1uny - Revision history

OCA at 07:48, 12 July 2023

OCA — Wed, 12 Jul 2023 07:48:18 GMT

←Older revision		Revision as of 07:48, 12 July 2023
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	<StructureSection load='1uny' size='340' side='right'caption='[[1uny]], [[Resolution\|resolution]] 2.30Å' scene=''>		<StructureSection load='1uny' size='340' side='right'caption='[[1uny]], [[Resolution\|resolution]] 2.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1uny]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UNY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1UNY FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1uny]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UNY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1UNY FirstGlance]. <br>
-	</td></tr><tr id='~~NonStdRes~~'><td class="sblockLbl"><b>[[~~Non-Standard_Residue~~\|~~NonStd Res~~:]]</b></td><td class="sblockDat"~~><scene name~~=~~'pdbligand=ACE:ACETYL+GROUP'>ACE</scene~~></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.3Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"><~~div style~~='~~overflow~~: ~~auto; max-height: 3em;~~'>[[1gcl\|1gcl]], [[1gcm\|1gcm]], [[1unt\|1unt]], [[1unv\|1unv]], [[1unw\|1unw]], [[1unx\|1unx]], [[1unu\|1unu]], [[1unz\|1unz]], [[1uo0\|1uo0]], [[1uo1\|1uo1]], [[1uo2\|1uo2]], [[1uo3\|1uo3]], [[1uo4\|1uo4]], [[1uo5\|1uo5]], [[1ce9\|1ce9]], [[1dgc\|1dgc]], [[1env\|1env]], [[1fav\|1fav]], [[1gk6\|1gk6]], [[1gzl\|1gzl]], [[1ihq\|1ihq]], [[1ij0\|1ij0]], [[1ij1\|1ij1]], [[1ij2\|1ij2]], [[1ij3\|1ij3]], [[1kql\|1kql]], [[1ld4\|1ld4]], [[1llm\|1llm]], [[1nkn\|1nkn]], [[1piq\|1piq]], [[1rb1\|1rb1]], [[1rb4\|1rb4]], [[1rb5\|1rb5]], [[1rb6\|1rb6]], [[1swi\|1swi]], [[1tmz\|1tmz]], [[1w5g\|1w5g]], [[1w5h\|1w5h]], [[1w5i\|1w5i]], [[1w5j\|1w5j]], [[1w5k\|1w5k]], [[1w5l\|1w5l]], [[1ysa\|1ysa]], [[1zii\|1zii]], [[1zij\|1zij]], [[1zik\|1zik]], [[1zil\|1zil]], [[1zim\|1zim]], [[1zta\|1zta]], [[2dgc\|2dgc]], [[2zta\|2zta]]</~~div~~></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1uny FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1uny OCA], [https://pdbe.org/1uny PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1uny RCSB], [https://www.ebi.ac.uk/pdbsum/1uny PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1uny ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1uny FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1uny OCA], [https://pdbe.org/1uny PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1uny RCSB], [https://www.ebi.ac.uk/pdbsum/1uny PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1uny ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/GCN4_YEAST GCN4_YEAST] Is a transcription factor that is responsible for the activation of more than 30 genes required for amino acid or for purine biosynthesis in response to amino acid or purine starvation. Binds and recognize the DNA sequence: 5'-TGA[CG]TCA-3'.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	==See Also==		==See Also==
		+	*[[Gcn4 3D Structures\|Gcn4 3D Structures]]
	*[[Gnc4 3D Structures\|Gnc4 3D Structures]]		*[[Gnc4 3D Structures\|Gnc4 3D Structures]]
	== References ==		== References ==
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	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Alvarez-Gutierrez~~, J M~~]]	+	[[Category: Saccharomyces cerevisiae]]
-	[[Category: Ghadiri~~, M R~~]]	+	[[Category: Alvarez-Gutierrez JM]]
-	[[Category: Redman~~, J E~~]]	+	[[Category: Ghadiri MR]]
-	[[Category: Stout~~, C D~~]]	+	[[Category: Redman JE]]
-	[[Category: Yadav~~, M K~~]]	+	[[Category: Stout CD]]
-	[[Category: Zhang, Y]]	+	[[Category: Yadav MK]]
-	~~[[Category: Cavity]]~~	+	[[Category: Zhang Y]]
-	~~[[Category: Four helix bundle~~]]	+

