1uo5 - Revision history

OCA at 09:04, 9 May 2024

OCA — Thu, 09 May 2024 09:04:10 GMT

←Older revision		Revision as of 09:04, 9 May 2024
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1uo5]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UO5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1UO5 FirstGlance]. <br>		<table><tr><td colspan='2'>[[1uo5]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UO5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1UO5 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=PIH:IODOPHENYL'>PIH</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.07Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=PIH:IODOPHENYL'>PIH</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1uo5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1uo5 OCA], [https://pdbe.org/1uo5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1uo5 RCSB], [https://www.ebi.ac.uk/pdbsum/1uo5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1uo5 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1uo5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1uo5 OCA], [https://pdbe.org/1uo5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1uo5 RCSB], [https://www.ebi.ac.uk/pdbsum/1uo5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1uo5 ProSAT]</span></td></tr>
	</table>		</table>
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	==See Also==		==See Also==
		+	*[[Gcn4 3D Structures\|Gcn4 3D Structures]]
	*[[Gnc4 3D Structures\|Gnc4 3D Structures]]		*[[Gnc4 3D Structures\|Gnc4 3D Structures]]
	== References ==		== References ==

OCA at 06:38, 26 October 2022

OCA — Wed, 26 Oct 2022 06:38:05 GMT

←Older revision		Revision as of 06:38, 26 October 2022
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	<StructureSection load='1uo5' size='340' side='right'caption='[[1uo5]], [[Resolution\|resolution]] 2.07Å' scene=''>		<StructureSection load='1uo5' size='340' side='right'caption='[[1uo5]], [[Resolution\|resolution]] 2.07Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1uo5]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UO5 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=1UO5 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1uo5]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UO5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1UO5 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:~~CHLORIDE~~+~~ION~~'>CL</scene>, <scene name='pdbligand=~~PIH~~:~~IODOPHENYL~~'>~~PIH~~</scene>~~</td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=PIH:IODOPHENYL'>PIH</scene></td></tr>
-	~~<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat">~~<scene name='pdbligand=~~ACE~~:~~ACETYL+GROUP~~'>~~ACE~~</scene~~></td></tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1uo5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1uo5 OCA], [https://pdbe.org/1uo5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1uo5 RCSB], [https://www.ebi.ac.uk/pdbsum/1uo5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1uo5 ProSAT]</span></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1gcl\|1gcl]], [[1gcm\|1gcm]], [[1unt\|1unt]], [[1unv\|1unv]], [[1unw\|1unw]], [[1unx\|1unx]], [[1unu\|1unu]], [[1uny\|1uny]], [[1unz\|1unz]], [[1uo0\|1uo0]], [[1uo1\|1uo1]], [[1uo2\|1uo2]], [[1uo3\|1uo3]], [[1uo4\|1uo4]], [[1ce9\|1ce9]], [[1dgc\|1dgc]], [[1env\|1env]], [[1fav\|1fav]], [[1gk6\|1gk6]], [[1gzl\|1gzl]], [[1ihq\|1ihq]], [[1ij0\|1ij0]], [[1ij1\|1ij1]], [[1ij2\|1ij2]], [[1ij3\|1ij3]], [[1kql\|1kql]], [[1ld4\|1ld4]], [[1llm\|1llm]], [[1nkn\|1nkn]], [[1piq\|1piq]], [[1rb1\|1rb1]], [[1rb4\|1rb4]], [[1rb5\|1rb5]], [[1rb6\|1rb6]], [[1swi\|1swi]], [[1tmz\|1tmz]], [[1w5g\|1w5g]], [[1w5h\|1w5h]], [[1w5i\|1w5i]], [[1w5j\|1w5j]], [[1w5k\|1w5k]], [[1w5l\|1w5l]], [[1ysa\|1ysa]], [[1zii\|1zii]], [[1zij\|1zij]], [[1zik\|1zik]], [[1zil\|1zil]], [[1zim\|1zim]], [[1zta\|1zta]], [[2dgc\|2dgc]], [[2zta\|2zta]]</div></td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=1uo5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1uo5 OCA], [~~http~~://pdbe.org/1uo5 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1uo5 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1uo5 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1uo5 ProSAT]</span></td></tr>	+
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/GCN4_YEAST GCN4_YEAST] Is a transcription factor that is responsible for the activation of more than 30 genes required for amino acid or for purine biosynthesis in response to amino acid or purine starvation. Binds and recognize the DNA sequence: 5'-TGA[CG]TCA-3'.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Alvarez-Gutierrez~~, J M~~]]	+	[[Category: Saccharomyces cerevisiae]]
-	[[Category: Redman~~, J E~~]]	+	[[Category: Alvarez-Gutierrez JM]]
-	[[Category: Yadav~~, M K~~]]	+	[[Category: Redman JE]]
-	[[Category: Zhang, Y]]	+	[[Category: Yadav MK]]
-	~~[[Category: Cavity]]~~	+	[[Category: Zhang Y]]
-	~~[[Category: Four helix bundle]]~~	+
-	~~[[Category: Iodobenzene~~]]	+

