1tqq - Revision history

OCA at 06:33, 23 August 2023

OCA — Wed, 23 Aug 2023 06:33:12 GMT

←Older revision		Revision as of 06:33, 23 August 2023
Line 3:		Line 3:
	<StructureSection load='1tqq' size='340' side='right'caption='[[1tqq]], [[Resolution\|resolution]] 2.75Å' scene=''>		<StructureSection load='1tqq' size='340' side='right'caption='[[1tqq]], [[Resolution\|resolution]] 2.75Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1tqq]] is a 3 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~"bacillus_coli"_migula_1895 "bacillus~~ coli~~" migula 1895~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TQQ OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=1TQQ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1tqq]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TQQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1TQQ FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=NCO:COBALT+HEXAMMINE(III)'>NCO</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.75Å</td></tr>
-	<tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat"~~>TOLC, MTCB, MUKA, REFI, B3035 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&~~id=~~562~~ "~~Bacillus coli~~" ~~Migula 1895]~~)</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NCO:COBALT+HEXAMMINE(III)'>NCO</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=1tqq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tqq OCA], [~~http~~://pdbe.org/1tqq PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1tqq RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1tqq PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1tqq ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1tqq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tqq OCA], [https://pdbe.org/1tqq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1tqq RCSB], [https://www.ebi.ac.uk/pdbsum/1tqq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1tqq ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/TOLC_ECOLI TOLC_ECOLI]] Outer membrane channel, which is required for the function of several efflux systems such as AcrAB-TolC, AcrEF-TolC, EmrAB-TolC and MacAB-TolC. These systems are involved in export of antibiotics and other toxic compounds from the cell. TolC is also involved in import of colicin E1 into the cells.<ref>PMID:6337123</ref> <ref>PMID:11274125</ref> <ref>PMID:15228545</ref> <ref>PMID:18955484</ref> <ref>PMID:23176499</ref>	+	[https://www.uniprot.org/uniprot/TOLC_ECOLI TOLC_ECOLI] Outer membrane channel, which is required for the function of several efflux systems such as AcrAB-TolC, AcrEF-TolC, EmrAB-TolC and MacAB-TolC. These systems are involved in export of antibiotics and other toxic compounds from the cell. TolC is also involved in import of colicin E1 into the cells.<ref>PMID:6337123</ref> <ref>PMID:11274125</ref> <ref>PMID:15228545</ref> <ref>PMID:18955484</ref> <ref>PMID:23176499</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 33:		Line 33:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Bacillus~~ coli ~~migula 1895~~]]	+	[[Category: Escherichia coli]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Edwards~~, P C~~]]	+	[[Category: Edwards PC]]
-	[[Category: Eswaran, J]]	+	[[Category: Eswaran J]]
-	[[Category: Higgins~~, M K~~]]	+	[[Category: Higgins MK]]
-	[[Category: Hughes, C]]	+	[[Category: Hughes C]]
-	[[Category: Koronakis, V]]	+	[[Category: Koronakis V]]
-	[[Category: Schertler~~, G F]]~~	+	[[Category: Schertler GF]]
-	~~[[Category: Alpha-barrel]]~~	+
-	~~[[Category: Beta-barrel]]~~	+
-	~~[[Category: Transport protein~~]]	+

OCA at 11:58, 24 December 2020

OCA — Thu, 24 Dec 2020 11:58:22 GMT

←Older revision		Revision as of 11:58, 24 December 2020
Line 1:		Line 1:

