1uqr - Revision history

OCA at 09:04, 9 May 2024

OCA — Thu, 09 May 2024 09:04:41 GMT

←Older revision		Revision as of 09:04, 9 May 2024
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	<StructureSection load='1uqr' size='340' side='right'caption='[[1uqr]], [[Resolution\|resolution]] 1.70Å' scene=''>		<StructureSection load='1uqr' size='340' side='right'caption='[[1uqr]], [[Resolution\|resolution]] 1.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1uqr]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Actpl Actpl~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UQR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1UQR FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1uqr]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Actinobacillus_pleuropneumoniae Actinobacillus pleuropneumoniae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UQR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1UQR FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>~~, ~~<scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-~~1~~,3-DIOL'>TRS</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.7Å</td></tr>
-	<tr id='~~activity~~'><td class="sblockLbl"><b>~~Activity~~:</b></td><td class="sblockDat"><~~span class~~='~~plainlinks~~'>~~[https:~~/~~/en.wikipedia.org/wiki/3-dehydroquinate_dehydratase 3-dehydroquinate dehydratase]~~, ~~with EC number [https~~:~~//www.brenda~~-~~enzymes.info/php/result_flat.php4?ecno=4.~~2.1~~.10 4.2.1.10]~~ </~~span~~></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1uqr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1uqr OCA], [https://pdbe.org/1uqr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1uqr RCSB], [https://www.ebi.ac.uk/pdbsum/1uqr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1uqr ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1uqr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1uqr OCA], [https://pdbe.org/1uqr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1uqr RCSB], [https://www.ebi.ac.uk/pdbsum/1uqr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1uqr ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/AROQ_ACTPL AROQ_ACTPL]] Catalyzes a trans-dehydration via an enolate intermediate (By similarity).[HAMAP-Rule:MF_00169]	+	[https://www.uniprot.org/uniprot/AROQ_ACTPL AROQ_ACTPL] Catalyzes a trans-dehydration via an enolate intermediate (By similarity).[HAMAP-Rule:MF_00169]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~3-dehydroquinate dehydratase]]~~	+	[[Category: Actinobacillus pleuropneumoniae]]
-	~~[[Category: Actpl~~]]	+
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Afonina, E]]	+	[[Category: Afonina E]]
-	[[Category: Bondt, H De]]	+	[[Category: De Bondt H]]
-	[[Category: Garcia-Ruiz~~, J M~~]]	+	[[Category: Garcia-Ruiz JM]]
-	[[Category: Gonzalez-Ramirez~~, L A~~]]	+	[[Category: Gonzalez-Ramirez LA]]
-	[[Category: Gulnik, S]]	+	[[Category: Gulnik S]]
-	[[Category: Lopez-Jaramillo, J]]	+	[[Category: Lopez-Jaramillo J]]
-	[[Category: Maes, D]]	+	[[Category: Maes D]]
-	[[Category: Yu, B]]	+	[[Category: Yu B]]
-	[[Category: Zegers, I]]	+	[[Category: Zegers I]]
-	~~[[Category: Aromatic amino acid biosynthesis]]~~	+
-	~~[[Category: Lyase]]~~	+
-	~~[[Category: Shikimate pathway~~]]	+

OCA at 06:04, 28 April 2021

OCA — Wed, 28 Apr 2021 06:04:59 GMT

←Older revision		Revision as of 06:04, 28 April 2021
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	<StructureSection load='1uqr' size='340' side='right'caption='[[1uqr]], [[Resolution\|resolution]] 1.70Å' scene=''>		<StructureSection load='1uqr' size='340' side='right'caption='[[1uqr]], [[Resolution\|resolution]] 1.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1uqr]] is a 12 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Actpl Actpl]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UQR OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1UQR FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1uqr]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Actpl Actpl]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UQR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1UQR FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/3-dehydroquinate_dehydratase 3-dehydroquinate dehydratase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.10 4.2.1.10] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/3-dehydroquinate_dehydratase 3-dehydroquinate dehydratase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.10 4.2.1.10] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1uqr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1uqr OCA], [~~http~~://pdbe.org/1uqr PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1uqr RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1uqr PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1uqr ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1uqr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1uqr OCA], [https://pdbe.org/1uqr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1uqr RCSB], [https://www.ebi.ac.uk/pdbsum/1uqr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1uqr ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/AROQ_ACTPL AROQ_ACTPL]] Catalyzes a trans-dehydration via an enolate intermediate (By similarity).[HAMAP-Rule:MF_00169]	+	[[https://www.uniprot.org/uniprot/AROQ_ACTPL AROQ_ACTPL]] Catalyzes a trans-dehydration via an enolate intermediate (By similarity).[HAMAP-Rule:MF_00169]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 07:04, 24 July 2019

