1u5c - Revision history

OCA at 06:38, 23 August 2023

OCA — Wed, 23 Aug 2023 06:38:43 GMT

←Older revision		Revision as of 06:38, 23 August 2023
Line 3:		Line 3:
	<StructureSection load='1u5c' size='340' side='right'caption='[[1u5c]], [[Resolution\|resolution]] 2.65Å' scene=''>		<StructureSection load='1u5c' size='340' side='right'caption='[[1u5c]], [[Resolution\|resolution]] 2.65Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1u5c]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Plafa Plafa~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1U5C OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1U5C FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1u5c]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Plasmodium_falciparum Plasmodium falciparum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1U5C OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1U5C FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=BIK:3~~,~~7-DIHYDROXY-~~2~~-NAPHTHOIC+ACID'>BIK</scene>, <scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.65Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"><~~div style~~='~~overflow~~: ~~auto; max~~-~~height: 3em;~~'>~~[[1u40\|1u40]], [[1u4s\|1u4s]], [[1u5a\|1u5a]]~~</~~div~~><~~/td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BIK:3,7-DIHYDROXY-2-NAPHTHOIC+ACID'>BIK</scene>, <scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene></td></tr>
-	~~<tr id~~='~~activity'><td class~~=~~"sblockLbl"><b>Activity~~:~~</b></td><td class="sblockDat"><span class='plainlinks~~'>~~[https://en.wikipedia.org/wiki/L-lactate_dehydrogenase L-lactate dehydrogenase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.27 1.1.1.27]~~ </~~span~~></td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1u5c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1u5c OCA], [https://pdbe.org/1u5c PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1u5c RCSB], [https://www.ebi.ac.uk/pdbsum/1u5c PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1u5c ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1u5c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1u5c OCA], [https://pdbe.org/1u5c PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1u5c RCSB], [https://www.ebi.ac.uk/pdbsum/1u5c PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1u5c ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/LDH_PLAFD LDH_PLAFD]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: L-lactate dehydrogenase]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Plafa~~]]	+	[[Category: Plasmodium falciparum]]
-	[[Category: Brady~~, R L~~]]	+	[[Category: Brady RL]]
-	[[Category: Cameron, A]]	+	[[Category: Cameron A]]
-	[[Category: Conners, R]]	+	[[Category: Conners R]]
-	[[Category: Read, J]]	+	[[Category: Read J]]
-	[[Category: Schambach, F]]	+	[[Category: Schambach F]]
-	[[Category: Sessions~~, R B]]~~	+	[[Category: Sessions RB]]
-	~~[[Category: Oxidoreductase]]~~	+
-	~~[[Category: Protein-ligand complex~~]]	+

OCA at 09:36, 29 September 2021

OCA — Wed, 29 Sep 2021 09:36:47 GMT

←Older revision		Revision as of 09:36, 29 September 2021
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	<StructureSection load='1u5c' size='340' side='right'caption='[[1u5c]], [[Resolution\|resolution]] 2.65Å' scene=''>		<StructureSection load='1u5c' size='340' side='right'caption='[[1u5c]], [[Resolution\|resolution]] 2.65Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1u5c]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Plafa Plafa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1U5C OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1U5C FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1u5c]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Plafa Plafa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1U5C OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1U5C FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BIK:3,7-DIHYDROXY-2-NAPHTHOIC+ACID'>BIK</scene>, <scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BIK:3,7-DIHYDROXY-2-NAPHTHOIC+ACID'>BIK</scene>, <scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1u40\|1u40]], [[1u4s\|1u4s]], [[1u5a\|1u5a]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1u40\|1u40]], [[1u4s\|1u4s]], [[1u5a\|1u5a]]</div></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/L-lactate_dehydrogenase L-lactate dehydrogenase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.27 1.1.1.27] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/L-lactate_dehydrogenase L-lactate dehydrogenase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.27 1.1.1.27] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1u5c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1u5c OCA], [~~http~~://pdbe.org/1u5c PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1u5c RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1u5c PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1u5c ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1u5c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1u5c OCA], [https://pdbe.org/1u5c PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1u5c RCSB], [https://www.ebi.ac.uk/pdbsum/1u5c PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1u5c ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==

OCA at 14:08, 25 December 2019

OCA — Wed, 25 Dec 2019 14:08:04 GMT

←Older revision		Revision as of 14:08, 25 December 2019
Line 1:		Line 1:

