1u3o - Revision history

OCA at 13:12, 9 May 2024

OCA — Thu, 09 May 2024 13:12:29 GMT

←Older revision		Revision as of 13:12, 9 May 2024
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	==Solution structure of rat Kalirin N-terminal SH3 domain==		==Solution structure of rat Kalirin N-terminal SH3 domain==
-	<StructureSection load='1u3o' size='340' side='right'caption='[[1u3o~~]], [[NMR_Ensembles_of_Models \| 20 NMR models~~]]' scene=''>	+	<StructureSection load='1u3o' size='340' side='right'caption='[[1u3o]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1u3o]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Buffalo_rat Buffalo rat~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1U3O OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1U3O FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1u3o]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1U3O OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1U3O FirstGlance]. <br>
-	</td></tr><tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat"~~>Kalirin, HAPIP, Duo ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&~~id=~~10116 Buffalo rat])~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1u3o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1u3o OCA], [https://pdbe.org/1u3o PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1u3o RCSB], [https://www.ebi.ac.uk/pdbsum/1u3o PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1u3o ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1u3o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1u3o OCA], [https://pdbe.org/1u3o PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1u3o RCSB], [https://www.ebi.ac.uk/pdbsum/1u3o PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1u3o ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/KALRN_RAT KALRN_RAT] Promotes the exchange of GDP by GTP. Activates specific Rho GTPase family members, thereby inducing various signaling mechanisms that regulate neuronal shape, growth, and plasticity, through their effects on the actin cytoskeleton. Induces lamellipodia independent of its GEF activity. Isoforms 1 and 7 are necessary for neuronal development and axonal outgrowth. Isoform 6 is required for dendritic spine formation.<ref>PMID:10692441</ref> <ref>PMID:11606631</ref> <ref>PMID:15950621</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Buffalo rat]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Chakrabarti, K~~]]	+	[[Category: Rattus norvegicus]]
-	[[Category: ~~Eipper, B A~~]]	+	[[Category: Chakrabarti K]]
-	[[Category: ~~King, G F~~]]	+	[[Category: Eipper BA]]
-	[[Category: ~~Maciejewski, M W~~]]	+	[[Category: King GF]]
-	[[Category: ~~Schiller, M R~~]]	+	[[Category: Maciejewski MW]]
-	[[Category: Schiller~~, N I~~]]	+	[[Category: Schiller MR]]
-	[[Category: ~~Cis-proline]]~~	+	[[Category: Schiller NI]]
-	~~[[Category: Sh3]]~~	+
-	~~[[Category: Signaling protein~~]]	+

OCA at 06:42, 2 March 2022

OCA — Wed, 02 Mar 2022 06:42:44 GMT

←Older revision		Revision as of 06:42, 2 March 2022
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	<StructureSection load='1u3o' size='340' side='right'caption='[[1u3o]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='1u3o' size='340' side='right'caption='[[1u3o]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1u3o]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1U3O OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=1U3O FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1u3o]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1U3O OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1U3O FirstGlance]. <br>
-	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Kalirin, HAPIP, Duo ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat])</td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Kalirin, HAPIP, Duo ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=1u3o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1u3o OCA], [~~http~~://pdbe.org/1u3o PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1u3o RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1u3o PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1u3o ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1u3o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1u3o OCA], [https://pdbe.org/1u3o PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1u3o RCSB], [https://www.ebi.ac.uk/pdbsum/1u3o PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1u3o ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==

OCA at 07:20, 30 December 2020

OCA — Wed, 30 Dec 2020 07:20:11 GMT

←Older revision		Revision as of 07:20, 30 December 2020
Line 1:		Line 1:

	==Solution structure of rat Kalirin N-terminal SH3 domain==		==Solution structure of rat Kalirin N-terminal SH3 domain==
-	<StructureSection load='1u3o' size='340' side='right' caption='[[1u3o]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>	+	<StructureSection load='1u3o' size='340' side='right'caption='[[1u3o]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1u3o]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1U3O OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1U3O FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1u3o]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1U3O OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=1U3O FirstGlance]. <br>
	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Kalirin, HAPIP, Duo ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat])</td></tr>		</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Kalirin, HAPIP, Duo ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1u3o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1u3o OCA], [http://pdbe.org/1u3o PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1u3o RCSB], [http://www.ebi.ac.uk/pdbsum/1u3o PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1u3o ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=1u3o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1u3o OCA], [http://pdbe.org/1u3o PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1u3o RCSB], [http://www.ebi.ac.uk/pdbsum/1u3o PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1u3o ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
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	</StructureSection>		</StructureSection>
	[[Category: Buffalo rat]]		[[Category: Buffalo rat]]
		+	[[Category: Large Structures]]
	[[Category: Chakrabarti, K]]		[[Category: Chakrabarti, K]]
	[[Category: Eipper, B A]]		[[Category: Eipper, B A]]