	==Structure of TolC in complex with hexamminecobalt==		==Structure of TolC in complex with hexamminecobalt==
-	<StructureSection load='1tqq' size='340' side='right' caption='[[1tqq]], [[Resolution\|resolution]] 2.75Å' scene=''>	+	<StructureSection load='1tqq' size='340' side='right'caption='[[1tqq]], [[Resolution\|resolution]] 2.75Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1tqq]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TQQ OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1TQQ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1tqq]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TQQ OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=1TQQ FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NCO:COBALT+HEXAMMINE(III)'>NCO</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NCO:COBALT+HEXAMMINE(III)'>NCO</scene></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">TOLC, MTCB, MUKA, REFI, B3035 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 "Bacillus coli" Migula 1895])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">TOLC, MTCB, MUKA, REFI, B3035 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 "Bacillus coli" Migula 1895])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1tqq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tqq OCA], [http://pdbe.org/1tqq PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1tqq RCSB], [http://www.ebi.ac.uk/pdbsum/1tqq PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1tqq ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=1tqq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tqq OCA], [http://pdbe.org/1tqq PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1tqq RCSB], [http://www.ebi.ac.uk/pdbsum/1tqq PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1tqq ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 34:		Line 34:
	</StructureSection>		</StructureSection>
	[[Category: Bacillus coli migula 1895]]		[[Category: Bacillus coli migula 1895]]
		+	[[Category: Large Structures]]
	[[Category: Edwards, P C]]		[[Category: Edwards, P C]]
	[[Category: Eswaran, J]]		[[Category: Eswaran, J]]

OCA at 08:42, 21 March 2018

OCA — Wed, 21 Mar 2018 08:42:47 GMT

←Older revision		Revision as of 08:42, 21 March 2018
Line 1:		Line 1:
		+
	==Structure of TolC in complex with hexamminecobalt==		==Structure of TolC in complex with hexamminecobalt==
	<StructureSection load='1tqq' size='340' side='right' caption='[[1tqq]], [[Resolution\|resolution]] 2.75Å' scene=''>		<StructureSection load='1tqq' size='340' side='right' caption='[[1tqq]], [[Resolution\|resolution]] 2.75Å' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NCO:COBALT+HEXAMMINE(III)'>NCO</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NCO:COBALT+HEXAMMINE(III)'>NCO</scene></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">TOLC, MTCB, MUKA, REFI, B3035 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 "Bacillus coli" Migula 1895])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">TOLC, MTCB, MUKA, REFI, B3035 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 "Bacillus coli" Migula 1895])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1tqq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tqq OCA], [http://pdbe.org/1tqq PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1tqq RCSB], [http://www.ebi.ac.uk/pdbsum/1tqq PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1tqq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tqq OCA], [http://pdbe.org/1tqq PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1tqq RCSB], [http://www.ebi.ac.uk/pdbsum/1tqq PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1tqq ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 13:		Line 14:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/tq/1tqq_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/tq/1tqq_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 18:30, 8 February 2016

OCA — Mon, 08 Feb 2016 18:30:42 GMT

←Older revision		Revision as of 18:30, 8 February 2016
Line 17:		Line 17:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1tqq ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 14:15, 10 September 2015

OCA — Thu, 10 Sep 2015 14:15:47 GMT

←Older revision		Revision as of 14:15, 10 September 2015
Line 2:		Line 2:
	<StructureSection load='1tqq' size='340' side='right' caption='[[1tqq]], [[Resolution\|resolution]] 2.75Å' scene=''>		<StructureSection load='1tqq' size='340' side='right' caption='[[1tqq]], [[Resolution\|resolution]] 2.75Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1tqq]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Escherichia_coli Escherichia~~ coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TQQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1TQQ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1tqq]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TQQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1TQQ FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NCO:COBALT+HEXAMMINE(III)'>NCO</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NCO:COBALT+HEXAMMINE(III)'>NCO</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">TOLC, MTCB, MUKA, REFI, B3035 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 ~~Escherichia~~ coli])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">TOLC, MTCB, MUKA, REFI, B3035 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 "Bacillus coli" Migula 1895])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1tqq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tqq OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1tqq RCSB], [http://www.ebi.ac.uk/pdbsum/1tqq PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1tqq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tqq OCA], [http://pdbe.org/1tqq PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1tqq RCSB], [http://www.ebi.ac.uk/pdbsum/1tqq PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 27:		Line 27:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1tqq" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Escherichia~~ coli]]	+	[[Category: Bacillus coli migula 1895]]
	[[Category: Edwards, P C]]		[[Category: Edwards, P C]]
	[[Category: Eswaran, J]]		[[Category: Eswaran, J]]

