1ubi - Revision history

OCA at 08:44, 14 February 2024

OCA — Wed, 14 Feb 2024 08:44:56 GMT

←Older revision		Revision as of 08:44, 14 February 2024
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	<StructureSection load='1ubi' size='340' side='right'caption='[[1ubi]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='1ubi' size='340' side='right'caption='[[1ubi]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1ubi]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UBI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1UBI FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1ubi]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UBI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1UBI FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ubi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ubi OCA], [https://pdbe.org/1ubi PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ubi RCSB], [https://www.ebi.ac.uk/pdbsum/1ubi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ubi ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.8Å</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ubi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ubi OCA], [https://pdbe.org/1ubi PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ubi RCSB], [https://www.ebi.ac.uk/pdbsum/1ubi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ubi ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/UBC_HUMAN UBC_HUMAN] Ubiquitin exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair; Lys-11-linked is involved in ERAD (endoplasmic reticulum-associated degradation) and in cell-cycle regulation; Lys-29-linked is involved in lysosomal degradation; Lys-33-linked is involved in kinase modification; Lys-48-linked is involved in protein degradation via the proteasome; Lys-63-linked is involved in endocytosis, DNA-damage responses as well as in signaling processes leading to activation of the transcription factor NF-kappa-B. Linear polymer chains formed via attachment by the initiator Met lead to cell signaling. Ubiquitin is usually conjugated to Lys residues of target proteins, however, in rare cases, conjugation to Cys or Ser residues has been observed. When polyubiquitin is free (unanchored-polyubiquitin), it also has distinct roles, such as in activation of protein kinases, and in signaling.<ref>PMID:16543144</ref> <ref>PMID:19754430</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 16:		Line 19:
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1ubi ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1ubi ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
-	<div style="background-color:#fffaf0;">
-	== Publication Abstract from PubMed ==
-	The small protein ubiquitin (76 amino acids) has been synthesized under optimized conditions by Merrifield solid-phase methodology using the N alpha-Fmoc protecting group. The crude polypeptide mixture was purified to homogeneity by gel filtration, dialysis and a combination of cation- and anion-exchange chromatography to yield ubiquitin. Amino acid analysis, enzymic digestion and sequencing by automated Edman degradation were used to authenticate the primary structure. Isoelectric focusing and m.s. were used to demonstrate that the final product was greater than 98% pure with a final yield of 93 mg (4.3%) from a single synthesis on a 0.25 nmol scale.
-
-	Synthetic, structural and biological studies of the ubiquitin system: the total chemical synthesis of ubiquitin.,Ramage R, Green J, Muir TW, Ogunjobi OM, Love S, Shaw K Biochem J. 1994 Apr 1;299 ( Pt 1):151-8. PMID:8166633<ref>PMID:8166633</ref>
-
-	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	</div>
-	<div class="pdbe-citations 1ubi" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Alexeev, D]]	+	[[Category: Alexeev D]]
-	[[Category: Bury~~, S M~~]]	+	[[Category: Bury SM]]
-	[[Category: Muir~~, T W~~]]	+	[[Category: Muir TW]]
-	[[Category: Ogunjobi~~, O M~~]]	+	[[Category: Ogunjobi OM]]
-	[[Category: Ramage, R]]	+	[[Category: Ramage R]]
-	[[Category: Sawyer, L]]	+	[[Category: Sawyer L]]
-	[[Category: Turner~~, M A]]~~	+	[[Category: Turner MA]]
-	~~[[Category: Chromosomal protein~~]]	+

OCA at 09:39, 29 September 2021

OCA — Wed, 29 Sep 2021 09:39:24 GMT

←Older revision		Revision as of 09:39, 29 September 2021
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	<StructureSection load='1ubi' size='340' side='right'caption='[[1ubi]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='1ubi' size='340' side='right'caption='[[1ubi]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1ubi]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UBI OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1UBI FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1ubi]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UBI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1UBI FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1ubi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ubi OCA], [~~http~~://pdbe.org/1ubi PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1ubi RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1ubi PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1ubi ProSAT]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ubi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ubi OCA], [https://pdbe.org/1ubi PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ubi RCSB], [https://www.ebi.ac.uk/pdbsum/1ubi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ubi ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 27:		Line 27:

	==See Also==		==See Also==
-	*[[~~Ubiquitin~~\|~~Ubiquitin~~]]	+	*[[3D structures of ubiquitin\|3D structures of ubiquitin]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 11:35, 4 December 2019