OCA at 05:57, 20 January 2021

OCA — Wed, 20 Jan 2021 05:57:29 GMT

←Older revision		Revision as of 05:57, 20 January 2021
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	<StructureSection load='1uo5' size='340' side='right'caption='[[1uo5]], [[Resolution\|resolution]] 2.07Å' scene=''>		<StructureSection load='1uo5' size='340' side='right'caption='[[1uo5]], [[Resolution\|resolution]] 2.07Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1uo5]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UO5 OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1UO5 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1uo5]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UO5 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=1UO5 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=PIH:IODOPHENYL'>PIH</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=PIH:IODOPHENYL'>PIH</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1gcl\|1gcl]], [[1gcm\|1gcm]], [[1unt\|1unt]], [[1unv\|1unv]], [[1unw\|1unw]], [[1unx\|1unx]], [[1unu\|1unu]], [[1uny\|1uny]], [[1unz\|1unz]], [[1uo0\|1uo0]], [[1uo1\|1uo1]], [[1uo2\|1uo2]], [[1uo3\|1uo3]], [[1uo4\|1uo4]], [[1ce9\|1ce9]], [[1dgc\|1dgc]], [[1env\|1env]], [[1fav\|1fav]], [[1gk6\|1gk6]], [[1gzl\|1gzl]], [[1ihq\|1ihq]], [[1ij0\|1ij0]], [[1ij1\|1ij1]], [[1ij2\|1ij2]], [[1ij3\|1ij3]], [[1kql\|1kql]], [[1ld4\|1ld4]], [[1llm\|1llm]], [[1nkn\|1nkn]], [[1piq\|1piq]], [[1rb1\|1rb1]], [[1rb4\|1rb4]], [[1rb5\|1rb5]], [[1rb6\|1rb6]], [[1swi\|1swi]], [[1tmz\|1tmz]], [[1w5g\|1w5g]], [[1w5h\|1w5h]], [[1w5i\|1w5i]], [[1w5j\|1w5j]], [[1w5k\|1w5k]], [[1w5l\|1w5l]], [[1ysa\|1ysa]], [[1zii\|1zii]], [[1zij\|1zij]], [[1zik\|1zik]], [[1zil\|1zil]], [[1zim\|1zim]], [[1zta\|1zta]], [[2dgc\|2dgc]], [[2zta\|2zta]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1gcl\|1gcl]], [[1gcm\|1gcm]], [[1unt\|1unt]], [[1unv\|1unv]], [[1unw\|1unw]], [[1unx\|1unx]], [[1unu\|1unu]], [[1uny\|1uny]], [[1unz\|1unz]], [[1uo0\|1uo0]], [[1uo1\|1uo1]], [[1uo2\|1uo2]], [[1uo3\|1uo3]], [[1uo4\|1uo4]], [[1ce9\|1ce9]], [[1dgc\|1dgc]], [[1env\|1env]], [[1fav\|1fav]], [[1gk6\|1gk6]], [[1gzl\|1gzl]], [[1ihq\|1ihq]], [[1ij0\|1ij0]], [[1ij1\|1ij1]], [[1ij2\|1ij2]], [[1ij3\|1ij3]], [[1kql\|1kql]], [[1ld4\|1ld4]], [[1llm\|1llm]], [[1nkn\|1nkn]], [[1piq\|1piq]], [[1rb1\|1rb1]], [[1rb4\|1rb4]], [[1rb5\|1rb5]], [[1rb6\|1rb6]], [[1swi\|1swi]], [[1tmz\|1tmz]], [[1w5g\|1w5g]], [[1w5h\|1w5h]], [[1w5i\|1w5i]], [[1w5j\|1w5j]], [[1w5k\|1w5k]], [[1w5l\|1w5l]], [[1ysa\|1ysa]], [[1zii\|1zii]], [[1zij\|1zij]], [[1zik\|1zik]], [[1zil\|1zil]], [[1zim\|1zim]], [[1zta\|1zta]], [[2dgc\|2dgc]], [[2zta\|2zta]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1uo5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1uo5 OCA], [http://pdbe.org/1uo5 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1uo5 RCSB], [http://www.ebi.ac.uk/pdbsum/1uo5 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1uo5 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=1uo5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1uo5 OCA], [http://pdbe.org/1uo5 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1uo5 RCSB], [http://www.ebi.ac.uk/pdbsum/1uo5 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1uo5 ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	==See Also==		==See Also==
-	*[[~~Gcn4~~\|~~Gcn4~~]]	+	*[[Gnc4 3D Structures\|Gnc4 3D Structures]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 11:44, 10 May 2019

