1ts5 - Revision history

OCA at 06:36, 9 August 2023

OCA — Wed, 09 Aug 2023 06:36:26 GMT

←Older revision		Revision as of 06:36, 9 August 2023
Line 3:		Line 3:
	<StructureSection load='1ts5' size='340' side='right'caption='[[1ts5]], [[Resolution\|resolution]] 3.10Å' scene=''>		<StructureSection load='1ts5' size='340' side='right'caption='[[1ts5]], [[Resolution\|resolution]] 3.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1ts5]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~"micrococcus_aureus"_(rosenbach_1884)_zopf_1885 "micrococcus~~ aureus~~" (rosenbach 1884) zopf 1885~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TS5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1TS5 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1ts5]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TS5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1TS5 FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ts5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ts5 OCA], [https://pdbe.org/1ts5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ts5 RCSB], [https://www.ebi.ac.uk/pdbsum/1ts5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ts5 ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 3.1Å</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ts5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ts5 OCA], [https://pdbe.org/1ts5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ts5 RCSB], [https://www.ebi.ac.uk/pdbsum/1ts5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ts5 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/TSST_STAAU TSST_STAAU]] Responsible for the symptoms of toxic shock syndrome.	+	[https://www.uniprot.org/uniprot/TSST_STAAU TSST_STAAU] Responsible for the symptoms of toxic shock syndrome.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 32:		Line 33:
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Earhart~~, C A~~]]	+	[[Category: Staphylococcus aureus]]
-	[[Category: Matsumura, M]]	+	[[Category: Earhart CA]]
-	[[Category: Mitchell~~, D T~~]]	+	[[Category: Matsumura M]]
-	[[Category: Murray~~, D L~~]]	+	[[Category: Mitchell DT]]
-	[[Category: Ohlendorf~~, D H~~]]	+	[[Category: Murray DL]]
-	[[Category: Pinheiro~~, D M~~]]	+	[[Category: Ohlendorf DH]]
-	[[Category: Schlievert~~, P M]]~~	+	[[Category: Pinheiro DM]]
-	~~[[Category: Superantigen]]~~	+	[[Category: Schlievert PM]]
-	~~[[Category: Toxin~~]]	+

OCA at 09:31, 29 September 2021

OCA — Wed, 29 Sep 2021 09:31:58 GMT

←Older revision		Revision as of 09:31, 29 September 2021
Line 3:		Line 3:
	<StructureSection load='1ts5' size='340' side='right'caption='[[1ts5]], [[Resolution\|resolution]] 3.10Å' scene=''>		<StructureSection load='1ts5' size='340' side='right'caption='[[1ts5]], [[Resolution\|resolution]] 3.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1ts5]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/"micrococcus_aureus"_(rosenbach_1884)_zopf_1885 "micrococcus aureus" (rosenbach 1884) zopf 1885]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TS5 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1TS5 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1ts5]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/"micrococcus_aureus"_(rosenbach_1884)_zopf_1885 "micrococcus aureus" (rosenbach 1884) zopf 1885]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TS5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1TS5 FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1ts5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ts5 OCA], [~~http~~://pdbe.org/1ts5 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1ts5 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1ts5 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1ts5 ProSAT]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ts5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ts5 OCA], [https://pdbe.org/1ts5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ts5 RCSB], [https://www.ebi.ac.uk/pdbsum/1ts5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ts5 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/TSST_STAAU TSST_STAAU]] Responsible for the symptoms of toxic shock syndrome.	+	[[https://www.uniprot.org/uniprot/TSST_STAAU TSST_STAAU]] Responsible for the symptoms of toxic shock syndrome.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 13:49, 25 December 2019

OCA — Wed, 25 Dec 2019 13:49:31 GMT

←Older revision		Revision as of 13:49, 25 December 2019
Line 1:		Line 1:

	==I140T MUTANT OF TOXIC SHOCK SYNDROME TOXIN-1 FROM S. AUREUS==		==I140T MUTANT OF TOXIC SHOCK SYNDROME TOXIN-1 FROM S. AUREUS==
-	<StructureSection load='1ts5' size='340' side='right' caption='[[1ts5]], [[Resolution\|resolution]] 3.10Å' scene=''>	+	<StructureSection load='1ts5' size='340' side='right'caption='[[1ts5]], [[Resolution\|resolution]] 3.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1ts5]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/"micrococcus_aureus"_(rosenbach_1884)_zopf_1885 "micrococcus aureus" (rosenbach 1884) zopf 1885]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TS5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1TS5 FirstGlance]. <br>		<table><tr><td colspan='2'>[[1ts5]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/"micrococcus_aureus"_(rosenbach_1884)_zopf_1885 "micrococcus aureus" (rosenbach 1884) zopf 1885]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TS5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1TS5 FirstGlance]. <br>
Line 31:		Line 31:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Earhart, C A]]		[[Category: Earhart, C A]]
	[[Category: Matsumura, M]]		[[Category: Matsumura, M]]