OCA — Wed, 24 Jul 2019 07:04:11 GMT

←Older revision		Revision as of 07:04, 24 July 2019
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	==Type II 3-dehydroquinate dehydratase (DHQase) from Actinobacillus pleuropneumoniae==		==Type II 3-dehydroquinate dehydratase (DHQase) from Actinobacillus pleuropneumoniae==
-	<StructureSection load='1uqr' size='340' side='right' caption='[[1uqr]], [[Resolution\|resolution]] 1.70Å' scene=''>	+	<StructureSection load='1uqr' size='340' side='right'caption='[[1uqr]], [[Resolution\|resolution]] 1.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1uqr]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/Actpl Actpl]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UQR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1UQR FirstGlance]. <br>		<table><tr><td colspan='2'>[[1uqr]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/Actpl Actpl]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UQR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1UQR FirstGlance]. <br>
Line 31:		Line 31:

	==See Also==		==See Also==
-	*[[Dehydroquinase\|Dehydroquinase]]	+	*[[Dehydroquinase 3D structures\|Dehydroquinase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 38:		Line 38:
	[[Category: 3-dehydroquinate dehydratase]]		[[Category: 3-dehydroquinate dehydratase]]
	[[Category: Actpl]]		[[Category: Actpl]]
		+	[[Category: Large Structures]]
	[[Category: Afonina, E]]		[[Category: Afonina, E]]
	[[Category: Bondt, H De]]		[[Category: Bondt, H De]]

OCA at 07:51, 28 March 2018

OCA — Wed, 28 Mar 2018 07:51:51 GMT

←Older revision		Revision as of 07:51, 28 March 2018
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-	==~~TYPE~~ II 3-~~DEHYDROQUINATE DEHYDRATASE~~ (~~DHQASE~~) ~~FROM ACTINOBACILLUS PLEUROPNEUMONIAE~~==	+
		+	==Type II 3-dehydroquinate dehydratase (DHQase) from Actinobacillus pleuropneumoniae==
	<StructureSection load='1uqr' size='340' side='right' caption='[[1uqr]], [[Resolution\|resolution]] 1.70Å' scene=''>		<StructureSection load='1uqr' size='340' side='right' caption='[[1uqr]], [[Resolution\|resolution]] 1.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
Line 5:		Line 6:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene></td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/3-dehydroquinate_dehydratase 3-dehydroquinate dehydratase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.10 4.2.1.10] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/3-dehydroquinate_dehydratase 3-dehydroquinate dehydratase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.10 4.2.1.10] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1uqr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1uqr OCA], [http://pdbe.org/1uqr PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1uqr RCSB], [http://www.ebi.ac.uk/pdbsum/1uqr PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1uqr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1uqr OCA], [http://pdbe.org/1uqr PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1uqr RCSB], [http://www.ebi.ac.uk/pdbsum/1uqr PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1uqr ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/uq/1uqr_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/uq/1uqr_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 18:41, 7 February 2016

OCA — Sun, 07 Feb 2016 18:41:16 GMT

←Older revision		Revision as of 18:41, 7 February 2016
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	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1uqr ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 04:08, 10 September 2015

