1ukz - Revision history

OCA at 13:16, 9 May 2024

OCA — Thu, 09 May 2024 13:16:41 GMT

←Older revision		Revision as of 13:16, 9 May 2024
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	<StructureSection load='1ukz' size='340' side='right'caption='[[1ukz]], [[Resolution\|resolution]] 1.90Å' scene=''>		<StructureSection load='1ukz' size='340' side='right'caption='[[1ukz]], [[Resolution\|resolution]] 1.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1ukz]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Atcc_18824 Atcc 18824~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UKZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1UKZ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1ukz]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UKZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1UKZ FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=AMP:ADENOSINE+MONOPHOSPHATE'>AMP</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.9Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=AMP:ADENOSINE+MONOPHOSPHATE'>AMP</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ukz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ukz OCA], [https://pdbe.org/1ukz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ukz RCSB], [https://www.ebi.ac.uk/pdbsum/1ukz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ukz ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ukz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ukz OCA], [https://pdbe.org/1ukz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ukz RCSB], [https://www.ebi.ac.uk/pdbsum/1ukz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ukz ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/KCY_YEAST KCY_YEAST]] Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and dUMP as phosphate acceptors, but can also use CMP, dCMP, AMP, GMP, dGMP and dTMP. ATP and dATP are the best phosphate donors, but can also use GTP, dGTP, dCTP, and dTTP to some degree.<ref>PMID:1333436</ref> <ref>PMID:2172245</ref> <ref>PMID:8391780</ref> <ref>PMID:2549068</ref>	+	[https://www.uniprot.org/uniprot/KCY_YEAST KCY_YEAST] Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and dUMP as phosphate acceptors, but can also use CMP, dCMP, AMP, GMP, dGMP and dTMP. ATP and dATP are the best phosphate donors, but can also use GTP, dGTP, dCTP, and dTTP to some degree.<ref>PMID:1333436</ref> <ref>PMID:2172245</ref> <ref>PMID:8391780</ref> <ref>PMID:2549068</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 35:		Line 36:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Atcc 18824]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Mueller-Dieckmann, H J~~]]	+	[[Category: Saccharomyces cerevisiae]]
-	[[Category: ~~Schulz, G E~~]]	+	[[Category: Mueller-Dieckmann H-J]]
-	[[Category: ~~Transferase~~]]	+	[[Category: Schulz GE]]

OCA at 06:12, 6 October 2021

OCA — Wed, 06 Oct 2021 06:12:53 GMT

←Older revision		Revision as of 06:12, 6 October 2021
Line 3:		Line 3:
	<StructureSection load='1ukz' size='340' side='right'caption='[[1ukz]], [[Resolution\|resolution]] 1.90Å' scene=''>		<StructureSection load='1ukz' size='340' side='right'caption='[[1ukz]], [[Resolution\|resolution]] 1.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1ukz]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Atcc_18824 Atcc 18824]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UKZ OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1UKZ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1ukz]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Atcc_18824 Atcc 18824]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UKZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1UKZ FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=AMP:ADENOSINE+MONOPHOSPHATE'>AMP</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=AMP:ADENOSINE+MONOPHOSPHATE'>AMP</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1ukz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ukz OCA], [~~http~~://pdbe.org/1ukz PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1ukz RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1ukz PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1ukz ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ukz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ukz OCA], [https://pdbe.org/1ukz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ukz RCSB], [https://www.ebi.ac.uk/pdbsum/1ukz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ukz ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/KCY_YEAST KCY_YEAST]] Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and dUMP as phosphate acceptors, but can also use CMP, dCMP, AMP, GMP, dGMP and dTMP. ATP and dATP are the best phosphate donors, but can also use GTP, dGTP, dCTP, and dTTP to some degree.<ref>PMID:1333436</ref> <ref>PMID:2172245</ref> <ref>PMID:8391780</ref> <ref>PMID:2549068</ref>	+	[[https://www.uniprot.org/uniprot/KCY_YEAST KCY_YEAST]] Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and dUMP as phosphate acceptors, but can also use CMP, dCMP, AMP, GMP, dGMP and dTMP. ATP and dATP are the best phosphate donors, but can also use GTP, dGTP, dCTP, and dTTP to some degree.<ref>PMID:1333436</ref> <ref>PMID:2172245</ref> <ref>PMID:8391780</ref> <ref>PMID:2549068</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 13:21, 1 January 2020