OCA at 08:39, 21 March 2018

OCA — Wed, 21 Mar 2018 08:39:37 GMT

←Older revision		Revision as of 08:39, 21 March 2018
Line 1:		Line 1:
		+
	==I140T MUTANT OF TOXIC SHOCK SYNDROME TOXIN-1 FROM S. AUREUS==		==I140T MUTANT OF TOXIC SHOCK SYNDROME TOXIN-1 FROM S. AUREUS==
	<StructureSection load='1ts5' size='340' side='right' caption='[[1ts5]], [[Resolution\|resolution]] 3.10Å' scene=''>		<StructureSection load='1ts5' size='340' side='right' caption='[[1ts5]], [[Resolution\|resolution]] 3.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1ts5]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/"micrococcus_aureus"_(rosenbach_1884)_zopf_1885 "micrococcus aureus" (rosenbach 1884) zopf 1885]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TS5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1TS5 FirstGlance]. <br>		<table><tr><td colspan='2'>[[1ts5]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/"micrococcus_aureus"_(rosenbach_1884)_zopf_1885 "micrococcus aureus" (rosenbach 1884) zopf 1885]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TS5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1TS5 FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ts5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ts5 OCA], [http://pdbe.org/1ts5 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1ts5 RCSB], [http://www.ebi.ac.uk/pdbsum/1ts5 PDBsum]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ts5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ts5 OCA], [http://pdbe.org/1ts5 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1ts5 RCSB], [http://www.ebi.ac.uk/pdbsum/1ts5 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1ts5 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 11:		Line 12:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ts/1ts5_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ts/1ts5_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 21:46, 8 February 2016

OCA — Mon, 08 Feb 2016 21:46:25 GMT

←Older revision		Revision as of 21:46, 8 February 2016
Line 15:		Line 15:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1ts5 ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 15:41, 10 September 2015

OCA — Thu, 10 Sep 2015 15:41:00 GMT

←Older revision		Revision as of 15:41, 10 September 2015
Line 2:		Line 2:
	<StructureSection load='1ts5' size='340' side='right' caption='[[1ts5]], [[Resolution\|resolution]] 3.10Å' scene=''>		<StructureSection load='1ts5' size='340' side='right' caption='[[1ts5]], [[Resolution\|resolution]] 3.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1ts5]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Staphylococcus_aureus Staphylococcus~~ aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TS5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1TS5 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1ts5]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/"micrococcus_aureus"_(rosenbach_1884)_zopf_1885 "micrococcus aureus" (rosenbach 1884) zopf 1885]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TS5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1TS5 FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ts5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ts5 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1ts5 RCSB], [http://www.ebi.ac.uk/pdbsum/1ts5 PDBsum]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ts5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ts5 OCA], [http://pdbe.org/1ts5 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1ts5 RCSB], [http://www.ebi.ac.uk/pdbsum/1ts5 PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1ts5" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Staphylococcus aureus]]
	[[Category: Earhart, C A]]		[[Category: Earhart, C A]]
	[[Category: Matsumura, M]]		[[Category: Matsumura, M]]

OCA at 02:21, 25 December 2014

OCA — Thu, 25 Dec 2014 02:21:33 GMT

←Older revision		Revision as of 02:21, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1ts5]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TS5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1TS5 FirstGlance]. <br>		<table><tr><td colspan='2'>[[1ts5]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TS5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1TS5 FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ts5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ts5 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1ts5 RCSB], [http://www.ebi.ac.uk/pdbsum/1ts5 PDBsum]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ts5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ts5 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1ts5 RCSB], [http://www.ebi.ac.uk/pdbsum/1ts5 PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/TSST_STAAU TSST_STAAU]] Responsible for the symptoms of toxic shock syndrome.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 28:		Line 30:
	</StructureSection>		</StructureSection>
	[[Category: Staphylococcus aureus]]		[[Category: Staphylococcus aureus]]
-	[[Category: Earhart, C A.]]	+	[[Category: Earhart, C A]]
-	[[Category: Matsumura, M.]]	+	[[Category: Matsumura, M]]
-	[[Category: Mitchell, D T.]]	+	[[Category: Mitchell, D T]]
-	[[Category: Murray, D L.]]	+	[[Category: Murray, D L]]
-	[[Category: Ohlendorf, D H.]]	+	[[Category: Ohlendorf, D H]]
-	[[Category: Pinheiro, D M.]]	+	[[Category: Pinheiro, D M]]
-	[[Category: Schlievert, P M.]]	+	[[Category: Schlievert, P M]]
	[[Category: Superantigen]]		[[Category: Superantigen]]
	[[Category: Toxin]]		[[Category: Toxin]]

