1uaw - Revision history

OCA at 23:50, 27 December 2023

OCA — Wed, 27 Dec 2023 23:50:24 GMT

←Older revision		Revision as of 23:50, 27 December 2023
Line 1:		Line 1:

	==Solution structure of the N-terminal RNA-binding domain of mouse Musashi1==		==Solution structure of the N-terminal RNA-binding domain of mouse Musashi1==
-	<StructureSection load='1uaw' size='340' side='right'caption='[[1uaw~~]], [[NMR_Ensembles_of_Models \| 15 NMR models~~]]' scene=''>	+	<StructureSection load='1uaw' size='340' side='right'caption='[[1uaw]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1uaw]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Lk3_transgenic_mice Lk3 transgenic mice~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UAW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1UAW FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1uaw]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UAW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1UAW FirstGlance]. <br>
-	</td></tr><tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"~~><div style~~=~~'overflow: auto; max-height: 3em;'>[[2mss\|2mss]], [[2mst\|2mst]]</div~~></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1uaw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1uaw OCA], [https://pdbe.org/1uaw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1uaw RCSB], [https://www.ebi.ac.uk/pdbsum/1uaw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1uaw ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1uaw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1uaw OCA], [https://pdbe.org/1uaw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1uaw RCSB], [https://www.ebi.ac.uk/pdbsum/1uaw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1uaw ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/MSI1H_MOUSE MSI1H_MOUSE]] RNA binding protein that regulates the expression of target mRNAs at the translation level. Regulates expression of the NOTCH1 antagonist NUMB. Binds RNA containing the sequence 5'-GUUAGUUAGUUAGUU-3' and other sequences containing the pattern 5'-[GA]U(1-3)AGU-3'. May play a role in the proliferation and maintenance of stem cells in the central nervous system.<ref>PMID:11359897</ref> <ref>PMID:12407178</ref>	+	[https://www.uniprot.org/uniprot/MSI1H_MOUSE MSI1H_MOUSE] RNA binding protein that regulates the expression of target mRNAs at the translation level. Regulates expression of the NOTCH1 antagonist NUMB. Binds RNA containing the sequence 5'-GUUAGUUAGUUAGUU-3' and other sequences containing the pattern 5'-[GA]U(1-3)AGU-3'. May play a role in the proliferation and maintenance of stem cells in the central nervous system.<ref>PMID:11359897</ref> <ref>PMID:12407178</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Lk3 transgenic mice~~]]	+	[[Category: Mus musculus]]
-	[[Category: Ikeda, T]]	+	[[Category: Ikeda T]]
-	[[Category: Katahira, M]]	+	[[Category: Katahira M]]
-	[[Category: Kobayashi, H]]	+	[[Category: Kobayashi H]]
-	[[Category: Miyanoiri, Y]]	+	[[Category: Miyanoiri Y]]
-	[[Category: Nagata, T]]	+	[[Category: Nagata T]]
-	[[Category: Okano, H]]	+	[[Category: Okano H]]
-	[[Category: Uesugi, S]]	+	[[Category: Uesugi S]]
-	[[Category: Watanabe, M]]	+	[[Category: Watanabe M]]
-	~~[[Category: Rna binding protein]]~~	+
-	~~[[Category: Rnp-type structure~~]]	+