OCA at 01:19, 25 December 2014

OCA — Thu, 25 Dec 2014 01:19:23 GMT

←Older revision		Revision as of 01:19, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1tqq]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TQQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1TQQ FirstGlance]. <br>		<table><tr><td colspan='2'>[[1tqq]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TQQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1TQQ FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NCO:COBALT+HEXAMMINE(III)'>NCO</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NCO:COBALT+HEXAMMINE(III)'>NCO</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">TOLC, MTCB, MUKA, REFI, B3035 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 Escherichia coli])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">TOLC, MTCB, MUKA, REFI, B3035 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 Escherichia coli])</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1tqq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tqq OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1tqq RCSB], [http://www.ebi.ac.uk/pdbsum/1tqq PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1tqq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tqq OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1tqq RCSB], [http://www.ebi.ac.uk/pdbsum/1tqq PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/TOLC_ECOLI TOLC_ECOLI]] Outer membrane channel, which is required for the function of several efflux systems such as AcrAB-TolC, AcrEF-TolC, EmrAB-TolC and MacAB-TolC. These systems are involved in export of antibiotics and other toxic compounds from the cell. TolC is also involved in import of colicin E1 into the cells.<ref>PMID:6337123</ref> <ref>PMID:11274125</ref> <ref>PMID:15228545</ref> <ref>PMID:18955484</ref> <ref>PMID:23176499</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 30:		Line 32:
	</StructureSection>		</StructureSection>
	[[Category: Escherichia coli]]		[[Category: Escherichia coli]]
-	[[Category: Edwards, P C.]]	+	[[Category: Edwards, P C]]
-	[[Category: Eswaran, J.]]	+	[[Category: Eswaran, J]]
-	[[Category: Higgins, M K.]]	+	[[Category: Higgins, M K]]
-	[[Category: Hughes, C.]]	+	[[Category: Hughes, C]]
-	[[Category: Koronakis, V.]]	+	[[Category: Koronakis, V]]
-	[[Category: Schertler, G F.]]	+	[[Category: Schertler, G F]]
	[[Category: Alpha-barrel]]		[[Category: Alpha-barrel]]
	[[Category: Beta-barrel]]		[[Category: Beta-barrel]]
	[[Category: Transport protein]]		[[Category: Transport protein]]

OCA at 20:58, 29 September 2014

OCA — Mon, 29 Sep 2014 20:58:09 GMT

←Older revision		Revision as of 20:58, 29 September 2014
Line 1:		Line 1:
-	[[~~Image:~~1tqq.~~png~~\|~~left~~\|200px]]	+	==Structure of TolC in complex with hexamminecobalt==
		+	<StructureSection load='1tqq' size='340' side='right' caption='[[1tqq]], [[Resolution\|resolution]] 2.75Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1tqq]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TQQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1TQQ FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NCO:COBALT+HEXAMMINE(III)'>NCO</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">TOLC, MTCB, MUKA, REFI, B3035 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 Escherichia coli])</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1tqq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tqq OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1tqq RCSB], [http://www.ebi.ac.uk/pdbsum/1tqq PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/tq/1tqq_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The trimeric TolC protein of Escherichia coli comprises an outer membrane beta-barrel and a contiguous alpha-helical barrel projecting across the periplasm. This provides a single 140 A long pore for multidrug efflux and protein export. We have previously reported that trivalent cations such as hexammine cobalt can severely inhibit the conductivity of the TolC pore reconstituted in planar lipid bilayers. Here, isothermal calorimetry shows that Co(NH(3))(6)(3+) binds to TolC with an affinity of 20 nM. The crystal structure of the TolC-Co(NH(3))(6)(3+) complex was determined to 2.75 A resolution, and showed no significant difference in the protein when compared with unliganded TolC. An electron density difference map revealed that a single ligand molecule binds at the centre of the periplasmic entrance, the sole constriction of TolC. The octahedral symmetry of the ligand and the three-fold rotational symmetry of the TolC entrance determine a binding site in which the ligand forms hydrogen bonds with the Asp(374) residue of each monomer. When Asp(374) was substituted by alanine, high affinity ligand binding was abolished and inhibition of TolC pore conductivity in lipid bilayers was alleviated. Comparable effects followed independent substitution of the neighbouring Asp(371), indicating that this aspartate ring also contributes to the high affinity ligand binding site. As the electronegative entrance is widely conserved in the TolC family, it may be a useful target for the development of inhibitors against multidrug resistant pathogenic bacteria.