OCA — Thu, 10 Sep 2015 04:08:34 GMT

←Older revision		Revision as of 04:08, 10 September 2015
Line 2:		Line 2:
	<StructureSection load='1uqr' size='340' side='right' caption='[[1uqr]], [[Resolution\|resolution]] 1.70Å' scene=''>		<StructureSection load='1uqr' size='340' side='right' caption='[[1uqr]], [[Resolution\|resolution]] 1.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1uqr]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Actinobacillus_pleuropneumoniae Actinobacillus pleuropneumoniae~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UQR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1UQR FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1uqr]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/Actpl Actpl]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UQR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1UQR FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene></td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/3-dehydroquinate_dehydratase 3-dehydroquinate dehydratase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.10 4.2.1.10] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/3-dehydroquinate_dehydratase 3-dehydroquinate dehydratase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.10 4.2.1.10] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1uqr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1uqr OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1uqr RCSB], [http://www.ebi.ac.uk/pdbsum/1uqr PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1uqr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1uqr OCA], [http://pdbe.org/1uqr PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1uqr RCSB], [http://www.ebi.ac.uk/pdbsum/1uqr PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1uqr" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 35:		Line 36:
	</StructureSection>		</StructureSection>
	[[Category: 3-dehydroquinate dehydratase]]		[[Category: 3-dehydroquinate dehydratase]]
-	[[Category: ~~Actinobacillus pleuropneumoniae~~]]	+	[[Category: Actpl]]
	[[Category: Afonina, E]]		[[Category: Afonina, E]]
	[[Category: Bondt, H De]]		[[Category: Bondt, H De]]

OCA at 17:31, 24 December 2014

OCA — Wed, 24 Dec 2014 17:31:03 GMT

←Older revision		Revision as of 17:31, 24 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1uqr]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/Actinobacillus_pleuropneumoniae Actinobacillus pleuropneumoniae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UQR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1UQR FirstGlance]. <br>		<table><tr><td colspan='2'>[[1uqr]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/Actinobacillus_pleuropneumoniae Actinobacillus pleuropneumoniae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UQR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1UQR FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene></td></tr>
-	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/3-dehydroquinate_dehydratase 3-dehydroquinate dehydratase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.10 4.2.1.10] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/3-dehydroquinate_dehydratase 3-dehydroquinate dehydratase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.10 4.2.1.10] </span></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1uqr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1uqr OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1uqr RCSB], [http://www.ebi.ac.uk/pdbsum/1uqr PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1uqr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1uqr OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1uqr RCSB], [http://www.ebi.ac.uk/pdbsum/1uqr PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/AROQ_ACTPL AROQ_ACTPL]] Catalyzes a trans-dehydration via an enolate intermediate (By similarity).[HAMAP-Rule:MF_00169]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 34:		Line 36:
	[[Category: 3-dehydroquinate dehydratase]]		[[Category: 3-dehydroquinate dehydratase]]
	[[Category: Actinobacillus pleuropneumoniae]]		[[Category: Actinobacillus pleuropneumoniae]]
-	[[Category: Afonina, E.]]	+	[[Category: Afonina, E]]
-	[[Category: Bondt, H De.]]	+	[[Category: Bondt, H De]]
-	[[Category: Garcia-Ruiz, J M.]]	+	[[Category: Garcia-Ruiz, J M]]
-	[[Category: Gonzalez-Ramirez, L A.]]	+	[[Category: Gonzalez-Ramirez, L A]]
-	[[Category: Gulnik, S.]]	+	[[Category: Gulnik, S]]
-	[[Category: Lopez-Jaramillo, J.]]	+	[[Category: Lopez-Jaramillo, J]]
-	[[Category: Maes, D.]]	+	[[Category: Maes, D]]
-	[[Category: Yu, B.]]	+	[[Category: Yu, B]]
-	[[Category: Zegers, I.]]	+	[[Category: Zegers, I]]
	[[Category: Aromatic amino acid biosynthesis]]		[[Category: Aromatic amino acid biosynthesis]]
	[[Category: Lyase]]		[[Category: Lyase]]
	[[Category: Shikimate pathway]]		[[Category: Shikimate pathway]]

OCA at 18:33, 29 September 2014

OCA — Mon, 29 Sep 2014 18:33:34 GMT

←Older revision		Revision as of 18:33, 29 September 2014
Line 1:		Line 1:
-	[[~~Image~~:1uqr.~~png\|left~~\|200px]]	+	==TYPE II 3-DEHYDROQUINATE DEHYDRATASE (DHQASE) FROM ACTINOBACILLUS PLEUROPNEUMONIAE==
		+	<StructureSection load='1uqr' size='340' side='right' caption='[[1uqr]], [[Resolution\|resolution]] 1.70Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1uqr]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/Actinobacillus_pleuropneumoniae Actinobacillus pleuropneumoniae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UQR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1UQR FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene><br>
		+	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/3-dehydroquinate_dehydratase 3-dehydroquinate dehydratase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.10 4.2.1.10] </span></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1uqr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1uqr OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1uqr RCSB], [http://www.ebi.ac.uk/pdbsum/1uqr PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/uq/1uqr_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The structure of the type II dehydroquinate dehydratase (DHQase) from Actinobacillus pleuropneumoniae, the third enzyme of the shikimate pathway, has been determined. Crystals diffracting to 1.7 A were obtained in space and on earth using the counter-diffusion technique. The structure was solved using molecular replacement and refined to high resolution. The overall structure of the dodecameric enzyme is described and compared with structures of DHQases from other bacteria. DHQases contain a flexible loop that presumably closes over the active site upon substrate binding. The enzyme can exist in an open or closed conformation. The present structure displays the open conformation, with a sulfate anion bound in the active site. The availability of this structure opens a route to structure-based antibiotics targetting this pathogenic bacterium.

