td class="sblockDat"><scene name='pdbligand=~~YCM~~:~~S-(~~2-~~AMINO~~-2-~~OXOETHYL)~~-L-~~CYSTEINE~~'>~~YCM~~</scene><~~/td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CPA:2-DEOXYCYTIDINE-2-DEOXYADENOSINE-3,5-MONOPHOSPHATE'>CPA</scene>, <scene name='pdbligand=YCM:S-(2-AMINO-2-OXOETHYL)-L-CYSTEINE'>YCM</scene></td></tr>
-	~~<tr id~~='~~related'><td class~~=~~"sblockLbl"><b>[[Related_structure\|Related~~:~~]]</b></td><td class="sblockDat"><div style='overflow: auto; max~~-~~height: 3em;~~'>~~[[1bsr\|1bsr]], [[11ba\|11ba]], [[11bg\|11bg]], [[1r5c\|1r5c]], [[1r3m\|1r3m]], [[1n1x\|1n1x]], [[1n3z\|1n3z]], [[1r5d\|1r5d]]~~</~~div></td></tr>~~	+
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Pancreatic_ribonuclease Pancreatic ribonuclease], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.27.5 3.1.27.5] </span></td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1tq9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tq9 OCA], [https://pdbe.org/1tq9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1tq9 RCSB], [https://www.ebi.ac.uk/pdbsum/1tq9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1tq9 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1tq9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tq9 OCA], [https://pdbe.org/1tq9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1tq9 RCSB], [https://www.ebi.ac.uk/pdbsum/1tq9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1tq9 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/RNS_BOVIN RNS_BOVIN]] This enzyme hydrolyzes both single- and double-stranded RNA.	+	[https://www.uniprot.org/uniprot/RNS_BOVIN RNS_BOVIN] This enzyme hydrolyzes both single- and double-stranded RNA.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	[[Category: Bos taurus]]		[[Category: Bos taurus]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Pancreatic ribonuclease]]~~	+	[[Category: Di Fiore A]]
-	~~[[Category:~~ Fiore, A Di]]	+	[[Category: Mazzarella L]]
-	[[Category: Mazzarella, L]]	+	[[Category: Merlino A]]
-	[[Category: Merlino, A]]	+	[[Category: Sica F]]
-	[[Category: Sica, F]]	+
-	~~[[Category: Cytotoxic action]]~~	+
-	~~[[Category: Hydrolase]]~~	+
-	~~[[Category: Protein-dinucleotide complex~~]]	+

OCA at 09:31, 29 September 2021

OCA — Wed, 29 Sep 2021 09:31:16 GMT

←Older revision		Revision as of 09:31, 29 September 2021
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	<StructureSection load='1tq9' size='340' side='right'caption='[[1tq9]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='1tq9' size='340' side='right'caption='[[1tq9]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1tq9]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TQ9 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1TQ9 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1tq9]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TQ9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1TQ9 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CPA:2-DEOXYCYTIDINE-2-DEOXYADENOSINE-3,5-MONOPHOSPHATE'>CPA</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CPA:2-DEOXYCYTIDINE-2-DEOXYADENOSINE-3,5-MONOPHOSPHATE'>CPA</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=YCM:S-(2-AMINO-2-OXOETHYL)-L-CYSTEINE'>YCM</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=YCM:S-(2-AMINO-2-OXOETHYL)-L-CYSTEINE'>YCM</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1bsr\|1bsr]], [[11ba\|11ba]], [[11bg\|11bg]], [[1r5c\|1r5c]], [[1r3m\|1r3m]], [[1n1x\|1n1x]], [[1n3z\|1n3z]], [[1r5d\|1r5d]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1bsr\|1bsr]], [[11ba\|11ba]], [[11bg\|11bg]], [[1r5c\|1r5c]], [[1r3m\|1r3m]], [[1n1x\|1n1x]], [[1n3z\|1n3z]], [[1r5d\|1r5d]]</div></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Pancreatic_ribonuclease Pancreatic ribonuclease], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.27.5 3.1.27.5] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Pancreatic_ribonuclease Pancreatic ribonuclease], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.27.5 3.1.27.5] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1tq9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tq9 OCA], [~~http~~://pdbe.org/1tq9 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1tq9 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1tq9 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1tq9 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1tq9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tq9 OCA], [https://pdbe.org/1tq9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1tq9 RCSB], [https://www.ebi.ac.uk/pdbsum/1tq9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1tq9 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/RNS_BOVIN RNS_BOVIN]] This enzyme hydrolyzes both single- and double-stranded RNA.	+	[[https://www.uniprot.org/uniprot/RNS_BOVIN RNS_BOVIN]] This enzyme hydrolyzes both single- and double-stranded RNA.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	==See Also==		==See Also==
	*[[Ribonuclease 3D structures\|Ribonuclease 3D structures]]		*[[Ribonuclease 3D structures\|Ribonuclease 3D structures]]
-	*[[Temp\|Temp]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 14:10, 25 December 2019

