1tud - Revision history

OCA at 08:42, 14 February 2024

OCA — Wed, 14 Feb 2024 08:42:11 GMT

←Older revision		Revision as of 08:42, 14 February 2024
Line 3:		Line 3:
	<StructureSection load='1tud' size='340' side='right'caption='[[1tud]], [[Resolution\|resolution]] 1.77Å' scene=''>		<StructureSection load='1tud' size='340' side='right'caption='[[1tud]], [[Resolution\|resolution]] 1.77Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1tud]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Chick Chick~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TUD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1TUD FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1tud]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TUD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1TUD FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1tud FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tud OCA], [https://pdbe.org/1tud PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1tud RCSB], [https://www.ebi.ac.uk/pdbsum/1tud PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1tud ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.77Å</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1tud FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tud OCA], [https://pdbe.org/1tud PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1tud RCSB], [https://www.ebi.ac.uk/pdbsum/1tud PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1tud ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/SPTN1_CHICK SPTN1_CHICK]] Morphologically, spectrin-like proteins appear to be related to spectrin, showing a flexible rod-like structure. They can bind actin but seem to differ in their calmodulin-binding activity. In nonerythroid tissues, spectrins, in association with some other proteins, may play an important role in membrane organization.	+	[https://www.uniprot.org/uniprot/SPTN1_CHICK SPTN1_CHICK] Morphologically, spectrin-like proteins appear to be related to spectrin, showing a flexible rod-like structure. They can bind actin but seem to differ in their calmodulin-binding activity. In nonerythroid tissues, spectrins, in association with some other proteins, may play an important role in membrane organization.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 18:		Line 19:
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1tud ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1tud ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
-	<div style="background-color:#fffaf0;">
-	== Publication Abstract from PubMed ==
-	We have analyzed the structure, stability and folding kinetics of circularly permuted forms of alpha-spectrin SH3 domain. All the possible permutations involving the disruption of the covalent linkage between two beta-strands forming a beta-hairpin have been done. The different proteins constructed here fold to a native conformation similar to that of wild-type protein, as demonstrated by nuclear magnetic resonance and circular dichroism. Although all the mutants have similar stabilities (they are 1 to 2 kcal mol-1 less stable than the wild-type) their rate constants for folding and unfolding are quite different. Protein engineering, in combination with kinetics indicates that the folding pathway has been changed in the circularly permuted proteins. We conclude that neither the order of secondary structure elements, nor the preservation of any of the beta-hairpins present in this domain, is crucial for the ability of the polypeptide to fold, but they influence the folding and unfolding kinetics and could determine its folding pathway.
-
-	The order of secondary structure elements does not determine the structure of a protein but does affect its folding kinetics.,Viguera AR, Blanco FJ, Serrano L J Mol Biol. 1995 Apr 7;247(4):670-81. PMID:7723022<ref>PMID:7723022</ref>
-
-	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	</div>
-	<div class="pdbe-citations 1tud" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
-	*[[Spectrin\|Spectrin]]	+	*[[Spectrin 3D structures\|Spectrin 3D structures]]
-	~~== References ==~~	+
-	~~<references/>~~	+
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Chick~~]]	+	[[Category: Gallus gallus]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Serrano, L]]	+	[[Category: Serrano L]]
-	[[Category: Viguera~~, A R~~]]	+	[[Category: Viguera AR]]
-	[[Category: Wilmanns, M]]	+	[[Category: Wilmanns M]]
-	~~[[Category: Calcium-binding]]~~	+
-	~~[[Category: Capping protein]]~~	+
-	~~[[Category: Cytoskeleton]]~~	+
-	~~[[Category: Duplication]]~~	+
-	~~[[Category: Sh3 domain~~]]	+

OCA at 09:32, 29 September 2021

OCA — Wed, 29 Sep 2021 09:32:51 GMT

←Older revision		Revision as of 09:32, 29 September 2021
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	<StructureSection load='1tud' size='340' side='right'caption='[[1tud]], [[Resolution\|resolution]] 1.77Å' scene=''>		<StructureSection load='1tud' size='340' side='right'caption='[[1tud]], [[Resolution\|resolution]] 1.77Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1tud]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Chick Chick]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TUD OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1TUD FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1tud]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Chick Chick]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TUD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1TUD FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1tud FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tud OCA], [~~http~~://pdbe.org/1tud PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1tud RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1tud PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1tud ProSAT]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1tud FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tud OCA], [https://pdbe.org/1tud PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1tud RCSB], [https://www.ebi.ac.uk/pdbsum/1tud PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1tud ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/SPTN1_CHICK SPTN1_CHICK]] Morphologically, spectrin-like proteins appear to be related to spectrin, showing a flexible rod-like structure. They can bind actin but seem to differ in their calmodulin-binding activity. In nonerythroid tissues, spectrins, in association with some other proteins, may play an important role in membrane organization.	+	[[https://www.uniprot.org/uniprot/SPTN1_CHICK SPTN1_CHICK]] Morphologically, spectrin-like proteins appear to be related to spectrin, showing a flexible rod-like structure. They can bind actin but seem to differ in their calmodulin-binding activity. In nonerythroid tissues, spectrins, in association with some other proteins, may play an important role in membrane organization.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 13:44, 25 December 2019