OCA at 21:52, 29 September 2014

OCA — Mon, 29 Sep 2014 21:52:42 GMT

←Older revision		Revision as of 21:52, 29 September 2014
Line 1:		Line 1:
-	[[~~Image~~:1ts5.~~png\|left~~\|200px]]	+	==I140T MUTANT OF TOXIC SHOCK SYNDROME TOXIN-1 FROM S. AUREUS==
		+	<StructureSection load='1ts5' size='340' side='right' caption='[[1ts5]], [[Resolution\|resolution]] 3.10Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1ts5]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TS5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1TS5 FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ts5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ts5 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1ts5 RCSB], [http://www.ebi.ac.uk/pdbsum/1ts5 PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ts/1ts5_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The three-dimensional structures of five mutants of toxic shock syndrome toxin-1 (TSST-1) have been determined. These mutations are in the long central alpha helix and are useful in mapping portions of TSST-1 involved in superantigenicity and lethality. The T128A, H135A, Q139K, and I140T mutations appear to reduce superantigenicity by altering the properties of the T-cell receptor interaction surface. The Q136A mutation is at a largely buried site and causes a dramatic change in the conformation of the beta7-beta9 loop which covers the back of the central alpha helix. As this mutation has the unique ability to reduce the toxin's lethality in rabbits while retaining its superantigenicity, it raises the possibility that this rear loop mediates the ability of TSST-1 to induce lethality and suggests a route for producing nonlethal toxins for therapeutic development.

-	~~{{STRUCTURE_1ts5\| PDB=1ts5 \| SCENE= }}~~	+	Structures of five mutants of toxic shock syndrome toxin-1 with reduced biological activity.,Earhart CA, Mitchell DT, Murray DL, Pinheiro DM, Matsumura M, Schlievert PM, Ohlendorf DH Biochemistry. 1998 May 19;37(20):7194-202. PMID:9585531<ref>PMID:9585531</ref>

-	~~===I140T MUTANT OF TOXIC SHOCK SYNDROME TOXIN-1 FROM S. AUREUS===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_9585531}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[1ts5]] is~~ a ~~2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Staphylococcus_aureus Staphylococcus aureus]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=1TS5 OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:009585531<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Staphylococcus aureus]]		[[Category: Staphylococcus aureus]]
	[[Category: Earhart, C A.]]		[[Category: Earhart, C A.]]

OCA: Protected "1ts5" [edit=sysop:move=sysop]

OCA — Sat, 05 Jan 2013 13:26:31 GMT

Protected "1ts5" [edit=sysop:move=sysop]

←Older revision

Revision as of 13:26, 5 January 2013

OCA at 13:26, 5 January 2013

OCA — Sat, 05 Jan 2013 13:26:28 GMT

←Older revision		Revision as of 13:26, 5 January 2013
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	[[Image:1ts5.png\|left\|200px]]		[[Image:1ts5.png\|left\|200px]]

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	{{STRUCTURE_1ts5\| PDB=1ts5 \| SCENE= }}		{{STRUCTURE_1ts5\| PDB=1ts5 \| SCENE= }}

	===I140T MUTANT OF TOXIC SHOCK SYNDROME TOXIN-1 FROM S. AUREUS===		===I140T MUTANT OF TOXIC SHOCK SYNDROME TOXIN-1 FROM S. AUREUS===

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	{{ABSTRACT_PUBMED_9585531}}		{{ABSTRACT_PUBMED_9585531}}

	==About this Structure==		==About this Structure==
-	~~1TS5~~ is a 2 ~~chains~~ structure ~~of sequences~~ from [http://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TS5 OCA].	+	[[1ts5]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TS5 OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~9585531~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:009585531</ref><references group="xtra"/>
	[[Category: Staphylococcus aureus]]		[[Category: Staphylococcus aureus]]
	[[Category: Earhart, C A.]]		[[Category: Earhart, C A.]]
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	[[Category: Superantigen]]		[[Category: Superantigen]]
	[[Category: Toxin]]		[[Category: Toxin]]
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-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 03:44:17 2009''