OCA at 06:14, 6 October 2021

OCA — Wed, 06 Oct 2021 06:14:37 GMT

←Older revision		Revision as of 06:14, 6 October 2021
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	<StructureSection load='1uny' size='340' side='right'caption='[[1uny]], [[Resolution\|resolution]] 2.30Å' scene=''>		<StructureSection load='1uny' size='340' side='right'caption='[[1uny]], [[Resolution\|resolution]] 2.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1uny]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UNY OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1UNY FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1uny]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UNY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1UNY FirstGlance]. <br>
	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1gcl\|1gcl]], [[1gcm\|1gcm]], [[1unt\|1unt]], [[1unv\|1unv]], [[1unw\|1unw]], [[1unx\|1unx]], [[1unu\|1unu]], [[1unz\|1unz]], [[1uo0\|1uo0]], [[1uo1\|1uo1]], [[1uo2\|1uo2]], [[1uo3\|1uo3]], [[1uo4\|1uo4]], [[1uo5\|1uo5]], [[1ce9\|1ce9]], [[1dgc\|1dgc]], [[1env\|1env]], [[1fav\|1fav]], [[1gk6\|1gk6]], [[1gzl\|1gzl]], [[1ihq\|1ihq]], [[1ij0\|1ij0]], [[1ij1\|1ij1]], [[1ij2\|1ij2]], [[1ij3\|1ij3]], [[1kql\|1kql]], [[1ld4\|1ld4]], [[1llm\|1llm]], [[1nkn\|1nkn]], [[1piq\|1piq]], [[1rb1\|1rb1]], [[1rb4\|1rb4]], [[1rb5\|1rb5]], [[1rb6\|1rb6]], [[1swi\|1swi]], [[1tmz\|1tmz]], [[1w5g\|1w5g]], [[1w5h\|1w5h]], [[1w5i\|1w5i]], [[1w5j\|1w5j]], [[1w5k\|1w5k]], [[1w5l\|1w5l]], [[1ysa\|1ysa]], [[1zii\|1zii]], [[1zij\|1zij]], [[1zik\|1zik]], [[1zil\|1zil]], [[1zim\|1zim]], [[1zta\|1zta]], [[2dgc\|2dgc]], [[2zta\|2zta]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1gcl\|1gcl]], [[1gcm\|1gcm]], [[1unt\|1unt]], [[1unv\|1unv]], [[1unw\|1unw]], [[1unx\|1unx]], [[1unu\|1unu]], [[1unz\|1unz]], [[1uo0\|1uo0]], [[1uo1\|1uo1]], [[1uo2\|1uo2]], [[1uo3\|1uo3]], [[1uo4\|1uo4]], [[1uo5\|1uo5]], [[1ce9\|1ce9]], [[1dgc\|1dgc]], [[1env\|1env]], [[1fav\|1fav]], [[1gk6\|1gk6]], [[1gzl\|1gzl]], [[1ihq\|1ihq]], [[1ij0\|1ij0]], [[1ij1\|1ij1]], [[1ij2\|1ij2]], [[1ij3\|1ij3]], [[1kql\|1kql]], [[1ld4\|1ld4]], [[1llm\|1llm]], [[1nkn\|1nkn]], [[1piq\|1piq]], [[1rb1\|1rb1]], [[1rb4\|1rb4]], [[1rb5\|1rb5]], [[1rb6\|1rb6]], [[1swi\|1swi]], [[1tmz\|1tmz]], [[1w5g\|1w5g]], [[1w5h\|1w5h]], [[1w5i\|1w5i]], [[1w5j\|1w5j]], [[1w5k\|1w5k]], [[1w5l\|1w5l]], [[1ysa\|1ysa]], [[1zii\|1zii]], [[1zij\|1zij]], [[1zik\|1zik]], [[1zil\|1zil]], [[1zim\|1zim]], [[1zta\|1zta]], [[2dgc\|2dgc]], [[2zta\|2zta]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1uny FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1uny OCA], [~~http~~://pdbe.org/1uny PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1uny RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1uny PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1uny ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1uny FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1uny OCA], [https://pdbe.org/1uny PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1uny RCSB], [https://www.ebi.ac.uk/pdbsum/1uny PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1uny ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 13:22, 1 January 2020