OCA — Fri, 10 May 2019 11:44:32 GMT

←Older revision		Revision as of 11:44, 10 May 2019
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	==Structure Based Engineering of Internal Molecular Surfaces Of Four Helix Bundles==		==Structure Based Engineering of Internal Molecular Surfaces Of Four Helix Bundles==
-	<StructureSection load='1uo5' size='340' side='right' caption='[[1uo5]], [[Resolution\|resolution]] 2.07Å' scene=''>	+	<StructureSection load='1uo5' size='340' side='right'caption='[[1uo5]], [[Resolution\|resolution]] 2.07Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1uo5]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UO5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1UO5 FirstGlance]. <br>		<table><tr><td colspan='2'>[[1uo5]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UO5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1UO5 FirstGlance]. <br>
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Alvarez-Gutierrez, J M]]		[[Category: Alvarez-Gutierrez, J M]]
	[[Category: Redman, J E]]		[[Category: Redman, J E]]

OCA at 07:52, 28 March 2018

OCA — Wed, 28 Mar 2018 07:52:39 GMT

←Older revision		Revision as of 07:52, 28 March 2018
Line 1:		Line 1:
-	==~~STRUCTURE BASED ENGINEERING OF INTERNAL MOLECULAR SURFACES OF FOUR HELIX BUNDLES~~==	+
		+	==Structure Based Engineering of Internal Molecular Surfaces Of Four Helix Bundles==
	<StructureSection load='1uo5' size='340' side='right' caption='[[1uo5]], [[Resolution\|resolution]] 2.07Å' scene=''>		<StructureSection load='1uo5' size='340' side='right' caption='[[1uo5]], [[Resolution\|resolution]] 2.07Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
Line 6:		Line 7:
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1gcl\|1gcl]], [[1gcm\|1gcm]], [[1unt\|1unt]], [[1unv\|1unv]], [[1unw\|1unw]], [[1unx\|1unx]], [[1unu\|1unu]], [[1uny\|1uny]], [[1unz\|1unz]], [[1uo0\|1uo0]], [[1uo1\|1uo1]], [[1uo2\|1uo2]], [[1uo3\|1uo3]], [[1uo4\|1uo4]], [[1ce9\|1ce9]], [[1dgc\|1dgc]], [[1env\|1env]], [[1fav\|1fav