1u5u - Revision history

OCA at 08:44, 14 February 2024

OCA — Wed, 14 Feb 2024 08:44:09 GMT

←Older revision		Revision as of 08:44, 14 February 2024
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	<StructureSection load='1u5u' size='340' side='right'caption='[[1u5u]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='1u5u' size='340' side='right'caption='[[1u5u]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1u5u]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Black_sea_rod Black sea rod~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1U5U OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1U5U FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1u5u]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Plexaura_homomalla Plexaura homomalla]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1U5U OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1U5U FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2Å</td></tr>
-	<tr id='~~activity~~'><td class="sblockLbl"><b>~~Activity~~:</b></td><td class="sblockDat"><~~span class~~='~~plainlinks~~'>~~[https://en.wikipedia.org/wiki/Hydroperoxide_dehydratase Hydroperoxide dehydratase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.92 4.2.1.92]~~ </~~span~~></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1u5u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1u5u OCA], [https://pdbe.org/1u5u PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1u5u RCSB], [https://www.ebi.ac.uk/pdbsum/1u5u PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1u5u ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1u5u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1u5u OCA], [https://pdbe.org/1u5u PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1u5u RCSB], [https://www.ebi.ac.uk/pdbsum/1u5u PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1u5u ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/AOSL_PLEHO AOSL_PLEHO]] Bifunctional enzyme which is responsible for allene oxide biosynthesis via a two-step reaction which involves conversion of arachidonic acid to a 8R-hydroperoxide intermediate followed by conversion of the hydroperoxide to allene oxide.<ref>PMID:9302294</ref> <ref>PMID:10559269</ref>	+	[https://www.uniprot.org/uniprot/AOSL_PLEHO AOSL_PLEHO] Bifunctional enzyme which is responsible for allene oxide biosynthesis via a two-step reaction which involves conversion of arachidonic acid to a 8R-hydroperoxide intermediate followed by conversion of the hydroperoxide to allene oxide.<ref>PMID:9302294</ref> <ref>PMID:10559269</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1u5u ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1u5u ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
-	<div style="background-color:#fffaf0;">
-	== Publication Abstract from PubMed ==
-	8R-Lipoxygenase and allene oxide synthase (AOS) are parts of a naturally occurring fusion protein from the coral Plexaura homomalla. AOS catalyses the production of an unstable epoxide (an allene oxide) from the fatty acid hydroperoxide generated by the lipoxygenase activity. Here, we report the structure of the AOS domain and its striking structural homology to catalase. Whereas nominal sequence identity between the enzymes had been previously described, the extent of structural homology observed was not anticipated, given that this enzyme activity had been exclusively associated with the P450 superfamily, and conservation of a catalase fold without catalase activity is unprecedented. Whereas the heme environment is largely conserved, the AOS heme is planar and the distal histidine is flanked by two hydrogen-bonding residues. These critical differences likely facilitate the switch from a catalatic activity to that of a fatty acid hydroperoxidase.
-
-	The structure of coral allene oxide synthase reveals a catalase adapted for metabolism of a fatty acid hydroperoxide.,Oldham ML, Brash AR, Newcomer ME Proc Natl Acad Sci U S A. 2005 Jan 11;102(2):297-302. Epub 2004 Dec 29. PMID:15625113<ref>PMID:15625113</ref>
-
-	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	</div>
-	<div class="pdbe-citations 1u5u" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Black sea rod]]
-	[[Category: Hydroperoxide dehydratase]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Brash, A R~~]]	+	[[Category: Plexaura homomalla]]
-	[[Category: ~~Newcomer, M E~~]]	+	[[Category: Brash AR]]
-	[[Category: ~~Oldham, M L~~]]	+	[[Category: Newcomer ME]]
-	[[Category: ~~Allene oxide synthase]]~~	+	[[Category: Oldham ML]]
-	~~[[Category: Catalase]]~~	+
-	~~[[Category: Eicosanoid]]~~	+
-	~~[[Category: Fusion protein]]~~	+
-	~~[[Category: Heme]]~~	+
-	~~[[Category: Lyase~~]]	+