OCA at 09:38, 29 September 2021

OCA — Wed, 29 Sep 2021 09:38:56 GMT

←Older revision		Revision as of 09:38, 29 September 2021
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	<StructureSection load='1uaw' size='340' side='right'caption='[[1uaw]], [[NMR_Ensembles_of_Models \| 15 NMR models]]' scene=''>		<StructureSection load='1uaw' size='340' side='right'caption='[[1uaw]], [[NMR_Ensembles_of_Models \| 15 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1uaw]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UAW OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1UAW FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1uaw]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UAW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1UAW FirstGlance]. <br>
-	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2mss\|2mss]], [[2mst\|2mst]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2mss\|2mss]], [[2mst\|2mst]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1uaw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1uaw OCA], [~~http~~://pdbe.org/1uaw PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1uaw RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1uaw PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1uaw ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1uaw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1uaw OCA], [https://pdbe.org/1uaw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1uaw RCSB], [https://www.ebi.ac.uk/pdbsum/1uaw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1uaw ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/MSI1H_MOUSE MSI1H_MOUSE]] RNA binding protein that regulates the expression of target mRNAs at the translation level. Regulates expression of the NOTCH1 antagonist NUMB. Binds RNA containing the sequence 5'-GUUAGUUAGUUAGUU-3' and other sequences containing the pattern 5'-[GA]U(1-3)AGU-3'. May play a role in the proliferation and maintenance of stem cells in the central nervous system.<ref>PMID:11359897</ref> <ref>PMID:12407178</ref>	+	[[https://www.uniprot.org/uniprot/MSI1H_MOUSE MSI1H_MOUSE]] RNA binding protein that regulates the expression of target mRNAs at the translation level. Regulates expression of the NOTCH1 antagonist NUMB. Binds RNA containing the sequence 5'-GUUAGUUAGUUAGUU-3' and other sequences containing the pattern 5'-[GA]U(1-3)AGU-3'. May play a role in the proliferation and maintenance of stem cells in the central nervous system.<ref>PMID:11359897</ref> <ref>PMID:12407178</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 14:09, 25 December 2019

OCA — Wed, 25 Dec 2019 14:09:34 GMT

←Older revision		Revision as of 14:09, 25 December 2019
Line 1:		Line 1:

	==Solution structure of the N-terminal RNA-binding domain of mouse Musashi1==		==Solution structure of the N-terminal RNA-binding domain of mouse Musashi1==
-	<StructureSection load='1uaw' size='340' side='right' caption='[[1uaw]], [[NMR_Ensembles_of_Models \| 15 NMR models]]' scene=''>	+	<StructureSection load='1uaw' size='340' side='right'caption='[[1uaw]], [[NMR_Ensembles_of_Models \| 15 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1uaw]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UAW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1UAW FirstGlance]. <br>		<table><tr><td colspan='2'>[[1uaw]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UAW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1UAW FirstGlance]. <br>
Line 32:		Line 32:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Lk3 transgenic mice]]		[[Category: Lk3 transgenic mice]]
	[[Category: Ikeda, T]]		[[Category: Ikeda, T]]

OCA at 08:58, 21 March 2018

OCA — Wed, 21 Mar 2018 08:58:31 GMT

←Older revision		Revision as of 08:58, 21 March 2018
Line 1:		Line 1:
		+
	==Solution structure of the N-terminal RNA-binding domain of mouse Musashi1==		==Solution structure of the N-terminal RNA-binding domain of mouse Musashi1==
	<StructureSection load='1uaw' size='340' side='right' caption='[[1uaw]], [[NMR_Ensembles_of_Models \| 15 NMR models]]' scene=''>		<StructureSection load='1uaw' size='340' side='right' caption='[[1uaw]], [[NMR_Ensembles_of_Models \| 15 NMR models]]' scene=''>
Line 4:		Line 5:
	<table><tr><td colspan='2'>[[1uaw]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UAW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1UAW FirstGlance]. <br>		<table><tr><td colspan='2'>[[1uaw]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UAW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1UAW FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2mss\|2mss]], [[2mst\|2mst]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2mss\|2mss]], [[2mst\|2mst]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1uaw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1uaw OCA], [http://pdbe.org/1uaw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1uaw RCSB], [http://www.ebi.ac.uk/pdbsum/1uaw PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1uaw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1uaw OCA], [http://pdbe.org/1uaw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1uaw RCSB], [http://www.ebi.ac.uk/pdbsum/1uaw PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1uaw ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 12:		Line 13:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ua/1uaw_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ua/1uaw_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 00:07, 9 February 2016

OCA — Tue, 09 Feb 2016 00:07:32 GMT

←Older revision		Revision as of 00:07, 9 February 2016
Line 16:		Line 16:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1uaw ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 16:41, 10 September 2015

