1ttx - Revision history

OCA at 18:16, 29 May 2024

OCA — Wed, 29 May 2024 18:16:37 GMT

←Older revision		Revision as of 18:16, 29 May 2024
Line 20:		Line 20:
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1ttx ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1ttx ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The aim of this research was to determine the structure of human beta-parvalbumin (109 amino acids) and to compare it with its paralog and ortholog proteins. The structure was determined in solution using multinuclear and multidimensional NMR methods and refined using substitution of the EF-hand Ca(2+) ion with a paramagnetic lanthanide. The resulting family of structures had a backbone rmsd of 0.50 A. Comparison with rat oncomodulin (X-ray, 1.3 A resolution) as well as with human (NMR, backbone rmsd of 0.49 A) and rat (X-ray, 2.0 A resolution) parvalbumins reveals small but reliable local differences, often but not always related to amino acid variability. The analysis of these structures has led us to propose an explanation for the different affinity for Ca(2+) between alpha- and beta-parvalbumins and between parvalbumins and calmodulins.
		+
		+	Solution structure of human beta-parvalbumin and structural comparison with its paralog alpha-parvalbumin and with their rat orthologs.,Babini E, Bertini I, Capozzi F, Del Bianco C, Hollender D, Kiss T, Luchinat C, Quattrone A Biochemistry. 2004 Dec 28;43(51):16076-85. PMID:15610002<ref>PMID:15610002</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 1ttx" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
	*[[Parvalbumin\|Parvalbumin]]		*[[Parvalbumin\|Parvalbumin]]
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 08:44, 1 May 2024

OCA — Wed, 01 May 2024 08:44:24 GMT

←Older revision		Revision as of 08:44, 1 May 2024
Line 1:		Line 1:

	==Solution Structure of human beta parvalbumin (oncomodulin) refined with a paramagnetism based strategy==		==Solution Structure of human beta parvalbumin (oncomodulin) refined with a paramagnetism based strategy==
-	<StructureSection load='1ttx' size='340' side='right'caption='[[1ttx~~]], [[NMR_Ensembles_of_Models \| 20 NMR models~~]]' scene=''>	+	<StructureSection load='1ttx' size='340' side='right'caption='[[1ttx]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1ttx]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TTX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1TTX FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1ttx]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TTX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1TTX FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
-	<tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat">~~Homo sapiens ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode~~=~~Info&srchmode~~=~~5&id=9606 HUMAN])~~</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ttx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ttx OCA], [https://pdbe.org/1ttx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ttx RCSB], [https://www.ebi.ac.uk/pdbsum/1ttx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ttx ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ttx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ttx OCA], [https://pdbe.org/1ttx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ttx RCSB], [https://www.ebi.ac.uk/pdbsum/1ttx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ttx ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/ONCO_HUMAN ONCO_HUMAN]] Has some calmodulin-like activity with respect to enzyme activation and growth regulation. Binds two calcium ions.	+	[https://www.uniprot.org/uniprot/ONCO_HUMAN ONCO_HUMAN] Has some calmodulin-like activity with respect to enzyme activation and growth regulation. Binds two calcium ions.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 20:		Line 20:
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1ttx ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1ttx ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
-	<div style="background-color:#fffaf0;">
-	== Publication Abstract from PubMed ==
-	The aim of this research was to determine the structure of human beta-parvalbumin (109 amino acids) and to compare it with its paralog and ortholog proteins. The structure was determined in solution using multinuclear and multidimensional NMR methods and refined using substitution of the EF-hand Ca(2+) ion with a paramagnetic lanthanide. The resulting family of structures had a backbone rmsd of 0.50 A. Comparison with rat oncomodulin (X-ray, 1.3 A resolution) as well as with human (NMR, backbone rmsd of 0.49 A) and rat (X-ray, 2.0 A resolution) parvalbumins reveals small but reliable local differences, often but not always related to amino acid variability. The analysis of these structures has led us to propose an explanation for the different affinity for Ca(2+) between alpha- and beta-parvalbumins and between parvalbumins and calmodulins.
-
-	Solution structure of human beta-parvalbumin and structural comparison with its paralog alpha-parvalbumin and with their rat orthologs.,Babini E, Bertini I, Capozzi F, Del Bianco C, Hollender D, Kiss T, Luchinat C, Quattrone A Biochemistry. 2004 Dec 28;43(51):16076-85. PMID:15610002<ref>PMID:15610002</ref>
-
-	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	</div>
-	<div class="pdbe-citations 1ttx" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
	*[[Parvalbumin\|Parvalbumin]]		*[[Parvalbumin\|Parvalbumin]]
-	== References ==
-	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Babini, E]]	+	[[Category: Babini E]]
-	[[Category: Bertini, I]]	+	[[Category: Bertini I]]
-	[[Category: ~~Bianco, C Del~~]]	+	[[Category: Capozzi F]]
-	[[Category: ~~Capozzi, F~~]]	+	[[Category: Del Bianco C]]
-	[[Category: Hollender, D]]	+	[[Category: Hollender D]]
-	[[Category: Kiss, T]]	+	[[Category: Kiss T]]
-	[[Category: Luchinat, C]]	+	[[Category: Luchinat C]]
-	[[Category: Quattrone, A]]	+	[[Category: Quattrone A]]
-	~~[[Category: SPINE, Structural Proteomics in Europe]]~~	+
-	~~[[Category: Ef-hand]]~~	+
-	~~[[Category: Lanthanide]]~~	+
-	~~[[Category: Metal binding protein]]~~	+
-	~~[[Category: Oncomodulin]]~~	+
-	~~[[Category: Spine]]~~	+
-	~~[[Category: Structural genomic]]~~	+
-	~~[[Category: Structural proteomics in europe~~]]	+