OCA — Wed, 01 Jan 2020 13:22:21 GMT

←Older revision		Revision as of 13:22, 1 January 2020
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	==Structure Based Engineering of Internal Molecular Surfaces Of Four Helix Bundles==		==Structure Based Engineering of Internal Molecular Surfaces Of Four Helix Bundles==
-	<StructureSection load='1uny' size='340' side='right' caption='[[1uny]], [[Resolution\|resolution]] 2.30Å' scene=''>	+	<StructureSection load='1uny' size='340' side='right'caption='[[1uny]], [[Resolution\|resolution]] 2.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1uny]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UNY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1UNY FirstGlance]. <br>		<table><tr><td colspan='2'>[[1uny]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UNY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1UNY FirstGlance]. <br>
Line 19:		Line 19:

	==See Also==		==See Also==
-	*[[~~Gcn4~~\|~~Gcn4~~]]	+	*[[Gnc4 3D Structures\|Gnc4 3D Structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Alvarez-Gutierrez, J M]]		[[Category: Alvarez-Gutierrez, J M]]
	[[Category: Ghadiri, M R]]		[[Category: Ghadiri, M R]]

OCA at 08:11, 28 March 2018

OCA — Wed, 28 Mar 2018 08:11:09 GMT

←Older revision		Revision as of 08:11, 28 March 2018
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-	==~~STRUCTURE BASED ENGINEERING OF INTERNAL MOLECULAR SURFACES OF FOUR HELIX BUNDLES~~==	+
		+	==Structure Based Engineering of Internal Molecular Surfaces Of Four Helix Bundles==
	<StructureSection load='1uny' size='340' side='right' caption='[[1uny]], [[Resolution\|resolution]] 2.30Å' scene=''>		<StructureSection load='1uny' size='340' side='right' caption='[[1uny]], [[Resolution\|resolution]] 2.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
Line 5:		Line 6:
	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1gcl\|1gcl]], [[1gcm\|1gcm]], [[1unt\|1unt]], [[1unv\|1unv]], [[1unw\|1unw]], [[1unx\|1unx]], [[1unu\|1unu]], [[1unz\|1unz]], [[1uo0\|1uo0]], [[1uo1\|1uo1]], [[1uo2\|1uo2]], [[1uo3\|1uo3]], [[1uo4\|1uo4]], [[1uo5\|1uo5]], [[1ce9\|1ce9]], [[1dgc\|1dgc]], [[1env\|1env]], [[1fav\|1fav]], [[1gk6\|1gk6]], [[1gzl\|1gzl]], [[1ihq\|1ihq]], [[1ij0\|1ij0]], [[1ij1\|1ij1]], [[1ij2\|1ij2]], [[1ij3\|1ij3]], [[1kql\|1kql]], [[1ld4\|1ld4]], [[1llm\|1llm]], [[1nkn\|1nkn]], [[1piq\|1piq]], [[1rb1\|1rb1]], [[1rb4\|1rb4]], [[1rb5\|1rb5]], [[1rb6\|1rb6]], [[1swi\|1swi]], [[1tmz\|1tmz]], [[1w5g\|1w5g]], [[1w5h\|1w5h]], [[1w5i\|1w5i]], [[1w5j\|1w5j]], [[1w5k\|1w5k]], [[1w5l\|1w5l]], [[1ysa\|1ysa]], [[1zii\|1zii]], [[1zij\|1zij]], [[1zik\|1zik]], [[1zil\|1zil]], [[1zim\|1zim]], [[1zta\|1zta]], [[2dgc\|2dgc]], [[2zta\|2zta]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1gcl\|1gcl]], [[1gcm\|1gcm]], [[1unt\|1unt]], [[1unv\|1unv]], [[1unw\|1unw]], [[1unx\|1unx]], [[1unu\|1unu]], [[1unz\|1unz]], [[1uo0\|1uo0]], [[1uo1\|1uo1]], [[1uo2\|1uo2]], [[1uo3\|1uo3]], [[1uo4\|1uo4]], [[1uo5\|1uo5]], [[1ce9\|1ce9]], [[1dgc\|1dgc]], [[1env\|1env]], [[1fav\|1fav]], [[1gk6\|1gk6]], [[1gzl\|1gzl]], [[1ihq\|1ihq]], [[1ij0\|1ij0]], [[1ij1\|1ij1]], [[1ij2\|1ij2]], [[1ij3\|1ij3]], [[1kql\|1kql]], [[1ld4\|1ld4]], [[1llm\|1llm]], [[1nkn\|1nkn]], [[1piq\|1piq]], [[1rb1\|1rb1]], [[1rb4\|1rb4]], [[1rb5\|1rb5]], [[1rb6\|1rb6]], [[1swi\|1swi]], [[1tmz\|1tmz]], [[1w5g\|1w5g]], [[1w5h\|1w5h]], [[1w5i\|1w5i]], [[1w5j\|1w5j]], [[1w5k\|1w5k]], [[1w5l\|1w5l]], [[1ysa\|1ysa]], [[1zii\|1zii]], [[1zij\|1zij]], [[1zik\|1zik]], [[1zil\|1zil]], [[1zim\|1zim]], [[1zta\|1zta]], [[2dgc\|2dgc]], [[2zta\|2zta]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1uny FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1uny OCA], [http://pdbe.org/1uny PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1uny RCSB], [http://www.ebi.ac.uk/pdbsum/1uny PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1uny FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1uny OCA], [http://pdbe.org/1uny PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1uny RCSB], [http://www.ebi.ac.uk/pdbsum/1uny PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1uny ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 21:16, 10 September 2015