OCA — Wed, 25 Dec 2019 14:10:23 GMT

←Older revision		Revision as of 14:10, 25 December 2019
Line 1:		Line 1:

	==Non-covalent swapped dimer of Bovine Seminal Ribonuclease in complex with 2'-DEOXYCYTIDINE-2'-DEOXYADENOSINE-3',5'-MONOPHOSPHATE==		==Non-covalent swapped dimer of Bovine Seminal Ribonuclease in complex with 2'-DEOXYCYTIDINE-2'-DEOXYADENOSINE-3',5'-MONOPHOSPHATE==
-	<StructureSection load='1tq9' size='340' side='right' caption='[[1tq9]], [[Resolution\|resolution]] 2.00Å' scene=''>	+	<StructureSection load='1tq9' size='340' side='right'caption='[[1tq9]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1tq9]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TQ9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1TQ9 FirstGlance]. <br>		<table><tr><td colspan='2'>[[1tq9]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TQ9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1TQ9 FirstGlance]. <br>
Line 33:		Line 33:

	==See Also==		==See Also==
-	*[[Ribonuclease\|Ribonuclease]]	+	*[[Ribonuclease 3D structures\|Ribonuclease 3D structures]]
	*[[Temp\|Temp]]		*[[Temp\|Temp]]
	== References ==		== References ==
Line 40:		Line 40:
	</StructureSection>		</StructureSection>
	[[Category: Bos taurus]]		[[Category: Bos taurus]]
		+	[[Category: Large Structures]]
	[[Category: Pancreatic ribonuclease]]		[[Category: Pancreatic ribonuclease]]
	[[Category: Fiore, A Di]]		[[Category: Fiore, A Di]]

OCA at 08:59, 21 March 2018

OCA — Wed, 21 Mar 2018 08:59:29 GMT

←Older revision		Revision as of 08:59, 21 March 2018
Line 1:		Line 1:
		+
	==Non-covalent swapped dimer of Bovine Seminal Ribonuclease in complex with 2'-DEOXYCYTIDINE-2'-DEOXYADENOSINE-3',5'-MONOPHOSPHATE==		==Non-covalent swapped dimer of Bovine Seminal Ribonuclease in complex with 2'-DEOXYCYTIDINE-2'-DEOXYADENOSINE-3',5'-MONOPHOSPHATE==
	<StructureSection load='1tq9' size='340' side='right' caption='[[1tq9]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='1tq9' size='340' side='right' caption='[[1tq9]], [[Resolution\|resolution]] 2.00Å' scene=''>
Line 7:		Line 8:
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1bsr\|1bsr]], [[11ba\|11ba]], [[11bg\|11bg]], [[1r5c\|1r5c]], [[1r3m\|1r3m]], [[1n1x\|1n1x]], [[1n3z\|1n3z]], [[1r5d\|1r5d]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1bsr\|1bsr]], [[11ba\|11ba]], [[11bg\|11bg]], [[1r5c\|1r5c]], [[1r3m\|1r3m]], [[1n1x\|1n1x]], [[1n3z\|1n3z]], [[1r5d\|1r5d]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Pancreatic_ribonuclease Pancreatic ribonuclease], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.27.5 3.1.27.5] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Pancreatic_ribonuclease Pancreatic ribonuclease], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.27.5 3.1.27.5] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1tq9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tq9 OCA], [http://pdbe.org/1tq9 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1tq9 RCSB], [http://www.ebi.ac.uk/pdbsum/1tq9 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1tq9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tq9 OCA], [http://pdbe.org/1tq9 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1tq9 RCSB], [http://www.ebi.ac.uk/pdbsum/1tq9 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1tq9 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 15:		Line 16:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/tq/1tq9_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/tq/1tq9_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 01:33, 8 February 2016