OCA — Wed, 01 Jan 2020 13:21:38 GMT

←Older revision		Revision as of 13:21, 1 January 2020
Line 1:		Line 1:

	==SUBSTRATE SPECIFICITY AND ASSEMBLY OF CATALYTIC CENTER DERIVED FROM TWO STRUCTURES OF LIGATED URIDYLATE KINASE==		==SUBSTRATE SPECIFICITY AND ASSEMBLY OF CATALYTIC CENTER DERIVED FROM TWO STRUCTURES OF LIGATED URIDYLATE KINASE==
-	<StructureSection load='1ukz' size='340' side='right' caption='[[1ukz]], [[Resolution\|resolution]] 1.90Å' scene=''>	+	<StructureSection load='1ukz' size='340' side='right'caption='[[1ukz]], [[Resolution\|resolution]] 1.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1ukz]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_18824 Atcc 18824]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UKZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1UKZ FirstGlance]. <br>		<table><tr><td colspan='2'>[[1ukz]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_18824 Atcc 18824]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UKZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1UKZ FirstGlance]. <br>
Line 36:		Line 36:
	</StructureSection>		</StructureSection>
	[[Category: Atcc 18824]]		[[Category: Atcc 18824]]
		+	[[Category: Large Structures]]
	[[Category: Mueller-Dieckmann, H J]]		[[Category: Mueller-Dieckmann, H J]]
	[[Category: Schulz, G E]]		[[Category: Schulz, G E]]
	[[Category: Transferase]]		[[Category: Transferase]]

OCA at 08:10, 28 March 2018

OCA — Wed, 28 Mar 2018 08:10:42 GMT

←Older revision		Revision as of 08:10, 28 March 2018
Line 1:		Line 1:
		+
	==SUBSTRATE SPECIFICITY AND ASSEMBLY OF CATALYTIC CENTER DERIVED FROM TWO STRUCTURES OF LIGATED URIDYLATE KINASE==		==SUBSTRATE SPECIFICITY AND ASSEMBLY OF CATALYTIC CENTER DERIVED FROM TWO STRUCTURES OF LIGATED URIDYLATE KINASE==
	<StructureSection load='1ukz' size='340' side='right' caption='[[1ukz]], [[Resolution\|resolution]] 1.90Å' scene=''>		<StructureSection load='1ukz' size='340' side='right' caption='[[1ukz]], [[Resolution\|resolution]] 1.90Å' scene=''>
Line 4:		Line 5:
	<table><tr><td colspan='2'>[[1ukz]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_18824 Atcc 18824]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UKZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1UKZ FirstGlance]. <br>		<table><tr><td colspan='2'>[[1ukz]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_18824 Atcc 18824]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UKZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1UKZ FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=AMP:ADENOSINE+MONOPHOSPHATE'>AMP</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=AMP:ADENOSINE+MONOPHOSPHATE'>AMP</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ukz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ukz OCA], [http://pdbe.org/1ukz PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1ukz RCSB], [http://www.ebi.ac.uk/pdbsum/1ukz PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ukz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ukz OCA], [http://pdbe.org/1ukz PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1ukz RCSB], [http://www.ebi.ac.uk/pdbsum/1ukz PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1ukz ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 12:		Line 13:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/uk/1ukz_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/uk/1ukz_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1ukz ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 01:51, 12 September 2015