OCA — Thu, 10 Sep 2015 16:41:09 GMT

←Older revision		Revision as of 16:41, 10 September 2015
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	<StructureSection load='1uaw' size='340' side='right' caption='[[1uaw]], [[NMR_Ensembles_of_Models \| 15 NMR models]]' scene=''>		<StructureSection load='1uaw' size='340' side='right' caption='[[1uaw]], [[NMR_Ensembles_of_Models \| 15 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1uaw]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Mus_musculus Mus musculus~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UAW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1UAW FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1uaw]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UAW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1UAW FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2mss\|2mss]], [[2mst\|2mst]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2mss\|2mss]], [[2mst\|2mst]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1uaw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1uaw OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1uaw RCSB], [http://www.ebi.ac.uk/pdbsum/1uaw PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1uaw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1uaw OCA], [http://pdbe.org/1uaw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1uaw RCSB], [http://www.ebi.ac.uk/pdbsum/1uaw PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1uaw" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Mus musculus~~]]	+	[[Category: Lk3 transgenic mice]]
	[[Category: Ikeda, T]]		[[Category: Ikeda, T]]
	[[Category: Katahira, M]]		[[Category: Katahira, M]]

OCA at 03:05, 25 December 2014

OCA — Thu, 25 Dec 2014 03:05:46 GMT

←Older revision		Revision as of 03:05, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1uaw]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UAW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1UAW FirstGlance]. <br>		<table><tr><td colspan='2'>[[1uaw]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UAW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1UAW FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2mss\|2mss]], [[2mst\|2mst]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2mss\|2mss]], [[2mst\|2mst]]</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1uaw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1uaw OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1uaw RCSB], [http://www.ebi.ac.uk/pdbsum/1uaw PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1uaw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1uaw OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1uaw RCSB], [http://www.ebi.ac.uk/pdbsum/1uaw PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/MSI1H_MOUSE MSI1H_MOUSE]] RNA binding protein that regulates the expression of target mRNAs at the translation level. Regulates expression of the NOTCH1 antagonist NUMB. Binds RNA containing the sequence 5'-GUUAGUUAGUUAGUU-3' and other sequences containing the pattern 5'-[GA]U(1-3)AGU-3'. May play a role in the proliferation and maintenance of stem cells in the central nervous system.<ref>PMID:11359897</ref> <ref>PMID:12407178</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	</StructureSection>		</StructureSection>
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
-	[[Category: Ikeda, T.]]	+	[[Category: Ikeda, T]]
-	[[Category: Katahira, M.]]	+	[[Category: Katahira, M]]
-	[[Category: Kobayashi, H.]]	+	[[Category: Kobayashi, H]]
-	[[Category: Miyanoiri, Y.]]	+	[[Category: Miyanoiri, Y]]
-	[[Category: Nagata, T.]]	+	[[Category: Nagata, T]]
-	[[Category: Okano, H.]]	+	[[Category: Okano, H]]
-	[[Category: Uesugi, S.]]	+	[[Category: Uesugi, S]]
-	[[Category: Watanabe, M.]]	+	[[Category: Watanabe, M]]
	[[Category: Rna binding protein]]		[[Category: Rna binding protein]]
	[[Category: Rnp-type structure]]		[[Category: Rnp-type structure]]