]], [[1gk6\|1gk6]], [[1gzl\|1gzl]], [[1ihq\|1ihq]], [[1ij0\|1ij0]], [[1ij1\|1ij1]], [[1ij2\|1ij2]], [[1ij3\|1ij3]], [[1kql\|1kql]], [[1ld4\|1ld4]], [[1llm\|1llm]], [[1nkn\|1nkn]], [[1piq\|1piq]], [[1rb1\|1rb1]], [[1rb4\|1rb4]], [[1rb5\|1rb5]], [[1rb6\|1rb6]], [[1swi\|1swi]], [[1tmz\|1tmz]], [[1w5g\|1w5g]], [[1w5h\|1w5h]], [[1w5i\|1w5i]], [[1w5j\|1w5j]], [[1w5k\|1w5k]], [[1w5l\|1w5l]], [[1ysa\|1ysa]], [[1zii\|1zii]], [[1zij\|1zij]], [[1zik\|1zik]], [[1zil\|1zil]], [[1zim\|1zim]], [[1zta\|1zta]], [[2dgc\|2dgc]], [[2zta\|2zta]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1gcl\|1gcl]], [[1gcm\|1gcm]], [[1unt\|1unt]], [[1unv\|1unv]], [[1unw\|1unw]], [[1unx\|1unx]], [[1unu\|1unu]], [[1uny\|1uny]], [[1unz\|1unz]], [[1uo0\|1uo0]], [[1uo1\|1uo1]], [[1uo2\|1uo2]], [[1uo3\|1uo3]], [[1uo4\|1uo4]], [[1ce9\|1ce9]], [[1dgc\|1dgc]], [[1env\|1env]], [[1fav\|1fav]], [[1gk6\|1gk6]], [[1gzl\|1gzl]], [[1ihq\|1ihq]], [[1ij0\|1ij0]], [[1ij1\|1ij1]], [[1ij2\|1ij2]], [[1ij3\|1ij3]], [[1kql\|1kql]], [[1ld4\|1ld4]], [[1llm\|1llm]], [[1nkn\|1nkn]], [[1piq\|1piq]], [[1rb1\|1rb1]], [[1rb4\|1rb4]], [[1rb5\|1rb5]], [[1rb6\|1rb6]], [[1swi\|1swi]], [[1tmz\|1tmz]], [[1w5g\|1w5g]], [[1w5h\|1w5h]], [[1w5i\|1w5i]], [[1w5j\|1w5j]], [[1w5k\|1w5k]], [[1w5l\|1w5l]], [[1ysa\|1ysa]], [[1zii\|1zii]], [[1zij\|1zij]], [[1zik\|1zik]], [[1zil\|1zil]], [[1zim\|1zim]], [[1zta\|1zta]], [[2dgc\|2dgc]], [[2zta\|2zta]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1uo5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1uo5 OCA], [http://pdbe.org/1uo5 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1uo5 RCSB], [http://www.ebi.ac.uk/pdbsum/1uo5 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1uo5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1uo5 OCA], [http://pdbe.org/1uo5 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1uo5 RCSB], [http://www.ebi.ac.uk/pdbsum/1uo5 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1uo5 ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 22:54, 9 September 2015

