1u8h - Revision history

OCA at 13:15, 9 May 2024

OCA — Thu, 09 May 2024 13:15:09 GMT

←Older revision		Revision as of 13:15, 9 May 2024
Line 3:		Line 3:
	<StructureSection load='1u8h' size='340' side='right'caption='[[1u8h]], [[Resolution\|resolution]] 2.10Å' scene=''>		<StructureSection load='1u8h' size='340' side='right'caption='[[1u8h]], [[Resolution\|resolution]] 2.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1u8h]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1U8H OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1U8H FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1u8h]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1U8H OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1U8H FirstGlance]. <br>
-	</td></tr><tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat">~~<div style='overflow: auto; max~~-~~height: 3em;'>[[2f5a\|2f5a]]~~, [[~~2f5b~~\|~~2f5b~~]], [[1u8i\|1u8i]], [[1u8j\|1u8j]], [[1u8k\|1u8k]], [[1u8l\|1u8l]], [[1u8m\|1u8m]], [[1u8n\|1u8n]], [[1u8o\|1u8o]], [[1u8p\|1u8p]], [[1u8q\|1u8q]], [[1u91\|1u91]], [[1u92\|1u92]], [[1u93\|1u93]], [[1u95\|1u95]]</div></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.1Å</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1u8h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1u8h OCA], [https://pdbe.org/1u8h PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1u8h RCSB], [https://www.ebi.ac.uk/pdbsum/1u8h PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1u8h ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1u8h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1u8h OCA], [https://pdbe.org/1u8h PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1u8h RCSB], [https://www.ebi.ac.uk/pdbsum/1u8h PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1u8h ProSAT]</span></td></tr>
	</table>		</table>
Line 29:		Line 29:
	==See Also==		==See Also==
	*[[Antibody 3D structures\|Antibody 3D structures]]		*[[Antibody 3D structures\|Antibody 3D structures]]
		+	*[[Monoclonal Antibodies 3D structures\|Monoclonal Antibodies 3D structures]]
	*[[3D structures of human antibody\|3D structures of human antibody]]		*[[3D structures of human antibody\|3D structures of human antibody]]
	== References ==		== References ==
Line 35:		Line 36:
	</StructureSection>		</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
		+	[[Category: Human immunodeficiency virus 1]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Bryson, S]]	+	[[Category: Bryson S]]
-	[[Category: Hynes~~, R C~~]]	+	[[Category: Hynes RC]]
-	[[Category: Julien, J P]]	+	[[Category: Julien J-P]]
-	[[Category: Pai~~, E F]]~~	+	[[Category: Pai EF]]
-	~~[[Category: Fab complex]]~~	+
-	~~[[Category: Gp41 peptide]]~~	+
-	~~[[Category: Hiv-1 neutralization]]~~	+
-	~~[[Category: Immune system~~]]	+

OCA at 09:37, 29 September 2021

OCA — Wed, 29 Sep 2021 09:37:32 GMT

←Older revision		Revision as of 09:37, 29 September 2021
Line 3:		Line 3:
	<StructureSection load='1u8h' size='340' side='right'caption='[[1u8h]], [[Resolution\|resolution]] 2.10Å' scene=''>		<StructureSection load='1u8h' size='340' side='right'caption='[[1u8h]], [[Resolution\|resolution]] 2.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1u8h]] is a 3 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1U8H OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1U8H FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1u8h]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1U8H OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1U8H FirstGlance]. <br>
-	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2f5a\|2f5a]], [[2f5b\|2f5b]], [[1u8i\|1u8i]], [[1u8j\|1u8j]], [[1u8k\|1u8k]], [[1u8l\|1u8l]], [[1u8m\|1u8m]], [[1u8n\|1u8n]], [[1u8o\|1u8o]], [[1u8p\|1u8p]], [[1u8q\|1u8q]], [[1u91\|1u91]], [[1u92\|1u92]], [[1u93\|1u93]], [[1u95\|1u95]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2f5a\|2f5a]], [[2f5b\|2f5b]], [[1u8i\|1u8i]], [[1u8j\|1u8j]], [[1u8k\|1u8k]], [[1u8l\|1u8l]], [[1u8m\|1u8m]], [[1u8n\|1u8n]], [[1u8o\|1u8o]], [[1u8p\|1u8p]], [[1u8q\|1u8q]], [[1u91\|1u91]], [[1u92\|1u92]], [[1u93\|1u93]], [[1u95\|1u95]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1u8h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1u8h OCA], [~~http~~://pdbe.org/1u8h PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1u8h RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1u8h PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1u8h ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1u8h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1u8h OCA], [https://pdbe.org/1u8h PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1u8h RCSB], [https://www.ebi.ac.uk/pdbsum/1u8h PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1u8h ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 29:		Line 29:
	==See Also==		==See Also==
	*[[Antibody 3D structures\|Antibody 3D structures]]		*[[Antibody 3D structures\|Antibody 3D structures]]
		+	*[[3D structures of human antibody\|3D structures of human antibody]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 13:43, 25 December 2019