OCA at 08:31, 21 March 2018

OCA — Wed, 21 Mar 2018 08:31:02 GMT

←Older revision		Revision as of 08:31, 21 March 2018
Line 1:		Line 1:
		+
	==Solution structure of rat Kalirin N-terminal SH3 domain==		==Solution structure of rat Kalirin N-terminal SH3 domain==
	<StructureSection load='1u3o' size='340' side='right' caption='[[1u3o]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='1u3o' size='340' side='right' caption='[[1u3o]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
Line 4:		Line 5:
	<table><tr><td colspan='2'>[[1u3o]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1U3O OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1U3O FirstGlance]. <br>		<table><tr><td colspan='2'>[[1u3o]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1U3O OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1U3O FirstGlance]. <br>
	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Kalirin, HAPIP, Duo ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat])</td></tr>		</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Kalirin, HAPIP, Duo ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1u3o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1u3o OCA], [http://pdbe.org/1u3o PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1u3o RCSB], [http://www.ebi.ac.uk/pdbsum/1u3o PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1u3o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1u3o OCA], [http://pdbe.org/1u3o PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1u3o RCSB], [http://www.ebi.ac.uk/pdbsum/1u3o PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1u3o ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
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	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/u3/1u3o_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/u3/1u3o_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 05:46, 9 February 2016

OCA — Tue, 09 Feb 2016 05:46:55 GMT

←Older revision		Revision as of 05:46, 9 February 2016
Line 14:		Line 14:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1u3o ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 19:13, 10 September 2015

OCA — Thu, 10 Sep 2015 19:13:02 GMT

←Older revision		Revision as of 19:13, 10 September 2015
Line 2:		Line 2:
	<StructureSection load='1u3o' size='340' side='right' caption='[[1u3o]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='1u3o' size='340' side='right' caption='[[1u3o]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1u3o]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Rattus_norvegicus Rattus norvegicus~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1U3O OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1U3O FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1u3o]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1U3O OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1U3O FirstGlance]. <br>
-	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Kalirin, HAPIP, Duo ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 ~~Rattus norvegicus~~])</td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Kalirin, HAPIP, Duo ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1u3o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1u3o OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1u3o RCSB], [http://www.ebi.ac.uk/pdbsum/1u3o PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1u3o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1u3o OCA], [http://pdbe.org/1u3o PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1u3o RCSB], [http://www.ebi.ac.uk/pdbsum/1u3o PDBsum]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 24:		Line 24:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1u3o" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Rattus norvegicus~~]]	+	[[Category: Buffalo rat]]
	[[Category: Chakrabarti, K]]		[[Category: Chakrabarti, K]]
	[[Category: Eipper, B A]]		[[Category: Eipper, B A]]

OCA at 12:27, 6 January 2015

OCA — Tue, 06 Jan 2015 12:27:22 GMT

←Older revision		Revision as of 12:27, 6 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1u3o]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1U3O OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1U3O FirstGlance]. <br>		<table><tr><td colspan='2'>[[1u3o]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1U3O OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1U3O FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Kalirin, HAPIP, Duo ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Rattus norvegicus])</td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Kalirin, HAPIP, Duo ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Rattus norvegicus])</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1u3o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1u3o OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1u3o RCSB], [http://www.ebi.ac.uk/pdbsum/1u3o PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1u3o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1u3o OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1u3o RCSB], [http://www.ebi.ac.uk/pdbsum/1u3o PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	</StructureSection>		</StructureSection>
	[[Category: Rattus norvegicus]]		[[Category: Rattus norvegicus]]
-	[[Category: Chakrabarti, K.]]	+	[[Category: Chakrabarti, K]]
-	[[Category: Eipper, B A.]]	+	[[Category: Eipper, B A]]
-	[[Category: King, G F.]]	+	[[Category: King, G F]]
-	[[Category: Maciejewski, M W.]]	+	[[Category: Maciejewski, M W]]
-	[[Category: Schiller, M R.]]	+	[[Category: Schiller, M R]]
-	[[Category: Schiller, N I.]]	+	[[Category: Schiller, N I]]
	[[Category: Cis-proline]]		[[Category: Cis-proline]]
	[[Category: Sh3]]		[[Category: Sh3]]
	[[Category: Signaling protein]]		[[Category: Signaling protein]]