OCA — Wed, 09 Sep 2015 22:54:55 GMT

←Older revision		Revision as of 22:54, 9 September 2015
Line 6:		Line 6:
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1gcl\|1gcl]], [[1gcm\|1gcm]], [[1unt\|1unt]], [[1unv\|1unv]], [[1unw\|1unw]], [[1unx\|1unx]], [[1unu\|1unu]], [[1uny\|1uny]], [[1unz\|1unz]], [[1uo0\|1uo0]], [[1uo1\|1uo1]], [[1uo2\|1uo2]], [[1uo3\|1uo3]], [[1uo4\|1uo4]], [[1ce9\|1ce9]], [[1dgc\|1dgc]], [[1env\|1env]], [[1fav\|1fav]], [[1gk6\|1gk6]], [[1gzl\|1gzl]], [[1ihq\|1ihq]], [[1ij0\|1ij0]], [[1ij1\|1ij1]], [[1ij2\|1ij2]], [[1ij3\|1ij3]], [[1kql\|1kql]], [[1ld4\|1ld4]], [[1llm\|1llm]], [[1nkn\|1nkn]], [[1piq\|1piq]], [[1rb1\|1rb1]], [[1rb4\|1rb4]], [[1rb5\|1rb5]], [[1rb6\|1rb6]], [[1swi\|1swi]], [[1tmz\|1tmz]], [[1w5g\|1w5g]], [[1w5h\|1w5h]], [[1w5i\|1w5i]], [[1w5j\|1w5j]], [[1w5k\|1w5k]], [[1w5l\|1w5l]], [[1ysa\|1ysa]], [[1zii\|1zii]], [[1zij\|1zij]], [[1zik\|1zik]], [[1zil\|1zil]], [[1zim\|1zim]], [[1zta\|1zta]], [[2dgc\|2dgc]], [[2zta\|2zta]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1gcl\|1gcl]], [[1gcm\|1gcm]], [[1unt\|1unt]], [[1unv\|1unv]], [[1unw\|1unw]], [[1unx\|1unx]], [[1unu\|1unu]], [[1uny\|1uny]], [[1unz\|1unz]], [[1uo0\|1uo0]], [[1uo1\|1uo1]], [[1uo2\|1uo2]], [[1uo3\|1uo3]], [[1uo4\|1uo4]], [[1ce9\|1ce9]], [[1dgc\|1dgc]], [[1env\|1env]], [[1fav\|1fav]], [[1gk6\|1gk6]], [[1gzl\|1gzl]], [[1ihq\|1ihq]], [[1ij0\|1ij0]], [[1ij1\|1ij1]], [[1ij2\|1ij2]], [[1ij3\|1ij3]], [[1kql\|1kql]], [[1ld4\|1ld4]], [[1llm\|1llm]], [[1nkn\|1nkn]], [[1piq\|1piq]], [[1rb1\|1rb1]], [[1rb4\|1rb4]], [[1rb5\|1rb5]], [[1rb6\|1rb6]], [[1swi\|1swi]], [[1tmz\|1tmz]], [[1w5g\|1w5g]], [[1w5h\|1w5h]], [[1w5i\|1w5i]], [[1w5j\|1w5j]], [[1w5k\|1w5k]], [[1w5l\|1w5l]], [[1ysa\|1ysa]], [[1zii\|1zii]], [[1zij\|1zij]], [[1zik\|1zik]], [[1zil\|1zil]], [[1zim\|1zim]], [[1zta\|1zta]], [[2dgc\|2dgc]], [[2zta\|2zta]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1uo5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1uo5 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1uo5 RCSB], [http://www.ebi.ac.uk/pdbsum/1uo5 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1uo5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1uo5 OCA], [http://pdbe.org/1uo5 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1uo5 RCSB], [http://www.ebi.ac.uk/pdbsum/1uo5 PDBsum]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 16:		Line 16:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1uo5" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==