OCA — Wed, 25 Dec 2019 13:43:02 GMT

←Older revision		Revision as of 13:43, 25 December 2019
Line 1:		Line 1:

	==Crystal structure of the HIV-1 Cross Neutralizing Monoclonal Antibody 2F5 in complex with gp41 Peptide ALDKWAS==		==Crystal structure of the HIV-1 Cross Neutralizing Monoclonal Antibody 2F5 in complex with gp41 Peptide ALDKWAS==
-	<StructureSection load='1u8h' size='340' side='right' caption='[[1u8h]], [[Resolution\|resolution]] 2.10Å' scene=''>	+	<StructureSection load='1u8h' size='340' side='right'caption='[[1u8h]], [[Resolution\|resolution]] 2.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1u8h]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1U8H OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1U8H FirstGlance]. <br>		<table><tr><td colspan='2'>[[1u8h]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1U8H OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1U8H FirstGlance]. <br>
Line 34:		Line 34:
	</StructureSection>		</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
		+	[[Category: Large Structures]]
	[[Category: Bryson, S]]		[[Category: Bryson, S]]
	[[Category: Hynes, R C]]		[[Category: Hynes, R C]]

OCA at 08:34, 21 March 2018

OCA — Wed, 21 Mar 2018 08:34:04 GMT

←Older revision		Revision as of 08:34, 21 March 2018
Line 1:		Line 1:
		+
	==Crystal structure of the HIV-1 Cross Neutralizing Monoclonal Antibody 2F5 in complex with gp41 Peptide ALDKWAS==		==Crystal structure of the HIV-1 Cross Neutralizing Monoclonal Antibody 2F5 in complex with gp41 Peptide ALDKWAS==
	<StructureSection load='1u8h' size='340' side='right' caption='[[1u8h]], [[Resolution\|resolution]] 2.10Å' scene=''>		<StructureSection load='1u8h' size='340' side='right' caption='[[1u8h]], [[Resolution\|resolution]] 2.10Å' scene=''>
Line 4:		Line 5:
	<table><tr><td colspan='2'>[[1u8h]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1U8H OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1U8H FirstGlance]. <br>		<table><tr><td colspan='2'>[[1u8h]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1U8H OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1U8H FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2f5a\|2f5a]], [[2f5b\|2f5b]], [[1u8i\|1u8i]], [[1u8j\|1u8j]], [[1u8k\|1u8k]], [[1u8l\|1u8l]], [[1u8m\|1u8m]], [[1u8n\|1u8n]], [[1u8o\|1u8o]], [[1u8p\|1u8p]], [[1u8q\|1u8q]], [[1u91\|1u91]], [[1u92\|1u92]], [[1u93\|1u93]], [[1u95\|1u95]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2f5a\|2f5a]], [[2f5b\|2f5b]], [[1u8i\|1u8i]], [[1u8j\|1u8j]], [[1u8k\|1u8k]], [[1u8l\|1u8l]], [[1u8m\|1u8m]], [[1u8n\|1u8n]], [[1u8o\|1u8o]], [[1u8p\|1u8p]], [[1u8q\|1u8q]], [[1u91\|1u91]], [[1u92\|1u92]], [[1u93\|1u93]], [[1u95\|1u95]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1u8h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1u8h OCA], [http://pdbe.org/1u8h PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1u8h RCSB], [http://www.ebi.ac.uk/pdbsum/1u8h PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1u8h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1u8h OCA], [http://pdbe.org/1u8h PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1u8h RCSB], [http://www.ebi.ac.uk/pdbsum/1u8h PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1u8h ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 10:		Line 11:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/u8/1u8h_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/u8/1u8h_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 27:		Line 28:

	==See Also==		==See Also==
-	*[[Antibody\|Antibody]]	+	*[[Antibody 3D structures\|Antibody 3D structures]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 18:34, 9 February 2016

OCA — Tue, 09 Feb 2016 18:34:55 GMT

←Older revision		Revision as of 18:34, 9 February 2016
Line 14:		Line 14:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1u8h ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 00:56, 11 September 2015

