1tt3 - Revision history

OCA at 10:29, 16 August 2023

OCA — Wed, 16 Aug 2023 10:29:17 GMT

←Older revision		Revision as of 10:29, 16 August 2023
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	==NMR soulution structure of omega-conotoxin [K10]MVIIA==		==NMR soulution structure of omega-conotoxin [K10]MVIIA==
-	<StructureSection load='1tt3' size='340' side='right'caption='[[1tt3~~]], [[NMR_Ensembles_of_Models \| 22 NMR models~~]]' scene=''>	+	<StructureSection load='1tt3' size='340' side='right'caption='[[1tt3]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1tt3]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TT3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1TT3 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1tt3]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Conus_magus Conus magus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TT3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1TT3 FirstGlance]. <br>
-	</td></tr><tr id='~~NonStdRes~~'><td class="sblockLbl"><b>[[~~Non-Standard_Residue~~\|~~NonStd Res~~:]]</b></td><td class="sblockDat"~~><scene name~~=~~'pdbligand=NH2:AMINO+GROUP'>NH2</scene~~></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"><~~div style~~='~~overflow~~: ~~auto; max-height: 3em;~~'>~~[[1omg\|1omg]], [[1mvj\|1mvj]], [[1dw4\|1dw4]], [[1ttk\|1ttk]]~~</~~div~~></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1tt3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tt3 OCA], [https://pdbe.org/1tt3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1tt3 RCSB], [https://www.ebi.ac.uk/pdbsum/1tt3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1tt3 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1tt3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tt3 OCA], [https://pdbe.org/1tt3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1tt3 RCSB], [https://www.ebi.ac.uk/pdbsum/1tt3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1tt3 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/~~CO17A_CONMA CO17A_CONMA]~~] Omega-conotoxins act at presynaptic membranes, they bind and block voltage-gated calcium channels. This toxin blocks ~~N-type calcium channels (~~Cav2.2/CACNA1B).	+	[https://www.uniprot.org/uniprot/O17A_CONMA O17A_CONMA] Omega-conotoxins act at presynaptic membranes, they bind and block voltage-gated calcium channels. This toxin blocks Cav2.2/CACNA1B calcium channels (IC(50)=0.67-208 nM) (PubMed:7826361, PubMed:26344359, PubMed:34589389). It acts by neutralizing the outer electronegativity and sterically hindering the ion access path to the entrance of the channel selectivity filter (PubMed:34234349). It also shows antiproliferative effects on different glioma cell lines (M059J, U-138MG and U-251MG) (PubMed:28202361). In vivo, is lethal to fish (PubMed:26344359, PubMed:34589389). In vivo, injection into mammals induces adverse effects, such as tremor, diminution of spontaneous locomotor activity and bad coordinated locomotion (PubMed:26344359). In addition, it causes reduction of tumor area in the mouse glioma model, that is induced by the orthotopic injection of GL261 cells into the brain (PubMed:28202361).<ref>PMID:26344359</ref> <ref>PMID:34234349</ref> <ref>PMID:7826361</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 23:		Line 23:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Conus magus]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Adams~~, D J~~]]	+	[[Category: Adams DJ]]
-	[[Category: Lewis~~, R J~~]]	+	[[Category: Lewis RJ]]
-	[[Category: Schroeder~~, C I~~]]	+	[[Category: Schroeder CI]]
-	[[Category: Smith~~, A B~~]]	+	[[Category: Smith AB]]
-	[[Category: Yasuda, T]]	+	[[Category: Yasuda T]]
-	~~[[Category: Cysteine knot]]~~	+
-	~~[[Category: Four loop frame work]]~~	+
-	~~[[Category: Toxin~~]]	+

OCA at 09:32, 29 September 2021

OCA — Wed, 29 Sep 2021 09:32:22 GMT

←Older revision		Revision as of 09:32, 29 September 2021
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	<StructureSection load='1tt3' size='340' side='right'caption='[[1tt3]], [[NMR_Ensembles_of_Models \| 22 NMR models]]' scene=''>		<StructureSection load='1tt3' size='340' side='right'caption='[[1tt3]], [[NMR_Ensembles_of_Models \| 22 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1tt3]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TT3 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1TT3 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1tt3]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TT3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1TT3 FirstGlance]. <br>
	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1omg\|1omg]], [[1mvj\|1mvj]], [[1dw4\|1dw4]], [[1ttk\|1ttk]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1omg\|1omg]], [[1mvj\|1mvj]], [[1dw4\|1dw4]], [[1ttk\|1ttk]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1tt3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tt3 OCA], [~~http~~://pdbe.org/1tt3 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1tt3 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1tt3 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1tt3 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1tt3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tt3 OCA], [https://pdbe.org/1tt3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1tt3 RCSB], [https://www.ebi.ac.uk/pdbsum/1tt3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1tt3 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/CO17A_CONMA CO17A_CONMA]] Omega-conotoxins act at presynaptic membranes, they bind and block voltage-gated calcium channels. This toxin blocks N-type calcium channels (Cav2.2/CACNA1B).	+	[[https://www.uniprot.org/uniprot/CO17A_CONMA CO17A_CONMA]] Omega-conotoxins act at presynaptic membranes, they bind and block voltage-gated calcium channels. This toxin blocks N-type calcium channels (Cav2.2/CACNA1B).
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 14:01, 25 December 2019