OCA at 09:36, 29 September 2021

OCA — Wed, 29 Sep 2021 09:36:54 GMT

←Older revision		Revision as of 09:36, 29 September 2021
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	<StructureSection load='1u5u' size='340' side='right'caption='[[1u5u]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='1u5u' size='340' side='right'caption='[[1u5u]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1u5u]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Black_sea_rod Black sea rod]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1U5U OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1U5U FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1u5u]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Black_sea_rod Black sea rod]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1U5U OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1U5U FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Hydroperoxide_dehydratase Hydroperoxide dehydratase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.92 4.2.1.92] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Hydroperoxide_dehydratase Hydroperoxide dehydratase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.92 4.2.1.92] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1u5u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1u5u OCA], [~~http~~://pdbe.org/1u5u PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1u5u RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1u5u PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1u5u ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1u5u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1u5u OCA], [https://pdbe.org/1u5u PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1u5u RCSB], [https://www.ebi.ac.uk/pdbsum/1u5u PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1u5u ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/AOSL_PLEHO AOSL_PLEHO]] Bifunctional enzyme which is responsible for allene oxide biosynthesis via a two-step reaction which involves conversion of arachidonic acid to a 8R-hydroperoxide intermediate followed by conversion of the hydroperoxide to allene oxide.<ref>PMID:9302294</ref> <ref>PMID:10559269</ref>	+	[[https://www.uniprot.org/uniprot/AOSL_PLEHO AOSL_PLEHO]] Bifunctional enzyme which is responsible for allene oxide biosynthesis via a two-step reaction which involves conversion of arachidonic acid to a 8R-hydroperoxide intermediate followed by conversion of the hydroperoxide to allene oxide.<ref>PMID:9302294</ref> <ref>PMID:10559269</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 13:34, 25 December 2019

OCA — Wed, 25 Dec 2019 13:34:05 GMT

←Older revision		Revision as of 13:34, 25 December 2019
Line 1:		Line 1:

	==The structure of an Allene Oxide Synthase reveals a novel use for a catalase fold==		==The structure of an Allene Oxide Synthase reveals a novel use for a catalase fold==
-	<StructureSection load='1u5u' size='340' side='right' caption='[[1u5u]], [[Resolution\|resolution]] 2.00Å' scene=''>	+	<StructureSection load='1u5u' size='340' side='right'caption='[[1u5u]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1u5u]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Black_sea_rod Black sea rod]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1U5U OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1U5U FirstGlance]. <br>		<table><tr><td colspan='2'>[[1u5u]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Black_sea_rod Black sea rod]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1U5U OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1U5U FirstGlance]. <br>
Line 35:		Line 35:
	[[Category: Black sea rod]]		[[Category: Black sea rod]]
	[[Category: Hydroperoxide dehydratase]]		[[Category: Hydroperoxide dehydratase]]
		+	[[Category: Large Structures]]
	[[Category: Brash, A R]]		[[Category: Brash, A R]]
	[[Category: Newcomer, M E]]		[[Category: Newcomer, M E]]

OCA at 08:25, 21 March 2018

OCA — Wed, 21 Mar 2018 08:25:46 GMT

←Older revision		Revision as of 08:25, 21 March 2018
Line 1:		Line 1:
		+
	==The structure of an Allene Oxide Synthase reveals a novel use for a catalase fold==		==The structure of an Allene Oxide Synthase reveals a novel use for a catalase fold==
	<StructureSection load='1u5u' size='340' side='right' caption='[[1u5u]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='1u5u' size='340' side='right' caption='[[1u5u]], [[Resolution\|resolution]] 2.00Å' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene></td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Hydroperoxide_dehydratase Hydroperoxide dehydratase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.92 4.2.1.92] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Hydroperoxide_dehydratase Hydroperoxide dehydratase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.92 4.2.1.92] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1u5u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1u5u OCA], [http://pdbe.org/1u5u PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1u5u RCSB], [http://www.ebi.ac.uk/pdbsum/1u5u PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1u5u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1u5u OCA], [http://pdbe.org/1u5u PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1u5u RCSB], [http://www.ebi.ac.uk/pdbsum/1u5u PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1u5u ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 13:		Line 14:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/u5/1u5u_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/u5/1u5u_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1u5u ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 21:41, 11 September 2015