OCA — Mon, 08 Feb 2016 01:33:09 GMT

←Older revision		Revision as of 01:33, 8 February 2016
Line 19:		Line 19:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1tq9 ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 06:38, 10 September 2015

OCA — Thu, 10 Sep 2015 06:38:12 GMT

←Older revision		Revision as of 06:38, 10 September 2015
Line 7:		Line 7:
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1bsr\|1bsr]], [[11ba\|11ba]], [[11bg\|11bg]], [[1r5c\|1r5c]], [[1r3m\|1r3m]], [[1n1x\|1n1x]], [[1n3z\|1n3z]], [[1r5d\|1r5d]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1bsr\|1bsr]], [[11ba\|11ba]], [[11bg\|11bg]], [[1r5c\|1r5c]], [[1r3m\|1r3m]], [[1n1x\|1n1x]], [[1n3z\|1n3z]], [[1r5d\|1r5d]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Pancreatic_ribonuclease Pancreatic ribonuclease], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.27.5 3.1.27.5] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Pancreatic_ribonuclease Pancreatic ribonuclease], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.27.5 3.1.27.5] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1tq9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tq9 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1tq9 RCSB], [http://www.ebi.ac.uk/pdbsum/1tq9 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1tq9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tq9 OCA], [http://pdbe.org/1tq9 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1tq9 RCSB], [http://www.ebi.ac.uk/pdbsum/1tq9 PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 29:		Line 29:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1tq9" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
	*[[Ribonuclease\|Ribonuclease]]		*[[Ribonuclease\|Ribonuclease]]
	*[[Temp\|Temp]]		*[[Temp\|Temp]]
-	*[[User:Jaime.Prilusky/Test/tree\|User:Jaime.Prilusky/Test/tree]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 19:34, 24 December 2014

OCA — Wed, 24 Dec 2014 19:34:46 GMT

←Older revision		Revision as of 19:34, 24 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1tq9]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TQ9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1TQ9 FirstGlance]. <br>		<table><tr><td colspan='2'>[[1tq9]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TQ9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1TQ9 FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CPA:2-DEOXYCYTIDINE-2-DEOXYADENOSINE-3,5-MONOPHOSPHATE'>CPA</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CPA:2-DEOXYCYTIDINE-2-DEOXYADENOSINE-3,5-MONOPHOSPHATE'>CPA</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=YCM:S-(2-AMINO-2-OXOETHYL)-L-CYSTEINE'>YCM</scene></td></tr>	+	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=YCM:S-(2-AMINO-2-OXOETHYL)-L-CYSTEINE'>YCM</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1bsr\|1bsr]], [[11ba\|11ba]], [[11bg\|11bg]], [[1r5c\|1r5c]], [[1r3m\|1r3m]], [[1n1x\|1n1x]], [[1n3z\|1n3z]], [[1r5d\|1r5d]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1bsr\|1bsr]], [[11ba\|11ba]], [[11bg\|11bg]], [[1r5c\|1r5c]], [[1r3m\|1r3m]], [[1n1x\|1n1x]], [[1n3z\|1n3z]], [[1r5d\|1r5d]]</td></tr>
-	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Pancreatic_ribonuclease Pancreatic ribonuclease], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.27.5 3.1.27.5] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Pancreatic_ribonuclease Pancreatic ribonuclease], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.27.5 3.1.27.5] </span></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1tq9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tq9 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1tq9 RCSB], [http://www.ebi.ac.uk/pdbsum/1tq9 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1tq9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tq9 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1tq9 RCSB], [http://www.ebi.ac.uk/pdbsum/1tq9 PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/RNS_BOVIN RNS_BOVIN]] This enzyme hydrolyzes both single- and double-stranded RNA.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 30:		Line 32:
	==See Also==		==See Also==
	*[[Ribonuclease\|Ribonuclease]]		*[[Ribonuclease\|Ribonuclease]]
		+	*[[Temp\|Temp]]
		+	*[[User:Jaime.Prilusky/Test/tree\|User:Jaime.Prilusky/Test/tree]]
	== References ==		== References ==
	<references/>		<references/>
Line 36:		Line 40:
	[[Category: Bos taurus]]		[[Category: Bos taurus]]
	[[Category: Pancreatic ribonuclease]]		[[Category: Pancreatic ribonuclease]]
-	[[Category: Fiore, A Di.]]	+	[[Category: Fiore, A Di]]
-	[[Category: Mazzarella, L.]]	+	[[Category: Mazzarella, L]]
-	[[Category: Merlino, A.]]	+	[[Category: Merlino, A]]
-	[[Category: Sica, F.]]	+	[[Category: Sica, F]]
	[[Category: Cytotoxic action]]		[[Category: Cytotoxic action]]
	[[Category: Hydrolase]]		[[Category: Hydrolase]]
	[[Category: Protein-dinucleotide complex]]		[[Category: Protein-dinucleotide complex]]