-	~~{{STRUCTURE_1uqr\| PDB=1uqr \| SCENE= }}~~	+	Structural study of the type II 3-dehydroquinate dehydratase from Actinobacillus pleuropneumoniae.,Maes D, Gonzalez-Ramirez LA, Lopez-Jaramillo J, Yu B, De Bondt H, Zegers I, Afonina E, Garcia-Ruiz JM, Gulnik S Acta Crystallogr D Biol Crystallogr. 2004 Mar;60(Pt 3):463-71. Epub 2004, Feb 25. PMID:14993670<ref>PMID:14993670</ref>

-	~~===TYPE II 3-DEHYDROQUINATE DEHYDRATASE (DHQASE) FROM ACTINOBACILLUS PLEUROPNEUMONIAE===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>

-	~~{{ABSTRACT_PUBMED_14993670}}~~	+	==See Also==
-		+	*[[Dehydroquinase\|Dehydroquinase]]
-	==~~About this Structure~~==	+	== References ==
-	[[~~1uqr~~]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/Actinobacillus_pleuropneumoniae Actinobacillus pleuropneumoniae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UQR OCA].	+	<references/>
-		+	__TOC__
-	==~~Reference~~==	+	</StructureSection>
-	<~~ref group="xtra">PMID:014993670<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: 3-dehydroquinate dehydratase]]		[[Category: 3-dehydroquinate dehydratase]]
	[[Category: Actinobacillus pleuropneumoniae]]		[[Category: Actinobacillus pleuropneumoniae]]

OCA: Protected "1uqr" [edit=sysop:move=sysop]

OCA — Sat, 05 Jan 2013 11:13:23 GMT

Protected "1uqr" [edit=sysop:move=sysop]

←Older revision

Revision as of 11:13, 5 January 2013

OCA at 11:13, 5 January 2013

OCA — Sat, 05 Jan 2013 11:13:19 GMT

←Older revision		Revision as of 11:13, 5 January 2013
Line 1:		Line 1:
-	{{Seed}}
	[[Image:1uqr.png\|left\|200px]]		[[Image:1uqr.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_1uqr", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
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	{{STRUCTURE_1uqr\| PDB=1uqr \| SCENE= }}		{{STRUCTURE_1uqr\| PDB=1uqr \| SCENE= }}

	===TYPE II 3-DEHYDROQUINATE DEHYDRATASE (DHQASE) FROM ACTINOBACILLUS PLEUROPNEUMONIAE===		===TYPE II 3-DEHYDROQUINATE DEHYDRATASE (DHQASE) FROM ACTINOBACILLUS PLEUROPNEUMONIAE===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_14993670}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 14993670 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_14993670}}		{{ABSTRACT_PUBMED_14993670}}

	==About this Structure==		==About this Structure==
-	~~1UQR~~ is a 12 ~~chains~~ structure ~~of sequences~~ from [http://en.wikipedia.org/wiki/Actinobacillus_pleuropneumoniae Actinobacillus pleuropneumoniae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UQR OCA].	+	[[1uqr]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/Actinobacillus_pleuropneumoniae Actinobacillus pleuropneumoniae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UQR OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~14993670~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:014993670</ref><references group="xtra"/>
	[[Category: 3-dehydroquinate dehydratase]]		[[Category: 3-dehydroquinate dehydratase]]
	[[Category: Actinobacillus pleuropneumoniae]]		[[Category: Actinobacillus pleuropneumoniae]]
Line 38:		Line 26:
	[[Category: Lyase]]		[[Category: Lyase]]
	[[Category: Shikimate pathway]]		[[Category: Shikimate pathway]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 15:49:48 2009''