1u6d - Revision history

OCA at 08:44, 14 February 2024

OCA — Wed, 14 Feb 2024 08:44:16 GMT

←Older revision		Revision as of 08:44, 14 February 2024
Line 3:		Line 3:
	<StructureSection load='1u6d' size='340' side='right'caption='[[1u6d]], [[Resolution\|resolution]] 1.85Å' scene=''>		<StructureSection load='1u6d' size='340' side='right'caption='[[1u6d]], [[Resolution\|resolution]] 1.85Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1u6d]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1U6D OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=1U6D FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1u6d]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1U6D OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1U6D FirstGlance]. <br>
-	</td></tr><tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat">~~Keap1 (~~[~~http://www~~.~~ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info~~&~~srchmode=5&id=9606 HUMAN])~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.85Å</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=1u6d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1u6d OCA], [~~http~~://pdbe.org/1u6d PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1u6d RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1u6d PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1u6d ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1u6d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1u6d OCA], [https://pdbe.org/1u6d PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1u6d RCSB], [https://www.ebi.ac.uk/pdbsum/1u6d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1u6d ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/KEAP1_HUMAN KEAP1_HUMAN]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 17:		Line 19:
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1u6d ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1u6d ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
-	<div style="background-color:#fffaf0;">
-	== Publication Abstract from PubMed ==
-	Keap1 is a substrate adaptor protein for an ubiquitin ligase complex that targets the Nrf2 transcription factor for degradation. Keap1 binds Nrf2 through its C-terminal Kelch domain, which contains six copies of the evolutionarily conserved kelch repeat sequence motif. The structure of the Kelch domain from human Keap1 has been determined by x-ray crystallography to a resolution of 1.85 A. The Kelch domain forms a 6-bladed beta-propeller structure, with residues at the C terminus forming the first strand in the first blade. Key structural roles have been identified for the highly conserved glycine, tyrosine, and tryptophan residues that define the kelch repeat sequence motif. In addition, we show that substitution of a single amino acid located within a loop that extends out from the bottom of the beta-propeller structure abolishes binding of Nrf2. The structure of the Kelch domain of Keap1 represents a high quality model for the superfamily of eukaryotic kelch repeat proteins and provides insight into how disease-causing mutations perturb the structural integrity of the Kelch domain.
-
-	Crystal structure of the Kelch domain of human Keap1.,Li X, Zhang D, Hannink M, Beamer LJ J Biol Chem. 2004 Dec 24;279(52):54750-8. Epub 2004 Oct 8. PMID:15475350<ref>PMID:15475350</ref>
-
-	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	</div>
-	<div class="pdbe-citations 1u6d" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
	*[[Kelch-like protein 3D structures\|Kelch-like protein 3D structures]]		*[[Kelch-like protein 3D structures\|Kelch-like protein 3D structures]]
-	== References ==
-	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Beamer~~, L J~~]]	+	[[Category: Beamer LJ]]
-	[[Category: Hannink, M]]	+	[[Category: Hannink M]]
-	[[Category: Li, X]]	+	[[Category: Li X]]
-	[[Category: Zhang, D]]	+	[[Category: Zhang D]]
-	~~[[Category: Beta-propeller]]~~	+
-	~~[[Category: Kelch repeat motif]]~~	+
-	~~[[Category: Protein binding~~]]	+

OCA at 07:23, 30 December 2020

OCA — Wed, 30 Dec 2020 07:23:05 GMT

←Older revision		Revision as of 07:23, 30 December 2020
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	==Crystal structure of the Kelch domain of human Keap1==		==Crystal structure of the Kelch domain of human Keap1==
-	<StructureSection load='1u6d' size='340' side='right' caption='[[1u6d]], [[Resolution\|resolution]] 1.85Å' scene=''>	+	<StructureSection load='1u6d' size='340' side='right'caption='[[1u6d]], [[Resolution\|resolution]] 1.85Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1u6d]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1U6D OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1U6D FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1u6d]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1U6D OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=1U6D FirstGlance]. <br>
	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Keap1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>		</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Keap1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1u6d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1u6d OCA], [http://pdbe.org/1u6d PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1u6d RCSB], [http://www.ebi.ac.uk/pdbsum/1u6d PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1u6d ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=1u6d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1u6d OCA], [http://pdbe.org/1u6d PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1u6d RCSB], [http://www.ebi.ac.uk/pdbsum/1u6d PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1u6d ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 28:		Line 28:

	==See Also==		==See Also==
-	*[[Kelch-like protein\|Kelch-like protein]]	+	*[[Kelch-like protein 3D structures\|Kelch-like protein 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 34:		Line 34:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Beamer, L J]]		[[Category: Beamer, L J]]
	[[Category: Hannink, M]]		[[Category: Hannink, M]]