-	~~{{STRUCTURE_1tqq\| PDB=1tqq \| SCENE= }}~~	+	Structure of the ligand-blocked periplasmic entrance of the bacterial multidrug efflux protein TolC.,Higgins MK, Eswaran J, Edwards P, Schertler GF, Hughes C, Koronakis V J Mol Biol. 2004 Sep 17;342(3):697-702. PMID:15342230<ref>PMID:15342230</ref>

-	~~===Structure~~ of ~~TolC in complex with hexamminecobalt===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_15342230}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[1tqq]] is a 3 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Escherichia_coli Escherichia coli]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=1TQQ OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:015342230<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Escherichia coli]]		[[Category: Escherichia coli]]
	[[Category: Edwards, P C.]]		[[Category: Edwards, P C.]]

OCA: Protected "1tqq" [edit=sysop:move=sysop]

OCA — Sat, 05 Jan 2013 11:56:15 GMT

Protected "1tqq" [edit=sysop:move=sysop]

←Older revision

Revision as of 11:56, 5 January 2013

OCA at 11:56, 5 January 2013

OCA — Sat, 05 Jan 2013 11:56:10 GMT

←Older revision		Revision as of 11:56, 5 January 2013
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-	{{Seed}}
	[[Image:1tqq.png\|left\|200px]]		[[Image:1tqq.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_1tqq", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
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	{{STRUCTURE_1tqq\| PDB=1tqq \| SCENE= }}		{{STRUCTURE_1tqq\| PDB=1tqq \| SCENE= }}

	===Structure of TolC in complex with hexamminecobalt===		===Structure of TolC in complex with hexamminecobalt===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_15342230}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 15342230 is the PubMed ID number.
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	{{ABSTRACT_PUBMED_15342230}}		{{ABSTRACT_PUBMED_15342230}}

	==About this Structure==		==About this Structure==
-	~~1TQQ~~ is a 3 ~~chains~~ structure ~~of sequences~~ from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TQQ OCA].	+	[[1tqq]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TQQ OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~15342230~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:015342230</ref><references group="xtra"/>
	[[Category: Escherichia coli]]		[[Category: Escherichia coli]]
	[[Category: Edwards, P C.]]		[[Category: Edwards, P C.]]
Line 33:		Line 21:
	[[Category: Alpha-barrel]]		[[Category: Alpha-barrel]]
	[[Category: Beta-barrel]]		[[Category: Beta-barrel]]
-		+	[[Category: Transport protein]]
-	~~''Page seeded by~~ [~~http~~:~~//oca.weizmann.ac.il/oca OCA~~ ] ~~on Tue Feb 17 01:35:11 2009''~~	+

OCA at 23:35, 16 February 2009

OCA — Mon, 16 Feb 2009 23:35:17 GMT

←Older revision		Revision as of 23:35, 16 February 2009
Line 20:		Line 20:

	==About this Structure==		==About this Structure==
-	1TQQ is a ~~[[Single protein]]~~ structure of ~~sequence~~ from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TQQ OCA].	+	1TQQ is a 3 chains structure of sequences from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TQQ OCA].

	==Reference==		==Reference==
-	Structure of the ligand-blocked periplasmic entrance of the bacterial multidrug efflux protein TolC., Higgins MK, Eswaran J, Edwards P, Schertler GF, Hughes C, Koronakis V, J Mol Biol. 2004 Sep 17;342(3):697-702. PMID:~~[http:~~//~~www.ncbi.nlm.nih.gov/pubmed/15342230 15342230]~~	+	<ref group="xtra">PMID:15342230</ref><references group="xtra"/>
	[[Category: Escherichia coli]]		[[Category: Escherichia coli]]
-	[[Category: Single protein]]
	[[Category: Edwards, P C.]]		[[Category: Edwards, P C.]]
	[[Category: Eswaran, J.]]		[[Category: Eswaran, J.]]
Line 35:		Line 34:
	[[Category: Beta-barrel]]		[[Category: Beta-barrel]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Mon Jul 28 05~~:43:~~39 2008~~''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 01:35:11 2009''