OCA — Sat, 12 Sep 2015 01:51:44 GMT

←Older revision		Revision as of 01:51, 12 September 2015
Line 2:		Line 2:
	<StructureSection load='1ukz' size='340' side='right' caption='[[1ukz]], [[Resolution\|resolution]] 1.90Å' scene=''>		<StructureSection load='1ukz' size='340' side='right' caption='[[1ukz]], [[Resolution\|resolution]] 1.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1ukz]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Saccharomyces_cerevisiae Saccharomyces cerevisiae~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UKZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1UKZ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1ukz]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_18824 Atcc 18824]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UKZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1UKZ FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=AMP:ADENOSINE+MONOPHOSPHATE'>AMP</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=AMP:ADENOSINE+MONOPHOSPHATE'>AMP</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ukz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ukz OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1ukz RCSB], [http://www.ebi.ac.uk/pdbsum/1ukz PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ukz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ukz OCA], [http://pdbe.org/1ukz PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1ukz RCSB], [http://www.ebi.ac.uk/pdbsum/1ukz PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[http://www.uniprot.org/uniprot/~~UMPK_YEAST UMPK_YEAST~~]] Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and dUMP as phosphate acceptors, but can also use CMP, dCMP, AMP, GMP, dGMP and dTMP. ATP and dATP are the best phosphate donors, but can also use GTP, dGTP, dCTP, and dTTP to some degree.<ref>PMID:~~2172245~~</ref> ~~[HAMAP-Rule:MF_03172]~~<ref>PMID:~~1333436~~</ref> <ref>PMID:8391780</ref>	+	[[http://www.uniprot.org/uniprot/KCY_YEAST KCY_YEAST]] Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and dUMP as phosphate acceptors, but can also use CMP, dCMP, AMP, GMP, dGMP and dTMP. ATP and dATP are the best phosphate donors, but can also use GTP, dGTP, dCTP, and dTTP to some degree.<ref>PMID:1333436</ref> <ref>PMID:2172245</ref> <ref>PMID:8391780</ref> <ref>PMID:2549068</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 26:		Line 26:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1ukz" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 33:		Line 34:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Saccharomyces cerevisiae~~]]	+	[[Category: Atcc 18824]]
	[[Category: Mueller-Dieckmann, H J]]		[[Category: Mueller-Dieckmann, H J]]
	[[Category: Schulz, G E]]		[[Category: Schulz, G E]]
	[[Category: Transferase]]		[[Category: Transferase]]

OCA at 22:16, 25 December 2014

OCA — Thu, 25 Dec 2014 22:16:33 GMT

←Older revision		Revision as of 22:16, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1ukz]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UKZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1UKZ FirstGlance]. <br>		<table><tr><td colspan='2'>[[1ukz]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UKZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1UKZ FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=AMP:ADENOSINE+MONOPHOSPHATE'>AMP</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=AMP:ADENOSINE+MONOPHOSPHATE'>AMP</scene></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ukz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ukz OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1ukz RCSB], [http://www.ebi.ac.uk/pdbsum/1ukz PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ukz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ukz OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1ukz RCSB], [http://www.ebi.ac.uk/pdbsum/1ukz PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/UMPK_YEAST UMPK_YEAST]] Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and dUMP as phosphate acceptors, but can also use CMP, dCMP, AMP, GMP, dGMP and dTMP. ATP and dATP are the best phosphate donors, but can also use GTP, dGTP, dCTP, and dTTP to some degree.<ref>PMID:2172245</ref> [HAMAP-Rule:MF_03172]<ref>PMID:1333436</ref> <ref>PMID:8391780</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 32:		Line 34:
	</StructureSection>		</StructureSection>
	[[Category: Saccharomyces cerevisiae]]		[[Category: Saccharomyces cerevisiae]]
-	[[Category: Mueller-Dieckmann, H J.]]	+	[[Category: Mueller-Dieckmann, H J]]
-	[[Category: Schulz, G E.]]	+	[[Category: Schulz, G E]]
	[[Category: Transferase]]		[[Category: Transferase]]

OCA at 23:34, 28 September 2014

OCA — Sun, 28 Sep 2014 23:34:32 GMT

←Older revision		Revision as of 23:34, 28 September 2014
Line 1:		Line 1:
-	[[~~Image~~:1ukz.~~png\|left~~\|200px]]	+	==SUBSTRATE SPECIFICITY AND ASSEMBLY OF CATALYTIC CENTER DERIVED FROM TWO STRUCTURES OF LIGATED URIDYLATE KINASE==
		+	<StructureSection load='1ukz' size='340' side='right' caption='[[1ukz]], [[Resolution\|resolution]] 1.90Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1ukz]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UKZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1UKZ FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=AMP:ADENOSINE+MONOPHOSPHATE'>AMP</scene><br>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ukz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ukz OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1ukz RCSB], [http://www.ebi.ac.uk/pdbsum/1ukz PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/uk/1ukz_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Two crystal structures of ligated uridylate kinase from Saccharomyces cerevisiae were determined by X-ray analyses. The ligands were ADP and AMP. Cocrystallization with ATP yielded crystals with ADP at the ATP site and a mixture of AMP and ADP at the NMP site. Cocrystallization with ADP gave rise to a distinct crystal type with ADP at the ATP site, but only AMP at the NMP site. In both cases, the substrates are kept in place by favorable crystal contacts. The structures have been refined to R-factors of 17.8% and 19.6% at resolutions of 2.1 A and 1.9 A, respectively. A comparison with the related cytosolic adenylate kinase from pig disclosed large induced-fit movements on substrate binding and the disassembly of the catalytic center in the absence of substrates. The relatively high side-activity of uridylate kinase for AMP is explained by the finding that the binding pocket is sized for an AMP, but constructed to bind UMP together with a water molecule.

