1uiz - Revision history

OCA at 23:54, 27 December 2023

OCA — Wed, 27 Dec 2023 23:54:24 GMT

←Older revision		Revision as of 23:54, 27 December 2023
Line 3:		Line 3:
	<StructureSection load='1uiz' size='340' side='right'caption='[[1uiz]], [[Resolution\|resolution]] 2.50Å' scene=''>		<StructureSection load='1uiz' size='340' side='right'caption='[[1uiz]], [[Resolution\|resolution]] 2.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1uiz]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/~~African_clawed_frog African clawed frog~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UIZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1UIZ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1uiz]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Xenopus_laevis Xenopus laevis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UIZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1UIZ FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1uiz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1uiz OCA], [https://pdbe.org/1uiz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1uiz RCSB], [https://www.ebi.ac.uk/pdbsum/1uiz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1uiz ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.5Å</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1uiz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1uiz OCA], [https://pdbe.org/1uiz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1uiz RCSB], [https://www.ebi.ac.uk/pdbsum/1uiz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1uiz ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/MIF_XENLA MIF_XENLA] Pro-inflammatory cytokine. Involved in the innate immune response to bacterial pathogens. The expression of MIF at sites of inflammation suggests a role as mediator in regulating the function of macrophages in host defense (By similarity). Has phenylpyruvate tautomerase and dopachrome tautomerase activity (in vitro), but the physiological substrate is not known. It is not clear whether the tautomerase activity has any physiological relevance, and whether it is important for cytokine activity. Required for normal neural development during embryogenesis.[UniProtKB:P14174]<ref>PMID:15024012</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 32:		Line 35:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: African clawed frog]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Ishibashi, T]]	+	[[Category: Xenopus laevis]]
-	[[Category: Iyaguchi, D]]	+	[[Category: Ishibashi T]]
-	[[Category: Maeno, M]]	+	[[Category: Iyaguchi D]]
-	[[Category: Nishihira, J]]	+	[[Category: Maeno M]]
-	[[Category: Suzuki, M]]	+	[[Category: Nishihira J]]
-	[[Category: Takamura, Y]]	+	[[Category: Suzuki M]]
-	[[Category: Tanaka, I]]	+	[[Category: Takamura Y]]
-	[[Category: Tochinai, S]]	+	[[Category: Tanaka I]]
-	~~[[Category: Cytokine]]~~	+	[[Category: Tochinai S]]
-	~~[[Category: Macrophage migration inhibitory factor]]~~	+
-	~~[[Category: Mif]]~~	+
-	~~[[Category: Tautomerase~~]]	+

OCA at 06:11, 6 October 2021

OCA — Wed, 06 Oct 2021 06:11:37 GMT

←Older revision		Revision as of 06:11, 6 October 2021
Line 3:		Line 3:
	<StructureSection load='1uiz' size='340' side='right'caption='[[1uiz]], [[Resolution\|resolution]] 2.50Å' scene=''>		<StructureSection load='1uiz' size='340' side='right'caption='[[1uiz]], [[Resolution\|resolution]] 2.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1uiz]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/African_clawed_frog African clawed frog]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UIZ OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1UIZ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1uiz]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/African_clawed_frog African clawed frog]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UIZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1UIZ FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1uiz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1uiz OCA], [~~http~~://pdbe.org/1uiz PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1uiz RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1uiz PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1uiz ProSAT]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1uiz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1uiz OCA], [https://pdbe.org/1uiz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1uiz RCSB], [https://www.ebi.ac.uk/pdbsum/1uiz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1uiz ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==

OCA at 13:30, 1 January 2020

OCA — Wed, 01 Jan 2020 13:30:09 GMT

←Older revision		Revision as of 13:30, 1 January 2020
Line 1:		Line 1:

	==Crystal Structure Of Macrophage Migration Inhibitory Factor From Xenopus Laevis.==		==Crystal Structure Of Macrophage Migration Inhibitory Factor From Xenopus Laevis.==
-	<StructureSection load='1uiz' size='340' side='right' caption='[[1uiz]], [[Resolution\|resolution]] 2.50Å' scene=''>	+	<StructureSection load='1uiz' size='340' side='right'caption='[[1uiz]], [[Resolution\|resolution]] 2.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1uiz]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/African_clawed_frog African clawed frog]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UIZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1UIZ FirstGlance]. <br>		<table><tr><td colspan='2'>[[1uiz]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/African_clawed_frog African clawed frog]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UIZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1UIZ FirstGlance]. <br>
Line 27:		Line 27:

	==See Also==		==See Also==
-	*[[Macrophage inhibitory factor\|Macrophage inhibitory factor]]	+	*[[Macrophage inhibitory factor 3D structures\|Macrophage inhibitory factor 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 33:		Line 33:
	</StructureSection>		</StructureSection>
	[[Category: African clawed frog]]		[[Category: African clawed frog]]
		+	[[Category: Large Structures]]
	[[Category: Ishibashi, T]]		[[Category: Ishibashi, T]]
	[[Category: Iyaguchi, D]]		[[Category: Iyaguchi, D]]