OCA — Wed, 25 Dec 2019 13:44:47 GMT

←Older revision		Revision as of 13:44, 25 December 2019
Line 1:		Line 1:

	==ALPHA-SPECTRIN SRC HOMOLOGY 3 DOMAIN, CIRCULAR PERMUTANT, CUT AT N47-D48==		==ALPHA-SPECTRIN SRC HOMOLOGY 3 DOMAIN, CIRCULAR PERMUTANT, CUT AT N47-D48==
-	<StructureSection load='1tud' size='340' side='right' caption='[[1tud]], [[Resolution\|resolution]] 1.77Å' scene=''>	+	<StructureSection load='1tud' size='340' side='right'caption='[[1tud]], [[Resolution\|resolution]] 1.77Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1tud]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Chick Chick]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TUD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1TUD FirstGlance]. <br>		<table><tr><td colspan='2'>[[1tud]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Chick Chick]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TUD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1TUD FirstGlance]. <br>
Line 35:		Line 35:
	</StructureSection>		</StructureSection>
	[[Category: Chick]]		[[Category: Chick]]
		+	[[Category: Large Structures]]
	[[Category: Serrano, L]]		[[Category: Serrano, L]]
	[[Category: Viguera, A R]]		[[Category: Viguera, A R]]

OCA at 08:35, 21 March 2018

OCA — Wed, 21 Mar 2018 08:35:48 GMT

←Older revision		Revision as of 08:35, 21 March 2018
Line 1:		Line 1:
		+
	==ALPHA-SPECTRIN SRC HOMOLOGY 3 DOMAIN, CIRCULAR PERMUTANT, CUT AT N47-D48==		==ALPHA-SPECTRIN SRC HOMOLOGY 3 DOMAIN, CIRCULAR PERMUTANT, CUT AT N47-D48==
	<StructureSection load='1tud' size='340' side='right' caption='[[1tud]], [[Resolution\|resolution]] 1.77Å' scene=''>		<StructureSection load='1tud' size='340' side='right' caption='[[1tud]], [[Resolution\|resolution]] 1.77Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1tud]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Chick Chick]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TUD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1TUD FirstGlance]. <br>		<table><tr><td colspan='2'>[[1tud]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Chick Chick]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TUD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1TUD FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1tud FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tud OCA], [http://pdbe.org/1tud PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1tud RCSB], [http://www.ebi.ac.uk/pdbsum/1tud PDBsum]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1tud FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tud OCA], [http://pdbe.org/1tud PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1tud RCSB], [http://www.ebi.ac.uk/pdbsum/1tud PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1tud ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 11:		Line 12:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/tu/1tud_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/tu/1tud_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 04:30, 10 February 2016

OCA — Wed, 10 Feb 2016 04:30:37 GMT

←Older revision		Revision as of 04:30, 10 February 2016
Line 15:		Line 15:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1tud ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 05:24, 11 September 2015

OCA — Fri, 11 Sep 2015 05:24:06 GMT

←Older revision		Revision as of 05:24, 11 September 2015
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	<StructureSection load='1tud' size='340' side='right' caption='[[1tud]], [[Resolution\|resolution]] 1.77Å' scene=''>		<StructureSection load='1tud' size='340' side='right' caption='[[1tud]], [[Resolution\|resolution]] 1.77Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1tud]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Gallus_gallus Gallus gallus~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TUD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1TUD FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1tud]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Chick Chick]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TUD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1TUD FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1tud FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tud OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1tud RCSB], [http://www.ebi.ac.uk/pdbsum/1tud PDBsum]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1tud FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tud OCA], [http://pdbe.org/1tud PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1tud RCSB], [http://www.ebi.ac.uk/pdbsum/1tud PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 25:		Line 25:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1tud" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 32:		Line 33:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Gallus gallus~~]]	+	[[Category: Chick]]
	[[Category: Serrano, L]]		[[Category: Serrano, L]]
	[[Category: Viguera, A R]]		[[Category: Viguera, A R]]

OCA at 11:48, 25 December 2014

OCA — Thu, 25 Dec 2014 11:48:27 GMT

←Older revision		Revision as of 11:48, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1tud]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TUD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1TUD FirstGlance]. <br>		<table><tr><td colspan='2'>[[1tud]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TUD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1TUD FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1tud FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tud OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1tud RCSB], [http://www.ebi.ac.uk/pdbsum/1tud PDBsum]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1tud FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tud OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1tud RCSB], [http://www.ebi.ac.uk/pdbsum/1tud PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/SPTN1_CHICK SPTN1_CHICK]] Morphologically, spectrin-like proteins appear to be related to spectrin, showing a flexible rod-like structure. They can bind actin but seem to differ in their calmodulin-binding activity. In nonerythroid tissues, spectrins, in association with some other proteins, may play an important role in membrane organization.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	</StructureSection>		</StructureSection>
	[[Category: Gallus gallus]]		[[Category: Gallus gallus]]
-	[[Category: Serrano, L.]]	+	[[Category: Serrano, L]]
-	[[Category: Viguera, A R.]]	+	[[Category: Viguera, A R]]
-	[[Category: Wilmanns, M.]]	+	[[Category: Wilmanns, M]]
	[[Category: Calcium-binding]]		[[Category: Calcium-binding]]
	[[Category: Capping protein]]		[[Category: Capping protein]]