OCA at 06:29, 10 November 2021

OCA — Wed, 10 Nov 2021 06:29:56 GMT

←Older revision		Revision as of 06:29, 10 November 2021
Line 3:		Line 3:
	<StructureSection load='1ttx' size='340' side='right'caption='[[1ttx]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='1ttx' size='340' side='right'caption='[[1ttx]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1ttx]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TTX OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=1TTX FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1ttx]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TTX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1TTX FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Homo sapiens ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Homo sapiens ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=1ttx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ttx OCA], [~~http~~://pdbe.org/1ttx PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1ttx RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1ttx PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1ttx ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ttx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ttx OCA], [https://pdbe.org/1ttx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ttx RCSB], [https://www.ebi.ac.uk/pdbsum/1ttx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ttx ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/ONCO_HUMAN ONCO_HUMAN]] Has some calmodulin-like activity with respect to enzyme activation and growth regulation. Binds two calcium ions.	+	[[https://www.uniprot.org/uniprot/ONCO_HUMAN ONCO_HUMAN]] Has some calmodulin-like activity with respect to enzyme activation and growth regulation. Binds two calcium ions.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 11:59, 24 December 2020

OCA — Thu, 24 Dec 2020 11:59:39 GMT

←Older revision		Revision as of 11:59, 24 December 2020
Line 1:		Line 1:

	==Solution Structure of human beta parvalbumin (oncomodulin) refined with a paramagnetism based strategy==		==Solution Structure of human beta parvalbumin (oncomodulin) refined with a paramagnetism based strategy==
-	<StructureSection load='1ttx' size='340' side='right' caption='[[1ttx]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>	+	<StructureSection load='1ttx' size='340' side='right'caption='[[1ttx]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1ttx]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TTX OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1TTX FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1ttx]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TTX OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=1TTX FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Homo sapiens ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Homo sapiens ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1ttx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ttx OCA], [http://pdbe.org/1ttx PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1ttx RCSB], [http://www.ebi.ac.uk/pdbsum/1ttx PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1ttx ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=1ttx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ttx OCA], [http://pdbe.org/1ttx PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1ttx RCSB], [http://www.ebi.ac.uk/pdbsum/1ttx PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1ttx ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 37:		Line 37:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Babini, E]]		[[Category: Babini, E]]
	[[Category: Bertini, I]]		[[Category: Bertini, I]]