OCA at 08:17, 28 March 2018

OCA — Wed, 28 Mar 2018 08:17:29 GMT

←Older revision		Revision as of 08:17, 28 March 2018
Line 1:		Line 1:
		+
	==Crystal Structure Of Macrophage Migration Inhibitory Factor From Xenopus Laevis.==		==Crystal Structure Of Macrophage Migration Inhibitory Factor From Xenopus Laevis.==
	<StructureSection load='1uiz' size='340' side='right' caption='[[1uiz]], [[Resolution\|resolution]] 2.50Å' scene=''>		<StructureSection load='1uiz' size='340' side='right' caption='[[1uiz]], [[Resolution\|resolution]] 2.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1uiz]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/African_clawed_frog African clawed frog]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UIZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1UIZ FirstGlance]. <br>		<table><tr><td colspan='2'>[[1uiz]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/African_clawed_frog African clawed frog]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UIZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1UIZ FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1uiz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1uiz OCA], [http://pdbe.org/1uiz PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1uiz RCSB], [http://www.ebi.ac.uk/pdbsum/1uiz PDBsum]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1uiz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1uiz OCA], [http://pdbe.org/1uiz PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1uiz RCSB], [http://www.ebi.ac.uk/pdbsum/1uiz PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1uiz ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 9:		Line 10:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ui/1uiz_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ui/1uiz_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 03:31, 8 February 2016

OCA — Mon, 08 Feb 2016 03:31:24 GMT

←Older revision		Revision as of 03:31, 8 February 2016
Line 13:		Line 13:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1uiz ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 07:27, 10 September 2015

OCA — Thu, 10 Sep 2015 07:27:03 GMT

←Older revision		Revision as of 07:27, 10 September 2015
Line 2:		Line 2:
	<StructureSection load='1uiz' size='340' side='right' caption='[[1uiz]], [[Resolution\|resolution]] 2.50Å' scene=''>		<StructureSection load='1uiz' size='340' side='right' caption='[[1uiz]], [[Resolution\|resolution]] 2.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1uiz]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Xenopus_laevis Xenopus laevis~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UIZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1UIZ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1uiz]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/African_clawed_frog African clawed frog]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UIZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1UIZ FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1uiz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1uiz OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1uiz RCSB], [http://www.ebi.ac.uk/pdbsum/1uiz PDBsum]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1uiz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1uiz OCA], [http://pdbe.org/1uiz PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1uiz RCSB], [http://www.ebi.ac.uk/pdbsum/1uiz PDBsum]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1uiz" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 30:		Line 31:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Xenopus laevis~~]]	+	[[Category: African clawed frog]]
	[[Category: Ishibashi, T]]		[[Category: Ishibashi, T]]
	[[Category: Iyaguchi, D]]		[[Category: Iyaguchi, D]]

OCA at 13:14, 6 January 2015

OCA — Tue, 06 Jan 2015 13:14:21 GMT

←Older revision		Revision as of 13:14, 6 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1uiz]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Xenopus_laevis Xenopus laevis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UIZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1UIZ FirstGlance]. <br>		<table><tr><td colspan='2'>[[1uiz]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Xenopus_laevis Xenopus laevis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UIZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1UIZ FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1uiz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1uiz OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1uiz RCSB], [http://www.ebi.ac.uk/pdbsum/1uiz PDBsum]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1uiz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1uiz OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1uiz RCSB], [http://www.ebi.ac.uk/pdbsum/1uiz PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 31:		Line 31:
	</StructureSection>		</StructureSection>
	[[Category: Xenopus laevis]]		[[Category: Xenopus laevis]]
-	[[Category: Ishibashi, T.]]	+	[[Category: Ishibashi, T]]
-	[[Category: Iyaguchi, D.]]	+	[[Category: Iyaguchi, D]]
-	[[Category: Maeno, M.]]	+	[[Category: Maeno, M]]
-	[[Category: Nishihira, J.]]	+	[[Category: Nishihira, J]]
-	[[Category: Suzuki, M.]]	+	[[Category: Suzuki, M]]
-	[[Category: Takamura, Y.]]	+	[[Category: Takamura, Y]]
-	[[Category: Tanaka, I.]]	+	[[Category: Tanaka, I]]
-	[[Category: Tochinai, S.]]	+	[[Category: Tochinai, S]]
	[[Category: Cytokine]]		[[Category: Cytokine]]
	[[Category: Macrophage migration inhibitory factor]]		[[Category: Macrophage migration inhibitory factor]]
	[[Category: Mif]]		[[Category: Mif]]
	[[Category: Tautomerase]]		[[Category: Tautomerase]]