OCA at 16:38, 15 January 2015

OCA — Thu, 15 Jan 2015 16:38:03 GMT

←Older revision		Revision as of 16:38, 15 January 2015
Line 23:		Line 23:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Alvarez-Gutierrez, J M.]]	+	[[Category: Alvarez-Gutierrez, J M]]
-	[[Category: Redman, J E.]]	+	[[Category: Redman, J E]]
-	[[Category: Yadav, M K.]]	+	[[Category: Yadav, M K]]
-	[[Category: Zhang, Y.]]	+	[[Category: Zhang, Y]]
	[[Category: Cavity]]		[[Category: Cavity]]
	[[Category: Four helix bundle]]		[[Category: Four helix bundle]]
	[[Category: Iodobenzene]]		[[Category: Iodobenzene]]

OCA at 08:33, 8 October 2014

OCA — Wed, 08 Oct 2014 08:33:54 GMT

←Older revision		Revision as of 08:33, 8 October 2014
Line 1:		Line 1:
-	[[~~Image:~~1uo5.~~png~~\|~~left~~\|~~200px~~]]	+	==STRUCTURE BASED ENGINEERING OF INTERNAL MOLECULAR SURFACES OF FOUR HELIX BUNDLES==
		+	<StructureSection load='1uo5' size='340' side='right' caption='[[1uo5]], [[Resolution\|resolution]] 2.07Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1uo5]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UO5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1UO5 FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=PIH:IODOPHENYL'>PIH</scene></td></tr>
		+	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1gcl\|1gcl]], [[1gcm\|1gcm]], [[1unt\|1unt]], [[1unv\|1unv]], [[1unw\|1unw]], [[1unx\|1unx]], [[1unu\|1unu]], [[1uny\|1uny]], [[1unz\|1unz]], [[1uo0\|1uo0]], [[1uo1\|1uo1]], [[1uo2\|1uo2]], [[1uo3\|1uo3]], [[1uo4\|1uo4]], [[1ce9\|1ce9]], [[1dgc\|1dgc]], [[1env\|1env]], [[1fav\|1fav]], [[1gk6\|1gk6]], [[1gzl\|1gzl]], [[1ihq\|1ihq]], [[1ij0\|1ij0]], [[1ij1\|1ij1]], [[1ij2\|1ij2]], [[1ij3\|1ij3]], [[1kql\|1kql]], [[1ld4\|1ld4]], [[1llm\|1llm]], [[1nkn\|1nkn]], [[1piq\|1piq]], [[1rb1\|1rb1]], [[1rb4\|1rb4]], [[1rb5\|1rb5]], [[1rb6\|1rb6]], [[1swi\|1swi]], [[1tmz\|1tmz]], [[1w5g\|1w5g]], [[1w5h\|1w5h]], [[1w5i\|1w5i]], [[1w5j\|1w5j]], [[1w5k\|1w5k]], [[1w5l\|1w5l]], [[1ysa\|1ysa]], [[1zii\|1zii]], [[1zij\|1zij]], [[1zik\|1zik]], [[1zil\|1zil]], [[1zim\|1zim]], [[1zta\|1zta]], [[2dgc\|2dgc]], [[2zta\|2zta]]</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1uo5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1uo5 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1uo5 RCSB], [http://www.ebi.ac.uk/pdbsum/1uo5 PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Cavities and clefts are frequently important sites of interaction between natural enzymes or receptors and their corresponding substrate or ligand molecules and exemplify the types of molecular surfaces that would facilitate engineering of artificial catalysts and receptors. Even so, structural characterizations of designed cavities are rare. To address this issue, we performed a systematic study of the structural effects of single-amino acid substitutions within the hydrophobic cores of tetrameric coiled-coil peptides. Peptides containing single glycine, serine, alanine, or threonine amino acid substitutions at the buried L9, L16, L23, and I26 hydrophobic core positions of a GCN4-based sequence were synthesized and studied by solution-phase and crystallographic techniques. All peptides adopt the expected tetrameric state and contain tunnels or internal cavities ranging in size from 80 to 370 A(3). Two closely related sequences containing an L16G substitution, one of which adopts an antiparallel configuration and one of which adopts a parallel configuration, illustrate that cavities of different volumes and shapes can be engineered from identical core substitutions. Finally, we demonstrate that two of the peptides (L9G and L9A) bind the small molecule iodobenzene when present during crystallization, leaving the general peptide quaternary structure intact but altering the local peptide conformation and certain superhelical parameters. These high-resolution descriptions of varied molecular surfaces within solvent-occluded internal cavities illustrate the breadth of design space available in even closely related peptides and offer valuable models for the engineering of de novo helical proteins.