	==Plasmodium falciparum lactate dehydrogenase complexed with 3,7-dihydroxynaphthalene-2-carboxylic acid and NAD+==		==Plasmodium falciparum lactate dehydrogenase complexed with 3,7-dihydroxynaphthalene-2-carboxylic acid and NAD+==
-	<StructureSection load='1u5c' size='340' side='right' caption='[[1u5c]], [[Resolution\|resolution]] 2.65Å' scene=''>	+	<StructureSection load='1u5c' size='340' side='right'caption='[[1u5c]], [[Resolution\|resolution]] 2.65Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1u5c]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Plafa Plafa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1U5C OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1U5C FirstGlance]. <br>		<table><tr><td colspan='2'>[[1u5c]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Plafa Plafa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1U5C OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1U5C FirstGlance]. <br>
Line 30:		Line 30:

	==See Also==		==See Also==
-	*[[Lactate ~~Dehydrogenase~~\|Lactate ~~Dehydrogenase~~]]	+	*[[Lactate dehydrogenase 3D structures\|Lactate dehydrogenase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 36:		Line 36:
	</StructureSection>		</StructureSection>
	[[Category: L-lactate dehydrogenase]]		[[Category: L-lactate dehydrogenase]]
		+	[[Category: Large Structures]]
	[[Category: Plafa]]		[[Category: Plafa]]
	[[Category: Brady, R L]]		[[Category: Brady, R L]]

OCA at 08:57, 21 March 2018

OCA — Wed, 21 Mar 2018 08:57:21 GMT

←Older revision		Revision as of 08:57, 21 March 2018
Line 1:		Line 1:
		+
	==Plasmodium falciparum lactate dehydrogenase complexed with 3,7-dihydroxynaphthalene-2-carboxylic acid and NAD+==		==Plasmodium falciparum lactate dehydrogenase complexed with 3,7-dihydroxynaphthalene-2-carboxylic acid and NAD+==
	<StructureSection load='1u5c' size='340' side='right' caption='[[1u5c]], [[Resolution\|resolution]] 2.65Å' scene=''>		<StructureSection load='1u5c' size='340' side='right' caption='[[1u5c]], [[Resolution\|resolution]] 2.65Å' scene=''>
Line 6:		Line 7:
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1u40\|1u40]], [[1u4s\|1u4s]], [[1u5a\|1u5a]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1u40\|1u40]], [[1u4s\|1u4s]], [[1u5a\|1u5a]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/L-lactate_dehydrogenase L-lactate dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.27 1.1.1.27] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/L-lactate_dehydrogenase L-lactate dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.27 1.1.1.27] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1u5c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1u5c OCA], [http://pdbe.org/1u5c PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1u5c RCSB], [http://www.ebi.ac.uk/pdbsum/1u5c PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1u5c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1u5c OCA], [http://pdbe.org/1u5c PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1u5c RCSB], [http://www.ebi.ac.uk/pdbsum/1u5c PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1u5c ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 12:		Line 13:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/u5/1u5c_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/u5/1u5c_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1u5c ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 15:34, 11 September 2015

OCA — Fri, 11 Sep 2015 15:34:46 GMT

←Older revision		Revision as of 15:34, 11 September 2015
Line 2:		Line 2:
	<StructureSection load='1u5c' size='340' side='right' caption='[[1u5c]], [[Resolution\|resolution]] 2.65Å' scene=''>		<StructureSection load='1u5c' size='340' side='right' caption='[[1u5c]], [[Resolution\|resolution]] 2.65Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1u5c]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Plasmodium_falciparum Plasmodium falciparum~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1U5C OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1U5C FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1u5c]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Plafa Plafa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1U5C OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1U5C FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BIK:3,7-DIHYDROXY-2-NAPHTHOIC+ACID'>BIK</scene>, <scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BIK:3,7-DIHYDROXY-2-NAPHTHOIC+ACID'>BIK</scene>, <scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1u40\|1u40]], [[1u4s\|1u4s]], [[1u5a\|1u5a]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1u40\|1u40]], [[1u4s\|1u4s]], [[1u5a\|1u5a]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/L-lactate_dehydrogenase L-lactate dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.27 1.1.1.27] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/L-lactate_dehydrogenase L-lactate dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.27 1.1.1.27] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1u5c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1u5c OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1u5c RCSB], [http://www.ebi.ac.uk/pdbsum/1u5c PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1u5c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1u5c OCA], [http://pdbe.org/1u5c PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1u5c RCSB], [http://www.ebi.ac.uk/pdbsum/1u5c PDBsum]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 26:		Line 26:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1u5c" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 34:		Line 35:
	</StructureSection>		</StructureSection>
	[[Category: L-lactate dehydrogenase]]		[[Category: L-lactate dehydrogenase]]
-	[[Category: ~~Plasmodium falciparum~~]]	+	[[Category: Plafa]]
	[[Category: Brady, R L]]		[[Category: Brady, R L]]
	[[Category: Cameron, A]]		[[Category: Cameron, A]]