OCA — Wed, 25 Dec 2019 14:01:07 GMT

←Older revision		Revision as of 14:01, 25 December 2019
Line 1:		Line 1:

	==NMR soulution structure of omega-conotoxin [K10]MVIIA==		==NMR soulution structure of omega-conotoxin [K10]MVIIA==
-	<StructureSection load='1tt3' size='340' side='right' caption='[[1tt3]], [[NMR_Ensembles_of_Models \| 22 NMR models]]' scene=''>	+	<StructureSection load='1tt3' size='340' side='right'caption='[[1tt3]], [[NMR_Ensembles_of_Models \| 22 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1tt3]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TT3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1TT3 FirstGlance]. <br>		<table><tr><td colspan='2'>[[1tt3]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TT3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1TT3 FirstGlance]. <br>
Line 23:		Line 23:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Adams, D J]]		[[Category: Adams, D J]]
	[[Category: Lewis, R J]]		[[Category: Lewis, R J]]

OCA at 08:50, 21 March 2018

OCA — Wed, 21 Mar 2018 08:50:46 GMT

←Older revision		Revision as of 08:50, 21 March 2018
Line 1:		Line 1:
		+
	==NMR soulution structure of omega-conotoxin [K10]MVIIA==		==NMR soulution structure of omega-conotoxin [K10]MVIIA==
	<StructureSection load='1tt3' size='340' side='right' caption='[[1tt3]], [[NMR_Ensembles_of_Models \| 22 NMR models]]' scene=''>		<StructureSection load='1tt3' size='340' side='right' caption='[[1tt3]], [[NMR_Ensembles_of_Models \| 22 NMR models]]' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1omg\|1omg]], [[1mvj\|1mvj]], [[1dw4\|1dw4]], [[1ttk\|1ttk]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1omg\|1omg]], [[1mvj\|1mvj]], [[1dw4\|1dw4]], [[1ttk\|1ttk]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1tt3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tt3 OCA], [http://pdbe.org/1tt3 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1tt3 RCSB], [http://www.ebi.ac.uk/pdbsum/1tt3 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1tt3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tt3 OCA], [http://pdbe.org/1tt3 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1tt3 RCSB], [http://www.ebi.ac.uk/pdbsum/1tt3 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1tt3 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==

OCA at 07:05, 11 September 2015

OCA — Fri, 11 Sep 2015 07:05:55 GMT

←Older revision		Revision as of 07:05, 11 September 2015
Line 5:		Line 5:
	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1omg\|1omg]], [[1mvj\|1mvj]], [[1dw4\|1dw4]], [[1ttk\|1ttk]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1omg\|1omg]], [[1mvj\|1mvj]], [[1dw4\|1dw4]], [[1ttk\|1ttk]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1tt3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tt3 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1tt3 RCSB], [http://www.ebi.ac.uk/pdbsum/1tt3 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1tt3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tt3 OCA], [http://pdbe.org/1tt3 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1tt3 RCSB], [http://www.ebi.ac.uk/pdbsum/1tt3 PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[http://www.uniprot.org/uniprot/~~CXO7A_CONMA CXO7A_CONMA~~]] Omega-conotoxins act at presynaptic membranes, they bind and block voltage-gated calcium channels. This toxin blocks N-type calcium channels (Cav2.2/CACNA1B).	+	[[http://www.uniprot.org/uniprot/CO17A_CONMA CO17A_CONMA]] Omega-conotoxins act at presynaptic membranes, they bind and block voltage-gated calcium channels. This toxin blocks N-type calcium channels (Cav2.2/CACNA1B).
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 17:		Line 17:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1tt3" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 13:00, 25 December 2014