OCA at 22:04, 28 September 2014

OCA — Sun, 28 Sep 2014 22:04:59 GMT

←Older revision		Revision as of 22:04, 28 September 2014
Line 1:		Line 1:
-	[[~~Image:~~1tq9.~~png~~\|~~left~~\|200px]]	+	==Non-covalent swapped dimer of Bovine Seminal Ribonuclease in complex with 2'-DEOXYCYTIDINE-2'-DEOXYADENOSINE-3',5'-MONOPHOSPHATE==
		+	<StructureSection load='1tq9' size='340' side='right' caption='[[1tq9]], [[Resolution\|resolution]] 2.00Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1tq9]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TQ9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1TQ9 FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CPA:2-DEOXYCYTIDINE-2-DEOXYADENOSINE-3,5-MONOPHOSPHATE'>CPA</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=YCM:S-(2-AMINO-2-OXOETHYL)-L-CYSTEINE'>YCM</scene></td></tr>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1bsr\|1bsr]], [[11ba\|11ba]], [[11bg\|11bg]], [[1r5c\|1r5c]], [[1r3m\|1r3m]], [[1n1x\|1n1x]], [[1n3z\|1n3z]], [[1r5d\|1r5d]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Pancreatic_ribonuclease Pancreatic ribonuclease], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.27.5 3.1.27.5] </span></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1tq9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tq9 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1tq9 RCSB], [http://www.ebi.ac.uk/pdbsum/1tq9 PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/tq/1tq9_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	A growing number of pancreatic-type ribonucleases (RNases) present cytotoxic activity against malignant cells. The cytoxicity of these enzymes is related to their resistance to the ribonuclease protein inhibitor (RI). In particular, bovine seminal ribonuclease (BS-RNase) is toxic to tumor cells both in vitro and in vivo. BS-RNase is a covalent dimer with two intersubunit disulfide bridges between Cys(31) of one chain and Cys(32) of the second and vice versa. The native enzyme is an equilibrium mixture of two isomers, MxM and M=M. In the former the two subunits swap their N-terminal helices. The cytotoxic action is a peculiar property of MxM. In the reducing environment of cytosol, M=M dissociates into monomers, which are strongly inhibited by RI, whereas MxM remains as a non-covalent dimer (NCD), which evades RI. We have solved the crystal structure of NCD, carboxyamidomethylated at residues Cys(31) and Cys(32) (NCD-CAM), in a complex with 2'-deoxycitidylyl(3'-5')-2'-deoxyadenosine. The molecule reveals a quaternary structural organization much closer to MxM than to other N-terminal-swapped non-covalent dimeric forms of RNases. Model building of the complexes between these non-covalent dimers and RI reveals that NCD-CAM is the only dimer equipped with a quaternary organization capable of interfering seriously with the binding of the inhibitor. Moreover, a detailed comparative structural analysis of the dimers has highlighted the residues, which are mostly important in driving the quaternary structure toward that found in NCD-CAM.