OCA at 13:04, 6 January 2015

OCA — Tue, 06 Jan 2015 13:04:41 GMT

←Older revision		Revision as of 13:04, 6 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1u5c]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Plasmodium_falciparum Plasmodium falciparum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1U5C OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1U5C FirstGlance]. <br>		<table><tr><td colspan='2'>[[1u5c]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Plasmodium_falciparum Plasmodium falciparum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1U5C OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1U5C FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BIK:3,7-DIHYDROXY-2-NAPHTHOIC+ACID'>BIK</scene>, <scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BIK:3,7-DIHYDROXY-2-NAPHTHOIC+ACID'>BIK</scene>, <scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1u40\|1u40]], [[1u4s\|1u4s]], [[1u5a\|1u5a]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1u40\|1u40]], [[1u4s\|1u4s]], [[1u5a\|1u5a]]</td></tr>
-	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/L-lactate_dehydrogenase L-lactate dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.27 1.1.1.27] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/L-lactate_dehydrogenase L-lactate dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.27 1.1.1.27] </span></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1u5c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1u5c OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1u5c RCSB], [http://www.ebi.ac.uk/pdbsum/1u5c PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1u5c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1u5c OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1u5c RCSB], [http://www.ebi.ac.uk/pdbsum/1u5c PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 35:		Line 35:
	[[Category: L-lactate dehydrogenase]]		[[Category: L-lactate dehydrogenase]]
	[[Category: Plasmodium falciparum]]		[[Category: Plasmodium falciparum]]
-	[[Category: Brady, R L.]]	+	[[Category: Brady, R L]]
-	[[Category: Cameron, A.]]	+	[[Category: Cameron, A]]
-	[[Category: Conners, R.]]	+	[[Category: Conners, R]]
-	[[Category: Read, J.]]	+	[[Category: Read, J]]
-	[[Category: Schambach, F.]]	+	[[Category: Schambach, F]]
-	[[Category: Sessions, R B.]]	+	[[Category: Sessions, R B]]
	[[Category: Oxidoreductase]]		[[Category: Oxidoreductase]]
	[[Category: Protein-ligand complex]]		[[Category: Protein-ligand complex]]

OCA at 23:33, 28 September 2014

OCA — Sun, 28 Sep 2014 23:33:49 GMT

←Older revision		Revision as of 23:33, 28 September 2014
Line 1:		Line 1:
-	[[~~Image:~~1u5c.~~png~~\|~~left~~\|200px]]	+	==Plasmodium falciparum lactate dehydrogenase complexed with 3,7-dihydroxynaphthalene-2-carboxylic acid and NAD+==
		+	<StructureSection load='1u5c' size='340' side='right' caption='[[1u5c]], [[Resolution\|resolution]] 2.65Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1u5c]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Plasmodium_falciparum Plasmodium falciparum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1U5C OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1U5C FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BIK:3,7-DIHYDROXY-2-NAPHTHOIC+ACID'>BIK</scene>, <scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1u40\|1u40]], [[1u4s\|1u4s]], [[1u5a\|1u5a]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/L-lactate_dehydrogenase L-lactate dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.27 1.1.1.27] </span></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1u5c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1u5c OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1u5c RCSB], [http://www.ebi.ac.uk/pdbsum/1u5c PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/u5/1u5c_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Gossypol is a di-sesquiterpene natural-product in the form of a functionalised binaphthyl and is isolated from cotton plants. The compound has long been known to exhibit anti-malarial and other biological activities. Previous studies have indicated that compounds of this type target Plasmodium falciparum lactate dehydrogenase (pfLDH), an essential enzyme for energy generation within the parasite. In this study, we report that simple naphthalene-based compounds, the core of the gossypol structure, exhibit weak inhibition of the parasite lactate dehydrogenase. Crystal structures of the complexes formed by binding of these naphthalene-based compounds to their target enzyme have been used to delineate the molecular features likely to form the gossypol binding site. Two modes of binding are observed: one overlapping the pyruvate but not the co-factor site, the other bridging the binding sites for the co-factor nicontinamide group and pyruvate substrate. This latter site encompasses molecular features unique to Plasmodium forms of LDH and is likely to represent the mode of binding for gossypol derivatives that show selectivity for the parasite enzymes. We also report a substrate analogue that unexpectedly binds within the adenine pocket of the co-factor groove. Although these core pharmacophore-like molecules only exhibit low levels of inhibitory activity, these molecular snapshots provide a rational basis for renewed structure-based development of naphthalene-based compounds as anti-malarial agents.