OCA at 18:44, 29 September 2014

OCA — Mon, 29 Sep 2014 18:44:47 GMT

←Older revision		Revision as of 18:44, 29 September 2014
Line 1:		Line 1:
-	[[~~Image:~~1uaw.~~png~~\|~~left~~\|200px]]	+	==Solution structure of the N-terminal RNA-binding domain of mouse Musashi1==
		+	<StructureSection load='1uaw' size='340' side='right' caption='[[1uaw]], [[NMR_Ensembles_of_Models \| 15 NMR models]]' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1uaw]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UAW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1UAW FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2mss\|2mss]], [[2mst\|2mst]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1uaw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1uaw OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1uaw RCSB], [http://www.ebi.ac.uk/pdbsum/1uaw PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ua/1uaw_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Musashi1 is an RNA-binding protein abundantly expressed in the developing mouse central nervous system. Its restricted expression in neural precursor cells suggests that it is involved in maintenance of the character of progenitor cells. Musashi1 contains two ribonucleoprotein-type RNA-binding domains (RBDs), RBD1 and RBD2, the affinity to RNA of RBD1 being much higher than that of RBD2. We previously reported the structure and mode of interaction with RNA of RBD2. Here, we have determined the structure and mode of interaction with RNA of RBD1. We have also analyzed the surface electrostatic potential and backbone dynamics of both RBDs. The two RBDs exhibit the same ribo-nucleoprotein-type fold and commonly make contact with RNA on the beta-sheet side. On the other hand, there is a remarkable difference in surface electrostatic potential, the beta-sheet of RBD1 being positively charged, which is favorable for binding negatively charged RNA, but that of RBD2 being almost neutral. There is also a difference in backbone dynamics, the central portion of the beta-sheet of RBD1 being flexible, but that of RBD2 not being flexible. The flexibility of RBD1 may be utilized in the recognition process to facilitate an induced fit. Thus, comparative studies have revealed the origin of the higher affinity of RBD1 than that of RBD2 and indicated that the affinity of an RBD to RNA is not governed by its fold alone but is also determined by its surface electrostatic potential and/or backbone dynamics. The biological role of RBD2 with lower affinity is also discussed.

-	~~{{STRUCTURE_1uaw\| PDB=1uaw \| SCENE= }}~~	+	Origin of higher affinity to RNA of the N-terminal RNA-binding domain than that of the C-terminal one of a mouse neural protein, musashi1, as revealed by comparison of their structures, modes of interaction, surface electrostatic potentials, and backbone dynamics.,Miyanoiri Y, Kobayashi H, Imai T, Watanabe M, Nagata T, Uesugi S, Okano H, Katahira M J Biol Chem. 2003 Oct 17;278(42):41309-15. Epub 2003 Aug 7. PMID:12907678<ref>PMID:12907678</ref>

-	~~===Solution structure~~ of the ~~N-terminal RNA-binding domain of mouse Musashi1===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_12907678}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[1uaw]] is a 1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Mus_musculus Mus musculus]~~. ~~Full experimental information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=1UAW OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:012907678<~~/~~ref~~><~~ref group="xtra">PMID:010080895</ref><references group="xtra"~~/>	+
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
	[[Category: Ikeda, T.]]		[[Category: Ikeda, T.]]

OCA at 09:43, 16 January 2013

OCA — Wed, 16 Jan 2013 09:43:35 GMT

←Older revision		Revision as of 09:43, 16 January 2013
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	[[Image:1uaw.png\|left\|200px]]		[[Image:1uaw.png\|left\|200px]]

-	<!--
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	{{STRUCTURE_1uaw\| PDB=1uaw \| SCENE= }}		{{STRUCTURE_1uaw\| PDB=1uaw \| SCENE= }}

	===Solution structure of the N-terminal RNA-binding domain of mouse Musashi1===		===Solution structure of the N-terminal RNA-binding domain of mouse Musashi1===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_12907678}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 12907678 is the PubMed ID number.
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	{{ABSTRACT_PUBMED_12907678}}		{{ABSTRACT_PUBMED_12907678}}

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	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~12907678~~</ref><ref group="xtra">PMID:~~10080895</ref><ref group="xtra">PMID:9047340~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:012907678</ref><ref group="xtra">PMID:010080895</ref><references group="xtra"/>
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
	[[Category: Ikeda, T.]]		[[Category: Ikeda, T.]]

OCA: Protected "1uaw" [edit=sysop:move=sysop]

OCA — Mon, 14 Mar 2011 19:13:50 GMT

Protected "1uaw" [edit=sysop:move=sysop]

←Older revision

Revision as of 19:13, 14 March 2011