1u5g - Revision history

OCA at 06:38, 23 August 2023

OCA — Wed, 23 Aug 2023 06:38:50 GMT

←Older revision		Revision as of 06:38, 23 August 2023
Line 3:		Line 3:
	<StructureSection load='1u5g' size='340' side='right'caption='[[1u5g]], [[Resolution\|resolution]] 2.10Å' scene=''>		<StructureSection load='1u5g' size='340' side='right'caption='[[1u5g]], [[Resolution\|resolution]] 2.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1u5g]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Lk3_transgenic_mice Lk3 transgenic mice~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1U5G OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1U5G FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1u5g]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1U5G OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1U5G FirstGlance]. <br>
-	</td></tr><tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"~~><div style='overflow: auto; max-height: 3em;'>[[1u5e\|1u5e]], [[1u5f\|1u5f]], [[1u5d\|1u5d]]</div></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.1Å</td></tr>
-	~~<tr~~ id~~='gene'><td class~~="~~sblockLbl~~">~~<b>~~[[~~Gene~~\|~~Gene:~~]]~~</b></td><td class="sblockDat">SCAP2 ([https://www~~.~~ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info~~&~~srchmode=5&id=10090 LK3 transgenic mice])~~</td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1u5g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1u5g OCA], [https://pdbe.org/1u5g PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1u5g RCSB], [https://www.ebi.ac.uk/pdbsum/1u5g PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1u5g ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1u5g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1u5g OCA], [https://pdbe.org/1u5g PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1u5g RCSB], [https://www.ebi.ac.uk/pdbsum/1u5g PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1u5g ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/SKAP2_MOUSE SKAP2_MOUSE] May be involved in B-cell and macrophage adhesion processes. In B-cells, may act by coupling the B-cell receptor (BCR) to integrin activation. May play a role in src signaling pathway.<ref>PMID:11063873</ref> <ref>PMID:15894167</ref> <ref>PMID:16135797</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Lk3 transgenic mice~~]]	+	[[Category: Mus musculus]]
-	[[Category: Eck~~, M J~~]]	+	[[Category: Eck MJ]]
-	[[Category: Neel~~, B G~~]]	+	[[Category: Neel BG]]
-	[[Category: Swanson, K]]	+	[[Category: Swanson K]]
-	[[Category: Tang, Y]]	+	[[Category: Tang Y]]
-	~~[[Category: Ph domain]]~~	+
-	~~[[Category: Signaling protein~~]]	+

OCA at 16:35, 20 October 2021

OCA — Wed, 20 Oct 2021 16:35:37 GMT

←Older revision		Revision as of 16:35, 20 October 2021
Line 3:		Line 3:
	<StructureSection load='1u5g' size='340' side='right'caption='[[1u5g]], [[Resolution\|resolution]] 2.10Å' scene=''>		<StructureSection load='1u5g' size='340' side='right'caption='[[1u5g]], [[Resolution\|resolution]] 2.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1u5g]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1U5G OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=1U5G FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1u5g]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1U5G OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1U5G FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1u5e\|1u5e]], [[1u5f\|1u5f]], [[1u5d\|1u5d]]</div></td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1u5e\|1u5e]], [[1u5f\|1u5f]], [[1u5d\|1u5d]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SCAP2 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SCAP2 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=1u5g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1u5g OCA], [~~http~~://pdbe.org/1u5g PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1u5g RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1u5g PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1u5g ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1u5g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1u5g OCA], [https://pdbe.org/1u5g PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1u5g RCSB], [https://www.ebi.ac.uk/pdbsum/1u5g PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1u5g ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==

OCA at 07:22, 30 December 2020

OCA — Wed, 30 Dec 2020 07:22:15 GMT

←Older revision		Revision as of 07:22, 30 December 2020
Line 1:		Line 1:

	==Crystal Structure of the PH Domain of SKAP-Hom==		==Crystal Structure of the PH Domain of SKAP-Hom==
-	<StructureSection load='1u5g' size='340' side='right' caption='[[1u5g]], [[Resolution\|resolution]] 2.10Å' scene=''>	+	<StructureSection load='1u5g' size='340' side='right'caption='[[1u5g]], [[Resolution\|resolution]] 2.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1u5g]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1U5G OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1U5G FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1u5g]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1U5G OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=1U5G FirstGlance]. <br>
-	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1u5e\|1u5e]], [[1u5f\|1u5f]], [[1u5d\|1u5d]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1u5e\|1u5e]], [[1u5f\|1u5f]], [[1u5d\|1u5d]]</div></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SCAP2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SCAP2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1u5g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1u5g OCA], [http://pdbe.org/1u5g PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1u5g RCSB], [http://www.ebi.ac.uk/pdbsum/1u5g PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1u5g ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=1u5g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1u5g OCA], [http://pdbe.org/1u5g PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1u5g RCSB], [http://www.ebi.ac.uk/pdbsum/1u5g PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1u5g ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 12:		Line 12:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/u5/1u5g_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/u5/1u5g_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 31:		Line 31:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Lk3 transgenic mice]]		[[Category: Lk3 transgenic mice]]
	[[Category: Eck, M J]]		[[Category: Eck, M J]]