OCA — Thu, 10 Sep 2015 21:16:31 GMT

←Older revision		Revision as of 21:16, 10 September 2015
Line 5:		Line 5:
	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1gcl\|1gcl]], [[1gcm\|1gcm]], [[1unt\|1unt]], [[1unv\|1unv]], [[1unw\|1unw]], [[1unx\|1unx]], [[1unu\|1unu]], [[1unz\|1unz]], [[1uo0\|1uo0]], [[1uo1\|1uo1]], [[1uo2\|1uo2]], [[1uo3\|1uo3]], [[1uo4\|1uo4]], [[1uo5\|1uo5]], [[1ce9\|1ce9]], [[1dgc\|1dgc]], [[1env\|1env]], [[1fav\|1fav]], [[1gk6\|1gk6]], [[1gzl\|1gzl]], [[1ihq\|1ihq]], [[1ij0\|1ij0]], [[1ij1\|1ij1]], [[1ij2\|1ij2]], [[1ij3\|1ij3]], [[1kql\|1kql]], [[1ld4\|1ld4]], [[1llm\|1llm]], [[1nkn\|1nkn]], [[1piq\|1piq]], [[1rb1\|1rb1]], [[1rb4\|1rb4]], [[1rb5\|1rb5]], [[1rb6\|1rb6]], [[1swi\|1swi]], [[1tmz\|1tmz]], [[1w5g\|1w5g]], [[1w5h\|1w5h]], [[1w5i\|1w5i]], [[1w5j\|1w5j]], [[1w5k\|1w5k]], [[1w5l\|1w5l]], [[1ysa\|1ysa]], [[1zii\|1zii]], [[1zij\|1zij]], [[1zik\|1zik]], [[1zil\|1zil]], [[1zim\|1zim]], [[1zta\|1zta]], [[2dgc\|2dgc]], [[2zta\|2zta]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1gcl\|1gcl]], [[1gcm\|1gcm]], [[1unt\|1unt]], [[1unv\|1unv]], [[1unw\|1unw]], [[1unx\|1unx]], [[1unu\|1unu]], [[1unz\|1unz]], [[1uo0\|1uo0]], [[1uo1\|1uo1]], [[1uo2\|1uo2]], [[1uo3\|1uo3]], [[1uo4\|1uo4]], [[1uo5\|1uo5]], [[1ce9\|1ce9]], [[1dgc\|1dgc]], [[1env\|1env]], [[1fav\|1fav]], [[1gk6\|1gk6]], [[1gzl\|1gzl]], [[1ihq\|1ihq]], [[1ij0\|1ij0]], [[1ij1\|1ij1]], [[1ij2\|1ij2]], [[1ij3\|1ij3]], [[1kql\|1kql]], [[1ld4\|1ld4]], [[1llm\|1llm]], [[1nkn\|1nkn]], [[1piq\|1piq]], [[1rb1\|1rb1]], [[1rb4\|1rb4]], [[1rb5\|1rb5]], [[1rb6\|1rb6]], [[1swi\|1swi]], [[1tmz\|1tmz]], [[1w5g\|1w5g]], [[1w5h\|1w5h]], [[1w5i\|1w5i]], [[1w5j\|1w5j]], [[1w5k\|1w5k]], [[1w5l\|1w5l]], [[1ysa\|1ysa]], [[1zii\|1zii]], [[1zij\|1zij]], [[1zik\|1zik]], [[1zil\|1zil]], [[1zim\|1zim]], [[1zta\|1zta]], [[2dgc\|2dgc]], [[2zta\|2zta]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1uny FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1uny OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1uny RCSB], [http://www.ebi.ac.uk/pdbsum/1uny PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1uny FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1uny OCA], [http://pdbe.org/1uny PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1uny RCSB], [http://www.ebi.ac.uk/pdbsum/1uny PDBsum]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 15:		Line 15:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1uny" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==