-	~~{{STRUCTURE_1uo5\| PDB=1uo5 \| SCENE= }}~~	+	Structure-based engineering of internal cavities in coiled-coil peptides.,Yadav MK, Redman JE, Leman LJ, Alvarez-Gutierrez JM, Zhang Y, Stout CD, Ghadiri MR Biochemistry. 2005 Jul 19;44(28):9723-32. PMID:16008357<ref>PMID:16008357</ref>

-	~~===STRUCTURE BASED ENGINEERING OF INTERNAL MOLECULAR SURFACES OF FOUR HELIX BUNDLES===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>

-	~~{{ABSTRACT_PUBMED_16008357}}~~	+	==See Also==
-		+	*[[Gcn4\|Gcn4]]
-	==~~About this Structure~~==	+	== References ==
-	[[~~1uo5~~]] ~~is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UO5 OCA].~~	+	<references/>
-		+	__TOC__
-	==~~Reference~~==	+	</StructureSection>
-	<~~ref group="xtra">PMID:016008357<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Alvarez-Gutierrez, J M.]]		[[Category: Alvarez-Gutierrez, J M.]]
	[[Category: Redman, J E.]]		[[Category: Redman, J E.]]

OCA: Protected "1uo5" [edit=sysop:move=sysop]

OCA — Sat, 05 Jan 2013 12:42:04 GMT

Protected "1uo5" [edit=sysop:move=sysop]

←Older revision

Revision as of 12:42, 5 January 2013

OCA at 12:42, 5 January 2013

OCA — Sat, 05 Jan 2013 12:42:01 GMT

←Older revision		Revision as of 12:42, 5 January 2013
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-	{{Seed}}
	[[Image:1uo5.png\|left\|200px]]		[[Image:1uo5.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_1uo5", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_1uo5\| PDB=1uo5 \| SCENE= }}		{{STRUCTURE_1uo5\| PDB=1uo5 \| SCENE= }}

	===STRUCTURE BASED ENGINEERING OF INTERNAL MOLECULAR SURFACES OF FOUR HELIX BUNDLES===		===STRUCTURE BASED ENGINEERING OF INTERNAL MOLECULAR SURFACES OF FOUR HELIX BUNDLES===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_16008357}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 16008357 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_16008357}}		{{ABSTRACT_PUBMED_16008357}}

	==About this Structure==		==About this Structure==
-	~~1UO5 is a~~ [[~~Single protein~~]] structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UO5 OCA].	+	[[1uo5]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UO5 OCA].

	==Reference==		==Reference==
-	~~Structure-based engineering of internal cavities in coiled-coil peptides., Yadav MK, Redman JE, Leman LJ, Alvarez-Gutierrez JM, Zhang Y, Stout CD, Ghadiri MR, Biochemistry. 2005 Jul 19;44(28):9723-32.~~ PMID:~~[http:~~//~~www.ncbi.nlm.nih.gov/pubmed/16008357 16008357]~~	+	<ref group="xtra">PMID:016008357</ref><references group="xtra"/>
-	~~[[Category: Single protein]]~~	+
	[[Category: Alvarez-Gutierrez, J M.]]		[[Category: Alvarez-Gutierrez, J M.]]
	[[Category: Redman, J E.]]		[[Category: Redman, J E.]]
Line 32:		Line 19:
	[[Category: Four helix bundle]]		[[Category: Four helix bundle]]
	[[Category: Iodobenzene]]		[[Category: Iodobenzene]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 14:15:06 2008''