OCA at 13:38, 12 October 2017

OCA — Thu, 12 Oct 2017 13:38:56 GMT

←Older revision		Revision as of 13:38, 12 October 2017
Line 1:		Line 1:
		+
	==Crystal Structure of the PH Domain of SKAP-Hom==		==Crystal Structure of the PH Domain of SKAP-Hom==
	<StructureSection load='1u5g' size='340' side='right' caption='[[1u5g]], [[Resolution\|resolution]] 2.10Å' scene=''>		<StructureSection load='1u5g' size='340' side='right' caption='[[1u5g]], [[Resolution\|resolution]] 2.10Å' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1u5e\|1u5e]], [[1u5f\|1u5f]], [[1u5d\|1u5d]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1u5e\|1u5e]], [[1u5f\|1u5f]], [[1u5d\|1u5d]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SCAP2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SCAP2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1u5g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1u5g OCA], [http://pdbe.org/1u5g PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1u5g RCSB], [http://www.ebi.ac.uk/pdbsum/1u5g PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1u5g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1u5g OCA], [http://pdbe.org/1u5g PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1u5g RCSB], [http://www.ebi.ac.uk/pdbsum/1u5g PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1u5g ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==

OCA at 06:24, 10 February 2016

OCA — Wed, 10 Feb 2016 06:24:36 GMT

←Older revision		Revision as of 06:24, 10 February 2016
Line 15:		Line 15:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1u5g ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 06:14, 11 September 2015

OCA — Fri, 11 Sep 2015 06:14:47 GMT

←Older revision		Revision as of 06:14, 11 September 2015
Line 2:		Line 2:
	<StructureSection load='1u5g' size='340' side='right' caption='[[1u5g]], [[Resolution\|resolution]] 2.10Å' scene=''>		<StructureSection load='1u5g' size='340' side='right' caption='[[1u5g]], [[Resolution\|resolution]] 2.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1u5g]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Mus_musculus Mus musculus~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1U5G OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1U5G FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1u5g]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1U5G OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1U5G FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1u5e\|1u5e]], [[1u5f\|1u5f]], [[1u5d\|1u5d]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1u5e\|1u5e]], [[1u5f\|1u5f]], [[1u5d\|1u5d]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SCAP2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 ~~Mus musculus~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SCAP2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1u5g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1u5g OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1u5g RCSB], [http://www.ebi.ac.uk/pdbsum/1u5g PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1u5g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1u5g OCA], [http://pdbe.org/1u5g PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1u5g RCSB], [http://www.ebi.ac.uk/pdbsum/1u5g PDBsum]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 25:		Line 25:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1u5g" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Mus musculus~~]]	+	[[Category: Lk3 transgenic mice]]
	[[Category: Eck, M J]]		[[Category: Eck, M J]]
	[[Category: Neel, B G]]		[[Category: Neel, B G]]

OCA at 12:44, 6 January 2015

OCA — Tue, 06 Jan 2015 12:44:48 GMT

←Older revision		Revision as of 12:44, 6 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1u5g]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1U5G OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1U5G FirstGlance]. <br>		<table><tr><td colspan='2'>[[1u5g]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1U5G OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1U5G FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1u5e\|1u5e]], [[1u5f\|1u5f]], [[1u5d\|1u5d]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1u5e\|1u5e]], [[1u5f\|1u5f]], [[1u5d\|1u5d]]</td></tr>
-	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SCAP2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SCAP2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus])</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1u5g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1u5g OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1u5g RCSB], [http://www.ebi.ac.uk/pdbsum/1u5g PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1u5g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1u5g OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1u5g RCSB], [http://www.ebi.ac.uk/pdbsum/1u5g PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 30:		Line 30:
	</StructureSection>		</StructureSection>
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
-	[[Category: Eck, M J.]]	+	[[Category: Eck, M J]]
-	[[Category: Neel, B G.]]	+	[[Category: Neel, B G]]
-	[[Category: Swanson, K.]]	+	[[Category: Swanson, K]]
-	[[Category: Tang, Y.]]	+	[[Category: Tang, Y]]
	[[Category: Ph domain]]		[[Category: Ph domain]]
	[[Category: Signaling protein]]		[[Category: Signaling protein]]