OCA at 17:07, 15 January 2015

OCA — Thu, 15 Jan 2015 17:07:53 GMT

←Older revision		Revision as of 17:07, 15 January 2015
Line 22:		Line 22:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Alvarez-Gutierrez, J M.]]	+	[[Category: Alvarez-Gutierrez, J M]]
-	[[Category: Ghadiri, M R.]]	+	[[Category: Ghadiri, M R]]
-	[[Category: Redman, J E.]]	+	[[Category: Redman, J E]]
-	[[Category: Stout, C D.]]	+	[[Category: Stout, C D]]
-	[[Category: Yadav, M K.]]	+	[[Category: Yadav, M K]]
-	[[Category: Zhang, Y.]]	+	[[Category: Zhang, Y]]
	[[Category: Cavity]]		[[Category: Cavity]]
	[[Category: Four helix bundle]]		[[Category: Four helix bundle]]

OCA at 08:28, 8 October 2014

OCA — Wed, 08 Oct 2014 08:28:43 GMT

←Older revision		Revision as of 08:28, 8 October 2014
Line 1:		Line 1:
-	[[~~Image:~~1uny.~~png~~\|~~left~~\|~~200px~~]]	+	==STRUCTURE BASED ENGINEERING OF INTERNAL MOLECULAR SURFACES OF FOUR HELIX BUNDLES==
		+	<StructureSection load='1uny' size='340' side='right' caption='[[1uny]], [[Resolution\|resolution]] 2.30Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1uny]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UNY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1UNY FirstGlance]. <br>
		+	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1gcl\|1gcl]], [[1gcm\|1gcm]], [[1unt\|1unt]], [[1unv\|1unv]], [[1unw\|1unw]], [[1unx\|1unx]], [[1unu\|1unu]], [[1unz\|1unz]], [[1uo0\|1uo0]], [[1uo1\|1uo1]], [[1uo2\|1uo2]], [[1uo3\|1uo3]], [[1uo4\|1uo4]], [[1uo5\|1uo5]], [[1ce9\|1ce9]], [[1dgc\|1dgc]], [[1env\|1env]], [[1fav\|1fav]], [[1gk6\|1gk6]], [[1gzl\|1gzl]], [[1ihq\|1ihq]], [[1ij0\|1ij0]], [[1ij1\|1ij1]], [[1ij2\|1ij2]], [[1ij3\|1ij3]], [[1kql\|1kql]], [[1ld4\|1ld4]], [[1llm\|1llm]], [[1nkn\|1nkn]], [[1piq\|1piq]], [[1rb1\|1rb1]], [[1rb4\|1rb4]], [[1rb5\|1rb5]], [[1rb6\|1rb6]], [[1swi\|1swi]], [[1tmz\|1tmz]], [[1w5g\|1w5g]], [[1w5h\|1w5h]], [[1w5i\|1w5i]], [[1w5j\|1w5j]], [[1w5k\|1w5k]], [[1w5l\|1w5l]], [[1ysa\|1ysa]], [[1zii\|1zii]], [[1zij\|1zij]], [[1zik\|1zik]], [[1zil\|1zil]], [[1zim\|1zim]], [[1zta\|1zta]], [[2dgc\|2dgc]], [[2zta\|2zta]]</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1uny FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1uny OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1uny RCSB], [http://www.ebi.ac.uk/pdbsum/1uny PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Cavities and clefts are frequently important sites of interaction between natural enzymes or receptors and their corresponding substrate or ligand molecules and exemplify the types of molecular surfaces that would facilitate engineering of artificial catalysts and receptors. Even so, structural characterizations of designed cavities are rare. To address this issue, we performed a systematic study of the structural effects of single-amino acid substitutions within the hydrophobic cores of tetrameric coiled-coil peptides. Peptides containing single glycine, serine, alanine, or threonine amino acid substitutions at the buried L9, L16, L23, and I26 hydrophobic core positions of a GCN4-based sequence were synthesized and studied by solution-phase and