OCA — Fri, 11 Sep 2015 21:41:43 GMT

←Older revision		Revision as of 21:41, 11 September 2015
Line 2:		Line 2:
	<StructureSection load='1u5u' size='340' side='right' caption='[[1u5u]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='1u5u' size='340' side='right' caption='[[1u5u]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1u5u]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Plexaura_homomalla Plexaura homomalla~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1U5U OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1U5U FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1u5u]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Black_sea_rod Black sea rod]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1U5U OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1U5U FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene></td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Hydroperoxide_dehydratase Hydroperoxide dehydratase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.92 4.2.1.92] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Hydroperoxide_dehydratase Hydroperoxide dehydratase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.92 4.2.1.92] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1u5u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1u5u OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1u5u RCSB], [http://www.ebi.ac.uk/pdbsum/1u5u PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1u5u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1u5u OCA], [http://pdbe.org/1u5u PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1u5u RCSB], [http://www.ebi.ac.uk/pdbsum/1u5u PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 27:		Line 27:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1u5u" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Black sea rod]]
	[[Category: Hydroperoxide dehydratase]]		[[Category: Hydroperoxide dehydratase]]
-	[[Category: Plexaura homomalla]]
	[[Category: Brash, A R]]		[[Category: Brash, A R]]
	[[Category: Newcomer, M E]]		[[Category: Newcomer, M E]]

OCA at 20:01, 25 December 2014

OCA — Thu, 25 Dec 2014 20:01:18 GMT

←Older revision		Revision as of 20:01, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1u5u]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Plexaura_homomalla Plexaura homomalla]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1U5U OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1U5U FirstGlance]. <br>		<table><tr><td colspan='2'>[[1u5u]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Plexaura_homomalla Plexaura homomalla]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1U5U OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1U5U FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene></td></tr>
-	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Hydroperoxide_dehydratase Hydroperoxide dehydratase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.92 4.2.1.92] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Hydroperoxide_dehydratase Hydroperoxide dehydratase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.92 4.2.1.92] </span></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1u5u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1u5u OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1u5u RCSB], [http://www.ebi.ac.uk/pdbsum/1u5u PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1u5u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1u5u OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1u5u RCSB], [http://www.ebi.ac.uk/pdbsum/1u5u PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/AOSL_PLEHO AOSL_PLEHO]] Bifunctional enzyme which is responsible for allene oxide biosynthesis via a two-step reaction which involves conversion of arachidonic acid to a 8R-hydroperoxide intermediate followed by conversion of the hydroperoxide to allene oxide.<ref>PMID:9302294</ref> <ref>PMID:10559269</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 31:		Line 33:
	[[Category: Hydroperoxide dehydratase]]		[[Category: Hydroperoxide dehydratase]]
	[[Category: Plexaura homomalla]]		[[Category: Plexaura homomalla]]
-	[[Category: Brash, A R.]]	+	[[Category: Brash, A R]]
-	[[Category: Newcomer, M E.]]	+	[[Category: Newcomer, M E]]
-	[[Category: Oldham, M L.]]	+	[[Category: Oldham, M L]]
	[[Category: Allene oxide synthase]]		[[Category: Allene oxide synthase]]
	[[Category: Catalase]]		[[Category: Catalase]]

OCA at 19:23, 29 September 2014

OCA — Mon, 29 Sep 2014 19:23:13 GMT

←Older revision		Revision as of 19:23, 29 September 2014
Line 1:		Line 1:
-	[[~~Image~~:1u5u.~~png\|left~~\|200px]]	+	==The structure of an Allene Oxide Synthase reveals a novel use for a catalase fold==
		+	<StructureSection load='1u5u' size='340' side='right' caption='[[1u5u]], [[Resolution\|resolution]] 2.00Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1u5u]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Plexaura_homomalla Plexaura homomalla]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1U5U OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1U5U FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene><br>
		+	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Hydroperoxide_dehydratase Hydroperoxide dehydratase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.92 4.2.1.92] </span></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1u5u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1u5u OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1u5u RCSB], [http://www.ebi.ac.uk/pdbsum/1u5u PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/u5/1u5u_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	8R-Lipoxygenase and allene oxide synthase (AOS) are parts of a naturally occurring fusion protein from the coral Plexaura homomalla. AOS catalyses the production of an unstable epoxide (an allene oxide) from the fatty acid hydroperoxide generated by the lipoxygenase activity. Here, we report the structure of the AOS domain and its striking structural homology to catalase. Whereas nominal sequence identity between the enzymes had been previously described, the extent of structural homology observed was not anticipated, given that this enzyme activity had been exclusively associated with the P450 superfamily, and conservation of a catalase fold without catalase activity is unprecedented. Whereas the heme environment is largely conserved, the AOS heme is planar and the distal histidine is flanked by two hydrogen-bonding residues. These critical differences likely facilitate the switch from a catalatic activity to that of a fatty acid hydroperoxidase.