OCA at 20:13, 28 September 2014

OCA — Sun, 28 Sep 2014 20:13:34 GMT

←Older revision		Revision as of 20:13, 28 September 2014
Line 1:		Line 1:
-	[[~~Image~~:1tud.~~png\|left~~\|200px]]	+	==ALPHA-SPECTRIN SRC HOMOLOGY 3 DOMAIN, CIRCULAR PERMUTANT, CUT AT N47-D48==
		+	<StructureSection load='1tud' size='340' side='right' caption='[[1tud]], [[Resolution\|resolution]] 1.77Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1tud]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TUD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1TUD FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1tud FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tud OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1tud RCSB], [http://www.ebi.ac.uk/pdbsum/1tud PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/tu/1tud_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	We have analyzed the structure, stability and folding kinetics of circularly permuted forms of alpha-spectrin SH3 domain. All the possible permutations involving the disruption of the covalent linkage between two beta-strands forming a beta-hairpin have been done. The different proteins constructed here fold to a native conformation similar to that of wild-type protein, as demonstrated by nuclear magnetic resonance and circular dichroism. Although all the mutants have similar stabilities (they are 1 to 2 kcal mol-1 less stable than the wild-type) their rate constants for folding and unfolding are quite different. Protein engineering, in combination with kinetics indicates that the folding pathway has been changed in the circularly permuted proteins. We conclude that neither the order of secondary structure elements, nor the preservation of any of the beta-hairpins present in this domain, is crucial for the ability of the polypeptide to fold, but they influence the folding and unfolding kinetics and could determine its folding pathway.

-	~~{{STRUCTURE_1tud\| PDB=1tud \| SCENE= }}~~	+	The order of secondary structure elements does not determine the structure of a protein but does affect its folding kinetics.,Viguera AR, Blanco FJ, Serrano L J Mol Biol. 1995 Apr 7;247(4):670-81. PMID:7723022<ref>PMID:7723022</ref>

-	~~===ALPHA-SPECTRIN SRC HOMOLOGY 3 DOMAIN~~, ~~CIRCULAR PERMUTANT, CUT AT N47-D48===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_7723022}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[1tud]] is~~ a ~~1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Gallus_gallus Gallus gallus]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=1TUD OCA].~~	+

	==See Also==		==See Also==
	*[[Spectrin\|Spectrin]]		*[[Spectrin\|Spectrin]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:007723022<~~/~~ref~~><~~references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Gallus gallus]]		[[Category: Gallus gallus]]
	[[Category: Serrano, L.]]		[[Category: Serrano, L.]]

OCA at 16:20, 20 October 2012

OCA — Sat, 20 Oct 2012 16:20:28 GMT

←Older revision		Revision as of 16:20, 20 October 2012
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	==About this Structure==		==About this Structure==
-	[[1tud]] is a 1 chain structure ~~of [[Spectrin]]~~ with sequence from [http://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TUD OCA].	+	[[1tud]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TUD OCA].

	==See Also==		==See Also==

OCA at 21:21, 26 July 2012

OCA — Thu, 26 Jul 2012 21:21:39 GMT

←Older revision		Revision as of 21:21, 26 July 2012
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	[[Image:1tud.png\|left\|200px]]		[[Image:1tud.png\|left\|200px]]

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	{{STRUCTURE_1tud\| PDB=1tud \| SCENE= }}		{{STRUCTURE_1tud\| PDB=1tud \| SCENE= }}

	===ALPHA-SPECTRIN SRC HOMOLOGY 3 DOMAIN, CIRCULAR PERMUTANT, CUT AT N47-D48===		===ALPHA-SPECTRIN SRC HOMOLOGY 3 DOMAIN, CIRCULAR PERMUTANT, CUT AT N47-D48===

-
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	==See Also==		==See Also==
-	*[[Spectrin]]	+	*[[Spectrin\|Spectrin]]

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~7723022~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:007723022</ref><references group="xtra"/>
	[[Category: Gallus gallus]]		[[Category: Gallus gallus]]
	[[Category: Serrano, L.]]		[[Category: Serrano, L.]]
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	[[Category: Cytoskeleton]]		[[Category: Cytoskeleton]]
	[[Category: Duplication]]		[[Category: Duplication]]
-	[[Category: Repeat]]
	[[Category: Sh3 domain]]		[[Category: Sh3 domain]]