-	~~{{STRUCTURE_1ukz\| PDB=1ukz \| SCENE= }}~~	+	Substrate specificity and assembly of the catalytic center derived from two structures of ligated uridylate kinase.,Muller-Dieckmann HJ, Schulz GE J Mol Biol. 1995 Mar 3;246(4):522-30. PMID:7877173<ref>PMID:7877173</ref>

-	~~===SUBSTRATE SPECIFICITY AND ASSEMBLY OF CATALYTIC CENTER DERIVED FROM TWO STRUCTURES OF LIGATED URIDYLATE KINASE===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_7877173}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[1ukz]] is~~ a ~~1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=1UKZ OCA].~~	+

	==See Also==		==See Also==
	*[[Uridylate kinase\|Uridylate kinase]]		*[[Uridylate kinase\|Uridylate kinase]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:007877173<~~/~~ref~~><~~references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Saccharomyces cerevisiae]]		[[Category: Saccharomyces cerevisiae]]
	[[Category: Mueller-Dieckmann, H J.]]		[[Category: Mueller-Dieckmann, H J.]]
	[[Category: Schulz, G E.]]		[[Category: Schulz, G E.]]
	[[Category: Transferase]]		[[Category: Transferase]]

OCA at 22:17, 20 October 2012

OCA — Sat, 20 Oct 2012 22:17:42 GMT

←Older revision		Revision as of 22:17, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[1ukz]] is a 1 chain structure ~~of [[Uridylate kinase]]~~ with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UKZ OCA].	+	[[1ukz]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UKZ OCA].

	==See Also==		==See Also==
Line 14:		Line 14:

	==Reference==		==Reference==
-	<ref group="xtra">PMID:007877173~~</ref><ref group="xtra">PMID:009144797~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:007877173</ref><references group="xtra"/>
	[[Category: Saccharomyces cerevisiae]]		[[Category: Saccharomyces cerevisiae]]
	[[Category: Mueller-Dieckmann, H J.]]		[[Category: Mueller-Dieckmann, H J.]]
	[[Category: Schulz, G E.]]		[[Category: Schulz, G E.]]
	[[Category: Transferase]]		[[Category: Transferase]]

OCA: Protected "1ukz" [edit=sysop:move=sysop]

OCA — Fri, 27 Jul 2012 15:50:33 GMT

Protected "1ukz" [edit=sysop:move=sysop]

←Older revision

Revision as of 15:50, 27 July 2012

OCA at 15:50, 27 July 2012

OCA — Fri, 27 Jul 2012 15:50:31 GMT

←Older revision		Revision as of 15:50, 27 July 2012
Line 1:		Line 1:
-	{{Seed}}
	[[Image:1ukz.png\|left\|200px]]		[[Image:1ukz.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_1ukz", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_1ukz\| PDB=1ukz \| SCENE= }}		{{STRUCTURE_1ukz\| PDB=1ukz \| SCENE= }}

	===SUBSTRATE SPECIFICITY AND ASSEMBLY OF CATALYTIC CENTER DERIVED FROM TWO STRUCTURES OF LIGATED URIDYLATE KINASE===		===SUBSTRATE SPECIFICITY AND ASSEMBLY OF CATALYTIC CENTER DERIVED FROM TWO STRUCTURES OF LIGATED URIDYLATE KINASE===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_7877173}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 7877173 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_7877173}}		{{ABSTRACT_PUBMED_7877173}}

	==About this Structure==		==About this Structure==
-	~~1UKZ~~ is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UKZ OCA].	+	[[1ukz]] is a 1 chain structure of [[Uridylate kinase]] with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UKZ OCA].
		+
		+	==See Also==
		+	*[[Uridylate kinase\|Uridylate kinase]]

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~7877173~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:007877173</ref><ref group="xtra">PMID:009144797</ref><references group="xtra"/>
	[[Category: Saccharomyces cerevisiae]]		[[Category: Saccharomyces cerevisiae]]
	[[Category: Mueller-Dieckmann, H J.]]		[[Category: Mueller-Dieckmann, H J.]]
	[[Category: Schulz, G E.]]		[[Category: Schulz, G E.]]
	[[Category: Transferase]]		[[Category: Transferase]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 18 09:31:55 2009''