-	~~{{STRUCTURE_1u5u\| PDB=1u5u \| SCENE= }}~~	+	The structure of coral allene oxide synthase reveals a catalase adapted for metabolism of a fatty acid hydroperoxide.,Oldham ML, Brash AR, Newcomer ME Proc Natl Acad Sci U S A. 2005 Jan 11;102(2):297-302. Epub 2004 Dec 29. PMID:15625113<ref>PMID:15625113</ref>

-	~~===The structure~~ of ~~an Allene Oxide Synthase reveals a novel use for a catalase fold===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_15625113}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[1u5u]] is a 2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Plexaura_homomalla Plexaura homomalla]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=1U5U OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:015625113<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Hydroperoxide dehydratase]]		[[Category: Hydroperoxide dehydratase]]
	[[Category: Plexaura homomalla]]		[[Category: Plexaura homomalla]]

OCA: Protected "1u5u" [edit=sysop:move=sysop]

OCA — Sat, 05 Jan 2013 12:24:33 GMT

Protected "1u5u" [edit=sysop:move=sysop]

←Older revision

Revision as of 12:24, 5 January 2013

OCA at 12:24, 5 January 2013

OCA — Sat, 05 Jan 2013 12:24:31 GMT

←Older revision		Revision as of 12:24, 5 January 2013
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-	{{Seed}}
	[[Image:1u5u.png\|left\|200px]]		[[Image:1u5u.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_1u5u", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_1u5u\| PDB=1u5u \| SCENE= }}		{{STRUCTURE_1u5u\| PDB=1u5u \| SCENE= }}

	===The structure of an Allene Oxide Synthase reveals a novel use for a catalase fold===		===The structure of an Allene Oxide Synthase reveals a novel use for a catalase fold===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_15625113}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 15625113 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_15625113}}		{{ABSTRACT_PUBMED_15625113}}

	==About this Structure==		==About this Structure==
-	~~1U5U~~ is a 2 ~~chains~~ structure ~~of sequences~~ from [http://en.wikipedia.org/wiki/Plexaura_homomalla Plexaura homomalla]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1U5U OCA].	+	[[1u5u]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Plexaura_homomalla Plexaura homomalla]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1U5U OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~15625113~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:015625113</ref><references group="xtra"/>
	[[Category: Hydroperoxide dehydratase]]		[[Category: Hydroperoxide dehydratase]]
	[[Category: Plexaura homomalla]]		[[Category: Plexaura homomalla]]
Line 34:		Line 22:
	[[Category: Fusion protein]]		[[Category: Fusion protein]]
	[[Category: Heme]]		[[Category: Heme]]
-		+	[[Category: Lyase]]
-	~~''Page seeded by~~ [~~http~~:~~//oca.weizmann.ac.il/oca OCA~~ ] ~~on Wed Feb 18 05:30:28 2009''~~	+

OCA at 03:30, 18 February 2009

OCA — Wed, 18 Feb 2009 03:30:29 GMT

←Older revision		Revision as of 03:30, 18 February 2009
Line 20:		Line 20:

	==About this Structure==		==About this Structure==
-	1U5U is a ~~[[Single protein]]~~ structure of ~~sequence~~ from [http://en.wikipedia.org/wiki/Plexaura_homomalla Plexaura homomalla]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1U5U OCA].	+	1U5U is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Plexaura_homomalla Plexaura homomalla]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1U5U OCA].

	==Reference==		==Reference==
-	The structure of coral allene oxide synthase reveals a catalase adapted for metabolism of a fatty acid hydroperoxide., Oldham ML, Brash AR, Newcomer ME, Proc Natl Acad Sci U S A. 2005 Jan 11;102(2):297-302. Epub 2004 Dec 29. PMID:~~[http:~~//~~www.ncbi.nlm.nih.gov/pubmed/15625113 15625113]~~	+	<ref group="xtra">PMID:15625113</ref><references group="xtra"/>
	[[Category: Hydroperoxide dehydratase]]		[[Category: Hydroperoxide dehydratase]]
	[[Category: Plexaura homomalla]]		[[Category: Plexaura homomalla]]
-	[[Category: Single protein]]
	[[Category: Brash, A R.]]		[[Category: Brash, A R.]]
	[[Category: Newcomer, M E.]]		[[Category: Newcomer, M E.]]
Line 36:		Line 35:
	[[Category: Heme]]		[[Category: Heme]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Tue Jul 29 12~~:12:~~38 2008~~''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 18 05:30:28 2009''