OCA — Fri, 11 Sep 2015 00:56:27 GMT

←Older revision		Revision as of 00:56, 11 September 2015
Line 4:		Line 4:
	<table><tr><td colspan='2'>[[1u8h]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1U8H OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1U8H FirstGlance]. <br>		<table><tr><td colspan='2'>[[1u8h]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1U8H OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1U8H FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2f5a\|2f5a]], [[2f5b\|2f5b]], [[1u8i\|1u8i]], [[1u8j\|1u8j]], [[1u8k\|1u8k]], [[1u8l\|1u8l]], [[1u8m\|1u8m]], [[1u8n\|1u8n]], [[1u8o\|1u8o]], [[1u8p\|1u8p]], [[1u8q\|1u8q]], [[1u91\|1u91]], [[1u92\|1u92]], [[1u93\|1u93]], [[1u95\|1u95]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2f5a\|2f5a]], [[2f5b\|2f5b]], [[1u8i\|1u8i]], [[1u8j\|1u8j]], [[1u8k\|1u8k]], [[1u8l\|1u8l]], [[1u8m\|1u8m]], [[1u8n\|1u8n]], [[1u8o\|1u8o]], [[1u8p\|1u8p]], [[1u8q\|1u8q]], [[1u91\|1u91]], [[1u92\|1u92]], [[1u93\|1u93]], [[1u95\|1u95]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1u8h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1u8h OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1u8h RCSB], [http://www.ebi.ac.uk/pdbsum/1u8h PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1u8h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1u8h OCA], [http://pdbe.org/1u8h PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1u8h RCSB], [http://www.ebi.ac.uk/pdbsum/1u8h PDBsum]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 24:		Line 24:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1u8h" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==

OCA at 13:31, 6 January 2015

OCA — Tue, 06 Jan 2015 13:31:13 GMT

←Older revision		Revision as of 13:31, 6 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1u8h]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1U8H OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1U8H FirstGlance]. <br>		<table><tr><td colspan='2'>[[1u8h]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1U8H OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1U8H FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2f5a\|2f5a]], [[2f5b\|2f5b]], [[1u8i\|1u8i]], [[1u8j\|1u8j]], [[1u8k\|1u8k]], [[1u8l\|1u8l]], [[1u8m\|1u8m]], [[1u8n\|1u8n]], [[1u8o\|1u8o]], [[1u8p\|1u8p]], [[1u8q\|1u8q]], [[1u91\|1u91]], [[1u92\|1u92]], [[1u93\|1u93]], [[1u95\|1u95]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2f5a\|2f5a]], [[2f5b\|2f5b]], [[1u8i\|1u8i]], [[1u8j\|1u8j]], [[1u8k\|1u8k]], [[1u8l\|1u8l]], [[1u8m\|1u8m]], [[1u8n\|1u8n]], [[1u8o\|1u8o]], [[1u8p\|1u8p]], [[1u8q\|1u8q]], [[1u91\|1u91]], [[1u92\|1u92]], [[1u93\|1u93]], [[1u95\|1u95]]</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1u8h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1u8h OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1u8h RCSB], [http://www.ebi.ac.uk/pdbsum/1u8h PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1u8h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1u8h OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1u8h RCSB], [http://www.ebi.ac.uk/pdbsum/1u8h PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 32:		Line 32:
	</StructureSection>		</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Bryson, S.]]	+	[[Category: Bryson, S]]
-	[[Category: Hynes, R C.]]	+	[[Category: Hynes, R C]]
-	[[Category: Julien, J P.]]	+	[[Category: Julien, J P]]
-	[[Category: Pai, E F.]]	+	[[Category: Pai, E F]]
	[[Category: Fab complex]]		[[Category: Fab complex]]
	[[Category: Gp41 peptide]]		[[Category: Gp41 peptide]]
	[[Category: Hiv-1 neutralization]]		[[Category: Hiv-1 neutralization]]
	[[Category: Immune system]]		[[Category: Immune system]]