OCA at 20:22, 29 September 2014

OCA — Mon, 29 Sep 2014 20:22:26 GMT

←Older revision		Revision as of 20:22, 29 September 2014
Line 1:		Line 1:
-	[[~~Image~~:1u3o.~~png\|left~~\|200px]]	+	==Solution structure of rat Kalirin N-terminal SH3 domain==
		+	<StructureSection load='1u3o' size='340' side='right' caption='[[1u3o]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1u3o]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1U3O OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1U3O FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Kalirin, HAPIP, Duo ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Rattus norvegicus])</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1u3o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1u3o OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1u3o RCSB], [http://www.ebi.ac.uk/pdbsum/1u3o PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/u3/1u3o_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	RhoGEFs are central controllers of small G-proteins in cells and are regulated by several mechanisms. There are at least 22 human RhoGEFs that contain SH3 domains, raising the possibility that, like several other enzymes, SH3 domains control the enzymatic activity of guanine nucleotide exchange factor (GEF) domains through intra- and/or intermolecular interactions. The structure of the N-terminal SH3 domain of Kalirin was solved using NMR spectroscopy, and it folds much like other SH3 domains. However, NMR chemical shift mapping experiments showed that this Kalirin SH3 domain is unique, containing novel cooperative binding site(s) for intramolecular PXXP ligands. Intramolecular Kalirin SH3 domain/ligand interactions, as well as binding of the Kalirin SH3 domain to the adaptor protein Crk, inhibit the GEF activity of Kalirin. This study establishes a novel molecular mechanism whereby intramolecular and intermolecular Kalirin SH3 domain/ligand interactions modulate GEF activity, a regulatory mechanism that is likely used by other RhoGEF family members.

-	~~{{STRUCTURE_1u3o\| PDB=1u3o \| SCENE= }}~~	+	Regulation of RhoGEF activity by intramolecular and intermolecular SH3 domain interactions.,Schiller MR, Chakrabarti K, King GF, Schiller NI, Eipper BA, Maciejewski MW J Biol Chem. 2006 Jul 7;281(27):18774-86. Epub 2006 Apr 27. PMID:16644733<ref>PMID:16644733</ref>

-	~~===Solution structure~~ of ~~rat Kalirin N-terminal SH3 domain===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_16644733}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[1u3o]] is a 1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Rattus_norvegicus Rattus norvegicus]~~. ~~Full experimental information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=1U3O OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:016644733<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Rattus norvegicus]]		[[Category: Rattus norvegicus]]
	[[Category: Chakrabarti, K.]]		[[Category: Chakrabarti, K.]]

OCA: Protected "1u3o" [edit=sysop:move=sysop]

OCA — Sat, 05 Jan 2013 11:02:21 GMT

Protected "1u3o" [edit=sysop:move=sysop]

←Older revision

Revision as of 11:02, 5 January 2013

OCA at 11:02, 5 January 2013

OCA — Sat, 05 Jan 2013 11:02:19 GMT

←Older revision		Revision as of 11:02, 5 January 2013
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-	{{Seed}}
	[[Image:1u3o.png\|left\|200px]]		[[Image:1u3o.png\|left\|200px]]

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	{{STRUCTURE_1u3o\| PDB=1u3o \| SCENE= }}		{{STRUCTURE_1u3o\| PDB=1u3o \| SCENE= }}

	===Solution structure of rat Kalirin N-terminal SH3 domain===		===Solution structure of rat Kalirin N-terminal SH3 domain===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_16644733}}, adds the Publication Abstract to the page
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	{{ABSTRACT_PUBMED_16644733}}		{{ABSTRACT_PUBMED_16644733}}

	==About this Structure==		==About this Structure==
-	~~1U3O~~ is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1U3O OCA].	+	[[1u3o]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1U3O OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~16644733~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:016644733</ref><references group="xtra"/>
	[[Category: Rattus norvegicus]]		[[Category: Rattus norvegicus]]
	[[Category: Chakrabarti, K.]]		[[Category: Chakrabarti, K.]]
Line 33:		Line 21:
	[[Category: Cis-proline]]		[[Category: Cis-proline]]
	[[Category: Sh3]]		[[Category: Sh3]]
-		+	[[Category: Signaling protein]]
-	~~''Page seeded by~~ [~~http~~:~~//oca.weizmann.ac.il/oca OCA~~ ] ~~on Tue Feb 17 06:57:18 2009''~~	+