OCA — Wed, 04 Dec 2019 11:35:34 GMT

←Older revision		Revision as of 11:35, 4 December 2019
Line 1:		Line 1:

	==SYNTHETIC STRUCTURAL AND BIOLOGICAL STUDIES OF THE UBIQUITIN SYSTEM. PART 1==		==SYNTHETIC STRUCTURAL AND BIOLOGICAL STUDIES OF THE UBIQUITIN SYSTEM. PART 1==
-	<StructureSection load='1ubi' size='340' side='right' caption='[[1ubi]], [[Resolution\|resolution]] 1.80Å' scene=''>	+	<StructureSection load='1ubi' size='340' side='right'caption='[[1ubi]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1ubi]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UBI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1UBI FirstGlance]. <br>		<table><tr><td colspan='2'>[[1ubi]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UBI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1UBI FirstGlance]. <br>
Line 10:		Line 10:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ub/1ubi_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ub/1ubi_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 25:		Line 25:
	</div>		</div>
	<div class="pdbe-citations 1ubi" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 1ubi" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Ubiquitin\|Ubiquitin]]
	== References ==		== References ==
	<references/>		<references/>
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	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Alexeev, D]]		[[Category: Alexeev, D]]
	[[Category: Bury, S M]]		[[Category: Bury, S M]]

OCA at 07:00, 29 November 2017

OCA — Wed, 29 Nov 2017 07:00:12 GMT

←Older revision		Revision as of 07:00, 29 November 2017
Line 1:		Line 1:
		+
	==SYNTHETIC STRUCTURAL AND BIOLOGICAL STUDIES OF THE UBIQUITIN SYSTEM. PART 1==		==SYNTHETIC STRUCTURAL AND BIOLOGICAL STUDIES OF THE UBIQUITIN SYSTEM. PART 1==
	<StructureSection load='1ubi' size='340' side='right' caption='[[1ubi]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='1ubi' size='340' side='right' caption='[[1ubi]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1ubi]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UBI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1UBI FirstGlance]. <br>		<table><tr><td colspan='2'>[[1ubi]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UBI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1UBI FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ubi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ubi OCA], [http://pdbe.org/1ubi PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1ubi RCSB], [http://www.ebi.ac.uk/pdbsum/1ubi PDBsum]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ubi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ubi OCA], [http://pdbe.org/1ubi PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1ubi RCSB], [http://www.ebi.ac.uk/pdbsum/1ubi PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1ubi ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
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	</div>		</div>
	<div class="pdbe-citations 1ubi" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 1ubi" style="background-color:#fffaf0;"></div>
-
-	==See Also==
-	*[[Ubiquitin\|Ubiquitin]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 03:05, 9 February 2016

OCA — Tue, 09 Feb 2016 03:05:43 GMT

←Older revision		Revision as of 03:05, 9 February 2016
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	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1ubi ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 17:59, 10 September 2015

OCA — Thu, 10 Sep 2015 17:59:51 GMT

←Older revision		Revision as of 17:59, 10 September 2015
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	<StructureSection load='1ubi' size='340' side='right' caption='[[1ubi]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='1ubi' size='340' side='right' caption='[[1ubi]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1ubi]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UBI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1UBI FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1ubi]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UBI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1UBI FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ubi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ubi OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1ubi RCSB], [http://www.ebi.ac.uk/pdbsum/1ubi PDBsum]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ubi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ubi OCA], [http://pdbe.org/1ubi PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1ubi RCSB], [http://www.ebi.ac.uk/pdbsum/1ubi PDBsum]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 23:		Line 23:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1ubi" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 30:		Line 31:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Alexeev, D]]		[[Category: Alexeev, D]]
	[[Category: Bury, S M]]		[[Category: Bury, S M]]

OCA at 12:53, 6 January 2015

OCA — Tue, 06 Jan 2015 12:53:03 GMT

←Older revision		Revision as of 12:53, 6 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1ubi]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UBI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1UBI FirstGlance]. <br>		<table><tr><td colspan='2'>[[1ubi]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UBI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1UBI FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ubi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ubi OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1ubi RCSB], [http://www.ebi.ac.uk/pdbsum/1ubi PDBsum]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ubi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ubi OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1ubi RCSB], [http://www.ebi.ac.uk/pdbsum/1ubi PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	</StructureSection>		</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Alexeev, D.]]	+	[[Category: Alexeev, D]]
-	[[Category: Bury, S M.]]	+	[[Category: Bury, S M]]
-	[[Category: Muir, T W.]]	+	[[Category: Muir, T W]]
-	[[Category: Ogunjobi, O M.]]	+	[[Category: Ogunjobi, O M]]
-	[[Category: Ramage, R.]]	+	[[Category: Ramage, R]]
-	[[Category: Sawyer, L.]]	+	[[Category: Sawyer, L]]
-	[[Category: Turner, M A.]]	+	[[Category: Turner, M A]]
	[[Category: Chromosomal protein]]		[[Category: Chromosomal protein]]