OCA at 19:55, 29 September 2014

OCA — Mon, 29 Sep 2014 19:55:24 GMT

←Older revision		Revision as of 19:55, 29 September 2014
Line 1:		Line 1:
-	[[~~Image:~~1u8h.~~png~~\|~~left~~\|200px]]	+	==Crystal structure of the HIV-1 Cross Neutralizing Monoclonal Antibody 2F5 in complex with gp41 Peptide ALDKWAS==
		+	<StructureSection load='1u8h' size='340' side='right' caption='[[1u8h]], [[Resolution\|resolution]] 2.10Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1u8h]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1U8H OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1U8H FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2f5a\|2f5a]], [[2f5b\|2f5b]], [[1u8i\|1u8i]], [[1u8j\|1u8j]], [[1u8k\|1u8k]], [[1u8l\|1u8l]], [[1u8m\|1u8m]], [[1u8n\|1u8n]], [[1u8o\|1u8o]], [[1u8p\|1u8p]], [[1u8q\|1u8q]], [[1u91\|1u91]], [[1u92\|1u92]], [[1u93\|1u93]], [[1u95\|1u95]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1u8h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1u8h OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1u8h RCSB], [http://www.ebi.ac.uk/pdbsum/1u8h PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/u8/1u8h_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The quest to create a human immunodeficiency virus type 1 (HIV-1) vaccine capable of eliciting broadly neutralizing antibodies against Env has been challenging. Among other problems, one difficulty in creating a potent immunogen resides in the substantial overall sequence variability of the HIV envelope protein. The membrane-proximal region (MPER) of gp41 is a particularly conserved tryptophan-rich region spanning residues 659 to 683, which is recognized by three broadly neutralizing monoclonal antibodies (bnMAbs), 2F5, Z13, and 4E10. In this study, we first describe the variability of residues in the gp41 MPER and report on the invariant nature of 15 out of 25 amino acids comprising this region. Subsequently, we evaluate the ability of the bnMAb 2F5 to recognize 31 varying sequences of the gp41 MPER at a molecular level. In 19 cases, resulting crystal structures show the various MPER peptides bound to the 2F5 Fab'. A variety of amino acid substitutions outside the 664DKW666 core epitope are tolerated. However, changes at the 664DKW666 motif itself are restricted to those residues that preserve the aspartate's negative charge, the hydrophobic alkyl-pi stacking arrangement between the beta-turn lysine and tryptophan, and the positive charge of the former. We also characterize a possible molecular mechanism of 2F5 escape by sequence variability at position 667, which is often observed in HIV-1 clade C isolates. Based on our results, we propose a somewhat more flexible molecular model of epitope recognition by bnMAb 2F5, which could guide future attempts at designing small-molecule MPER-like vaccines capable of eliciting 2F5-like antibodies.

-	~~{{STRUCTURE_1u8h\| PDB=1u8h \| SCENE= }}~~	+	Crystallographic definition of the epitope promiscuity of the broadly neutralizing anti-human immunodeficiency virus type 1 antibody 2F5: vaccine design implications.,Bryson S, Julien JP, Hynes RC, Pai EF J Virol. 2009 Nov;83(22):11862-75. Epub 2009 Sep 9. PMID:19740978<ref>PMID:19740978</ref>

-	~~===Crystal structure~~ of the ~~HIV-1 Cross Neutralizing Monoclonal Antibody 2F5 in complex with gp41 Peptide ALDKWAS===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>

-	~~{{ABSTRACT_PUBMED_19740978}}~~	+	==See Also==
-		+	*[[Antibody\|Antibody]]
-	==~~About this Structure~~==	+	== References ==
-	[[~~1u8h~~]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1U8H OCA].	+	<references/>
-		+	__TOC__
-	==~~Reference~~==	+	</StructureSection>
-	<~~ref group="xtra">PMID:019740978<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Bryson, S.]]		[[Category: Bryson, S.]]

OCA: Protected "1u8h" [edit=sysop:move=sysop]

OCA — Sat, 05 Jan 2013 13:19:46 GMT

Protected "1u8h" [edit=sysop:move=sysop]

←Older revision

Revision as of 13:19, 5 January 2013

OCA at 13:19, 5 January 2013

OCA — Sat, 05 Jan 2013 13:19:43 GMT

←Older revision		Revision as of 13:19, 5 January 2013
Line 1:		Line 1:
-	{{Seed}}
	[[Image:1u8h.png\|left\|200px]]		[[Image:1u8h.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_1u8h", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_1u8h\| PDB=1u8h \| SCENE= }}		{{STRUCTURE_1u8h\| PDB=1u8h \| SCENE= }}

	===Crystal structure of the HIV-1 Cross Neutralizing Monoclonal Antibody 2F5 in complex with gp41 Peptide ALDKWAS===		===Crystal structure of the HIV-1 Cross Neutralizing Monoclonal Antibody 2F5 in complex with gp41 Peptide ALDKWAS===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_19740978}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 19740978 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_19740978}}		{{ABSTRACT_PUBMED_19740978}}

	==About this Structure==		==About this Structure==
-	~~1U8H~~ is a 3 ~~chains~~ structure ~~of sequences~~ from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1U8H OCA].	+	[[1u8h]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1U8H OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~19740978~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:019740978</ref><references group="xtra"/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Bryson, S.]]		[[Category: Bryson, S.]]
Line 33:		Line 21:
	[[Category: Hiv-1 neutralization]]		[[Category: Hiv-1 neutralization]]
	[[Category: Immune system]]		[[Category: Immune system]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jan 6 08:56:47 2010''