crystallographic techniques. All peptides adopt the expected tetrameric state and contain tunnels or internal cavities ranging in size from 80 to 370 A(3). Two closely related sequences containing an L16G substitution, one of which adopts an antiparallel configuration and one of which adopts a parallel configuration, illustrate that cavities of different volumes and shapes can be engineered from identical core substitutions. Finally, we demonstrate that two of the peptides (L9G and L9A) bind the small molecule iodobenzene when present during crystallization, leaving the general peptide quaternary structure intact but altering the local peptide conformation and certain superhelical parameters. These high-resolution descriptions of varied molecular surfaces within solvent-occluded internal cavities illustrate the breadth of design space available in even closely related peptides and offer valuable models for the engineering of de novo helical proteins.

-	~~{{STRUCTURE_1uny\| PDB=1uny \| SCENE= }}~~	+	Structure-based engineering of internal cavities in coiled-coil peptides.,Yadav MK, Redman JE, Leman LJ, Alvarez-Gutierrez JM, Zhang Y, Stout CD, Ghadiri MR Biochemistry. 2005 Jul 19;44(28):9723-32. PMID:16008357<ref>PMID:16008357</ref>

-	~~===STRUCTURE BASED ENGINEERING OF INTERNAL MOLECULAR SURFACES OF FOUR HELIX BUNDLES===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>

-	~~{{ABSTRACT_PUBMED_16008357}}~~	+	==See Also==
-		+	*[[Gcn4\|Gcn4]]
-	==~~About this Structure~~==	+	== References ==
-	[[~~1uny~~]] ~~is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UNY OCA].~~	+	<references/>
-		+	__TOC__
-	==~~Reference~~==	+	</StructureSection>
-	<~~ref group="xtra">PMID:016008357<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Alvarez-Gutierrez, J M.]]		[[Category: Alvarez-Gutierrez, J M.]]
	[[Category: Ghadiri, M R.]]		[[Category: Ghadiri, M R.]]

OCA: Protected "1uny" [edit=sysop:move=sysop]

OCA — Sat, 05 Jan 2013 13:00:20 GMT

Protected "1uny" [edit=sysop:move=sysop]

←Older revision

Revision as of 13:00, 5 January 2013

OCA at 13:00, 5 January 2013

OCA — Sat, 05 Jan 2013 13:00:18 GMT

←Older revision		Revision as of 13:00, 5 January 2013
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-	{{Seed}}
	[[Image:1uny.png\|left\|200px]]		[[Image:1uny.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_1uny", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_1uny\| PDB=1uny \| SCENE= }}		{{STRUCTURE_1uny\| PDB=1uny \| SCENE= }}

	===STRUCTURE BASED ENGINEERING OF INTERNAL MOLECULAR SURFACES OF FOUR HELIX BUNDLES===		===STRUCTURE BASED ENGINEERING OF INTERNAL MOLECULAR SURFACES OF FOUR HELIX BUNDLES===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_16008357}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 16008357 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_16008357}}		{{ABSTRACT_PUBMED_16008357}}

	==About this Structure==		==About this Structure==
-	~~1UNY is a~~ [[~~Single protein~~]] structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UNY OCA].	+	[[1uny]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UNY OCA].