OCA at 08:46, 21 March 2018

OCA — Wed, 21 Mar 2018 08:46:08 GMT

←Older revision		Revision as of 08:46, 21 March 2018
Line 1:		Line 1:
		+
	==Crystal structure of the Kelch domain of human Keap1==		==Crystal structure of the Kelch domain of human Keap1==
	<StructureSection load='1u6d' size='340' side='right' caption='[[1u6d]], [[Resolution\|resolution]] 1.85Å' scene=''>		<StructureSection load='1u6d' size='340' side='right' caption='[[1u6d]], [[Resolution\|resolution]] 1.85Å' scene=''>
Line 4:		Line 5:
	<table><tr><td colspan='2'>[[1u6d]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1U6D OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1U6D FirstGlance]. <br>		<table><tr><td colspan='2'>[[1u6d]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1U6D OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1U6D FirstGlance]. <br>
	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Keap1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>		</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Keap1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1u6d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1u6d OCA], [http://pdbe.org/1u6d PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1u6d RCSB], [http://www.ebi.ac.uk/pdbsum/1u6d PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1u6d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1u6d OCA], [http://pdbe.org/1u6d PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1u6d RCSB], [http://www.ebi.ac.uk/pdbsum/1u6d PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1u6d ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 10:		Line 11:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/u6/1u6d_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/u6/1u6d_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 22:01, 8 February 2016

OCA — Mon, 08 Feb 2016 22:01:24 GMT

←Older revision		Revision as of 22:01, 8 February 2016
Line 2:		Line 2:
	<StructureSection load='1u6d' size='340' side='right' caption='[[1u6d]], [[Resolution\|resolution]] 1.85Å' scene=''>		<StructureSection load='1u6d' size='340' side='right' caption='[[1u6d]], [[Resolution\|resolution]] 1.85Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1u6d]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1U6D OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1U6D FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1u6d]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1U6D OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1U6D FirstGlance]. <br>
-	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Keap1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~])</td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Keap1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1u6d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1u6d OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1u6d RCSB], [http://www.ebi.ac.uk/pdbsum/1u6d PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1u6d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1u6d OCA], [http://pdbe.org/1u6d PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1u6d RCSB], [http://www.ebi.ac.uk/pdbsum/1u6d PDBsum]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 14:		Line 14:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1u6d ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 24:		Line 24:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1u6d" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
-	*[[Kelch-like ~~ECH-associated~~ protein 1\|Kelch-like ~~ECH-associated~~ protein 1]]	+	*[[Kelch-like protein\|Kelch-like protein]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Beamer, L J]]		[[Category: Beamer, L J]]
	[[Category: Hannink, M]]		[[Category: Hannink, M]]

OCA at 13:44, 6 January 2015

OCA — Tue, 06 Jan 2015 13:44:30 GMT

←Older revision		Revision as of 13:44, 6 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1u6d]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1U6D OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1U6D FirstGlance]. <br>		<table><tr><td colspan='2'>[[1u6d]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1U6D OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1U6D FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Keap1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Keap1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1u6d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1u6d OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1u6d RCSB], [http://www.ebi.ac.uk/pdbsum/1u6d PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1u6d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1u6d OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1u6d RCSB], [http://www.ebi.ac.uk/pdbsum/1u6d PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 32:		Line 32:
	</StructureSection>		</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Beamer, L J.]]	+	[[Category: Beamer, L J]]
-	[[Category: Hannink, M.]]	+	[[Category: Hannink, M]]
-	[[Category: Li, X.]]	+	[[Category: Li, X]]
-	[[Category: Zhang, D.]]	+	[[Category: Zhang, D]]
	[[Category: Beta-propeller]]		[[Category: Beta-propeller]]
	[[Category: Kelch repeat motif]]		[[Category: Kelch repeat motif]]
	[[Category: Protein binding]]		[[Category: Protein binding]]

OCA at 21:56, 29 September 2014

OCA — Mon, 29 Sep 2014 21:56:38 GMT

←Older revision		Revision as of 21:56, 29 September 2014
Line 1:		Line 1:
-	[[~~Image~~:1u6d.~~png\|left~~\|200px]]	+	==Crystal structure of the Kelch domain of human Keap1==
		+	<StructureSection load='1u6d' size='340' side='right' caption='[[1u6d]], [[Resolution\|resolution]] 1.85Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1u6d]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1U6D OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1U6D FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Keap1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1u6d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1u6d OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1u6d RCSB], [http://www.ebi.ac.uk/pdbsum/1u6d PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/u6/1u6d_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Keap1 is a substrate adaptor protein for an ubiquitin ligase complex that targets the Nrf2 transcription factor for degradation. Keap1 binds Nrf2 through its C-terminal Kelch domain, which contains six copies of the evolutionarily conserved kelch repeat sequence motif. The structure of the Kelch domain from human Keap1 has been determined by x-ray crystallography to a resolution of 1.85 A. The Kelch domain forms a 6-bladed beta-propeller structure, with residues at the C terminus forming the first strand in the first blade. Key structural roles have been identified for the highly conserved glycine, tyrosine, and tryptophan residues that define the kelch repeat sequence motif. In addition, we show that substitution of a single amino acid located within a loop that extends out from the bottom of the beta-propeller structure abolishes binding of Nrf2. The structure of the Kelch domain of Keap1 represents a high quality model for the superfamily of eukaryotic kelch repeat proteins and provides insight into how disease-causing mutations perturb the structural integrity of the Kelch domain.