-	~~{{STRUCTURE_1u5c\| PDB=1u5c \| SCENE= }}~~	+	Mapping the binding site for gossypol-like inhibitors of Plasmodium falciparum lactate dehydrogenase.,Conners R, Schambach F, Read J, Cameron A, Sessions RB, Vivas L, Easton A, Croft SL, Brady RL Mol Biochem Parasitol. 2005 Aug;142(2):137-48. Epub 2005 Apr 18. PMID:15978953<ref>PMID:15978953</ref>

-	~~===Plasmodium falciparum lactate dehydrogenase complexed with 3~~,~~7-dihydroxynaphthalene-2-carboxylic acid and NAD+===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_15978953}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[1u5c]] is~~ a ~~1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Plasmodium_falciparum Plasmodium falciparum]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=1U5C OCA].~~	+

	==See Also==		==See Also==
	*[[Lactate Dehydrogenase\|Lactate Dehydrogenase]]		*[[Lactate Dehydrogenase\|Lactate Dehydrogenase]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:015978953<~~/~~ref~~><~~references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: L-lactate dehydrogenase]]		[[Category: L-lactate dehydrogenase]]
	[[Category: Plasmodium falciparum]]		[[Category: Plasmodium falciparum]]

OCA at 19:59, 20 October 2012

OCA — Sat, 20 Oct 2012 19:59:11 GMT

←Older revision		Revision as of 19:59, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[1u5c]] is a 1 chain structure ~~of [[Lactate Dehydrogenase]]~~ with sequence from [http://en.wikipedia.org/wiki/Plasmodium_falciparum Plasmodium falciparum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1U5C OCA].	+	[[1u5c]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Plasmodium_falciparum Plasmodium falciparum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1U5C OCA].

	==See Also==		==See Also==

OCA: Protected "1u5c" [edit=sysop:move=sysop]

OCA — Fri, 27 Jul 2012 09:04:39 GMT

Protected "1u5c" [edit=sysop:move=sysop]

←Older revision

Revision as of 09:04, 27 July 2012

OCA at 09:04, 27 July 2012

OCA — Fri, 27 Jul 2012 09:04:37 GMT

←Older revision		Revision as of 09:04, 27 July 2012
Line 1:		Line 1:
-	{{Seed}}
	[[Image:1u5c.png\|left\|200px]]		[[Image:1u5c.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_1u5c", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_1u5c\| PDB=1u5c \| SCENE= }}		{{STRUCTURE_1u5c\| PDB=1u5c \| SCENE= }}

	===Plasmodium falciparum lactate dehydrogenase complexed with 3,7-dihydroxynaphthalene-2-carboxylic acid and NAD+===		===Plasmodium falciparum lactate dehydrogenase complexed with 3,7-dihydroxynaphthalene-2-carboxylic acid and NAD+===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_15978953}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 15978953 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_15978953}}		{{ABSTRACT_PUBMED_15978953}}

	==About this Structure==		==About this Structure==
-	~~1U5C~~ is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Plasmodium_falciparum Plasmodium falciparum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1U5C OCA].	+	[[1u5c]] is a 1 chain structure of [[Lactate Dehydrogenase]] with sequence from [http://en.wikipedia.org/wiki/Plasmodium_falciparum Plasmodium falciparum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1U5C OCA].
		+
		+	==See Also==
		+	*[[Lactate Dehydrogenase\|Lactate Dehydrogenase]]

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~15978953~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:015978953</ref><references group="xtra"/>
	[[Category: L-lactate dehydrogenase]]		[[Category: L-lactate dehydrogenase]]
	[[Category: Plasmodium falciparum]]		[[Category: Plasmodium falciparum]]
Line 32:		Line 23:
	[[Category: Schambach, F.]]		[[Category: Schambach, F.]]
	[[Category: Sessions, R B.]]		[[Category: Sessions, R B.]]
		+	[[Category: Oxidoreductase]]
	[[Category: Protein-ligand complex]]		[[Category: Protein-ligand complex]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 18 02:26:28 2009''