OCA at 09:33, 3 October 2018

OCA — Wed, 03 Oct 2018 09:33:17 GMT

←Older revision		Revision as of 09:33, 3 October 2018
Line 3:		Line 3:
	<StructureSection load='1ttx' size='340' side='right' caption='[[1ttx]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='1ttx' size='340' side='right' caption='[[1ttx]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1ttx]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TTX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1TTX FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1ttx]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TTX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1TTX FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Homo sapiens ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ttx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ttx OCA], [http://pdbe.org/1ttx PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1ttx RCSB], [http://www.ebi.ac.uk/pdbsum/1ttx PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1ttx ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ttx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ttx OCA], [http://pdbe.org/1ttx PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1ttx RCSB], [http://www.ebi.ac.uk/pdbsum/1ttx PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1ttx ProSAT]</span></td></tr>
	</table>		</table>
Line 13:		Line 14:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/tt/1ttx_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/tt/1ttx_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 35:		Line 36:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human]]
	[[Category: Babini, E]]		[[Category: Babini, E]]
	[[Category: Bertini, I]]		[[Category: Bertini, I]]

OCA at 09:26, 2 January 2017

OCA — Mon, 02 Jan 2017 09:26:44 GMT

←Older revision		Revision as of 09:26, 2 January 2017
Line 1:		Line 1:
-	==Solution ~~Stucture~~ of human beta parvalbumin (oncomodulin) refined with a paramagnetism based strategy==	+
		+	==Solution Structure of human beta parvalbumin (oncomodulin) refined with a paramagnetism based strategy==
	<StructureSection load='1ttx' size='340' side='right' caption='[[1ttx]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='1ttx' size='340' side='right' caption='[[1ttx]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1ttx]] is a 1 chain structure ~~with sequence from [http://en.wikipedia.org/wiki/Human Human]~~. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TTX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1TTX FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1ttx]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TTX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1TTX FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Homo sapiens ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ttx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ttx OCA], [http://pdbe.org/1ttx PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1ttx RCSB], [http://www.ebi.ac.uk/pdbsum/1ttx PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1ttx ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ttx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ttx OCA], [http://pdbe.org/1ttx PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1ttx RCSB], [http://www.ebi.ac.uk/pdbsum/1ttx PDBsum]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
Line 35:		Line 35:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Human]]
	[[Category: Babini, E]]		[[Category: Babini, E]]
	[[Category: Bertini, I]]		[[Category: Bertini, I]]

OCA at 15:14, 7 February 2016

OCA — Sun, 07 Feb 2016 15:14:03 GMT

←Older revision		Revision as of 15:14, 7 February 2016
Line 17:		Line 17:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1ttx ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 02:42, 10 September 2015

OCA — Thu, 10 Sep 2015 02:42:15 GMT

←Older revision		Revision as of 02:42, 10 September 2015
Line 2:		Line 2:
	<StructureSection load='1ttx' size='340' side='right' caption='[[1ttx]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='1ttx' size='340' side='right' caption='[[1ttx]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1ttx]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TTX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1TTX FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1ttx]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TTX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1TTX FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Homo sapiens ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Homo sapiens ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ttx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ttx OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1ttx RCSB], [http://www.ebi.ac.uk/pdbsum/1ttx PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ttx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ttx OCA], [http://pdbe.org/1ttx PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1ttx RCSB], [http://www.ebi.ac.uk/pdbsum/1ttx PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 27:		Line 27:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1ttx" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 34:		Line 35:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Babini, E]]		[[Category: Babini, E]]
	[[Category: Bertini, I]]		[[Category: Bertini, I]]