OCA at 20:44, 29 September 2014

OCA — Mon, 29 Sep 2014 20:44:03 GMT

←Older revision		Revision as of 20:44, 29 September 2014
Line 1:		Line 1:
-	[[~~Image~~:1uiz.~~png\|left~~\|200px]]	+	==Crystal Structure Of Macrophage Migration Inhibitory Factor From Xenopus Laevis.==
		+	<StructureSection load='1uiz' size='340' side='right' caption='[[1uiz]], [[Resolution\|resolution]] 2.50Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1uiz]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Xenopus_laevis Xenopus laevis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UIZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1UIZ FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1uiz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1uiz OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1uiz RCSB], [http://www.ebi.ac.uk/pdbsum/1uiz PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ui/1uiz_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Macrophage migration inhibitory factor (MIF) is an immunoregulatory cytokine involved in both acquired and innate immunity. MIF also has many functions outside the immune system, such as isomerase and oxidoreductase activities and control of cell proliferation. Considering the involvement of MIF in various intra- and extracellular events, we expected that MIF might also be important in vertebrate development. To elucidate the possible role of MIF in developmental processes, we knocked down MIF in embryos of the African clawed frog Xenopus laevis, using MIF-specific morpholino oligomers (MOs). For the synthesis of the MOs, we cloned a cDNA for a Xenopus homolog of MIF. Sequence analysis, determination of the isomerase activity, and x-ray crystallographic analysis revealed that the protein encoded by the cDNA was the ortholog of mammalian MIF. We carried out whole mount in situ hybridization of MIF mRNA and found that MIF was expressed at high levels in the neural tissues of normal embryos. Although early embryogenesis of MO-injected embryos proceeded normally until the gastrula stage, their neurulation was completely inhibited. At the tailbud stage, the MO-injected embryos lacked neural and mesodermal tissues, and also showed severe defects in their head and tail structures. Thus, MIF was found to be essential for axis formation and neural development of Xenopus embryos.

-	~~{{STRUCTURE_1uiz\| PDB=1uiz \| SCENE= }}~~	+	Xenopus laevis macrophage migration inhibitory factor is essential for axis formation and neural development.,Suzuki M, Takamura Y, Maeno M, Tochinai S, Iyaguchi D, Tanaka I, Nishihira J, Ishibashi T J Biol Chem. 2004 May 14;279(20):21406-14. Epub 2004 Mar 15. PMID:15024012<ref>PMID:15024012</ref>

-	~~===Crystal Structure Of Macrophage Migration Inhibitory Factor~~ From ~~Xenopus Laevis~~.~~===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>

-	~~{{ABSTRACT_PUBMED_15024012}}~~	+	==See Also==
-		+	*[[Macrophage inhibitory factor\|Macrophage inhibitory factor]]
-	==~~About this Structure~~==	+	== References ==
-	[[~~1uiz~~]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Xenopus_laevis Xenopus laevis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UIZ OCA].	+	<references/>
-		+	__TOC__
-	==~~Reference~~==	+	</StructureSection>
-	<~~ref group="xtra">PMID:015024012<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Xenopus laevis]]		[[Category: Xenopus laevis]]
	[[Category: Ishibashi, T.]]		[[Category: Ishibashi, T.]]

OCA: Protected "1uiz" [edit=sysop:move=sysop]

OCA — Sat, 05 Jan 2013 11:34:33 GMT

Protected "1uiz" [edit=sysop:move=sysop]

←Older revision

Revision as of 11:34, 5 January 2013

OCA at 11:34, 5 January 2013

OCA — Sat, 05 Jan 2013 11:34:30 GMT

←Older revision		Revision as of 11:34, 5 January 2013
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	[[Image:1uiz.png\|left\|200px]]		[[Image:1uiz.png\|left\|200px]]

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	{{STRUCTURE_1uiz\| PDB=1uiz \| SCENE= }}		{{STRUCTURE_1uiz\| PDB=1uiz \| SCENE= }}

	===Crystal Structure Of Macrophage Migration Inhibitory Factor From Xenopus Laevis.===		===Crystal Structure Of Macrophage Migration Inhibitory Factor From Xenopus Laevis.===

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	{{ABSTRACT_PUBMED_15024012}}		{{ABSTRACT_PUBMED_15024012}}

	==About this Structure==		==About this Structure==
-	~~1UIZ~~ is a 4 ~~chains~~ structure ~~of sequences~~ from [http://en.wikipedia.org/wiki/Xenopus_laevis Xenopus laevis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UIZ OCA].	+	[[1uiz]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Xenopus_laevis Xenopus laevis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UIZ OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~15024012~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:015024012</ref><references group="xtra"/>
	[[Category: Xenopus laevis]]		[[Category: Xenopus laevis]]
	[[Category: Ishibashi, T.]]		[[Category: Ishibashi, T.]]
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	[[Category: Mif]]		[[Category: Mif]]
	[[Category: Tautomerase]]		[[Category: Tautomerase]]
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-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 18:29:37 2009''