	==Reference==		==Reference==
-	~~Structure-based engineering of internal cavities in coiled-coil peptides., Yadav MK, Redman JE, Leman LJ, Alvarez-Gutierrez JM, Zhang Y, Stout CD, Ghadiri MR, Biochemistry. 2005 Jul 19;44(28):9723-32.~~ PMID:~~[http:~~//~~www.ncbi.nlm.nih.gov/pubmed/16008357 16008357]~~	+	<ref group="xtra">PMID:016008357</ref><references group="xtra"/>
-	~~[[Category: Single protein]]~~	+
	[[Category: Alvarez-Gutierrez, J M.]]		[[Category: Alvarez-Gutierrez, J M.]]
	[[Category: Ghadiri, M R.]]		[[Category: Ghadiri, M R.]]
Line 33:		Line 20:
	[[Category: Cavity]]		[[Category: Cavity]]
	[[Category: Four helix bundle]]		[[Category: Four helix bundle]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 12:33:22 2008''

OCA at 09:33, 28 July 2008

OCA — Mon, 28 Jul 2008 09:33:26 GMT

←Older revision		Revision as of 09:33, 28 July 2008
Line 1:		Line 1:
-	[[Image:1uny.~~gif~~\|left\|200px]]	+	{{Seed}}
		+	[[Image:1uny.png\|left\|200px]]

	<!--		<!--
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	{{STRUCTURE_1uny\| PDB=1uny \| SCENE= }}		{{STRUCTURE_1uny\| PDB=1uny \| SCENE= }}

-	~~'''~~STRUCTURE BASED ENGINEERING OF INTERNAL MOLECULAR SURFACES OF FOUR HELIX BUNDLES~~'''~~	+	===STRUCTURE BASED ENGINEERING OF INTERNAL MOLECULAR SURFACES OF FOUR HELIX BUNDLES===


-	~~==Overview==~~	+	<!--
-	Cavities and clefts are frequently important sites of interaction between natural enzymes or receptors and their corresponding substrate or ligand molecules and exemplify the types of molecular surfaces that would facilitate engineering of artificial catalysts and receptors. Even so, structural characterizations of designed cavities are rare. To address this ~~issue~~, ~~we performed a systematic study of the structural effects of single-amino acid substitutions within the hydrophobic cores of tetrameric coiled-coil peptides. Peptides containing single glycine~~, ~~serine, alanine, or threonine amino acid substitutions at~~ the ~~buried L9, L16, L23, and I26 hydrophobic core positions of a GCN4-based sequence were synthesized and studied by solution-phase and crystallographic techniques. All peptides adopt~~ the ~~expected tetrameric state and contain tunnels or internal cavities ranging in size from 80 to 370 A~~(3). Two closely related sequences containing an L16G substitution, one of which adopts an antiparallel configuration and one of which adopts a parallel configuration, illustrate that cavities of different volumes and shapes can be engineered from identical core substitutions. ~~Finally, we demonstrate that two of the peptides (L9G and L9A~~) ~~bind the small molecule iodobenzene when present during crystallization~~, ~~leaving~~ the ~~general peptide quaternary structure intact but altering the local peptide conformation and certain superhelical parameters~~. ~~These high~~-~~resolution descriptions of varied molecular surfaces within solvent~~-~~occluded internal cavities illustrate the breadth of design space available in even closely related peptides and offer valuable models for the engineering of de novo helical proteins.~~	+	The line below this paragraph, {{ABSTRACT_PUBMED_16008357}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 16008357 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_16008357}}

	==About this Structure==		==About this Structure==
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	[[Category: Cavity]]		[[Category: Cavity]]
	[[Category: Four helix bundle]]		[[Category: Four helix bundle]]
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Sat May 3 11~~:29:06 2008''	+
		+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 12:33:22 2008''