OCA — Thu, 25 Dec 2014 13:00:02 GMT

←Older revision		Revision as of 13:00, 25 December 2014
Line 7:		Line 7:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1tt3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tt3 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1tt3 RCSB], [http://www.ebi.ac.uk/pdbsum/1tt3 PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1tt3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tt3 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1tt3 RCSB], [http://www.ebi.ac.uk/pdbsum/1tt3 PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/CXO7A_CONMA CXO7A_CONMA]] Omega-conotoxins act at presynaptic membranes, they bind and block voltage-gated calcium channels. This toxin blocks N-type calcium channels (Cav2.2/CACNA1B).
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Adams, D J.]]	+	[[Category: Adams, D J]]
-	[[Category: Lewis, R J.]]	+	[[Category: Lewis, R J]]
-	[[Category: Schroeder, C I.]]	+	[[Category: Schroeder, C I]]
-	[[Category: Smith, A B.]]	+	[[Category: Smith, A B]]
-	[[Category: Yasuda, T.]]	+	[[Category: Yasuda, T]]
	[[Category: Cysteine knot]]		[[Category: Cysteine knot]]
	[[Category: Four loop frame work]]		[[Category: Four loop frame work]]
	[[Category: Toxin]]		[[Category: Toxin]]

OCA at 08:20, 8 October 2014

OCA — Wed, 08 Oct 2014 08:20:17 GMT

←Older revision		Revision as of 08:20, 8 October 2014
Line 1:		Line 1:
-	[[~~Image:~~1tt3.~~png~~\|~~left~~\|~~200px~~]]	+	==NMR soulution structure of omega-conotoxin [K10]MVIIA==
		+	<StructureSection load='1tt3' size='340' side='right' caption='[[1tt3]], [[NMR_Ensembles_of_Models \| 22 NMR models]]' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1tt3]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TT3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1TT3 FirstGlance]. <br>
		+	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1omg\|1omg]], [[1mvj\|1mvj]], [[1dw4\|1dw4]], [[1ttk\|1ttk]]</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1tt3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tt3 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1tt3 RCSB], [http://www.ebi.ac.uk/pdbsum/1tt3 PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Neurotransmitter release from preganglionic parasympathetic neurons is resistant to inhibition by selective antagonists of L-, N-, P/Q-, R-, and T-type calcium channels. In this study, the effects of different omega-conotoxins from genus Conus were investigated on current flow-through cloned voltage-sensitive calcium channels expressed in Xenopus oocytes and nerve-evoked transmitter release from the intact preganglionic cholinergic nerves innervating the rat submandibular ganglia. Our results indicate that omega-conotoxin CVID from Conus catus inhibits a pharmacologically distinct voltage-sensitive calcium channel involved in neurotransmitter release, whereas omega-conotoxin MVIIA had no effect. omega-Conotoxin CVID and MVIIA inhibited depolarization-activated Ba(2+) currents recorded from oocytes expressing N-type but not L- or R-type calcium channels. High affinity inhibition of the CVID-sensitive calcium channel was enhanced when position 10 of the omega-conotoxin was occupied by the smaller residue lysine as found in CVID instead of an arginine as found in MVIIA. Given that relatively small differences in the sequence of the N-type calcium channel alpha(1B) subunit can influence omega-conotoxin access (Feng, Z. P., Hamid, J., Doering, C., Bosey, G. M., Snutch, T. P., and Zamponi, G. W. (2001) J. Biol. Chem. 276, 15728-15735), it is likely that the calcium channel in preganglionic nerve terminals targeted by CVID is a N-type (Ca(v)2.2) calcium channel variant.

-	~~{{STRUCTURE_1tt3\| PDB=1tt3 \| SCENE= }}~~	+	Omega-conotoxin CVID inhibits a pharmacologically distinct voltage-sensitive calcium channel associated with transmitter release from preganglionic nerve terminals.,Adams DJ, Smith AB, Schroeder CI, Yasuda T, Lewis RJ J Biol Chem. 2003 Feb 7;278(6):4057-62. Epub 2002 Nov 18. PMID:12441339<ref>PMID:12441339</ref>

-	~~===NMR soulution structure~~ of ~~omega-conotoxin [K10]MVIIA===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_12441339}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[1tt3]] is a 1 chain structure~~. ~~Full experimental information is available from [http://oca~~.~~weizmann~~.~~ac.il~~/~~oca-bin/ocashort?id=1TT3 OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:015166237<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Adams, D J.]]		[[Category: Adams, D J.]]
	[[Category: Lewis, R J.]]		[[Category: Lewis, R J.]]

OCA: Protected "1tt3" [edit=sysop:move=sysop]

OCA — Sat, 05 Jan 2013 13:37:33 GMT

Protected "1tt3" [edit=sysop:move=sysop]

←Older revision

Revision as of 13:37, 5 January 2013

OCA at 13:37, 5 January 2013

OCA — Sat, 05 Jan 2013 13:37:30 GMT

←Older revision		Revision as of 13:37, 5 January 2013
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-	{{Seed}}
	[[Image:1tt3.png\|left\|200px]]		[[Image:1tt3.png\|left\|200px]]

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	{{STRUCTURE_1tt3\| PDB=1tt3 \| SCENE= }}		{{STRUCTURE_1tt3\| PDB=1tt3 \| SCENE= }}

	===NMR soulution structure of omega-conotoxin [K10]MVIIA===		===NMR soulution structure of omega-conotoxin [K10]MVIIA===

-
-	<!--
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-	(as it appears on PubMed at http://www.pubmed.gov), where 12441339 is the PubMed ID number.
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	{{ABSTRACT_PUBMED_12441339}}		{{ABSTRACT_PUBMED_12441339}}

	==About this Structure==		==About this Structure==
-	~~1TT3 is a~~ [[~~Single protein~~]] structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TT3 OCA].	+	[[1tt3]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TT3 OCA].