OCA at 21:11, 28 September 2014

OCA — Sun, 28 Sep 2014 21:11:05 GMT

←Older revision		Revision as of 21:11, 28 September 2014
Line 1:		Line 1:
-	[[~~Image~~:1ubi.~~png\|left~~\|200px]]	+	==SYNTHETIC STRUCTURAL AND BIOLOGICAL STUDIES OF THE UBIQUITIN SYSTEM. PART 1==
		+	<StructureSection load='1ubi' size='340' side='right' caption='[[1ubi]], [[Resolution\|resolution]] 1.80Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1ubi]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UBI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1UBI FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ubi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ubi OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1ubi RCSB], [http://www.ebi.ac.uk/pdbsum/1ubi PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ub/1ubi_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The small protein ubiquitin (76 amino acids) has been synthesized under optimized conditions by Merrifield solid-phase methodology using the N alpha-Fmoc protecting group. The crude polypeptide mixture was purified to homogeneity by gel filtration, dialysis and a combination of cation- and anion-exchange chromatography to yield ubiquitin. Amino acid analysis, enzymic digestion and sequencing by automated Edman degradation were used to authenticate the primary structure. Isoelectric focusing and m.s. were used to demonstrate that the final product was greater than 98% pure with a final yield of 93 mg (4.3%) from a single synthesis on a 0.25 nmol scale.

-	~~{{STRUCTURE_1ubi\| PDB=1ubi \| SCENE= }}~~	+	Synthetic, structural and biological studies of the ubiquitin system: the total chemical synthesis of ubiquitin.,Ramage R, Green J, Muir TW, Ogunjobi OM, Love S, Shaw K Biochem J. 1994 Apr 1;299 ( Pt 1):151-8. PMID:8166633<ref>PMID:8166633</ref>

-	~~===SYNTHETIC STRUCTURAL AND BIOLOGICAL STUDIES OF THE UBIQUITIN SYSTEM. PART 1===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_8166633}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[1ubi]] is~~ a ~~1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Homo_sapiens Homo sapiens]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=1UBI OCA].~~	+

	==See Also==		==See Also==
	*[[Ubiquitin\|Ubiquitin]]		*[[Ubiquitin\|Ubiquitin]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:008166633<~~/~~ref~~><~~ref group="xtra">PMID:012112697</ref><ref group="xtra">PMID:012211038</ref><ref group="xtra">PMID:014695246</ref><references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Alexeev, D.]]		[[Category: Alexeev, D.]]

OCA at 12:25, 20 October 2012

OCA — Sat, 20 Oct 2012 12:25:47 GMT

←Older revision		Revision as of 12:25, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[1ubi]] is a 1 chain structure ~~of [[Ubiquitin]]~~ with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UBI OCA].	+	[[1ubi]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UBI OCA].

	==See Also==		==See Also==

OCA at 08:41, 26 July 2012

OCA — Thu, 26 Jul 2012 08:41:09 GMT

←Older revision		Revision as of 08:41, 26 July 2012
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	[[Image:1ubi.png\|left\|200px]]		[[Image:1ubi.png\|left\|200px]]

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	{{STRUCTURE_1ubi\| PDB=1ubi \| SCENE= }}		{{STRUCTURE_1ubi\| PDB=1ubi \| SCENE= }}

	===SYNTHETIC STRUCTURAL AND BIOLOGICAL STUDIES OF THE UBIQUITIN SYSTEM. PART 1===		===SYNTHETIC STRUCTURAL AND BIOLOGICAL STUDIES OF THE UBIQUITIN SYSTEM. PART 1===

-
-	<!--
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	==See Also==		==See Also==
-	*[[Ubiquitin]]	+	*[[Ubiquitin\|Ubiquitin]]

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~8166633~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:008166633</ref><ref group="xtra">PMID:012112697</ref><ref group="xtra">PMID:012211038</ref><ref group="xtra">PMID:014695246</ref><references group="xtra"/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Alexeev, D.]]		[[Category: Alexeev, D.]]