-	~~{{STRUCTURE_1tq9\| PDB=1tq9 \| SCENE= }}~~	+	Structure and stability of the non-covalent swapped dimer of bovine seminal ribonuclease: an enzyme tailored to evade ribonuclease protein inhibitor.,Sica F, Di Fiore A, Merlino A, Mazzarella L J Biol Chem. 2004 Aug 27;279(35):36753-60. Epub 2004 Jun 9. PMID:15192098<ref>PMID:15192098</ref>

-	~~===Non-covalent swapped dimer of Bovine Seminal Ribonuclease in complex with 2'-DEOXYCYTIDINE-2'-DEOXYADENOSINE-3'~~,~~5'-MONOPHOSPHATE===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_15192098}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[1tq9]] is~~ a ~~2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Bos_taurus Bos taurus]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=1TQ9 OCA].~~	+

	==See Also==		==See Also==
	*[[Ribonuclease\|Ribonuclease]]		*[[Ribonuclease\|Ribonuclease]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:015192098<~~/~~ref~~><ref group="xtra">PMID:015048772</ref><ref group="xtra">PMID:010082366</ref><ref group="xtra">PMID:010543951</ref><ref group="xtra">PMID:012833549</ref><ref group="xtra">PMID:014596923</ref><references group="xtra"/>	+	__TOC__
		+	</StructureSection>
	[[Category: Bos taurus]]		[[Category: Bos taurus]]
	[[Category: Pancreatic ribonuclease]]		[[Category: Pancreatic ribonuclease]]

OCA at 08:27, 20 October 2012

OCA — Sat, 20 Oct 2012 08:27:41 GMT

←Older revision		Revision as of 08:27, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[1tq9]] is a 2 chain structure ~~of [[Ribonuclease]]~~ with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TQ9 OCA].	+	[[1tq9]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TQ9 OCA].

	==See Also==		==See Also==
Line 14:		Line 14:

	==Reference==		==Reference==
-	<ref group="xtra">PMID:015192098</ref><ref group="xtra">PMID:015048772</ref><ref group="xtra">PMID:010082366</ref><ref group="xtra">PMID:010543951</ref><ref group="xtra">PMID:012833549</ref><ref group="xtra">PMID:014596923~~</ref><ref group="xtra">PMID:007731986~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:015192098</ref><ref group="xtra">PMID:015048772</ref><ref group="xtra">PMID:010082366</ref><ref group="xtra">PMID:010543951</ref><ref group="xtra">PMID:012833549</ref><ref group="xtra">PMID:014596923</ref><references group="xtra"/>
	[[Category: Bos taurus]]		[[Category: Bos taurus]]
	[[Category: Pancreatic ribonuclease]]		[[Category: Pancreatic ribonuclease]]

OCA at 19:36, 25 July 2012

OCA — Wed, 25 Jul 2012 19:36:37 GMT

←Older revision		Revision as of 19:36, 25 July 2012
Line 1:		Line 1:
	[[Image:1tq9.png\|left\|200px]]		[[Image:1tq9.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_1tq9", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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	{{STRUCTURE_1tq9\| PDB=1tq9 \| SCENE= }}		{{STRUCTURE_1tq9\| PDB=1tq9 \| SCENE= }}

	===Non-covalent swapped dimer of Bovine Seminal Ribonuclease in complex with 2'-DEOXYCYTIDINE-2'-DEOXYADENOSINE-3',5'-MONOPHOSPHATE===		===Non-covalent swapped dimer of Bovine Seminal Ribonuclease in complex with 2'-DEOXYCYTIDINE-2'-DEOXYADENOSINE-3',5'-MONOPHOSPHATE===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_15192098}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 15192098 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_15192098}}		{{ABSTRACT_PUBMED_15192098}}

	==About this Structure==		==About this Structure==
-	[[1tq9]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TQ9 OCA].	+	[[1tq9]] is a 2 chain structure of [[Ribonuclease]] with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TQ9 OCA].
		+
		+	==See Also==
		+	*[[Ribonuclease\|Ribonuclease]]

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~15192098~~</ref><ref group="xtra">PMID:~~15048772~~</ref><ref group="xtra">PMID:~~10082366~~</ref><ref group="xtra">PMID:~~10543951~~</ref><ref group="xtra">PMID:~~12833549~~</ref><ref group="xtra">PMID:~~14596923~~</ref><ref group="xtra">PMID:~~7731986~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:015192098</ref><ref group="xtra">PMID:015048772</ref><ref group="xtra">PMID:010082366</ref><ref group="xtra">PMID:010543951</ref><ref group="xtra">PMID:012833549</ref><ref group="xtra">PMID:014596923</ref><ref group="xtra">PMID:007731986</ref><references group="xtra"/>
	[[Category: Bos taurus]]		[[Category: Bos taurus]]
	[[Category: Pancreatic ribonuclease]]		[[Category: Pancreatic ribonuclease]]