	==Reference==		==Reference==
-	Omega-conotoxin CVID inhibits a pharmacologically distinct voltage-sensitive calcium channel associated with transmitter release from preganglionic nerve terminals., Adams DJ, Smith AB, Schroeder CI, Yasuda T, Lewis RJ, J Biol Chem. 2003 Feb 7;278(6):4057-62. Epub 2002 Nov 18. PMID:~~[http:~~//~~www.ncbi.nlm.nih.gov/pubmed/12441339 12441339]~~	+	<ref group="xtra">PMID:015166237</ref><references group="xtra"/>
-	~~[[Category: Single protein]]~~	+
	[[Category: Adams, D J.]]		[[Category: Adams, D J.]]
	[[Category: Lewis, R J.]]		[[Category: Lewis, R J.]]
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	[[Category: Cysteine knot]]		[[Category: Cysteine knot]]
	[[Category: Four loop frame work]]		[[Category: Four loop frame work]]
-		+	[[Category: Toxin]]
-	~~''Page seeded by~~ [~~http~~:~~//oca.weizmann.ac.il/oca OCA~~ ] ~~on Mon Jul 28 23:37:12 2008''~~	+

OCA at 20:37, 28 July 2008

OCA — Mon, 28 Jul 2008 20:37:15 GMT

←Older revision		Revision as of 20:37, 28 July 2008
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-	[[Image:1tt3.~~jpg~~\|left\|200px]]	+	{{Seed}}
		+	[[Image:1tt3.png\|left\|200px]]

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	{{STRUCTURE_1tt3\| PDB=1tt3 \| SCENE= }}		{{STRUCTURE_1tt3\| PDB=1tt3 \| SCENE= }}

-	~~'''~~NMR soulution structure of omega-conotoxin [K10]MVIIA~~'''~~	+	===NMR soulution structure of omega-conotoxin [K10]MVIIA===


-	~~==Overview==~~	+	<!--
-	~~Neurotransmitter release from preganglionic parasympathetic neurons is resistant to inhibition by selective antagonists of L~~-~~, N~~-, ~~P/Q-, R-, and T-type calcium channels. In this study~~, the effects of different omega-conotoxins from genus Conus were investigated on current flow-through cloned voltage-sensitive calcium channels expressed in Xenopus oocytes and nerve-evoked transmitter release from the intact preganglionic cholinergic nerves innervating the rat submandibular ganglia. Our results indicate that omega-conotoxin CVID from Conus catus inhibits a pharmacologically distinct voltage-sensitive calcium channel involved in neurotransmitter release, whereas omega-conotoxin MVIIA had no effect. omega-Conotoxin CVID and MVIIA inhibited depolarization-activated Ba(2+) currents recorded from oocytes expressing N-type but not L- or R-type calcium channels. High affinity inhibition of the CVID-sensitive calcium channel was enhanced when position 10 of the omega-conotoxin was occupied by the smaller residue lysine as ~~found in CVID instead of an arginine as found in MVIIA~~. ~~Given that relatively small differences in the sequence of the N-type calcium channel alpha(1B) subunit can influence omega-conotoxin access (Feng, Z~~. ~~P., Hamid, J., Doering, C., Bosey, G. M., Snutch, T. P., and Zamponi, G. W. (2001~~) ~~J. Biol. Chem. 276~~, ~~15728-15735), it~~ is ~~likely that~~ the ~~calcium channel in preganglionic nerve terminals targeted by CVID is a N~~-~~type (Ca(v)2.2) calcium channel variant.~~	+	The line below this paragraph, {{ABSTRACT_PUBMED_12441339}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 12441339 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_12441339}}

	==About this Structure==		==About this Structure==
-	1TT3 is a [[Single protein]] structure. Full ~~crystallographic~~ information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TT3 OCA].	+	1TT3 is a [[Single protein]] structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TT3 OCA].

	==Reference==		==Reference==
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	[[Category: Cysteine knot]]		[[Category: Cysteine knot]]
	[[Category: Four loop frame work]]		[[Category: Four loop frame work]]
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Sat May 3 10~~:19:46 2008''	+
		+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 23:37:12 2008''