OCA at 19:33, 29 September 2014

OCA — Mon, 29 Sep 2014 19:33:02 GMT

←Older revision		Revision as of 19:33, 29 September 2014
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-	[[~~Image:~~1u5g.~~png~~\|~~left~~\|200px]]	+	==Crystal Structure of the PH Domain of SKAP-Hom==
		+	<StructureSection load='1u5g' size='340' side='right' caption='[[1u5g]], [[Resolution\|resolution]] 2.10Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1u5g]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1U5G OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1U5G FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1u5e\|1u5e]], [[1u5f\|1u5f]], [[1u5d\|1u5d]]</td></tr>
		+	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SCAP2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus])</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1u5g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1u5g OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1u5g RCSB], [http://www.ebi.ac.uk/pdbsum/1u5g PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/u5/1u5g_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	PH domains, by binding to phosphoinositides, often serve as membrane-targeting modules. Using crystallographic, biochemical, and cell biological approaches, we have uncovered a mechanism that the integrin-signaling adaptor Skap-hom uses to mediate cytoskeletal interactions. Skap-hom is a homodimer containing an N-terminal four-helix bundle dimerization domain, against which its two PH domains pack in a conformation incompatible with phosphoinositide binding. The isolated PH domains bind PI[3,4,5]P(3), and mutations targeting the dimerization domain or the PH domain's PI[3,4,5]P(3)-binding pocket prevent Skap-hom localization to ruffles. Targeting is retained when the PH domain is deleted or by combined mutation of the PI[3,4,5]P(3)-binding pocket and the PH/dimerization domain interface. Thus, the dimerization and PH domain form a PI[3,4,5]P(3)-responsive molecular switch that controls Skap-hom function.

-	~~{{STRUCTURE_1u5g\| PDB=1u5g \| SCENE= }}~~	+	The Skap-hom dimerization and PH domains comprise a 3'-phosphoinositide-gated molecular switch.,Swanson KD, Tang Y, Ceccarelli DF, Poy F, Sliwa JP, Neel BG, Eck MJ Mol Cell. 2008 Nov 21;32(4):564-75. PMID:19026786<ref>PMID:19026786</ref>

-	~~===Crystal Structure~~ of the ~~PH Domain of SKAP-Hom===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_19026786}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[1u5g]] is a 4 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Mus_musculus Mus musculus]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=1U5G OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:019026786<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
	[[Category: Eck, M J.]]		[[Category: Eck, M J.]]

OCA: Protected "1u5g" [edit=sysop:move=sysop]

OCA — Sat, 05 Jan 2013 12:43:03 GMT

Protected "1u5g" [edit=sysop:move=sysop]

←Older revision

Revision as of 12:43, 5 January 2013

OCA at 12:42, 5 January 2013

OCA — Sat, 05 Jan 2013 12:42:58 GMT

←Older revision		Revision as of 12:42, 5 January 2013
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-	{{Seed}}
	[[Image:1u5g.png\|left\|200px]]		[[Image:1u5g.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_1u5g", creates the "Structure Box" on the page.
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-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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	{{STRUCTURE_1u5g\| PDB=1u5g \| SCENE= }}		{{STRUCTURE_1u5g\| PDB=1u5g \| SCENE= }}

	===Crystal Structure of the PH Domain of SKAP-Hom===		===Crystal Structure of the PH Domain of SKAP-Hom===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_19026786}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 19026786 is the PubMed ID number.
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	{{ABSTRACT_PUBMED_19026786}}		{{ABSTRACT_PUBMED_19026786}}

	==About this Structure==		==About this Structure==
-	~~1U5G~~ is a 4 ~~chains~~ structure ~~of sequences~~ from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1U5G OCA].	+	[[1u5g]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1U5G OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~19026786~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:019026786</ref><references group="xtra"/>
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
	[[Category: Eck, M J.]]		[[Category: Eck, M J.]]
Line 31:		Line 19:
	[[Category: Ph domain]]		[[Category: Ph domain]]
	[[Category: Signaling protein]]		[[Category: Signaling protein]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jan 18 11:24:48 2010''