-	~~{{STRUCTURE_1u6d\| PDB=1u6d \| SCENE= }}~~	+	Crystal structure of the Kelch domain of human Keap1.,Li X, Zhang D, Hannink M, Beamer LJ J Biol Chem. 2004 Dec 24;279(52):54750-8. Epub 2004 Oct 8. PMID:15475350<ref>PMID:15475350</ref>

-	~~===Crystal structure~~ of the ~~Kelch domain~~ of ~~human Keap1===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>

-	~~{{ABSTRACT_PUBMED_15475350}}~~	+	==See Also==
-		+	*[[Kelch-like ECH-associated protein 1\|Kelch-like ECH-associated protein 1]]
-	==~~About this Structure~~==	+	== References ==
-	[[~~1u6d]] is a~~ 1 ~~chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca~~-~~bin/ocashort?id=1U6D OCA~~].	+	<references/>
-		+	__TOC__
-	==~~Reference~~==	+	</StructureSection>
-	<~~ref group="xtra">PMID:015475350<~~/~~ref~~><~~ref group="xtra">PMID:015583386</ref><references group="xtra"~~/>	+
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Beamer, L J.]]		[[Category: Beamer, L J.]]

OCA at 09:27, 16 January 2013

OCA — Wed, 16 Jan 2013 09:27:44 GMT

←Older revision		Revision as of 09:27, 16 January 2013
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	[[Image:1u6d.png\|left\|200px]]		[[Image:1u6d.png\|left\|200px]]

-	<!--
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	{{STRUCTURE_1u6d\| PDB=1u6d \| SCENE= }}		{{STRUCTURE_1u6d\| PDB=1u6d \| SCENE= }}

	===Crystal structure of the Kelch domain of human Keap1===		===Crystal structure of the Kelch domain of human Keap1===

-
-	<!--
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	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~15475350~~</ref><ref group="xtra">PMID:~~15583386~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:015475350</ref><ref group="xtra">PMID:015583386</ref><references group="xtra"/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Beamer, L J.]]		[[Category: Beamer, L J.]]

OCA: Protected "1u6d" [edit=sysop:move=sysop]

OCA — Mon, 14 Mar 2011 23:57:53 GMT

Protected "1u6d" [edit=sysop:move=sysop]

←Older revision

Revision as of 23:57, 14 March 2011

OCA at 23:57, 14 March 2011

OCA — Mon, 14 Mar 2011 23:57:52 GMT

←Older revision		Revision as of 23:57, 14 March 2011
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-	{{Seed}}
	[[Image:1u6d.png\|left\|200px]]		[[Image:1u6d.png\|left\|200px]]

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	==About this Structure==		==About this Structure==
-	~~1U6D~~ is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1U6D OCA].	+	[[1u6d]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1U6D OCA].

	==Reference==		==Reference==
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	[[Category: Beta-propeller]]		[[Category: Beta-propeller]]
	[[Category: Kelch repeat motif]]		[[Category: Kelch repeat motif]]
-		+	[[Category: Protein binding]]
-	~~''Page seeded by~~ [~~http~~:~~//oca.weizmann.ac.il/oca OCA~~ ] ~~on Tue Feb 17 03:50:53 2009''~~	+

OCA at 01:50, 17 February 2009

OCA — Tue, 17 Feb 2009 01:50:58 GMT

←Older revision		Revision as of 01:50, 17 February 2009
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	==About this Structure==		==About this Structure==
-	1U6D is a ~~[[Single protein]]~~ structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1U6D OCA].	+	1U6D is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1U6D OCA].

	==Reference==		==Reference==
-	~~Crystal structure of the Kelch domain of human Keap1., Li X, Zhang D, Hannink M, Beamer LJ, J Biol Chem. 2004 Dec 24;279(52):54750-8. Epub 2004 Oct 8.~~ PMID:~~[http:~~/~~/www.ncbi.nlm.nih.gov/pubmed/15475350 15475350]~~	+	<ref group="xtra">PMID:15475350</ref><ref group="xtra">PMID:15583386</ref><references group="xtra"/>
-		+
-	Crystallization and initial crystallographic analysis of the Kelch domain from human Keap1., Li X, Zhang D, Hannink M, Beamer LJ, Acta Crystallogr D Biol Crystallogr. 2004 Dec;60(Pt 12 Pt 2):2346-8. Epub, 2004 Nov 26. PMID:~~[http:~~//~~www.ncbi.nlm.nih.gov/pubmed/15583386 15583386]~~	+
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Single protein]]
	[[Category: Beamer, L J.]]		[[Category: Beamer, L J.]]
	[[Category: Hannink, M.]]		[[Category: Hannink, M.]]
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	[[Category: Kelch repeat motif]]		[[Category: Kelch repeat motif]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Mon Jul 28 07~~:13:~~19 2008~~''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 03:50:53 2009''