OCA at 16:11, 24 December 2014

OCA — Wed, 24 Dec 2014 16:11:59 GMT

←Older revision		Revision as of 16:11, 24 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1ttx]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TTX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1TTX FirstGlance]. <br>		<table><tr><td colspan='2'>[[1ttx]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TTX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1TTX FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Homo sapiens ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Homo sapiens ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ttx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ttx OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1ttx RCSB], [http://www.ebi.ac.uk/pdbsum/1ttx PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ttx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ttx OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1ttx RCSB], [http://www.ebi.ac.uk/pdbsum/1ttx PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/ONCO_HUMAN ONCO_HUMAN]] Has some calmodulin-like activity with respect to enzyme activation and growth regulation. Binds two calcium ions.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 33:		Line 35:
	</StructureSection>		</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Babini, E.]]	+	[[Category: Babini, E]]
-	[[Category: Bertini, I.]]	+	[[Category: Bertini, I]]
-	[[Category: Bianco, C Del.]]	+	[[Category: Bianco, C Del]]
-	[[Category: Capozzi, F.]]	+	[[Category: Capozzi, F]]
-	[[Category: Hollender, D.]]	+	[[Category: Hollender, D]]
-	[[Category: Kiss, T.]]	+	[[Category: Kiss, T]]
-	[[Category: Luchinat, C.]]	+	[[Category: Luchinat, C]]
-	[[Category: Quattrone, A.]]	+	[[Category: Quattrone, A]]
-	[[Category: SPINE, Structural Proteomics in Europe.]]	+	[[Category: SPINE, Structural Proteomics in Europe]]
	[[Category: Ef-hand]]		[[Category: Ef-hand]]
	[[Category: Lanthanide]]		[[Category: Lanthanide]]

OCA at 23:26, 28 September 2014

OCA — Sun, 28 Sep 2014 23:26:39 GMT

←Older revision		Revision as of 23:26, 28 September 2014
Line 1:		Line 1:
-	[[~~Image:~~1ttx.~~png~~\|~~left~~\|200px]]	+	==Solution Stucture of human beta parvalbumin (oncomodulin) refined with a paramagnetism based strategy==
		+	<StructureSection load='1ttx' size='340' side='right' caption='[[1ttx]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1ttx]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TTX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1TTX FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Homo sapiens ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ttx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ttx OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1ttx RCSB], [http://www.ebi.ac.uk/pdbsum/1ttx PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/tt/1ttx_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The aim of this research was to determine the structure of human beta-parvalbumin (109 amino acids) and to compare it with its paralog and ortholog proteins. The structure was determined in solution using multinuclear and multidimensional NMR methods and refined using substitution of the EF-hand Ca(2+) ion with a paramagnetic lanthanide. The resulting family of structures had a backbone rmsd of 0.50 A. Comparison with rat oncomodulin (X-ray, 1.3 A resolution) as well as with human (NMR, backbone rmsd of 0.49 A) and rat (X-ray, 2.0 A resolution) parvalbumins reveals small but reliable local differences, often but not always related to amino acid variability. The analysis of these structures has led us to propose an explanation for the different affinity for Ca(2+) between alpha- and beta-parvalbumins and between parvalbumins and calmodulins.

-	~~{{STRUCTURE_1ttx\| PDB=1ttx \| SCENE= }}~~	+	Solution structure of human beta-parvalbumin and structural comparison with its paralog alpha-parvalbumin and with their rat orthologs.,Babini E, Bertini I, Capozzi F, Del Bianco C, Hollender D, Kiss T, Luchinat C, Quattrone A Biochemistry. 2004 Dec 28;43(51):16076-85. PMID:15610002<ref>PMID:15610002</ref>

-	~~===Solution Stucture~~ of ~~human beta parvalbumin (oncomodulin) refined with a paramagnetism based strategy===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_15610002}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[1ttx]] is a 1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Homo_sapiens Homo sapiens]~~. ~~Full experimental information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=1TTX OCA].~~	+

	==See Also==		==See Also==
	*[[Parvalbumin\|Parvalbumin]]		*[[Parvalbumin\|Parvalbumin]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:015610002<~~/~~ref~~><~~references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Babini, E.]]		[[Category: Babini, E.]]